論文
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Yohei Takashima, Seiko Tetsusashi, Shintaro Tanaka, Takaaki Tsuruoka, Kensuke Akamatsu
RSC Advances 13 ( 11 ) 7464 - 7467 2023年
出版者・発行元：Royal Society of Chemistry (RSC)
Polypyrrole-coated palladium nanoparticles could be directly generated inside a metal–organic frameworks. The resulting MOF composites exhibited higher semihydrogenation capability than the analog composite without polypyrrole coating.
DOI： 10.1039/d2ra08190c
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Yohei Takashima, Seiko Tetsusashi, Mai Takano, Shintaro Tanaka, Yui Murakami, Takaaki Tsuruoka, Kensuke Akamatsu
Dalton Transactions 52 ( 32 ) 11158 - 11162 2023年
出版者・発行元：Royal Society of Chemistry (RSC)
In this study, we demonstrated the direct synthesis of sodium dihydrogen phosphate (PA) containing palladium nanoparticles (PdNPs) supported on a metal–organic framework (MOF) for hydrogenation catalysis.
DOI： 10.1039/d2dt04109j
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Evaluation of thermal stability of DNA oligonucleotide structures embedded in hydrogels 招待あり 査読あり 国際誌
D. Yamaguchi, M. Yoshida, S. Nakano
DNA 2 ( 4 ) 302 - 313 2022年12月
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Controlling liquid-liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner. 査読あり 国際誌
Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Chemical communications (Cambridge, England) 58 ( 93 ) 12931 - 12934 2022年11月
共著
We constructed a minimum liquid-liquid phase separation model system to form liquid droplets using only G-quadruplex-forming oligonucleotides and R- and G-rich oligopeptides. We found that the G-quadruplex structure is an essential component for RNA to form droplets with the peptide. Based on this model system and our findings, droplet redissolution via structure transition from a G-quadruplex to a duplex was achieved in a sequence-specific manner.
DOI： 10.1039/d2cc04366a
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Covalent Stem Cell-Combining Injectable Materials with Enhanced Stemness and Controlled Differentiation In Vivo 査読あり
Natsumi Ueda, Shiho Sawada, Fumiya Yuasa, Karen Kato, Koji Nagahama
ACS Applied Materials & Interfaces 14 ( 47 ) 52618 - 52633 2022年11月
担当区分：最終著者, 責任著者
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ポリエチレングリコールによるアトピー性皮膚炎予防の可能性
厳原美穂、甲元一也
Fragrance Journal 50 ( 11 ) 54 - 57 2022年11月
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Controlling liquid–liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner 査読あり 国際誌
Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi-Karimata, Naoki Sugimoto and Daisuke Miyoshi
Chem. Commun. 58 ( 93 ) 12931 - 12934 2022年11月
We constructed a minimum liquid-liquid phase separation model system to form liquid droplets using only G-quadruplex-forming oligonucleotides and R- and G-rich oligopeptides. We found that the G-quadruplex structure is an essential component for RNA to form droplets with the peptide. Based on this model system and our findings, droplet redissolution via structure transition from a G-quadruplex to a duplex was achieved in a sequence-specific manner.
DOI： 10.1039/D2CC04366A
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Two-Dimensional Metal–Organic Framework-Based Cellular Scaffolds with High Protein Adsorption, Retention, and Replenishment Capabilities 査読あり
Tokitaka Katayama, Shintaro Tanaka, Takaaki Tsuruoka, and Koji Nagahama
ACS Applied Materials & Interfaces 14 ( 30 ) 34443 - 34454 2022年8月
担当区分：最終著者, 責任著者
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Two-Dimensional Metal–Organic Framework-Based Cellular Scaffolds with High Protein Adsorption, Retention, and Replenishment Capabilities 査読あり
Tokitaka Katayama, Shintaro Tanaka, Takaaki Tsuruoka, Koji Nagahama
ACS Applied Materials & Interfaces 2022年8月
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Evaluation of weak interactions of proteins and organic cations with DNA duplex structures 査読あり 国際誌
R. Morimoto, M. Horita, D. Yamaguchi, H. Nakai, and S. Nakano
Biophys. J. 121 ( 15 ) 2873 - 2881 2022年8月
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細胞内環境で安定化される核酸非構造を狙った分子標的薬の開発 招待あり
川内敬子・橋本佳樹・杉本 渉・三好大輔
バイオマテリアル = Journal of Japanese Society for Biomaterials : 生体材料 40 ( 3 ) 206 - 211 2022年7月
担当区分：責任著者
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核酸の化学修飾と構造や相分離能の相関 招待あり
鶴田 充生・取井 猛流・杉本 渉・川内 敬子・三好 大輔
月刊「細胞」（ニューサイエンス社） 53 ( 14 ) 910 - 913 2022年6月
担当区分：最終著者, 責任著者
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Exportin-inspired artificial cell nuclear-exporting nanosystems 査読あり
Mitsuo Inui , Yuta Hamada , Nana Sejima , Natsumi Ueda , Tokitaka Katayama , Kimika Ono, Koji Nagahama
Nanoscale Advances 4 2637 - 2641 2022年5月
担当区分：最終著者, 責任著者
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Significant structural change in human c-Myc promoter G-quadruplex 査読あり 国際共著
Nikita Kundu, Taniya Sharma, Sarvpreet Kaur, Mamta Singh, Vinit Kumar, Uttam Sharma, Aklank Jain, Jadala Shankaraswamy, Daisuke Miyoshi, Sarika Saxena
RSC Adv. 12 7594 - 7604 2022年4月
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Kimika Ono, Manami Sumiya, Naohiro Yoshinobu, Tatsuya Dode, Tokitaka Katayama, Natsumi Ueda, Koji Nagahama
ACS Applied Bio Materials 5 ( 2 ) 471 - 482 2022年2月
担当区分：最終著者, 責任著者
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Toshiyuki Goto, Shuhei Torii, Aoi Kondo, Kazumasa Kanda, Junji Kawakami, Yosky Kataoka, Takahito Nishikata
Journal of Developmental Biology 10 ( 1 ) 10 - 10 2022年2月
出版者・発行元：MDPI AG
In many animal species, the body axis is determined by the relocalization of maternal determinants, organelles, or unique cell populations in a cytoskeleton-dependent manner. In the ascidian first cell cycle, the myoplasm, including mitochondria, endoplasmic reticulum (ER), and maternal mRNAs, move to the future posterior side concomitantly (called ooplasmic segregation or cytoplasmic and cortical reorganization). This translocation consists of first and second phases depending on the actin and microtubule, respectively. However, the transition from first to second phase, that is, translocation of myoplasmic components from microfilaments to microtubules, has been poorly investigated. In this study, we analyzed the relationship between these cytoskeletons and myoplasmic components during the first cell cycle and their role in morphogenesis by inhibitor experiments. Owing to our improved visualization techniques, there was unexpected F-actin accumulation at the vegetal pole during this transition period. When this F-actin was depolymerized, the microtubule structure was strongly affected, the myoplasmic components, including maternal mRNA, were mislocalized, and the anteroposterior axis formation was disordered. These results suggested the importance of F-actin during the first cell cycle and the existence of interactions between microfilaments and microtubules, implying the enigmatic mechanism of ooplasmic segregation. Solving this mystery leads us to an improved understanding of ascidian early development.
DOI： 10.3390/jdb10010010
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Dynamic Changes in the Aassociation between Maternal mRNAs and Endoplasmic Reticulum during Ascidian Early Embryogenesis. 査読あり
Goto T, Torii S, Kondo A, Yagi H, Suekane M, Kataoka Y, Nishikata T
Development Genes and Evolution 232 ( 1 ) 1 - 14 2022年2月
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Actin Filament in the First Cell Cycle Contributes to the Determination of the Anteroposterior Axis in Ascidian Development. 査読あり
Goto T, Torii S, Kondo A, Kanda K, Kataoka Y, Nishikata T
Journal of Developmental Biology 10 ( 1 ) 10 - 23 2022年2月
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Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene 査読あり
Wataru Sugimoto, Natsuki Kinoshita, Minori Nakata, Tatsuya Ohyama, Hisae Minatojima-Minaminachi, Takahito Nishikata, Naoki Sugimoto, Daisuke Miyoshi, Keiko Kawauchi
Chem. Commun. 58 48 - 51 2022年1月
担当区分：責任著者
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De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide. 査読あり 国際共著 国際誌
Keisuke Shimizu, Batsaikhan Mijiddorj, Masataka Usami, Ikuro Mizoguchi, Shuhei Yoshida, Shiori Akayama, Yoshio Hamada, Akifumi Ohyama, Kenji Usui, Izuru Kawamura, Ryuji Kawano
Nature nanotechnology 17 67 - 75 2022年1月
The amino-acid sequence of a protein encodes information on its three-dimensional structure and specific functionality. De novo design has emerged as a method to manipulate the primary structure for the development of artificial proteins and peptides with desired functionality. This paper describes the de novo design of a pore-forming peptide, named SV28, that has a β-hairpin structure and assembles to form a stable nanopore in a bilayer lipid membrane. This large synthetic nanopore is an entirely artificial device for practical applications. The peptide forms multidispersely sized nanopore structures ranging from 1.7 to 6.3 nm in diameter and can detect DNAs. To form a monodispersely sized nanopore, we redesigned the SV28 by introducing a glycine-kink mutation. The resulting redesigned peptide forms a monodisperse pore with a diameter of 1.7 nm leading to detection of a single polypeptide chain. Such de novo design of a β-hairpin peptide has the potential to create artificial nanopores, which can be size adjusted to a target molecule.