Papers -
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Destabilization of DNA G-quadruplexes by chemical environment changes during tumor progression facilitates transcription Reviewed International journal
Hisae Tateishi-Karimata, Keiko Kawauchi, Naoki Sugimoto
J Am Chem Soc. 140 642 - 651 2018.1
Joint Work
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Crystal conversion between metal-organic frameworks with different crystal topologies for efficient crystal design on two-dimensional substrates Reviewed
T. Tsuruoka, K. Inoue, A. Miyanaga, K. Tobiishi, T. Ohhashi, M. Hata, Y. Takashima, K. Akamatsu
J. Cryst. Growth 487 1 - 7 2018
Joint Work
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ポリイミドフィルムの表面改質と銅薄膜のダイレクトめっき技術
髙嶋洋平、鶴岡孝章、赤松謙祐
MATERIAL STAGE 18 29 - 33 2018
Joint Work
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Wrapping Flexible Metal-Organic Framework with Organic Polymers via Site-Specific Radical Polymerization from Its Crystal Surface
Y. Takashima, K. Fukudome, A. Horikoshi, T. Tsuruoka, K. Akamats
Polyhedron 155 275 - 280 2018
Joint Work
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Controlling the Orientation of Metal−Organic Framework Crystals by an Interfacial Growth Approach Using a Metal Ion-Doped Polymer Substrate
T. Ohhashi, T. Tsuruoka, S. Fujimoto, Y. Takashima, K. Akamatsu
Cryst. Growth Des 18 402 - 408 2018
Joint Work
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Controlling the Orientation of Metal−Organic Framework Crystals by an Interfacial Growth Approach Using a Metal Ion-Doped Polymer Substrate
T. Ohhashi, T. Tsuruoka, S. Fujimoto, Y. Takashima, K. Akamatsu
Cryst. Growth Des 18 402 - 408 2018
Joint Work
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ポリイミドフィルムの表面改質と銅薄膜のダイレクトめっき技術
MATERIAL STAGE 18 29 - 33 2018
Single Work
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Wrapping Flexible Metal-Organic Framework with Organic Polymers via Site-Specific Radical Polymerization from Its Crystal Surface
Y. Takashima, K. Fukudome, A. Horikoshi, T. Tsuruoka, K. Akamatsu
Polyhedron 155 275 - 280 2018
Joint Work
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Design of anti-alzheimer’s disease agents focusing on a specific interaction with target biomolecules Reviewed
Yoshio Hamada, Kenji Usui
Neuromethods 132 207 - 228 2018
Joint Work
Publisher：Humana Press Inc.
Alzheimer’s disease (AD) is the most common cause of dementia, characterized by progressive intellectual deterioration. Amyloid β peptide (Aβ), the main component of senile plaques in the brains of patients with AD, is formed from amyloid precursor protein (APP) by two processing enzymes. According to the amyloid hypothesis, a processing enzyme β-secretase (BACE1
β-site APP cleaving enzyme) that triggers Aβ formation in the rate-limiting first step of Aβ processing appears to be a promising molecular target for therapeutic intervention in AD. Many researchers have revealed BACE1 inhibitors for the AD treatment. Early BACE1 inhibitors were designed based on the first reported X-ray crystal structure, 1FKN, of a complex between recombinant BACE1 and inhibitor OM99-2. Although OM99-2 seemed to interact with BACE1-Arg235 side chain by hydrogen bonding, we found that a quantum chemical interaction, such as σ-π interaction or π-π stacking, plays a critical role in BACE1 inhibition mechanism. Moreover, we proposed a novel “electron-donor bioisostere” concept in drug discovery study and designed potent BACE1 inhibitors using this concept. -
Channel current analysis estimates the pore-formation and the penetration of transmembrane peptides Reviewed
Sekiya, Y., Sakashita, S., Shimizu, K., Usui, K., Kawano, R.
Analyst 143 ( 15 ) 2018
Joint Work
DOI： 10.1039/c8an00243f
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Crystal conversion between metal-organic frameworks with different crystal topologies for efficient crystal design on two-dimensional substrates Reviewed
T. Tsuruoka, K. Inoue, A. Miyanaga, K. Tobiishi, T. Ohhashi, M. Hata, Y. Takashima, K. Akamatsu
J. Cryst. Growth 487 1 - 7 2018
Joint Work
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Controlling the Orientation of Metal−Organic Framework Crystals by an Interfacial Growth Approach Using a Metal Ion-Doped Polymer Substrate Reviewed
T. Ohhashi, T. Tsuruoka, S. Fujimoto, Y. Takashima, K. Akamatsu
Cryst. Growth Des 18 402 - 408 2018
Joint Work
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Wrapping Flexible Metal-Organic Framework with Organic Polymers via Site-Specific Radical Polymerization from Its Crystal Surface
Y. Takashima, K. Fukudome, A. Horikoshi, T. Tsuruoka, K. Akamatsu
Polyhedron 155 275 - 280 2018
Joint Work
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ポリイミドフィルムの表面改質と銅薄膜のダイレクトめっき技術
髙嶋洋平、鶴岡孝章、赤松謙祐
MATERIAL STAGE 18 29 - 33 2018
Joint Work
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Controlling the Orientation of Metal-Organic Framework Crystals by an Interfacial Growth Approach Using a Metal Ion-Doped Polymer Substrate Reviewed
Takashi Ohhashi, Takaaki Tsuruoka, Seiya Fujimoto, Yohei Takashima, Kensuke Akamatsu
Cryst. Growth Des. 18 402 - 408 2018
Joint Work
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Crystal Conversion between Metal-Organic Frameworks with Different Crystal Topologies for Efficient Crystal Design on Two Dimensional Substrates Reviewed
Takaaki Tsuruoka, Kohei Inoue, Ayumi Miyanaga, Kaho Tobiishi, Takashi Ohhashi, Manami Hata, Yohei Takashima, Kensuke Akamatsu
J. Cryst. Growth 487 1 - 7 2018
Joint Work
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Tuning Light Emission towards White Light from a Naphthalenediimide-Based Entangled Metal-Organic Framework by Mixing Aromatic Guest Molecules Invited Reviewed
Rebeca Sola-Llano, Virginia Martínez-Martínez, Shuhei Furukawa, Yohei Takashima, Iñigo López-Arbeloa
Polymers 10 188 2018
Joint Work
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Modulation of the ribozyme and deoxyribozyme activities using tetraalkylammonium ions Reviewed
S. Nakano, T. Watabe, and N. Sugimoto
ChemPhysChem 18 ( 24 ) 3614 - 3619 2017.12
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生体分子の挙動解析研究を目標としたマイクロ波照射システムの開発 ～ペプチドのバイオミネラリゼーションにおけるマイクロ波影響解析をモデルとして～ Reviewed
臼井健二, 富樫浩行, 圓東那津実, 尾崎誠, 有本米次郎, 裏鍛武史, 大沢隆二, 皆木幸一, 中西伸浩, 梅谷智弘
日本電磁波エネルギー応用学会論文誌 17 - 24 2017.12
Joint Work
Authorship：Lead author
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Catalytic activities of ribozymes and DNAzymes in water and mixed aqueous media Invited Reviewed
S. Nakano, M. Horita, M. Kobayashi, and N. Sugimoto
Catalysis 7 ( 12 ) 355 - 348 2017.11