Faculty of Frontiers of Innovative Research in Science and Technology

Papers -

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Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite Reviewed

Usuda M, Kametani M, Hamada M, Suehiro Y, Matayoshi S, Okawa R, Naka S, Matsumoto-Nakano M, Akitomo T, Mitsuhata C, Koumoto K, Kawauchi K, Nishikata T, Yagi M, Mizoguchi T, Fujikawa K, Taniguchi T, Nakano K, Nomura R

International Journal of Molecular Science 24 11371 2023.7

Joint Work

DOI： doi.org/10.3390/ijms241411371

Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite. Reviewed International journal

Momoko Usuda, Mariko Kametani, Masakazu Hamada, Yuto Suehiro, Saaya Matayoshi, Rena Okawa, Shuhei Naka, Michiyo Matsumoto-Nakano, Tatsuya Akitomo, Chieko Mitsuhata, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano, Ryota Nomura

International journal of molecular sciences 24 ( 14 ) 2023.7

Hydroxyapatite adsorbs various substances, but little is known about the effects on oral bacteria of adsorption onto hydroxyapatite derived from scallop shells. In the present study, we analyzed the effects of adsorption of Streptococcus mutans onto scallop-derived hydroxyapatite. When scallop-derived hydroxyapatite was mixed with S. mutans, a high proportion of the bacterial cells adsorbed onto the hydroxyapatite in a time-dependent manner. An RNA sequencing analysis of S. mutans adsorbed onto hydroxyapatite showed that the upregulation of genes resulted in abnormalities in pathways involved in glycogen and histidine metabolism and biosynthesis compared with cells in the absence of hydroxyapatite. S. mutans adsorbed onto hydroxyapatite was not killed, but the growth of the bacteria was inhibited. Electron microscopy showed morphological changes in S. mutans cells adsorbed onto hydroxyapatite. Our results suggest that hydroxyapatite derived from scallop shells showed a high adsorption ability for S. mutans. This hydroxyapatite also caused changes in gene expression related to the metabolic and biosynthetic processes, including the glycogen and histidine of S. mutans, which may result in a morphological change in the surface layer and the inhibition of the growth of the bacteria.

DOI： 10.3390/ijms241411371

PubMed

Thixotropic β‑Chitin Nanofiber Hydrogel with a Living BodyResponsive Self-Hardening Property and Its Application as a Sprayable Antiadhesion Barrier Reviewed

Nagahama K, Tobiishi K, Ueda N, Dode T, Sobuj SI, Yuasa F, Yamashita K, Nishikata T

American Chemical Society Applied Bio Materials 2023 ( 6 ) 2636 - 2643 2023.7

Joint Work

Authorship：Last author

DOI： 10.1021/acsabm.3c00221

Co-generation of palladium nanoparticles and phosphate supported on metal-organic frameworks as hydrogenation catalysts Reviewed

Yohei Takashima, Seiko Tetsusashi, Mai Takano, Shintaro Tanaka, Yui Murakami, Takaaki Tsuruoka, Kensuke Akamatsu

Dalton Trans. 52 11158 - 11162 2023.7

Authorship：Lead author,　Corresponding author

Other Link： https://pubs.rsc.org/en/content/articlelanding/2023/dt/d2dt04109j

The iron chelator deferriferrichrysin induces paraptosis via extracellular signal-related kinase activation in cancer cells Invited Reviewed

Natsuki Kinoshita, Masaya Gessho, Takeru Torii, Yukako Ashida, Minori Akamatsu, Alvin Kunyao Guo, Sunmin Lee, Tatsuya Katsuno 3, Wataru Nakajima Yemima Budirahardja, Daisuke Miyoshi, Takehiko Todokoro, Hiroki Ishida, Takahito Nishikata, Keiko Kawauchi

Genes Cells 2023.6

DOI： 10.1111/gtc.13053

Quantification of the concentration in a droplet formed by liquid–liquid phase separation of G-quadruplex-forming RNA Reviewed

Kohei Yokosawa, Mitsuki Tsuruta, Shinji Kajimoto, Naoki Sugimoto, Daisuke Miyoshi, Takakazu Nakabayashi

Chem. Phys. Lett. 826 140634 - 140634 2023.6

Publisher：Elsevier BV

DOI： 10.1016/j.cplett.2023.140634

The iron chelator deferriferrichrysin induces paraptosis via extracellular-signal-regulated kinase activation in cancer cells Reviewed International coauthorship

Kinoshita N, Gessho M, Torii T, Ashida Y, Akamatsu M, Guo AK, Lee S, Katsuno T, Nakajima W, Budirahardja Y, Miyoshi D, Todokoro T, Ishida H, Nishikata T, Kawauchi K

Genes to Cells 28 ( 9 ) 653 - 662 2023.6

Authorship：Last author,　Corresponding author

DOI： doi.org/10.1111/gtc.13053

Simple and fast screening for structure-selective G-quadruplex ligands. Reviewed International journal

Yoshiki Hashimoto, Yoshiki Imagawa, Kaho Nagano, Ryuichi Maeda, Naho Nagahama, Takeru Torii, Natsuki Kinoshita, Nagisa Takamiya, Keiko Kawauchi, Hisae Tatesishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi

Chemical communications (Cambridge, England) 59 ( 33 ) 4891 - 4894 2023.4

Joint Work

Structural selectivity of G-quadruplex ligands is essential for cellular applications since there is an excess of nucleic acids forming duplex structures compared to G-quadruplex structures in living cells. In this study, we developed new structure-selective G-quadruplex ligands utilizing a simple and fast screening system. The affinity, selectivity, enzymatic inhibitory activity and cytotoxicity of the structure-selective G-quadruplex ligands were demonstrated along with a structural selectivity-cytotoxicity relationship of G-quadruplex ligands.

DOI： 10.1039/d3cc00556a

PubMed

Not all 2',4'-bridged modifications stabilize DNA/RNA duplexes Reviewed

Tomoka Akita, Elisa Tomita-Sudo, Shin Itoh, Nae Sakimoto, Takeshi Masuda, Akifumi Nakamura, Yoshiyuki Onishi, Makoto Koizumi Junji Kawakami

Nucleosides, Nucleotides & Nucleic Acids 2023.3

Joint Work

2’,4’-Bridged modifications such as 2’-O,4’-C-methylene-bridged nucleotides (LNAs) and 2’-O,4’-C-ethylene-bridged nucleotides (ENAs) provide high binding affinity for duplex formation. Stabilization by the introduction of the bridged nucleic acids is considered to be due to pre-organization. In this study, we found that the introduction of 2’,4’-C-bridged 2’-deoxynucleotides (CRNs; Conformationally Restricted Nucleotides) into DNA/RNA duplexes leads to destabilization, as opposed to the previously accepted notion that 2’,4’-bridged modifications always lead to stabilization.

Other Link： https://www.tandfonline.com/doi/full/10.1080/15257770.2023.2232414

Biomolecular Liquid–Liquid Phase Separation for Biotechnology Invited Reviewed

Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi and Daisuke Miyoshi

BioTech 12 ( 2 ) 26 2023.3

Authorship：Corresponding author

DOI： 10.3390/biotech12020026

Construction of a Method to Design Fibril-Forming Peptides Applied to Biomaterials from 20 Beta-Sheet Peptides by Statistical Analysis Reviewed

Kazuya Iwata, Taisei Terao, Akira Takekawa, Tomohiro Umetani, Kenji Usui

Peptide Science 2022 141 - 142 2023.3

Authorship：Last author,　Corresponding author

High-performance bulk Bi0.4Sb1.6Te3.0 thermoelectrics prepared from nanocrystal precursor synthesized via chemical precipitation Reviewed

Ryosuke Fujiwara, Yohei Takashima, Takaaki Tsuruoka, Muneyuki Naito, Junya Murai, Kensuke Akamatsu

Journal of Solid State Chemistry 319 123777 - 123777 2023.3

Publisher：Elsevier BV

DOI： 10.1016/j.jssc.2022.123777

Direct generation of polypyrrole-coated palladium nanoparticles inside a metal-organic framework for a semihydrogenation catalyst Reviewed

Yohei Takashima, Seiko Tetsusashi, Shintaro Tanaka, Takaaki Tsuruoka, Kensuke Akamatsu

RSC Adv. 13 7464 - 7467 2023.3

Authorship：Lead author

Other Link： https://pubs.rsc.org/en/content/articlelanding/2023/ra/d2ra08190c

Simple and fast screening for structure-selective G-quadruplex ligands Reviewed International journal

Chem. Commun. 59 ( 33 ) 4891 - 4894 2023.2

Authorship：Corresponding author

DOI： 10.1039/D3CC00556A

PubMed

Morphological Evidence for Novel Roles of Microtubules in Macrophage Phagocytosis Reviewed

Seta Y, Kawakatsu K, Degawa S, Goto T, Nishikata T

International Journal of Molecular Science 24 1373 2023.1

Joint Work

Authorship：Last author,　Corresponding author

DOI： doi.org/10.3390/ijms24021373

RNA 高次構造を標的とした光線力学療法の展望 Invited

取井猛流・木下菜月・橋本佳樹・杉本渉・川内敬子・三好大輔

38 ( 13 ) 1154 - 1156 2023

Authorship：Last author,　Corresponding author

グアニン四重らせん構造による転移因子LINE-1の発現抑制名

月生雅也, 李先民, Yemima Suryani Budirahardja, 鶴田充生, 橋本佳樹, 高宮渚, 木下菜月, 建石寿枝, 杉本直己, 三好大輔, 川内敬子

日本女性科学者の会学術誌 23 48 - 48 2023

Publisher：(一社)日本女性科学者の会

High-performance bulk Bi0.4Sb1.6Te3.0 thermoelectrics prepared from nanocrystal precursor synthesized via chemical precipitation

R. Fujiwara, Y.Takashima, T. Tsuruoka, M. Naito, J. Murai, K. Akamatsu

Journal of Solid State Chemistry 319 123777 2023

“Direct generation of polypyrrole-coated palladium nanoparticles inside a metal-organic framework for a semihydrogenation catalyst

Y. Takashima, S. Tetsusashi, S. Tanaka, T. Tsuruoka, K. Akamatsu

RSC Adv 13 7464 - 7467 2023

“Co-generation of palladium nanoparticles and phosphate supported on metal-organic frameworks as hydrogenation catalysts

Y. Takashima, S. Tetsusashi, M. Takano, S. Tanaka, Y. Murakami, T. Tsuruoka, K. Akamatsu

Dalton Trans 52 11158 - 11162 2023

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