論文
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Modification of the release rate of curcumin from the cavity of renatured β-1,3-1,6-glucan nanoparticles by changing the molecular weight of the constituent polysaccharide chains 査読あり
Yuki Nonoguchi, Ayumu Kodama, Toshio Suzuki, Kazuya Koumoto
Chemistry Letters 49 ( 10 ) 1150 - 1153 2020年7月
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杉本 渉, 川内 敬子, 三好 大輔
Medical Science Digest 46 ( 9 ) 26 - 27 2020年7月
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Competing Roles of Two Kinds of Ligand during Nonclassical Crystallization of Pillared-Layer Metal-Organic Frameworks Elucidated Using Microfluidic Systems
Yoko Tanaka, Yu Kitamura, Ryuji Kawano, Kan Shoji, Moe Hiratani, Tetsuo Honma, Hikaru Takaya, Hirofumi Yoshikawa, Takaaki Tsuruoka, Daisuke Tanaka
Chemistry - A European Journal 26 ( 41 ) 8889 - 8896 2020年7月
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim To diversify metal-organic frameworks (MOFs), multi-component MOFs constructed from more than two kinds of bridging ligand have been actively investigated due to the high degree of design freedom afforded by the combination of multiple ligands. Predicting the synthesis conditions for such MOFs requires an understanding of the crystallization mechanism, which has so far remained elusive. In this context, microflow systems are efficient tools for capturing non-equilibrium states as they facilitate precise and efficient mixing with reaction times that correspond to the distance from the mixing point, thus enabling reliable control of non-equilibrium crystallization processes. Herein, we prepared coordination polymers with pillared-layer structures and observed the intermediates in the syntheses with an in-situ measurement system that combines microflow reaction with UV/Vis and X-ray absorption fine-structure spectroscopies, thereby enabling their rapid nucleation to be monitored. Based on the results, a three-step nonclassical nucleation mechanism involving two kinds of intermediate is proposed.
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Takeru Torii, Wataru Sugimoto, Keiko Kawauchi, Daisuke Miyoshi
Journal of Data Mining in Genomics & Proteomics 2020年6月
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Miho Takagi-Sato, Koji Morita, Yoshiyuki Onishi, Yuuka Watahiki, Taku Ishigaki, Tomoka Akita, Erisa Tomita, Junji Kawakami, Makoto Koizumi
Nucleosides, Nucleotides & Nucleic Acids 39 ( 6 ) 838 - 852 2020年6月
出版者・発行元：Informa UK Limited
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Comparison of macrophage activation using γ-globulin and serum-derived macrophage activating factor. 査読あり
Akamatsu M, Mashiba R, Kawakatsu K, Ishikawa M, Nishikata T.
Anticancer Research 40 ( 8 ) 4707 - 4710 2020年6月
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Kazuki Kohata, Daisuke Miyoshi
Biophys. Rev. 12 669 - 676 2020年5月
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Living cells are highly crowded with large and small biomolecules. The total concentration of biomolecules can reach 400 mg/ml, and 40% of the cell volume is occupied by biomolecules. Droplet formation in cells via liquid-liquid phase separation may play a role in controlling biochemical reactions in this complex molecular environment. Liquid-liquid phase separation generally involves nucleic acids and proteins as anionic and cationic components, respectively. Significant characteristics of droplets, which make them different from protein aggregation or fibril formation, are reversibility of formation and responsiveness to the molecular environment. In this review, we quantitatively describe the molecular environment inside cells and droplets that participate in controlling central dogma reactions. Finally, we discuss the importance of droplets under conditions of molecular crowding within living cells.
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Miyazaki H , Hamada Y , Takaishi H , Minamino Y , Ikeda H , Mekata H , Takaishi M , Yamashita K , Usui K
Analyst 145 3211 - 3216 2020年5月
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Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA 査読あり
H. Tateishi-Karimata, D. Banerjee, T. Ohyama, S. Matsumoto, D. Miyoshi, S. Nakano, and N. Sugimoto
Biochemical and Biophysical Research Communications 525 ( 1 ) 177 - 183 2020年4月
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Coordination-Driven Self-Assembly on Polymer Surfaces for Efficient Synthesis of [Au(SPh)]<inf>n</inf> Coordination Polymer-Based Films
Takaaki Tsuruoka, Takashi Ohhashi, Jumpei Watanabe, Rikuto Yamada, Shoya Hirao, Yohei Takashima, Aude Demessence, Shefali Vaidya, Oleksandra Veselska, Alexandra Fateeva, Kensuke Akamatsu
Crystal Growth and Design 20 ( 3 ) 1961 - 1968 2020年3月
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出版者・発行元：American Chemical Society ({ACS})
We describe a simple bottom-up strategy to generate [Au(SPh)] (SPh: thiophenolate) coordination polymer (CP) based thin films by employing an interfacial self-assembly on a nylon substrate. This method utilizes Au ion-doped nylon film as a precursor of [Au(SPh)] CP and a support substrate to control the kinetics of the reduction of the Au ion from Au(III) to Au(I) and the complexation of Au(I) ions as well as SPh on the surface of the nylon film. The obtained CPs exhibit a fibril morphology with high crystallinity, which leads to a luminescent property. Further, we systematically study the formation mechanism of [Au(SPh)] CPs on the substrates. Amorphous CPs formed at an early stage of reaction are transformed to crystalline CPs based on the rearrangement of components during the reaction. The findings described herein offer novel and interesting openings for the synthesis of Au ion-based CPs that demonstrate desired functions for a wide range of applications. n n n
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Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA. 査読あり 国際誌
Hisae Tateishi-Karimata, Dipanwita Banerjee, Tatsuya Ohyama, Saki Matsumoto, Daisuke Miyoshi, Shu-Ich Nakano, Naoki Sugimoto
Biochemical and biophysical research communications 2020年2月
Telomeric G-quadruplex topology has the ability to regulate telomerase activity, which counteracts the shortening of telomere with successive cell divisions, thereby causing genomic longevity. However, the detailed mechanism of G-quadruplexes topologies formed by telomeric sequences requires further investigation. In this study, we quantitatively investigated the effect of cosolutes, particularly the varying number of hydroxyl groups, on the structural transition between hybrid type and parallel G-quadruplexes formed by telomeric DNA sequences. Cosolutes with one or no hydroxyl groups in the vicinal position more efficiently induced the transition to parallel G-quadruplex from hybrid G-quadruplex than those with more hydroxyl groups. We also examined the effect of cosolute structures on the hydration of G-quadruplex formation; the results indicated that cosolutes with fewer hydroxyl groups lead to the release of greater amount of water during G-quadruplex formation. Molecular dynamics results showed that the parallel G-quadruplex was more dehydrated than the hybrid type G-quadruplex. Generally, a dehydrated structure is favored under crowding condition. Thus, depending on the surrounding cosolutes, the G-quadruplex topology can be controlled by the G-quadruplex hydration state.
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Solubilization of poorly water-soluble bioactive molecules in neutral aqueous media by complexation with renatured beta-1,3-1,6-glucan nanoparticles 査読あり 国際誌
Ayumu Kodama, Akifumi Nakagawa, Yuki Nonoguchi, Haruka Sakurai, Chieko Yano, Toshio Suzuki, Kazuya Koumoto
Biopolymers 111 ( 4 ) e23349 2020年2月
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MMP24 as a Target of YAP is a Potential Prognostic Factor in Cancer Patients 査読あり 国際誌
Wataru Sugimoto, Katsuhiko Ito, Hiroaki Hirata, Yoshinori Abe, Takeru Torii, Yasumasa Mitsui, Yemima Budirahardja, Nobuyuki Tanaka, Keiko Kawauchi
Bioengineering 7 ( 18 ) 1 - 12 2020年2月
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担当区分：最終著者, 責任著者
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Therapeutic effect of intravenously administered autologous adipose-derived stem cells on chronic stage stroke patients. 査読あり
Masamitsu Ichihashi, Masaki Tanaka, Takashi Iizuka, Narumi Nagoe, Youko Sato, Hitomi Takahashi, Asami Ueda, Hiroko Tokura, Narumi Takanashi, Takahito Nishikata, Osamu Matsuo, Hideya Ando, and Ken-ichiMizutani
International Journal of Stem Cell Research & Therapy 7 070 2020年
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Coordination-Driven Self-Assembly on Polymer Surface for Efficient Synthesis of [Au(SPh)]n Coordination Polymer-Based Films
T. Tsuruoka, T. Ohhashi, J. Watanabe, R. Yamda, S. Hirao, T. Takashima, A. Demessence, S. Vaidya, O. Veselska, A. Fateeva, K. Akamatsu
Cryst. Growth 1961 - 1968 2020年
単著
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Controlled syntheses of Ag nanoparticles inside MOFs by using amine-boranes as vapour phase reductants 査読あり
Yohei Takashima, Yasushi Sato, Takaaki Tsuruoka, Kensuke Akamatsu
Dalton Transactions 2020年
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好熱性細菌および酵母菌による多段階培養発酵技術から得られた 発酵エキスの皮膚に対する有用性 査読あり
川野 大地, 廖 筝筝, 聶 菁, 伊達 朗, Eduardo Perez, Jose Fernandez, Corey Webb, Kristen Huber, Jeffry B. Stock, 川上 純司, 付 子華
日本香粧品学会誌 44 ( 3 ) 194 - 202 2020年
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Different reactivity of Sp and Rp isomers of phosphorothioate-modified oligonucleotides in a duplex structure 査読あり
Md Ariful Islam, Aki Fujisaka, Junji Kawakami, Takao Yamaguchi, Satoshi Obika
Bioorg. Med. Chem. Lett. 30 ( 14 ) 127166 - 127166 2020年
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Novel purification process for amyloid beta peptide(1-40) 招待あり 査読あり
Usui, K., Yokota, S.-I., Iwata, K., Hamada, Y.
Processes 8 2020年
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Miyazaki, H., Samejima, Y., Iwata, K., Minamino, Y., Hikida, S., Ariumi, H., Ikeda, H., Hamada, Y., Yamashita, K., Usui, K.
International Journal of Molecular Sciences 21 2020年