Faculty of Frontiers of Innovative Research in Science and Technology

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Specific recognition of the basic N peptide by an RNA（共著）

J. Kawakami, H. Tokitoh, Y. Tanabe, and N. Sugimoto

Nucleic Acids Symposium Series 49 353 - 354 2005.9

Joint Work

Authorship：Lead author

Central dogma for a molecular design based on DNA: DNB (databasing/designable nanobio) -> ENB (engineering nanobio) -> FNB (functional nanobio) Reviewed

S. Nakano and N. Sugimoto

Chemistry Letters 34 1206 - 1211 2005.7

Single Work

DOI： 10.1246/cl.2005.1206

Protein-detecting microarrays: Current accomplishments and requirements Reviewed

Kin-Ya Tomizaki, Kenji Usui, Hisakazu Mihara

ChemBioChem 6 ( 6 ) 782 - 799 2005.5

Joint Work

The sequencing of the human genome has been successfully completed and offers the chance of obtaining a large amount of valuable information for understanding complex cellular events simply and rapidly in a single experiment. Interestingly, in addressing these proteomic studies, the importance of protein-detecting microarray technology is increasing. In the coming few years, microarray technology will become a significantly promising and indispensable research/diagnostic tool from just a speculative technology. It is clear that the protein-detecting microarray is supported by three independent but strongly related technologies (surface chemistry, detection methods, and capture agents). Firstly, a variety of surface-modification methodologies are now widely available and offer site-specific immobilization of capture agents onto surfaces in such a way as to keep the native conformation and activity. Secondly, sensitive and parallel detection apparatuses are being developed to provide highly engineered microarray platforms for simultaneous data acquisition. Lastly, in the development of capture agents, antibodies are now probably the most prominent capture agents for analyzing protein abundances. Alternative scaffolds, such as phage-displayed antibody and protein fragments, which provide the advantage of increasing diversity of proteinic capture agents, however, are under development. An approach involving recombinant proteins fused with affinity tag(s) and coupled with a highly engineered surface chemistry wilt provide simple production protocols and specific orientations of capture agents on the -microarray formats. Peptides and other small molecules can be employed in screening highly potent ligands as well as in measuring enzymatic activities. Protein-detecting microarrays supported by the three key technologies should contribute in accelerating diagnostic/biological research and drug discovery. © 2005 Wiley-VCH Verlag GmbH &amp
Co. KGaA.

DOI： 10.1002/cbic.200400232

PubMed

Studies on Fluorescent Dyes and Surface Chemistry focusing on Practical Peptide Array Preparation Reviewed

NOKIHARA Kiyoshi, USUI Kenji, YONEMURA Koichi, OHYAMA Takafumi, OKA Yasuo, TOMIZAKI Kin‐ya, MIHARA Hisakazu

Pept Sci 2004 145 - 148 2005.3

Joint Work

J-GLOBAL

Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.

Qu X, Kawauchi-Kamata K, Miah SM, Hatani T, Yamamura H, Sada K

Biochemistry 44 ( 10 ) 3891 - 3898 2005.3

Joint Work

DOI： 10.1021/bi048353o

PubMed

Thermodynamic analysis of duplex formation of the heterochiral DNA with L-deoxyadenosine（共著） Reviewed

J. Kawakami, K. Tsujita, and N. Sugimoto

Analytical Sciences 21 ( 2 ) 77 - 82 2005.2

Joint Work

Authorship：Lead author

Site-selective RNA cleavage by DNA bearing a base pair-mimic nucleoside Reviewed

S. Nakano, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto

J. Am. Chem. Soc. 127 518 - 519 2005.1

Single Work

DOI： 10.1021/ja045445s

Nucleic acid with guanidinium modification exhibits efficient cellular uptake.

西方敬人

Angew. Chem. Int. Ed. Engl ( 44 ) 6682 - 6685 2005

Single Work

Site-Selective Deposition of Gold on Glass Substrates Using Monolayer-Protected Gold Nanoparticles

K. Akamatsu, H. Terahata, J. Hasegawa, H. Nawafune

J. Surf, Finish, Soc. Jpn 56 427 - 428 2005

Joint Work

（学術雑誌、2005）56, 427-428

Fabrication and Structural Control of Fe/Ti Oxide Thin Films with Graded Compositional Profiles by Liquid Phase Deposition

S. Deki, S. Iizuka, K. Akamatsu, M. Mizuhata and A. Kajinami

J. Ame. Ceram. Soc. 88 731 - 736 2005

Joint Work

（学術雑誌、2005) 88, 731-736

Selective Electroless Copper Deposition on Aluminum Nitride Substrate with Patterned Copper Seed Layer

H. Yanagimoto, S. Deki, K. Akamatsu, and K. Gotoh

Thin Solid Films 491 18 - 22 2005

Joint Work

（学術雑誌、2005) 491, 18-22

A novel fabrication technique for interacting ferromagnetic-metal nanoparticle systems:fine-tuning of particle dimeter and interparticle spacing

S. Tomita, K. Akamatsu, H. Shinkai, S. Ikeda, H. Nawafune, C. Mitsumata, T. Kashiwagi, M. Hagiwara

Mater. Res. Soc. Proceedings 853E I5.10.1 - I5.10.6 2005

Joint Work

（学術雑誌、2005） 853E. I5.10.1-I5.10.6

Site-Selective Deposition of Gold on Glass Substrates Using Monolayer-Protected Gold Nanoparticles

K. Akamatsu, H. Terahata, J. Hasegawa, H. Nawafune

J. Surf. Finish. Soc. Jpn 56 427 - 428 2005

Joint Work

（学術雑誌、2005）56. 427-428

Band Gap Engineering of CdTe nanocrystals Through Chemical Surface Modification

K. Akamatsu, T. Tsuruoka, H. Nawafune

J. Am. Chem. Soc. 127 1634 - 1635 2005

Joint Work

（学術雑誌、2005） 127. 1634-1635

Stereocontrolled Synthesis and Optical Properties of All-cis Poly(phenylene vinylene)s (PPVs): A Method for Direct Patterning of PPVs

H. Katayama, M. Nagao, T. Nishimura, Y. Matsui, K. Umeda, K. Akamatsu, T. Tsuruoka, H. Nawafune, F. Ozawa

J. Am. Chem. Soc. 127 4350 - 4353 2005

Joint Work

（学術雑誌、2005） 127. 4350-4353

An SPR Sensor Chip for Sensitive Detection of Small Molecules Using Molecularly Imprinted Polymer with Embedded Gold Nanoparticle

J. Matsui, K. Akamatsu, N. Hara, D. Miyoshi, H. Nawafune, K. Tamaki, N. Sugimoto

Anal. Chem. 77 4282 - 4285 2005

Joint Work

（学術雑誌、2005） 77. 4282-4285

Controlling Interparticle Spacing Among Metal Nanoparticles Through Metal-Catalyzed Decomposition of Surrounding Polymer Matrix

K. Akamatsu, H. Shinkai, S. Ikeda, S. Adachi, H. Nawafune, S. Tomita

J. Am. Chem. Soc. 127 7980 - 7981 2005

Joint Work

（学術雑誌、2005） 127. 7980-7981

Tuning magnetic interactions in ferromagnetic-metal nanoparticle systems

S. Tomita, K. Akamatsu, H. Shinkai, S. Ikeda, H. Nawafune, C. Mitsumata, T. Kashiwagi, and M, Hagiwara

Phys. Rev. B 71 180414(R)1 - 4 2005

Joint Work

（学術雑誌、2005） 71. 180414(R)1-4

Surface Functionalization of Mixed Monolayer-Protected Semiconductor Nanocrystals

T. Tsuruoka, K. Akamatsu, H. Nawafune

Trans. Mater. Res. Soc 30 1227 - 1230 2005

Joint Work

（学術雑誌、2005） 30, 1227-1230

Synthesis and Structural Control of Metal-Containing Polyimide Nanocomposite

H. Shinkai, S. Ikeda, K. Akamatsu, H. Nawafune, S. Tomita

Trans. Mater. Res. Soc. Jpn. 30 1223 - 1226 2005

Joint Work

（学術雑誌、2005）30, pp. 1223-1226

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