論文
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Direct formation of ZIF-8 crystal thin films on the surface of a zinc ion-doped polymer substrate 査読あり
Takaaki Tsuruoka, Kaito Araki, Kouga Kawauchi, Yohei Takashima, Kensuke Akamatsu
Inorganics 12 21 2024年1月
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“Interfacial analysis of the ion-transport process controlling the steady-state current in a two-phase electrodeposition system using polyelectrolyte membranes
S. Yamada, Y. Takashima, T. Tsuruoka, K. Akamatsu
RSC Applied Interfaces 2024年
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Structural transformation of silver(I)-thiolate coordination polymer film at solid–liquid interfaces
M. Fukuoka, Y. Takashima, K. Akamatsu, A. Demessence, T. Tsuruoka
CrystEngComm 26 6269 - 6273 2024年
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Preparation of golf ball-like polymer particles bearing site-selective functional groups
T. Morishita, I. Maitani, T. Michiura, N. Suzuki, T. Suzuki, K. Akamatsu, H. Minami
ACS Appl. Mater.Interfaces in press 2024年
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Structure and Thermoelectric Characterization of p-Type SnTe Nanobulk Material Synthesized by Charge Compensation Chemical Reaction
Ryosuke Fujiwara, Yuta Ikeda, Takuto Kawaguchi, Yohei Takashima , Takaaki Tsuruoka and Kensuke Akamatsu
Energies 17 ( 190 ) 2024年
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Cr(NO3)3 as a New Etching Reagent for an Al-based Metal-Organic Framework to Control Its Crystal Size and Defects
Y. Takashima, N. Tanabe, S. Tanaka, T. Tsuruoka, K. Akamatsu
Cryst. Growth Des 24 1766 - 1773 2024年
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Direct Formation of ZIF-8 Crystal Thin Films on the Surface of a Zinc Ion-Doped Polymer Substrate
T. Tsuruoka, K. Araki, K. Kawauchi, Y. Takashima, K. Akamatsu
Inroganics 12 ( 21 ) 2024年
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Shunsuke Yamada, Yohei Takashima, Takaaki Tsuruoka, Kensuke Akamatsu
RSC Applied Interfaces 2024年
出版者・発行元：Royal Society of Chemistry (RSC)
An interfacial model has been developed for describing ion transport kinetics at the membrane/solution interface in the new solid-electrodeposition system.
DOI： 10.1039/d4lf00112e
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Asuka Nishibe, Ryohei Akiyoshi, Akinori Saeki, Kazuyoshi Ogasawara, Takaaki Tsuruoka, Daisuke Tanaka
Chemical Communications 2024年
出版者・発行元：Royal Society of Chemistry (RSC)
The impact of inorganic (–Cd–S–)<sub>n</sub> assemblies on semiconductive properties is demonstrated by systematically synthesizing one-dimensional Cd(ii) benzenethiolate coordination polymers.
DOI： 10.1039/d3cc05689a
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Ryosuke Fujiwara, Yuta Ikeda, Takuto Kawaguchi, Yohei Takashima, Takaaki Tsuruoka, Kensuke Akamatsu
Energies 17 ( 1 ) 190 - 190 2023年12月
出版者・発行元：MDPI AG
SnTe is the most widely studied p-type thermoelectric (TE) alternative to PbTe. In this study, we prepared a nanostructured SnTe bulk material via spark plasma sintering from a precursor synthesized by a chemical precipitation process without using organic molecules. The sintered sample comprised tiny grains (100–300 nm) with high-density grain boundaries. Eventually, because the material would contain no impurities acting as scattering nodes of charge carriers, the material exhibited a relatively high electrical conductivity of 7.07 × 105 Sm−1 at 310 K. The material demonstrated low lattice thermal conductivity (0.87 Wm−1K−1 at 764 K), which can be owing to the increasing phonon scattering at grain boundaries. The maximum ZT was 0.31 at 764 K in the measured temperature range. This study provides a method for the design of phase-pure and surfactant-free SnTe thermoelectric materials that exhibit low lattice thermal conductivity and high carrier mobility using a chemical synthetic approach.
DOI： 10.3390/en17010190
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Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments 査読あり
Torii T, Sugimoto W, Itoh K, Kinoshita N, Gessho M, Goto T, Uehara I, Nakajima W, Budirahardja Y, Miyoshi D, Nishikata T, Tanaka N, Kawauchi K
Cell Death and Disease 14 766 2023年11月
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Comparison of evolutionary relationships between Branchiostoma floridae, Ciona intestinalis, and Homo sapiens globins provide evidence of gene co-option and convergent evolution 査読あり
Yano N, Minamoto T, Yamaguchi H, Goto T, Nishikata T
International Journal of Molecular Science 24 16009 2023年11月
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Kaoru Karasawa, Eva Duchoslav, Lyle Burton, Junji Kawakami, Takashi Baba
Analytical Chemistry 95 ( 44 ) 16352 - 16358 2023年10月
共著
We report the first sequencing of morpholino antisense oligonucleotides (phosphorodiamidate morpholino oligomers, PMOs) using electron capture dissociation (ECD) mass spectrometry. In this research, we found dissociation of the backbone of 18- to 25-mer PMOs to produce d and z ions as the major ions, and 100% cleavage coverage (sequence coverage) was obtained with these ions. This is a critical contrast with beam-type collision-induced dissociation, which dominantly induces base loss, so it is difficult to obtain sequence information. The results showed that an electron beam energy (typically 15 eV) can be used universally for PMOs with different sequences, lengths, and charge states so that no detailed optimization is required for multiprecursor targeting liquid chromatography coupled with tandem mass spectrometry measurements. We also confirmed that the ECD reaction speed was compatible with the high-performance liquid chromatography time scale. Finally, we demonstrated a liquid chromatography electron capture dissociation tandem mass spectrometry workflow to survey the modification sites of the emulated PMO impurities.
DOI： 10.1021/acs.analchem.3c03621
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Mitochondrial Dynamics of Bcl-2 Family Proteins during 17-β-Estradiol-Induced Apoptosis Correlate with the Malignancy of Endometrial Cancer Cells 査読あり
Takahiro Yaguchi, Misaki Kameno, Hirofumi Taira, and Junji Kawakami
Biochemstry 62 ( 21 ) 3041 - 3049 2023年10月
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複数種の液体クロマトグラフ質量分析計を用いたモデル核酸医薬品の分析データの比較 査読あり
Kenji Hirose, Tokuyuki Yoshida, Maki Terasaki, Hiroshi Sezaki, Kaoru Karasawa, Noriyuki Iwasaki, Kentaro Takahara, Naomi Takiguchi, Mitsuaki Sekiguchi, Hirokazu Nankai, Emi Saito, Hideaki Sato, Takashi Osawa, Takao Yamaguchi, Kosuke Ito, Junji Kawakami, Satoshi Obika, and Takao Inoue
54 439 - 454 2023年10月
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Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments 査読あり 国際誌
Takeru Torii, Wataru Sugimoto, Katsuhiko Itoh, Natsuki Kinoshita, Masaya Gessho, Toshiyuki Goto, Ikuno Uehara, Wataru Nakajima, Yemima Budirahardja, Daisuke Miyoshi, Takahito Nishikata, Nobuyuki Tanaka, Hiroaki Hirata, Keiko Kawauchi
Cell Death & Disease 14 ( 11 ) 766766 - 766 2023年8月
Tumor suppressor p53 plays a central role in response to DNA damage. DNA-damaging agents modulate nuclear actin dynamics, influencing cell behaviors; however, whether p53 affects the formation of nuclear actin filaments remains unclear. In this study, we found that p53 depletion promoted the formation of nuclear actin filaments in response to DNA-damaging agents, such as doxorubicin (DOXO) and etoposide (VP16). Even though the genetic probes used for the detection of nuclear actin filaments exerted a promotive effect on actin polymerization, the detected formation of nuclear actin filaments was highly dependent on both p53 depletion and DNA damage. Whilst active p53 is known to promote caspase-1 expression, the overexpression of caspase-1 reduced DNA damage-induced formation of nuclear actin filaments in p53-depleted cells. In contrast, co-treatment with DOXO and the pan-caspase inhibitor Q-VD-OPh or the caspase-1 inhibitor Z-YVAD-FMK induced the formation of nuclear actin filament formation even in cells bearing wild-type p53. These results suggest that the p53-caspase-1 axis suppresses DNA damage-induced formation of nuclear actin filaments. In addition, we found that the expression of nLifeact-GFP, the filamentous-actin-binding peptide Lifeact fused with the nuclear localization signal (NLS) and GFP, modulated the structure of nuclear actin filaments to be phalloidin-stainable in p53-depleted cells treated with the DNA-damaging agent, altering the chromatin structure and reducing the transcriptional activity. The level of phosphorylated H2AX (γH2AX), a marker of DNA damage, in these cells also reduced upon nLifeact-GFP expression, whilst details of the functional relationship between the formation of nLifeact-GFP-decorated nuclear actin filaments and DNA repair remained to be elucidated. Considering that the loss of p53 is associated with cancer progression, the results of this study raise a possibility that the artificial reinforcement of nuclear actin filaments by nLifeact-GFP may enhance the cytotoxic effect of DNA-damaging agents in aggressive cancer cells through a reduction in gene transcription.
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Kenji Usui, Makoto Ozaki, Kan Hirao, Tsubasa Kosaka, Natsumi Endo, Shuhei Yoshida, Shin-ichiro Yokota, Yonejiro Arimoto, Ryuji Osawa, Nobuhiro Nakanishi, Kin-ya Tomizaki, Tomohiro Umetani, Fumihiro Kayamori
Scientific Reports 13 12027 2023年7月
担当区分：最終著者, 責任著者
Microwaves are used for diverse applications such as mobile phones, ovens, and therapy devices. However, there are few reports on the effects of microwaves on diseases other than cancer, and on physiological processes. Here, we focused on CaCO3 mineralization as a model of biomineralization and attempted to elucidate the effect of microwaves on CaCO3 mineralization using peptides. We conducted AFM, ζ potential, HPLC, ICP-AES, and relative permittivity measurements. Our findings show that microwaves alter the nanomorphology of the CaCO3 precipitate, from sphere-like particles to string-like structures. Furthermore, microwaves have little effect on the mineralization when the mineralization ability of a peptide is high, but a large effect when the precipitation ability is low. Our findings may be applicable to not only the treatment of teeth and bones but also the development of organic–inorganic nanobiomaterials. This methodology can be expanded to other molecular/atomic reactions under various microwave conditions to alter reaction activity parameters.
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Thixotropic β-Chitin Nanofiber Hydrogel with a Living Body-Responsive Self-Hardening Property and Its Application as a Sprayable Antiadhesion Barrier 査読あり 国際誌
Koji Nagahama, Kaho Tobiishi, Natsumi Ueda, Tatsuya Dode, Shahidul Islam Sobuj, Fumiya Yuasa, Kazuhiko Yamashita, Takahito Nishikata
ACS Applied Bio Materials 6 ( 7 ) 2636 - 2643 2023年7月
担当区分：筆頭著者, 責任著者
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Effect of linearly polarized microwaves on nanomorphology of calcium carbonate mineralization using peptides 査読あり
Kenji Usui, Makoto Ozaki, Kan Hirao, Tsubasa Kosaka, Natsumi Endo, Shuhei Yoshida, Shin-ichiro Yokota, Yonejiro Arimoto, Ryuji Osawa, Nobuhiro Nakanishi, Kin-ya Tomizaki, Tomohiro Umetani, Fumihiro Kayamori
Scientific Reports 13 12027 2023年7月
Microwaves are used for diverse applications such as mobile phones, ovens, and therapy devices. However, there are few reports on the effects of microwaves on diseases other than cancer, and on physiological processes. Here, we focused on CaCO3 mineralization as a model of biomineralization and attempted to elucidate the effect of microwaves on CaCO3 mineralization using peptides. We conducted AFM, ζ potential, HPLC, ICP-AES, and relative permittivity measurements. Our findings show that microwaves alter the nanomorphology of the CaCO3 precipitate, from sphere-like particles to string-like structures. Furthermore, microwaves have little effect on the mineralization when the mineralization ability of a peptide is high, but a large effect when the precipitation ability is low. Our findings may be applicable to not only the treatment of teeth and bones but also the development of organic–inorganic nanobiomaterials. This methodology can be expanded to other molecular/atomic reactions under various microwave conditions to alter reaction activity parameters.
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Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite 査読あり
Momoko Usuda, Mariko Kametani, Masakazu Hamada, Yuto Suehiro, Saaya Matayoshi, Rena Okawa, Shuhei Naka, Michiyo Matsumoto-Nakano, Tatsuya Akitomo, Chieko Mitsuhata, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano and Ryota Nomura
Int J Mol Sci 24 11371 2023年7月