Papers -
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Miyazaki, H., Takaishi, H., Ikeda, H., Ariumi, H., Hamada, Y., Yamashita, K., Usui, K.
Processes 8 2020
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Effect of tryptophan residues on gold mineralization by a gold reducing peptide Reviewed
Ozaki, M., Yoshida, S., Oura, M., Tsuruoka, T., Usui, K.
RSC Advances 10 2020
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Bioinspired cell nuclear nanotransporters generated by self‐assembly of amphiphilic polysaccharide‐amino acid derivatives conjugates Reviewed
Koji Nagahama, Yoshinori Sano, Mitsuo Inui, Seika Aoyama, Tokitaka Katayama, Kimika Ono
Advanced Biosystems 4 1900189 2020
Joint Work
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美容医療 new horizon －幹細胞への期待－ Invited Reviewed
市橋正光、長濱宏治
日本香粧品学会誌 44 30 - 35 2020
Joint Work
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細胞移植用インジェクタブルゲルの開発 Invited Reviewed
長濱宏治
Precision Medicine 3 724 - 728 2020
Single Work
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A thin hydrogel barrier linked onto cell surface sialic acids through covalent bonds induces cancer cell death in vivo Reviewed
Kimika Ono, Yuka Sanada, Yuka Kimura, Seika Aoyama, Natsumi Ueda, Tokitaka Katayama, Koji Nagahama
Biomaterials Science 8 577 - 585 2020
Joint Work
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Yohei Takashima, Yasushi Sato, Takaaki Tsuruoka, Kensuke Akamatsu
Dalton Transactions 49 ( 47 ) 17169 - 17172 2020
Joint Work
Publisher：Royal Society of Chemistry ({RSC})
<p>In this work, by using a series of amine–boranes as vapour phase reductants, we succeeded in synthesizing Ag nanoparticles in a controlled manner inside MOFs.</p>
DOI： 10.1039/D0DT03259J
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Effect of tryptophan residues on gold mineralization by a gold reducing peptide
Makoto Ozaki, Shuhei Yoshida, Maho Oura, Takaaki Tsuruoka, Kenji Usui
RSC Advances 2020
Joint Work
DOI： 10.1039/D0RA07098J
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Flexible and luminescent fibers of a 1D Au(i)–thiophenolate coordination polymer and formation of gold nanoparticle-based composite materials for SERS
Shefali Vaidya, Oleksandra Veselska, Antonii Zhadan, Marlène Daniel, Gilles Ledoux, Alexandra Fateeva, Takaaki Tsuruoka, Aude Demessence
Journal of Materials Chemistry C 2020
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Y. Takashima, Y. Sato, T. Tsuruoka, K. Akamatsu
Dalton Trans 49 ( 47 ) 17169 - 17172 2020
Joint Work
Authorship：Lead author, Corresponding author Publisher：Royal Society of Chemistry (RSC)
<p>In this work, by using a series of amine–boranes as vapour phase reductants, we succeeded in synthesizing Ag nanoparticles in a controlled manner inside MOFs.</p>
DOI： 10.1039/d0dt03259j
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Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in beta-(1,3-1,6)-d-Glucan with On-Off Switch Reviewed International journal
Shodai Hino, Shuhei Satake, Hideyuki Shinmori, Shigeki Kawabata, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Kouta Sugikawa, Riku Kawasaki, Atsushi Ikeda
CHEMISTRY-AN ASIAN JOURNAL 15 ( 3 ) 365 - 370 2019.12
Joint Work
Publisher：WILEY-V C H VERLAG GMBH
5,15-Diazaporphyrins, which have a large absorption at wavelengths over 600 nm, were dissolved in water by complex formation with beta-(1,3-1,6)-d-glucans. Aqueous solutions of these complexes were relatively stable compared with their trimethyl-beta-cyclodextrin-complexed analogues. beta-Glucan-complexed diazaporphyrins showed quenched fluorescence and had low singlet-oxygen-generation abilities owing to random self-aggregation. However, external stimuli, such as the presence of liposomes or intracellular uptake, restored the fluorescence and singlet-oxygen-generation abilities of beta-glucan-complexed diazaporphyrins. Consequently, beta-glucan-complexed diazaporphyrins showed very high photodynamic activities toward HeLa cells.
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Shikhar Tyagi, Sarika Saxena, Nikita Kundu, Taniya Sharma, Amlan Chakraborty, Sarvpreet Kaur, Daisuke Miyoshi, Jadala Shankaraswamy
RSC Advances 9 40255 - 40262 2019.12
Joint Work
We described a novel synthetic peptide in which a glutamine residue binds through hydrogen bonding to a guanine-base and a trytophan residue intercalates with K+ resulting in stabilization of a human telomeric G-quadruplex with high selectivity over its complementary c-rich strand and a double-stranded DNA and its complementary C-rich strand. This peptide offers great potential for cancer treatment by inhibiting the telomere extension by telomerase.
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Structural effect of amine N-oxides on the facilitation of alpha-glucosidase-catalyzed hydrolysis reactions Reviewed International journal
Takuma Aoki, Yuichi Nakagawa, Ryutaro Genjima, Kazuya Koumoto
BIOPROCESS AND BIOSYSTEMS ENGINEERING 43 ( 3 ) 541 - 548 2019.11
Joint Work
Publisher：SPRINGER
Activation and stabilization of enzymes is an important issue in their industrial application. We recently reported that synthetic betaines, derived from cellular metabolites, structure-dependently increased the activity and stability of various enzymes including hydrolases, oxidases, and synthetases simply by mixing them into the reaction buffer. In this report, we focus on amine N-oxides, which are similarly important metabolites in cells with a highly polarized N-oxide bond, and investigate their enzyme stabilization and activation behavior. It was revealed that synthetic amine N-oxides structure-dependently activate alpha-glucosidase-catalyzed hydrolysis reactions similarly to betaines. The subsequent comparison of the kinetic parameters, the optimal concentration range for activation, and the maximal activity, suggested that amine N-oxides facilitate hydrolysis reactions via the same mechanism as betaines, because no differences were confirmed. However, the enzyme stabilization effect of amine N-oxides was slightly superior to that of betaines and the temporal stability of the enzyme in aqueous solutions was higher in the low amine N-oxide concentration range. The rheological properties, CD spectra, and dynamic fluorescence quenching experiments suggested that the suppression of unfavorable conformational perturbation was related to the difference in the hydration environments provided by the surrounding water molecules. Thus, we clarified that amine N-oxides facilitate enzyme reactions as a result of their similarity to betaines and provide a superior stabilizing effect for enzymes. Amine N-oxides show potential for application in enzyme storage and long-term reactions.
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Turn-on fluorescence and photodynamic activity of beta-(1,3-1,6)-d-glucan-complexed porphyrin derivatives inside HeLa cells Reviewed International journal
Shodai Hino, Rikushi Funada, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 18 ( 12 ) 2854 - 2858 2019.11
Joint Work
Publisher：ROYAL SOC CHEMISTRY
Fluorescence intensities of water-soluble beta-(1,3-1,6)-d-glucan (beta-1,3-glucan)-complexed porphyrin derivatives were very weak as a result of self-quenching. However, beta-1,3-glucan-complexed tetra(aminophenyl)porphyrin exhibited 'off-state' to 'on-state' fluorescence switching activity by intracellular uptake. Furthermore, the internalised complex showed a high level of photodynamic activity toward HeLa cells under photoirradiation at long wavelengths.
DOI： 10.1039/C9PP00208A
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Bulky cations greatly increase the turnover of a native hammerhead ribozyme Reviewed
S. Nakano, H. Yamashita, K. Tanabe, N. Sugimoto
9 35820 - 35824 2019.11
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The RAS mRNA G-quadruplex: making undruggable cancer targets druggable
Keiko Kawauchi, Wataru Sugimoto, Daisuke Miyoshi
The Atlas of Science 2019.10
Joint Work
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DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death. Reviewed
Itoh K, Ebata T, Hirata H, Torii T, Sugimoto W, Onodera K, Nakajima W, Uehara I, Okuzaki D, Yamauchi S, Budirahardja Y, Nishikata T, Tanaka N, Kawauchi K.
Molecules 24 ( 17 ) E3175 2019.9
Joint Work
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Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity. Reviewed International journal
Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald FL, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y.
Science Adv. 5 2019.9
Joint Work
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Stabilization of DNA loop structures by large cations Reviewed
S. Nakano, T. Ayusawa, Y. Tanino, N. Sugimoto
J. Phys. Chem. B 123 7687 - 7694 2019.8
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研究課題設定を重視した科学技術人材育成プログラムROOTのデザインと実装
伊藤 真之, 臼井 英之, 長野 寛之, 巳波 弘佳, 甲元 一也, 蛯名 邦禎
日本科学教育学会年会論文集 43 399 - 400 2019.8
Joint Work