講演・口頭発表等 - 杉本　直己

Quantify specific interactions determining G-quadruplex and i-motif formation during cancer progression

H. Tateishi-Karimata, K. Kawauchi, S. Takahashi, and N. Sugimoto

To B or Not to B Symposium 2025 

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開催年月日： 2025年3月

“To B or not to B” in Nucleic Acids Chemistry 招待あり

N. Sugimoto

The Seminar of Department of Pharmacy, University of Naples Federico II  (Naples)  2025年2月  University of Naples “Federico II”

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開催年月日： 2025年2月

国名：イタリア共和国  

Nucleic acids (DNA and RNA) are genetic materials in living organisms and formed by a sequence of nucleobases. The stability of nucleic acids structures cannot be determined from only the sequence composition, as this property critically depends on the surrounding environment of the solution. The intracellular condition is greatly different from that of the diluted buffer typically used for standard experiments and is not constant in each local area of the cell. Thus, to make excellent nanomaterials with nucleic acids working in cells, stability predictions should reflect the situation under intracellular conditions and are required importantly. In this lecture, I will provide an overview of the basic concepts, methods, and applications of predicting the stabilities of nucleic acid structures.1-12 I explain the theory of the most successful prediction method based on a nearest-neighbor (NN) model. To improve the versality of prediction, corrections for various solution conditions considered hydration have been investigated. I also describe advances in the prediction of non-canonical structures of G-quadruplexes and i-motifs. Finally, studies of intracellular analysis and stability prediction are discussed for the application of NN parameters for human health and diseases.


“To B or not to B” in Nucleic Acids Chemistry 招待あり

N. Sugimoto

The Seminar of Department of Molecular Medicine of the University of Padua  (Padua)  2025年1月  University of Padua

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開催年月日： 2025年1月

国名：イタリア共和国  

Nucleic acids (DNA and RNA) are genetic materials in living organisms and formed by a sequence of nucleobases. The stability of nucleic acids structures cannot be determined from only the sequence composition, as this property critically depends on the surrounding environment of the solution. The intracellular condition is greatly different from that of the diluted buffer typically used for standard experiments and is not constant in each local area of the cell. Thus, to make excellent nanomaterials with nucleic acids working in cells, stability predictions should reflect the situation under intracellular conditions and are required importantly. In this lecture, I will provide an overview of the basic concepts, methods, and pplications of predicting the stabilities of nucleic acid structures.1-12 I explain the theory of the most successful prediction method based on a nearest-neighbor (NN) model. To improve the versality of prediction, corrections for various solution conditions considered hydration have been investigated. I also describe advances in the prediction of non-canonical structures of G-quadruplexes and i-motifs. Finally,studies of ntracellular analysis and stability prediction are discussed for the application of NN parameters for human health and diseases.

All about “To B or not to B” in Nucleic Acids Chemistry 招待あり

N. Sugimoto

The 7th Asian Chemical Biology Conference 2025 (ACBC)  (Kowloon)  2025年1月  The Hong Kong University of Science and Technology

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開催年月日： 2025年1月

国名：ホンコン(香港)特別行政区  

Nucleic acids (DNA and RNA) are genetic materials in living organisms and formed by a sequence of nucleobases. The stability of nucleic acids structures cannot be determined from only the sequence composition, as this property critically depends on the surrounding environment of the solution. The intracellular condition is greatly different from that of the diluted buffer typically used for standard experiments and is not constant in each local area of the cell. Thus, to make excellent nanomaterials with nucleic acids working in cells, stability predictions should reflect the situation under intracellular conditions and are required importantly. In this lecture, I will provide an overview of the basic concepts, methods, and applications of predicting the stabilities of nucleic acid structures.1-11 I explain the theory of the most successful prediction method based on a nearest-neighbor (NN) model. To improve the versality of prediction, corrections for various solution conditions considered hydration have been investigated. I also describe advances in the prediction of non-canonical structures of G-quadruplexes and i-motifs. Finally, studies of intracellular analysis and stability prediction are discussed for the application of NN parameters for human health and diseases.

“To B or not to B” in Nucleic Acids Chemistry 招待あり

N. Sugimoto

Special Departmental Seminar of Chemistry Department of City University of Hong Kong  (Kowloon)  2025年1月  City University of Hong Kong

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開催年月日： 2025年1月

国名：ホンコン(香港)特別行政区  

Nucleic acids (DNA and RNA) are genetic materials in living organisms and formed by a sequence of nucleobases. The stability of nucleic acids structures cannot be determined from only the sequence composition, as this property critically depends on the surrounding environment of the solution. The intracellular condition is greatly different from that of the diluted buffer typically used for standard experiments and is not constant in each local area of the cell. Thus, to make excellent nanomaterials with nucleic acids working in cells, stability predictions should reflect the situation under intracellular conditions and are required importantly. In this lecture, I will provide an overview of the basic concepts, methods, and applications of predicting the stabilities of nucleic acid structures.1-11 I explain the theory of the most successful prediction method based on a nearest-neighbor (NN) model. To improve the versality of prediction, corrections for various solution conditions considered hydration have been investigated. I also describe advances in the prediction of non-canonical structures of G-quadruplexes and i-motifs. Finally, studies of intracellular analysis and stability prediction are discussed for the application of NN parameters for human health and diseases.

"To B or not to B” in Nucleic Acids Chemistry 招待あり

N. Sugimoto

the 11th Asian Biological Inorganic Chemistry Conference  (Guilin)  2024年12月  Asian Bioinorganic Chemistry Steering Committee

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開催年月日： 2024年12月

国名：中華人民共和国  

Nucleic acids (DNA and RNA) are genetic materials in living organisms and formed by a sequence of nucleobases. The stability of nucleic acids structures cannot be determined from only the sequence composition, as this property critically depends on the surrounding environment of the solution. The intracellular condition is greatly different from that of the diluted buffer typically used for standard experiments and is not constant in each local area of the cell. Thus, to make excellent nanomaterials with nucleic acids working in cells, stability predictions should reflect the situation under intracellular conditions and are required importantly. In this lecture, I will provide an overview of the basic concepts, methods, and applications of predicting the stabilities of nucleic acid structures. I explain the theory of the most successful prediction method based on a nearest-neighbor (NN) model. To improve the versality of prediction, corrections for various solution conditions considered hydration have been investigated.1-6 I also describe advances in the prediction of non-canonical structures of G-quadruplexes and i-motifs. Finally, studies of ligands binding to canonical and non-canonical structures of nucleic acids are discussed for human health and diseases.

神経変性疾患に関わる核酸の周辺環境に依存した構造解析とその制御, 福岡国際会議場・マリンメッセ福岡

建石寿枝, 杉本直己

第50回日本分子生物学会年会 

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開催年月日： 2024年11月

To B Or Not To B” In Nucleic Acids Chemistry 招待あり

N. Sugimoto

Solutions in Chemistry 2024  (Sveti Martin na Muri)  2024年11月  The Croatian Chemical Society

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開催年月日： 2024年11月

国名：クロアチア共和国  

Nucleic acids (DNA and RNA) are genetic materials in living organisms and formed by a sequence of nucleobases. The stability of nucleic acids structures cannot be determined from only the sequence composition, as this property critically depends on the surrounding environment of the solution. The intracellular condition is greatly different from that of the diluted buffer typically used for standard experiments and is not constant in each local area of the cell. Thus, to make excellent nanomaterials with nucleic acids working in cells, stability predictions should reflect the situation under intracellular conditions and are required importantly. In this lecture, I will provide an overview of the basic concepts, methods, and applications of predicting the stabilities of nucleic acid structures. I explain the theory of the most successful prediction method based on a nearest-neighbor (NN) model. To improve the versality of prediction, corrections for various solution conditions considered hydration have been investigated.1-6 I also describe advances in the prediction of non-canonical structures of G-quadruplexes and i-motifs. Finally, studies of ligands binding to canonical and non-canonical structures of nucleic acids are discussed for human health and diseases.

Beyond the Watson-Crick Double Helix: Make New History of Nucleic Acids (9) 招待あり

N. Sugimoto

Asia 3 Roundtable on Nucleic Acids 2024  (Busan)  2024年11月  A3RONA 2024 Organizing Committee

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開催年月日： 2024年11月

国名：大韓民国  

Nucleic acids (DNA and RNA) are genetic materials in living organisms and formed by a sequence of nucleobases. The stability of nucleic acids structures cannot be determined from only the sequence composition, as this property critically depends on the surrounding environment of the solution. The intracellular condition is greatly different from that of the diluted buffer typically used for standard experiments and is not constant in each local area of the cell. Thus, to make excellent nanomaterials with nucleic acids working in cells, stability predictions should reflect the situation under intracellular conditions and are required importantly. In this lecture, I will provide an overview of the basic concepts, methods, and applications of predicting the stabilities of nucleic acid structures. I explain the theory of the most successful prediction method based on a nearest-neighbor (NN) model. To improve the versality of prediction, corrections for various solution conditions considered hydration have been investigated. I also describe advances in the prediction of non-canonical structures of G-quadruplexes and i-motifs. Finally, studies of intracellular analysis and stability prediction are discussed for the application of NN parameters for human health and diseases.

“To B or not to B” in Nucleic Acids Chemistry 招待あり

N. Sugimoto

The Seminar of Bioanalytical Chemistry Department, Faculty of Chemistry  (Poznan)  2024年10月  Adam Mickiewicz University

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開催年月日： 2024年10月

国名：ポーランド共和国  

Nearest-neighbor parameters with AI beyond experiments: Prediction of RNA secondary structures containing mismatches

H. Tateishi-Karimata, B. Dipanwita, S. Takahashi, T. Fukunaga, M. Hamada, N. Sugimoto

Advances in Noncanonical Nucleic Acids “ANNA2024” 

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開催年月日： 2024年10月

Nearest-neighbor parameters meet AI: Functional prediction of DNAzyme

S. Takahashi, S. Ghosh, H. Tateishi-Karimata, T, Fukunaga, M. Hamada, N. Sugimoto

Advances in Noncanonical Nucleic Acids “ANNA2024” 

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開催年月日： 2024年10月

“To B or not to B” in Nucleic Acids Chemistry 招待あり

N. Sugimoto

Giants and Forerunners in Nucleic Acid Chemistry  (Ljubljana)  2024年10月  the Slovenian Academy of Sciences and Arts

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開催年月日： 2024年10月

国名：スロベニア共和国  

Quantitative Investigation of i-Motif Structures in the CDH1 Gene Under pH and Potassium Ion Fluctuation

K. Chen, H. Tateishi-Karimata, N. Sugimoto

第15回 日本女性科学者の会 学術大会 

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開催年月日： 2024年10月

細胞内核酸の安定性と機能を予測・決定するための重要因子を明らかにする疑似細胞システム

建石 寿枝, 高橋 俊太郎, 杉本 直己

第73回高分子討論会 

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開催年月日： 2024年9月

RNA複製酵素の精密性に及ぼす分子環境の効果

高橋 俊太郎, 建石 寿枝, 杉本 直己

第73回高分子討論会 

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開催年月日： 2024年9月

四重鎖DNAを内包した人工ウイルスキャプシドの創製, つくば国際会議場

石井 楽乃, 稲葉 央, 遠藤 玉樹, 建石 寿枝, 杉本 直己, 松浦 和則

第18回バイオ関連化学シンポジウム 

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開催年月日： 2024年9月

RNA複製エラーを引き起こす非ワトソン−クリック型塩基対形成

高橋 俊太郎, 建石 寿枝, 杉本 直己

第18回バイオ関連化学シンポジウム 

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開催年月日： 2024年9月

擬似細胞システムを使った細胞内の四重らせん構造の解析

建石寿枝, 高橋俊太郎, 川内敬子, Chen Kun, 凌一葦, 奥田修二郎, 遠藤玉樹, 杉本直己

第18回バイオ関連化学シンポジウム 

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開催年月日： 2024年9月

分子クラウディング環境に応答するグアニン四重鎖形成領域のゲノムワイドスクリーニング

遠藤玉樹, 奥田修二郎, 凌一葦, 建石寿枝, 杉本直己

第18回バイオ関連化学シンポジウム 

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開催年月日： 2024年9月