Papers -
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Dangling ends perturb the stability of RNA duplexes responsive to surrounding conditions Reviewed
H. Tateishi-Karimata, S. Pramanik, S. Nakano, D. Miyoshi, and N. Sugimoto
ChemMedChem 9 ( 9 ) 2150 - 2155 2014.7
Joint Work
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Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds Reviewed
S. Nakano, Y. Kitagawa, D. Miyoshi, N. Sugimoto
FEBS Open Bio 4 643 - 650 2014.7
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Drastic stabilization of parallel DNA hybridizations by a polylysine comb-type copolymer with hydrophilic graft chain Reviewed
D. Miyoshi, Y. Ueda, N. Shimada, S. Nakano, N. Sugimoto, and A. Maruyama
ChemMedChem 9 ( 9 ) 2156 - 2163 2014.7
Joint Work
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A Designed Small Protein For Controlling Site-Specific Mineralization Of Silica And Calcium On Dnas Reviewed
Kenji Usui, Kazuma Nagai, Hiroto Nishiyama, Aoi Yamada, Makoto Ozaki, Takaaki Tsuruoka, Kin-ya Tomizaki
PROTEIN SCIENCE 23 143 - 143 2014.7
Joint Work
Publisher：WILEY-BLACKWELL
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Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro Reviewed
T. Shimo, K. Tachibana, K. Saito, T. Yoshida, E. Tomita, R. Waki, T. Yamamoto, T. Doi, T. Inoue, J. Kawakami and S. Obika
Nucleic Acids Res. 42 8174 - 8187 2014.6
Joint Work
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A nanocomposite approach to develop biodegradable thermogels exhibiting excellent cell-compatibility for injectable cell delivery Reviewed
N. Oyama, H. Minami, D. Kawano, M. Miyazaki, T. Maeda, K. Toma, A. Hotta, K. Nagahama
Biomaterials Science 2 ( 8 ) 1057 - 1062 2014.6
Joint Work
Authorship：Lead author
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Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers.
Higuchi S, Watanabe TM, Kawauchi K, Ichimura T, Fujita H
Journal of bioscience and bioengineering 117 ( 6 ) 749 - 755 2014.6
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Refinement and verification of test conditions for colony-forming unit assay in rat bone marrow cells with preservable colony specimens Reviewed
Takamatsu K., Wakata A., Tabata H., and Nishikata T.
Comparative Clinical Pathology 23 ( 3 ) 569 - 575 2014.5
Joint Work
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In vitro assays predictive of telomerase inhibitory effect of G-quadruplex ligands in cell nuclei Reviewed
H. Yaku, T. Murashima, D. Miyoshi, N. Sugimoto
The Journal of Physical Chemistry B 118 ( 10 ) 2605 - 2614 2014.3
Joint Work
DOI： 10.1021/jp410669t
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Effects of molecular crowding on the structures, interactions, and functions of nucleic acids Reviewed
S. Nakano, D. Miyoshi, and N. Sugimoto
Chem. Rev. 114 2733 - 2758 2014.3
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Site-Specific Control of Silica Mineralization on DNA Using Designed Peptides Reviewed
K. Usui, K. Nagai, H. Nishiyama, A. yamada, T. Tsuruoka, S. Fujii, K.-y. Tomizaki
Peptide Science 2013 2415 - 2416 2014.3
Joint Work
Authorship：Lead author
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A simple "add and measure" FRET-based telomeric tandem repeat sequence detection and telomerase assay method Reviewed
K. Kawamura, H. Yaku, D. Miyoshi, T. Murashima
Organic & Biomolecular Chemistry 12 ( 6 ) 936 - 941 2014.2
Joint Work
DOI： 10.1039/c3ob42092b
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Peptides targeting G-quadruplex structures Reviewed
Kenji Usui, Arisa Okada
Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications 459 - 475 2014.1
Publisher：Springer Berlin Heidelberg
Research in recent decades has revealed that some DNA and RNA secondary structures modulate a variety of cellular events. One secondary structure, the Guanine(G)-quadruplex, also regulates various cellular events that are mostly related to serious diseases. Systems capable of controlling DNA and RNA G-quadruplex structures would therefore be useful for the modulation of various cellular events to produce biological effects. Because of their biological importance, many G-quadruplex-targeting compounds have been described. However, the next generation of targeting molecules should exhibit increased G-quadruplex sequence specificity, a higher structure-inducing or -collapsing ability, and a greater degree of functionality, including on–off switches of binding ability and cellular penetration. Peptides might be good candidates for these next-generation Gquadruplex- targeting molecules due to the following advantages: (1) their easy design and synthesis, (2) their ability to mimic protein–G–quadruplex interactions, (3) the possibility of employing artificial amino acids in addition to naturally occurring amino acids, and (4) the ability to combine G-quadruplex-binding sequences with other functional sequences. Accordingly, several peptide-based compounds, such as furan-based cyclic peptides, PNA-conjugated peptides, and small molecule-peptide conjugates, have been developed. In this chapter, we introduce all these peptide ligands and describe most of the approaches for targeting G-quadruplex structures. We then conclude that peptides are among the most promising functional ligands for G-quadruplexes to control various biological events in next-generation approaches.
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Mechanistic study on the facilitation of enzymatic hydrolysis by α-glucosidase in the presence of betaine-type metabolite analogs Reviewed
Yuichi Nakagawa, Shiro Sehata, Satoshi Fujii, Hiroaki Yamamoto, Akihiko Tsuda, Kazuya Koumoto
Tetrahedron 70 5895 - 5903 2014
Joint Work
Authorship：Lead author
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Reduced Graphene Oxide Upconversion Nanoparticle Hybrid for Electrochemiluminescent Sensing of a Prognostic Indicator in Early-Stage Cancer Reviewed
Li Wu, Jiasi Wang, Meili Yin, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto, Xiaogang Qu
Small 10 330 - 336 2014
Joint Work
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A fluorescent probe for detection of an intracellular prognostic indicator in early-stage cancer (10.1039/c4cc08789e Reviewed
Haiwei Ji, Yijia Guan, L Wu, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto Xiaogang Qu
Chem. Commun. 51 1479 - 1482 2014
Joint Work
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Preparation of hydrogels for the study of the effects of spatial confinement on DNA Reviewed
Shu-ichi Nakano, Masatoshi Yoshida, Daisuke Yamaguchi, Naoki Sugimoto
Transact. Mat. Res. Soc. Japan 39 435 - 438 2014
Joint Work
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Dangling ends perturb the stability of RNA duplex responsive to surrounding condition Invited Reviewed
H. Tateishi-Karimata, S. Pramanik, S. Nakano, D. Miyoshi and N. Sugimoto
ChemMedChem 9 ( 9 ) 2150 - 2155 2014
Joint Work
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Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds Reviewed
Shu-ichi Nakano, Yuichi Kitagawa, Daisuke Miyoshi, Naoki Sugimoto
FEBS Open Bio 4 643 - 650 2014
Joint Work
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Drastic stabilization of parallel DNA hybridizations by a polylysine comb-type copolymer with hydrophilic graft chain Reviewed
Daisuke Miyoshi, Yu-mi Ueda, Naohiko Shimada, Shu-ichi Nakano, Naoki Sugimoto, Atsushi Maruyama
ChemMedChem 9 ( 9 ) 2156 - 2163 2014
Joint Work
Authorship：Lead author