論文
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Comprehensive analysis of stability and variability of DNA minimal i-motif structures 招待あり 査読あり
K. Ashida, A. Kitabayashi, K. Nishiyama, and S. Nakano
Molecules 30 1831 2025年4月
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One-Pot Synthesis and Immobilization of Gold Nanoparticles Using Peptidyl Microbeads
Shuhei Yoshida, Koki Yoshida, Taichi Isozaki, Maho Oura, Makoto Ozaki, Takaaki Tsuruoka, Kenji Usui
Molecules 30 1689 2025年4月
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Liquid-liquid phase separation induced by i-motif DNA under molecular crowding conditions 招待あり 査読あり
Ryosuke Suzuki, Mitsuki Tsuruta, Sumit Shil, Kosei Morohashi, Keiko Kawauchi, Daisuke Miyoshia
Polymer J. 2025年4月
担当区分：責任著者
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Tendon Tissue Regeneration With Cell Orientation Using an Injectable Alginate-Cell Cross-linked Gel 査読あり
Jun Yamaguchi, Kentaro Homan, Tomohiro Onodera, Masatake Matsuoka, Shoutaro Arakawa, Natsumi Ueda, Nana Kawate, Takayuki Nonoyama, Yoshinori Katsuyama, Koji Nagahama, Mitsuru Saito, Norimasa Iwasaki
The American Journal of Sports Medicine 2025年3月
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Three- and four-stranded nucleic acid structures and their ligands 招待あり 査読あり
Yoshiki Hashimoto, Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi, and Daisuke Miyoshi
RSC Chemical Biology 6 466 - 491 2025年3月
担当区分：責任著者
DOI： 10.1039/D4CB00287C
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ケミカルバイオロジーの冒険（１２） 核酸を標的とした低分子・中分子化合物 招待あり
堂野主税、勝田陽介、三好大輔
現代化学 648 32 - 39 2025年2月
担当区分：最終著者
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Roles of Loop Region in Folding Kinetics and Transcription Inhibition of DNA G-Quadruplexes 査読あり
Minori Nakata, Naoki Kosaka, Keiko Kawauchi, Daisuke Miyoshi
64 609 - 619 2025年2月
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Development of a New Structural Transformation Reaction in Cr-Based MOFs Induced by Fluoride 査読あり
Shintaro Tanaka, Ryoya Miyata, Reon Teramoto, Junya Sugimoto, Takaaki Tsuruoka, Kensuke Akamatsu, Yohei Takashima
Chem. Asian J e202401717 2025年2月
担当区分：最終著者, 責任著者
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Development of detection system for lead ions in mixture solutions using UV-Vis measurements with peptide immobilized microbeads
Shuhei Yoshida, Koki Yoshida, Yoshio Hamada, Takaaki Tsuruoka, Kenji Usui
Scientific Reports 15 3249 2025年1月
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Complex and Non-sequential Current Signatures of a β-Hairpin Peptide Confined in a Nanopore 国際共著
Misa Yamaji, Mauro Chinappi, Blasco Morozzo della Rocca, Kenji Usui, Ryuji Kawano
Analytical Chemistry 97 2044 - 2051 2025年1月
出版者・発行元：American Chemical Society (ACS)
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Roles of Loop Region in Folding Kinetics and Transcription Inhibition of DNA G-Quadruplexes 査読あり
Minori Nakata, Naoki Kosaka, Keiko Kawauchi, Daisuke Miyoshi
Biochemistry 64 609 - 619 2025年1月
担当区分：責任著者
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Factors affecting liquid-liquid phase separation of RGG peptides with DNA G-Quadruplex 査読あり
Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi, Daisuke Miyoshi
ChemMedChem 20 ( 2 ) e202400460 2025年1月
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The role of cytosine methylation in regulating the topology and liquid-liquid phase separation of DNA G-quadruplexes 査読あり
Mitsuki Tsuruta, Sumit Shil, Shinya Taniguchi, Keiko Kawauchi, Daisuke Miyoshi
Chemical Science 16 ( 10 ) 4213 - 4225 2025年1月
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Sequence-Specific Free Energy Changes in DNA/RNA Induced by a Single LNA-T Modification in Antisense Oligonucleotides 査読あり
Elisa Tomita-Sudo, Tomoka Akita, Nae Sakimoto, Saori Tahara-Takamine, Junji Kawakami
International Journal of Molecular Sciences 25 13240 - 13240 2024年12月
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Bioinformatic analysis of actin-binding proteins in the nucleolus during heat shock 招待あり 査読あり
Shinya Taniguchi, Takeru Torii, Toshiyuki Goto, Kohei Takeuchi, Rine Katsumi, Mako Sumida, Sunmin Lee, Wataru Sugimoto, Masaya Gessho, Katsuhiko Itoh, Hiroaki Hirata, Junji Kawakami, Daisuke Miyoshi, Keiko Kawauchi
Genes 15 1580 2024年12月
担当区分：最終著者, 責任著者
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L-Histidine Modulates the Catalytic Activity and Conformational Changes of the HD3 Deoxyribozyme 査読あり
Nae Sakimoto, Hirofumi Imanaka, Elisa Tomita-Sudo, Tomoka Akita, Junji Kawakami
genes 15 1481 2024年11月
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NRAS DNA G-quadruplex-targeting molecules for sequence-selective enzyme inhibition 査読あり
Yoshiki Hashimoto, Hiroki Kubo, Keiko Kawauchi, Daisuke Miyoshi
Chem. Commun. 60 13179 - 13182 2024年11月
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異なるカチオン共存下におけるG4 アプタマーの構造変化のカロリメトリーを用いた検出 招待あり 査読あり
冨田 恵麗沙，石垣 卓，廣瀬 雅子, 加藤 眞紀, 川上 純司
熱測定 51 ( 4 ) 148 - 152 2024年10月
担当区分：最終著者
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NRAS DNA G-quadruplex-targeting molecules for sequence-selective enzyme inhibition 招待あり 査読あり
Yoshiki Hashimoto, Hiroki Kubo, Keiko Kawauchi and Daisuke Miyoshi
Chem. Commun. 2024年10月
担当区分：責任著者
DOI： 10.1039/D4CC03753G
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The role of cytosine methylation in regulating the topology and liquid-liquid phase separation of DNA G-quadruplexes 査読あり
Mitsuki Tsuruta, Sumit Shil, Shinya Taniguchi, Keiko Kawauchi and Daisuke Miyoshi
Chem. Sci. 16 4213 - 4225 2024年10月
担当区分：責任著者
DOI： 10.1039/D4SC06959E
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Structural transformation of silver(I)-thiolate coordination plymer film at solid-liquid interfaces 査読あり 国際共著
Myu Fukuoka, Yohei Takashima, Kensuke Akamatsu, Aude Demessence, Takaaki Tsuruoka
CrystEngComm 26 6269 - 6273 2024年10月
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Factors Affecting Liquid-Liquid Phase Separation of RGG Peptides with DNA G-Quadruplex 招待あり 査読あり
Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi, Daisuke Miyoshi
ChemMedChem 2024年9月
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Bioinformatic Analysis of Actin-Binding Proteins in the Nucleolus During Heat Shock 招待あり 査読あり
Shinya Taniguchi, Takeru Torii ,Toshiyuki Goto, Kohei Takeuchi, Rine Katsumi, Mako Sumida, Sunmin Lee, Wataru Sugimoto, Masaya Gessho, Katsuhiko Itoh, Hiroaki Hirata, Junji Kawakami, Daisuke Miyoshi and Keiko Kawauchi
Genes 15 ( 12 ) 1580 2024年9月
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Non-canonical olfactory pathway activation induces cell fusion of cervical cancer cells. 査読あり 国際誌
Keigo Araki, Takeru Torii, Kohei Takeuchi, Natsuki Kinoshita, Ryoto Urano, Rinka Nakajima, Yaxuan Zhou, Tokuo Kobayashi, Tadayoshi Hanyu, Kiyoshi Ohtani, Kimiharu Ambe, Keiko Kawauchi
Neoplasia 57 101044 - 101044 2024年8月
担当区分：最終著者
Multinucleation occurs in various types of advanced cancers and contributes to their malignant characteristics, including anticancer drug resistance. Therefore, inhibiting multinucleation can improve cancer prognosis; however, the molecular mechanisms underlying multinucleation remain elusive. Here, we introduced a genetic mutation in cervical cancer cells to induce cell fusion-mediated multinucleation. The olfactory receptor OR1N2 was heterozygously mutated in these fused cells; the same OR1N2 mutation was detected in multinucleated cells from clinical cervical cancer specimens. The mutation-induced structural change in the OR1N2 protein activated protein kinase A (PKA), which, in turn, mediated the non-canonical olfactory pathway. PKA phosphorylated and activated furin protease, resulting in the cleavage of the fusogenic protein syncytin-1. Because this cleaved form of syncytin-1, processed by furin, participates in cell fusion, furin inhibitors could suppress multinucleation and reduce surviving cell numbers after anticancer drug treatment. The improved anticancer drug efficacy indicates a promising therapeutic approach for advanced cervical cancers.
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Quantitative Effects of the Loop Region on Topology, Thermodynamics, and Cation Binding of DNA G-quadruplexes 査読あり
Minori Nakata, Naoki Kosaka, Keiko Kawauchi, Daisuke Miyoshi
ACS Omega 9 35028 - 35036 2024年7月
担当区分：最終著者, 責任著者
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Development of a CaCO3 Precipitation Method Using a Peptide and Microwaves Generated by a Magnetron 査読あり
Fumihiro Kayamori, Hiroyuki Togashi, Natsumi Endo, Makoto Ozaki, Kan Hirao, Yonejiro Arimoto, Ryuji Osawa, Takaaki Tsuruoka, Takahito Imai, Kin-ya Tomizaki, Tomohiro Umetani, Nobuhiro Nakanishi, Kenji Usui
Processes 12 1327 - 1327 2024年6月
出版者・発行元：MDPI AG
Microwave applications, such as microwave ovens and mobile phones, are ubiquitous and indispensable in modern society. As the utilization of microwave technology is becoming more widespread, the effects of microwaves on living organisms and physiological processes have received increased attention. This study aimed to investigate the effects of microwaves on calcium carbonate biomineralization as a model biochemical process. A magnetron oscillator was used to generate 2450 MHz microwaves because magnetrons are relatively inexpensive and widespread. We conducted transmission electron microscopy (TEM), atomic force microscopy (AFM), TEM-electron energy-loss spectroscopy (EELS), dynamic light scattering (DLS), and high-performance liquid chromatography (HPLC) measurements to analyze the calcium carbonate precipitates. Our findings showed the formation of string-like precipitates of calcium carbonate upon microwave irradiation from one direction, similar to those obtained using a semiconductor oscillator, as reported previously. This implied that the distribution of the frequency had little effect on the morphology. Furthermore, spherical precipitates were obtained upon microwave irradiation from two directions, indicating that the morphology could be controlled by varying the direction of microwave irradiation. Magnetrons are versatile and also used in large-scale production; thus, this method has potential in medical and industrial applications.
DOI： 10.3390/pr12071327
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Development of a CaCO3 Precipitation Method Using a Peptide and Microwaves Generated by a Magnetron 査読あり
Fumihiro Kayamori Hiroyuki Togashi Natsumi Endo Makoto Ozaki Kan Hirao Yonejiro Arimoto Ryuji Osawa Takaaki Tsuruoka Takahito Imai Kin-ya Tomizaki Tomohiro Umetani Nobuhiro Nakanishi Kenji Usui
Processes 12 ( 7 ) 1327 2024年6月
Microwave applications, such as microwave ovens and mobile phones, are ubiquitous and indispensable in modern society. As the utilization of microwave technology is becoming more widespread, the effects of microwaves on living organisms and physiological processes have received increased attention. This study aimed to investigate the effects of microwaves on calcium carbonate biomineralization as a model biochemical process. A magnetron oscillator was used to generate 2450 MHz microwaves because magnetrons are relatively inexpensive and widespread. We conducted transmission electron microscopy (TEM), atomic force microscopy (AFM), TEM-electron energy-loss spectroscopy (EELS), dynamic light scattering (DLS), and high-performance liquid chromatography (HPLC) measurements to analyze the calcium carbonate precipitates. Our findings showed the formation of string-like precipitates of calcium carbonate upon microwave irradiation from one direction, similar to those obtained using a semiconductor oscillator, as reported previously. This implied that the distribution of the frequency had little effect on the morphology. Furthermore, spherical precipitates were obtained upon microwave irradiation from two directions, indicating that the morphology could be controlled by varying the direction of microwave irradiation. Magnetrons are versatile and also used in large-scale production; thus, this method has potential in medical and industrial applications.
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Inhibition of RNA phosphodiester backbone cleavage in the presence of organic cations of different sizes 招待あり 査読あり 国際誌
S. Yoshioka, A. Doi, and S. Nakano
ChemBioChem 25 ( 13 ) e202400276 2024年5月
共著
担当区分：最終著者, 責任著者 出版者・発行元：Wiley
Living cells contain various types of organic cations that may interact with nucleic acids. In order to understand the nucleic acid–binding properties of organic cations of different sizes, we investigated the ability of simple organic cations to inhibit the RNA phosphodiester bond cleavage promoted by Mg2+, Pb2+, and RNA-cleaving serum proteins. Kinetic analysis using chimeric DNA–RNA oligonucleotides showed that the cleavage at ribonucleotide sites was inhibited in the presence of monovalent cations comprising alkyl chains or benzene rings. The comparison of the cleavage rates in the presence of quaternary ammonium and phosphonium ions indicated that the steric hindrance effect of organic cations on their binding to the RNA backbone is significant when the cation size is larger than the phosphate–phosphate distance of a single-stranded nucleic acid. The cleavage inhibition was also observed for ribonucleotides located in long loops but not in short loops of oligonucleotide structures, indicating less efficient binding of bulky cations to structurally constrained regions. These results reveal the unique nucleic acid–binding properties of bulky cations distinct from those of metal ions.
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Interfacial analysis of the ion-transport process controlling the steady-state current in a two-phase electrodeposition system using polyelectrolyte membranes 査読あり
Shunsuke Yamada, Yohei Takashima, Takaaki Tsuruoka, Kensuke Akamatsu
RSC Appl. Interfaces 1 1069 - 1076 2024年5月
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Hiroyuki Togawa, Takashi Okubo, Kazuki Horiuchi, Takao Yamaguchi, Elisa Tomita-Sudo, Tomoka Akita, Junji Kawakami, Satoshi Obika
Journal of Chromatography A 1721 464847 2024年4月
共著
In recent years, several small interfering RNA (siRNA) therapeutics have been approved, and most of them are phosphorothioate (PS)-modified for improving nuclease resistance. This chemical modification induces chirality in the phosphorus atom, leading to the formation of diastereomers. Recent studies have revealed that Sp and Rp configurations of PS modifications of siRNAs have different biological properties, such as nuclease resistance and RNA-induced silencing complex (RISC) loading. These results highlight the importance of determining diastereomeric distribution in quality control. Although various analytical approaches have been used to separate diastereomers (mainly single-stranded oligonucleotides), it becomes more difficult to separate all of them as the number of PS modifications increases. Despite siRNA exhibits efficacy in the double-stranded form, few reports have examined the separation of diastereomers in the double-stranded form. In this study, we investigated the applicability of non-denaturing anion-exchange chromatography (AEX) for the separation of PS-modified siRNA diastereomers. Separation of the four isomers of the two PS bonds tended to improve in the double-stranded form compared to the single-stranded form. In addition, the effects of the analytical conditions and PS-modified position on the separation were evaluated. Moreover, the elution order of the Sp and Rp configurations was confirmed, and the steric difference between them, i.e., the direction of the anionic sulfur atom, appeared to be important for the separation mechanism in non-denaturing AEX. Consequently, all 16 peak tops of the four PS modifications were detected in one sequence, and approximately 30 peak tops were detected out of 64 isomers of six PS bonds, indicating that non-denaturing AEX is a useful technique for the quality control of PS-modified siRNA therapeutics.
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細胞内環境で安定化する核酸構造を標的にした低分子薬の開発 招待あり
橋本 佳樹, 川内 敬子, 三好 大輔
MEDCHEM NEWS (日本薬学会） 34 ( 1 ) 36 - 42 2024年4月
担当区分：最終著者, 責任著者
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Basic protein- and peptide-induced stabilization of long-loop DNA G-quadruplexes 査読あり 国際誌
K. Tanabe, K. Miyazaki, H. Umeno, M. Takemoto, and S. Nakano
Biochimie 219 110 - 117 2024年4月
共著
担当区分：最終著者, 責任著者 出版者・発行元：Elsevier
The human genome contains many G-quadruplex-forming sequences, including sequences containing long single-stranded loops that are believed to be unfavorable for G-quadruplex formation. The intracellular environment of biological cells is crowded with proteins with charged surfaces. Understanding the effects of protein-rich environments is important for understanding the formation of G-quadruplexes in an intracellular environment. In this study, we investigated the structural stability of DNA G-quadruplexes in the presence of several types of globular proteins (lysozyme, cytochrome c, bovine serum albumin, myoglobin, histone proteins, and serum proteins), unstructured polypeptides (protamine and poly-l-lysine), and oligopeptides (RGG/RG-domain peptides and short repeated peptides). Thermal melting studies of G-quadruplex-forming oligonucleotides derived from the human telomeric repeat sequence revealed that environments containing high concentrations of proteins and peptides differently affected the G-quadruplex stability according to their loop lengths. We found that weak electrostatic interactions of G-quadruplex loops with basic proteins and peptides improved the stability of long-loop G-quadruplexes and the interactions were strengthened under crowded conditions simulated by dextran. The comparison of the effects of different types of proteins and peptides indicated that excluded volume interactions and structural flexibility of both DNA and polypeptide chains influenced the efficiency of their interactions. This study provides insights into long-loop G-quadruplex stability in a crowded intracellular environment and the recognition of G-quadruplexes by arginine-rich domains of G-quadruplex-binding proteins.
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Hisae Tateishi-Karimata, Keiko Kawauchi, Shuntaro Takahashi, Naoki Sugimoto
Journal of the American Chemical Society 146 ( 12 ) 8005 - 8015 2024年3月
出版者・発行元：American Chemical Society (ACS)
DOI： 10.1021/jacs.3c11160
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Yohei Takashima, Naoto Tanabe, Shintaro Tanaka, Takaaki Tsuruoka, Kensuke Akamatsu
Crystal Growth & Design 24 ( 4 ) 1766 - 1773 2024年2月
出版者・発行元：American Chemical Society (ACS)
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Cr(NO3)3 as a new etching reagent for an Al-based metal-organic framework to control its crystal size and defects 査読あり
Yohei Takashima, Naoto Tanabe, Shintaro Tanaka, Takaaki Tsuruoka, Kensuke Akamatsu
Cryst. Growth Des. 24 1766 - 1773 2024年2月
担当区分：筆頭著者, 責任著者
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Structure and thermoelectric characterization of p-Type SnTe nanobulk material synthesized by charge compensation chemical reaction 査読あり
Ryosuke Fujiwara, Yuta Ikeda, Takuto Kawaguchi, Yohei Takashima, Takaaki Tsuruoka, Kensuke Akamatsu
Energies 17 190 2024年2月
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Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci 査読あり
Ryota Nomura, Yuto Suehiro, Fumikazu Tojo, Saaya Matayoshi, Rena Okawa, Masakazu Hamada, Shuhei Naka, Michiyo Matsumoto-Nakano, Rika Unesaki, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Tatsuya Akitomo, Chieko Mitsuhata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi and Kazuhiko Nakano
25 1075 2024年1月
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Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β -1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci 査読あり
Nomura R, Suehiro Y, Tojo F, Matayoshi S, Okawa R, Hamada M, Naka S, Matsumoto-Nakano M, Unesaki R, Koumoto K, Kawauchi K, Nishikata T, Akitomo T, Mitsuhata C, Yagi M, Mizoguchi T, Fujikawa K, Taniguchi T, Nakano K
International Journal of Molecular Science 25 1075 2024年1月
共著
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Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci. 査読あり 国際誌
Ryota Nomura, Yuto Suehiro, Fumikazu Tojo, Saaya Matayoshi, Rena Okawa, Masakazu Hamada, Shuhei Naka, Michiyo Matsumoto-Nakano, Rika Unesaki, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Tatsuya Akitomo, Chieko Mitsuhata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano
International journal of molecular sciences 25 ( 2 ) 2024年1月
Shikonin is extracted from the roots of Lithospermum erythrorhizon, and shikonin extracts have been shown to have inhibitory effects on several bacteria. However, shikonin extracts are difficult to formulate because of their poor water solubility. In the present study, we prepared a shikonin dispersion, which was solubilized by the inclusion of β-1,3-1,6 glucan, and analysed the inhibitory effects of this dispersion on Streptococcus mutans and non-mutans streptococci. The shikonin dispersion showed pronounced anti-S. mutans activity, and inhibited growth of and biofilm formation by this bacterium. The shikonin dispersion also showed antimicrobial and antiproliferative effects against non-mutans streptococci. In addition, a clinical trial was conducted in which 20 subjects were asked to brush their teeth for 1 week using either shikonin dispersion-containing or non-containing toothpaste, respectively. The shikonin-containing toothpaste decreased the number of S. mutans in the oral cavity, while no such effect was observed after the use of the shikonin-free toothpaste. These results suggest that shikonin dispersion has an inhibitory effect on S. mutans and non-mutans streptococci, and toothpaste containing shikonin dispersion may be effective in preventing dental caries.
DOI： 10.3390/ijms25021075
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Direct Formation of ZIF-8 Crystal Thin Films on the Surface of a Zinc Ion-Doped Polymer Substrate 査読あり
Takaaki Tsuruoka, Kaito Araki, Kouga Kawauchi, Yohei Takashima, Kensuke Akamatsu
Inorganics 12 ( 1 ) 21 - 21 2024年1月
担当区分：筆頭著者, 責任著者 出版者・発行元：MDPI AG
Thin films of metal–organic frameworks (MOFs) on polymer substrates and MOF/polymer mixed-matrix membranes play crucial roles in advancing the field of gas separation membranes. In this paper, we present a novel method for the direct formation of continuous ZIF-8 crystal films on a polymer substrate doped with Zn²+. Our approach involves ion exchange between the doped zinc ions within the substrate and sodium ions in the presence of a CH3COONa additive, as well as interfacial complexation with eluted zinc ions and 2-methylimidazole (2-MeIM). The key factors affecting the formation of ZIF-8 crystals on the substrate were the concentrations of CH3COONa and 2-MeIM. A time-course analysis revealed that the nucleation rate during the early stages of the reaction significantly affected the surface morphology of the resulting ZIF-8 crystal films. Specifically, a higher nucleation rate led to the formation of continuous small ZIF-8 crystal films. This innovative approach enables the fabrication of densely packed, uniform ZIF-8 crystal films.
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Direct formation of ZIF-8 crystal thin films on the surface of a zinc ion-doped polymer substrate 査読あり
Takaaki Tsuruoka, Kaito Araki, Kouga Kawauchi, Yohei Takashima, Kensuke Akamatsu
Inorganics 12 21 2024年1月
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“Interfacial analysis of the ion-transport process controlling the steady-state current in a two-phase electrodeposition system using polyelectrolyte membranes
S. Yamada, Y. Takashima, T. Tsuruoka, K. Akamatsu
RSC Applied Interfaces 2024年
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Structural transformation of silver(I)-thiolate coordination polymer film at solid–liquid interfaces
M. Fukuoka, Y. Takashima, K. Akamatsu, A. Demessence, T. Tsuruoka
CrystEngComm 26 6269 - 6273 2024年
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Preparation of golf ball-like polymer particles bearing site-selective functional groups
T. Morishita, I. Maitani, T. Michiura, N. Suzuki, T. Suzuki, K. Akamatsu, H. Minami
ACS Appl. Mater.Interfaces in press 2024年
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Structure and Thermoelectric Characterization of p-Type SnTe Nanobulk Material Synthesized by Charge Compensation Chemical Reaction
Ryosuke Fujiwara, Yuta Ikeda, Takuto Kawaguchi, Yohei Takashima , Takaaki Tsuruoka and Kensuke Akamatsu
Energies 17 ( 190 ) 2024年
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Cr(NO3)3 as a New Etching Reagent for an Al-based Metal-Organic Framework to Control Its Crystal Size and Defects
Y. Takashima, N. Tanabe, S. Tanaka, T. Tsuruoka, K. Akamatsu
Cryst. Growth Des 24 1766 - 1773 2024年
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Direct Formation of ZIF-8 Crystal Thin Films on the Surface of a Zinc Ion-Doped Polymer Substrate
T. Tsuruoka, K. Araki, K. Kawauchi, Y. Takashima, K. Akamatsu
Inroganics 12 ( 21 ) 2024年
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Shunsuke Yamada, Yohei Takashima, Takaaki Tsuruoka, Kensuke Akamatsu
RSC Applied Interfaces 2024年
出版者・発行元：Royal Society of Chemistry (RSC)
An interfacial model has been developed for describing ion transport kinetics at the membrane/solution interface in the new solid-electrodeposition system.
DOI： 10.1039/d4lf00112e
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Asuka Nishibe, Ryohei Akiyoshi, Akinori Saeki, Kazuyoshi Ogasawara, Takaaki Tsuruoka, Daisuke Tanaka
Chemical Communications 2024年
出版者・発行元：Royal Society of Chemistry (RSC)
The impact of inorganic (–Cd–S–)<sub>n</sub> assemblies on semiconductive properties is demonstrated by systematically synthesizing one-dimensional Cd(ii) benzenethiolate coordination polymers.
DOI： 10.1039/d3cc05689a
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Ryosuke Fujiwara, Yuta Ikeda, Takuto Kawaguchi, Yohei Takashima, Takaaki Tsuruoka, Kensuke Akamatsu
Energies 17 ( 1 ) 190 - 190 2023年12月
出版者・発行元：MDPI AG
SnTe is the most widely studied p-type thermoelectric (TE) alternative to PbTe. In this study, we prepared a nanostructured SnTe bulk material via spark plasma sintering from a precursor synthesized by a chemical precipitation process without using organic molecules. The sintered sample comprised tiny grains (100–300 nm) with high-density grain boundaries. Eventually, because the material would contain no impurities acting as scattering nodes of charge carriers, the material exhibited a relatively high electrical conductivity of 7.07 × 105 Sm−1 at 310 K. The material demonstrated low lattice thermal conductivity (0.87 Wm−1K−1 at 764 K), which can be owing to the increasing phonon scattering at grain boundaries. The maximum ZT was 0.31 at 764 K in the measured temperature range. This study provides a method for the design of phase-pure and surfactant-free SnTe thermoelectric materials that exhibit low lattice thermal conductivity and high carrier mobility using a chemical synthetic approach.
DOI： 10.3390/en17010190
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Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments 査読あり
Torii T, Sugimoto W, Itoh K, Kinoshita N, Gessho M, Goto T, Uehara I, Nakajima W, Budirahardja Y, Miyoshi D, Nishikata T, Tanaka N, Kawauchi K
Cell Death and Disease 14 766 2023年11月
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Comparison of evolutionary relationships between Branchiostoma floridae, Ciona intestinalis, and Homo sapiens globins provide evidence of gene co-option and convergent evolution 査読あり
Yano N, Minamoto T, Yamaguchi H, Goto T, Nishikata T
International Journal of Molecular Science 24 16009 2023年11月
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Kaoru Karasawa, Eva Duchoslav, Lyle Burton, Junji Kawakami, Takashi Baba
Analytical Chemistry 95 ( 44 ) 16352 - 16358 2023年10月
共著
We report the first sequencing of morpholino antisense oligonucleotides (phosphorodiamidate morpholino oligomers, PMOs) using electron capture dissociation (ECD) mass spectrometry. In this research, we found dissociation of the backbone of 18- to 25-mer PMOs to produce d and z ions as the major ions, and 100% cleavage coverage (sequence coverage) was obtained with these ions. This is a critical contrast with beam-type collision-induced dissociation, which dominantly induces base loss, so it is difficult to obtain sequence information. The results showed that an electron beam energy (typically 15 eV) can be used universally for PMOs with different sequences, lengths, and charge states so that no detailed optimization is required for multiprecursor targeting liquid chromatography coupled with tandem mass spectrometry measurements. We also confirmed that the ECD reaction speed was compatible with the high-performance liquid chromatography time scale. Finally, we demonstrated a liquid chromatography electron capture dissociation tandem mass spectrometry workflow to survey the modification sites of the emulated PMO impurities.
DOI： 10.1021/acs.analchem.3c03621
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Mitochondrial Dynamics of Bcl-2 Family Proteins during 17-β-Estradiol-Induced Apoptosis Correlate with the Malignancy of Endometrial Cancer Cells 査読あり
Takahiro Yaguchi, Misaki Kameno, Hirofumi Taira, and Junji Kawakami
Biochemstry 62 ( 21 ) 3041 - 3049 2023年10月
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複数種の液体クロマトグラフ質量分析計を用いたモデル核酸医薬品の分析データの比較 査読あり
Kenji Hirose, Tokuyuki Yoshida, Maki Terasaki, Hiroshi Sezaki, Kaoru Karasawa, Noriyuki Iwasaki, Kentaro Takahara, Naomi Takiguchi, Mitsuaki Sekiguchi, Hirokazu Nankai, Emi Saito, Hideaki Sato, Takashi Osawa, Takao Yamaguchi, Kosuke Ito, Junji Kawakami, Satoshi Obika, and Takao Inoue
54 439 - 454 2023年10月
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Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments 査読あり 国際誌
Takeru Torii, Wataru Sugimoto, Katsuhiko Itoh, Natsuki Kinoshita, Masaya Gessho, Toshiyuki Goto, Ikuno Uehara, Wataru Nakajima, Yemima Budirahardja, Daisuke Miyoshi, Takahito Nishikata, Nobuyuki Tanaka, Hiroaki Hirata, Keiko Kawauchi
Cell Death & Disease 14 ( 11 ) 766766 - 766 2023年8月
Tumor suppressor p53 plays a central role in response to DNA damage. DNA-damaging agents modulate nuclear actin dynamics, influencing cell behaviors; however, whether p53 affects the formation of nuclear actin filaments remains unclear. In this study, we found that p53 depletion promoted the formation of nuclear actin filaments in response to DNA-damaging agents, such as doxorubicin (DOXO) and etoposide (VP16). Even though the genetic probes used for the detection of nuclear actin filaments exerted a promotive effect on actin polymerization, the detected formation of nuclear actin filaments was highly dependent on both p53 depletion and DNA damage. Whilst active p53 is known to promote caspase-1 expression, the overexpression of caspase-1 reduced DNA damage-induced formation of nuclear actin filaments in p53-depleted cells. In contrast, co-treatment with DOXO and the pan-caspase inhibitor Q-VD-OPh or the caspase-1 inhibitor Z-YVAD-FMK induced the formation of nuclear actin filament formation even in cells bearing wild-type p53. These results suggest that the p53-caspase-1 axis suppresses DNA damage-induced formation of nuclear actin filaments. In addition, we found that the expression of nLifeact-GFP, the filamentous-actin-binding peptide Lifeact fused with the nuclear localization signal (NLS) and GFP, modulated the structure of nuclear actin filaments to be phalloidin-stainable in p53-depleted cells treated with the DNA-damaging agent, altering the chromatin structure and reducing the transcriptional activity. The level of phosphorylated H2AX (γH2AX), a marker of DNA damage, in these cells also reduced upon nLifeact-GFP expression, whilst details of the functional relationship between the formation of nLifeact-GFP-decorated nuclear actin filaments and DNA repair remained to be elucidated. Considering that the loss of p53 is associated with cancer progression, the results of this study raise a possibility that the artificial reinforcement of nuclear actin filaments by nLifeact-GFP may enhance the cytotoxic effect of DNA-damaging agents in aggressive cancer cells through a reduction in gene transcription.
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Kenji Usui, Makoto Ozaki, Kan Hirao, Tsubasa Kosaka, Natsumi Endo, Shuhei Yoshida, Shin-ichiro Yokota, Yonejiro Arimoto, Ryuji Osawa, Nobuhiro Nakanishi, Kin-ya Tomizaki, Tomohiro Umetani, Fumihiro Kayamori
Scientific Reports 13 12027 2023年7月
担当区分：最終著者, 責任著者
Microwaves are used for diverse applications such as mobile phones, ovens, and therapy devices. However, there are few reports on the effects of microwaves on diseases other than cancer, and on physiological processes. Here, we focused on CaCO3 mineralization as a model of biomineralization and attempted to elucidate the effect of microwaves on CaCO3 mineralization using peptides. We conducted AFM, ζ potential, HPLC, ICP-AES, and relative permittivity measurements. Our findings show that microwaves alter the nanomorphology of the CaCO3 precipitate, from sphere-like particles to string-like structures. Furthermore, microwaves have little effect on the mineralization when the mineralization ability of a peptide is high, but a large effect when the precipitation ability is low. Our findings may be applicable to not only the treatment of teeth and bones but also the development of organic–inorganic nanobiomaterials. This methodology can be expanded to other molecular/atomic reactions under various microwave conditions to alter reaction activity parameters.
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Thixotropic β-Chitin Nanofiber Hydrogel with a Living Body-Responsive Self-Hardening Property and Its Application as a Sprayable Antiadhesion Barrier 査読あり 国際誌
Koji Nagahama, Kaho Tobiishi, Natsumi Ueda, Tatsuya Dode, Shahidul Islam Sobuj, Fumiya Yuasa, Kazuhiko Yamashita, Takahito Nishikata
ACS Applied Bio Materials 6 ( 7 ) 2636 - 2643 2023年7月
担当区分：筆頭著者, 責任著者
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Effect of linearly polarized microwaves on nanomorphology of calcium carbonate mineralization using peptides 査読あり
Kenji Usui, Makoto Ozaki, Kan Hirao, Tsubasa Kosaka, Natsumi Endo, Shuhei Yoshida, Shin-ichiro Yokota, Yonejiro Arimoto, Ryuji Osawa, Nobuhiro Nakanishi, Kin-ya Tomizaki, Tomohiro Umetani, Fumihiro Kayamori
Scientific Reports 13 12027 2023年7月
Microwaves are used for diverse applications such as mobile phones, ovens, and therapy devices. However, there are few reports on the effects of microwaves on diseases other than cancer, and on physiological processes. Here, we focused on CaCO3 mineralization as a model of biomineralization and attempted to elucidate the effect of microwaves on CaCO3 mineralization using peptides. We conducted AFM, ζ potential, HPLC, ICP-AES, and relative permittivity measurements. Our findings show that microwaves alter the nanomorphology of the CaCO3 precipitate, from sphere-like particles to string-like structures. Furthermore, microwaves have little effect on the mineralization when the mineralization ability of a peptide is high, but a large effect when the precipitation ability is low. Our findings may be applicable to not only the treatment of teeth and bones but also the development of organic–inorganic nanobiomaterials. This methodology can be expanded to other molecular/atomic reactions under various microwave conditions to alter reaction activity parameters.
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Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite 査読あり
Momoko Usuda, Mariko Kametani, Masakazu Hamada, Yuto Suehiro, Saaya Matayoshi, Rena Okawa, Shuhei Naka, Michiyo Matsumoto-Nakano, Tatsuya Akitomo, Chieko Mitsuhata, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano and Ryota Nomura
Int J Mol Sci 24 11371 2023年7月
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Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite 査読あり
Usuda M, Kametani M, Hamada M, Suehiro Y, Matayoshi S, Okawa R, Naka S, Matsumoto-Nakano M, Akitomo T, Mitsuhata C, Koumoto K, Kawauchi K, Nishikata T, Yagi M, Mizoguchi T, Fujikawa K, Taniguchi T, Nakano K, Nomura R
International Journal of Molecular Science 24 11371 2023年7月
共著
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Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite. 査読あり 国際誌
Momoko Usuda, Mariko Kametani, Masakazu Hamada, Yuto Suehiro, Saaya Matayoshi, Rena Okawa, Shuhei Naka, Michiyo Matsumoto-Nakano, Tatsuya Akitomo, Chieko Mitsuhata, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano, Ryota Nomura
International journal of molecular sciences 24 ( 14 ) 2023年7月
Hydroxyapatite adsorbs various substances, but little is known about the effects on oral bacteria of adsorption onto hydroxyapatite derived from scallop shells. In the present study, we analyzed the effects of adsorption of Streptococcus mutans onto scallop-derived hydroxyapatite. When scallop-derived hydroxyapatite was mixed with S. mutans, a high proportion of the bacterial cells adsorbed onto the hydroxyapatite in a time-dependent manner. An RNA sequencing analysis of S. mutans adsorbed onto hydroxyapatite showed that the upregulation of genes resulted in abnormalities in pathways involved in glycogen and histidine metabolism and biosynthesis compared with cells in the absence of hydroxyapatite. S. mutans adsorbed onto hydroxyapatite was not killed, but the growth of the bacteria was inhibited. Electron microscopy showed morphological changes in S. mutans cells adsorbed onto hydroxyapatite. Our results suggest that hydroxyapatite derived from scallop shells showed a high adsorption ability for S. mutans. This hydroxyapatite also caused changes in gene expression related to the metabolic and biosynthetic processes, including the glycogen and histidine of S. mutans, which may result in a morphological change in the surface layer and the inhibition of the growth of the bacteria.
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Thixotropic β‑Chitin Nanofiber Hydrogel with a Living BodyResponsive Self-Hardening Property and Its Application as a Sprayable Antiadhesion Barrier 査読あり
Nagahama K, Tobiishi K, Ueda N, Dode T, Sobuj SI, Yuasa F, Yamashita K, Nishikata T
American Chemical Society Applied Bio Materials 2023 ( 6 ) 2636 - 2643 2023年7月
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Co-generation of palladium nanoparticles and phosphate supported on metal-organic frameworks as hydrogenation catalysts 査読あり
Yohei Takashima, Seiko Tetsusashi, Mai Takano, Shintaro Tanaka, Yui Murakami, Takaaki Tsuruoka, Kensuke Akamatsu
Dalton Trans. 52 11158 - 11162 2023年7月
担当区分：筆頭著者, 責任著者
その他リンク： https://pubs.rsc.org/en/content/articlelanding/2023/dt/d2dt04109j
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The iron chelator deferriferrichrysin induces paraptosis via extracellular signal-related kinase activation in cancer cells 招待あり 査読あり
Natsuki Kinoshita, Masaya Gessho, Takeru Torii, Yukako Ashida, Minori Akamatsu, Alvin Kunyao Guo, Sunmin Lee, Tatsuya Katsuno 3, Wataru Nakajima Yemima Budirahardja, Daisuke Miyoshi, Takehiko Todokoro, Hiroki Ishida, Takahito Nishikata, Keiko Kawauchi
Genes Cells 2023年6月
DOI： 10.1111/gtc.13053
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Quantification of the concentration in a droplet formed by liquid–liquid phase separation of G-quadruplex-forming RNA 査読あり
Kohei Yokosawa, Mitsuki Tsuruta, Shinji Kajimoto, Naoki Sugimoto, Daisuke Miyoshi, Takakazu Nakabayashi
Chem. Phys. Lett. 826 140634 - 140634 2023年6月
出版者・発行元：Elsevier BV
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The iron chelator deferriferrichrysin induces paraptosis via extracellular-signal-regulated kinase activation in cancer cells 査読あり 国際共著
Kinoshita N, Gessho M, Torii T, Ashida Y, Akamatsu M, Guo AK, Lee S, Katsuno T, Nakajima W, Budirahardja Y, Miyoshi D, Todokoro T, Ishida H, Nishikata T, Kawauchi K
Genes to Cells 28 ( 9 ) 653 - 662 2023年6月
担当区分：最終著者, 責任著者
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Simple and fast screening for structure-selective G-quadruplex ligands. 査読あり 国際誌
Yoshiki Hashimoto, Yoshiki Imagawa, Kaho Nagano, Ryuichi Maeda, Naho Nagahama, Takeru Torii, Natsuki Kinoshita, Nagisa Takamiya, Keiko Kawauchi, Hisae Tatesishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Chemical communications (Cambridge, England) 59 ( 33 ) 4891 - 4894 2023年4月
共著
Structural selectivity of G-quadruplex ligands is essential for cellular applications since there is an excess of nucleic acids forming duplex structures compared to G-quadruplex structures in living cells. In this study, we developed new structure-selective G-quadruplex ligands utilizing a simple and fast screening system. The affinity, selectivity, enzymatic inhibitory activity and cytotoxicity of the structure-selective G-quadruplex ligands were demonstrated along with a structural selectivity-cytotoxicity relationship of G-quadruplex ligands.
DOI： 10.1039/d3cc00556a
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Not all 2',4'-bridged modifications stabilize DNA/RNA duplexes 査読あり
Tomoka Akita, Elisa Tomita-Sudo, Shin Itoh, Nae Sakimoto, Takeshi Masuda, Akifumi Nakamura, Yoshiyuki Onishi, Makoto Koizumi Junji Kawakami
Nucleosides, Nucleotides & Nucleic Acids 2023年3月
共著
2’,4’-Bridged modifications such as 2’-O,4’-C-methylene-bridged nucleotides (LNAs) and 2’-O,4’-C-ethylene-bridged nucleotides (ENAs) provide high binding affinity for duplex formation. Stabilization by the introduction of the bridged nucleic acids is considered to be due to pre-organization. In this study, we found that the introduction of 2’,4’-C-bridged 2’-deoxynucleotides (CRNs; Conformationally Restricted Nucleotides) into DNA/RNA duplexes leads to destabilization, as opposed to the previously accepted notion that 2’,4’-bridged modifications always lead to stabilization.
その他リンク： https://www.tandfonline.com/doi/full/10.1080/15257770.2023.2232414
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Biomolecular Liquid–Liquid Phase Separation for Biotechnology 招待あり 査読あり
Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi and Daisuke Miyoshi
BioTech 12 ( 2 ) 26 2023年3月
担当区分：責任著者
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Construction of a Method to Design Fibril-Forming Peptides Applied to Biomaterials from 20 Beta-Sheet Peptides by Statistical Analysis 査読あり
Kazuya Iwata, Taisei Terao, Akira Takekawa, Tomohiro Umetani, Kenji Usui
Peptide Science 2022 141 - 142 2023年3月
担当区分：最終著者, 責任著者
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High-performance bulk Bi0.4Sb1.6Te3.0 thermoelectrics prepared from nanocrystal precursor synthesized via chemical precipitation 査読あり
Ryosuke Fujiwara, Yohei Takashima, Takaaki Tsuruoka, Muneyuki Naito, Junya Murai, Kensuke Akamatsu
Journal of Solid State Chemistry 319 123777 - 123777 2023年3月
出版者・発行元：Elsevier BV
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Direct generation of polypyrrole-coated palladium nanoparticles inside a metal-organic framework for a semihydrogenation catalyst 査読あり
Yohei Takashima, Seiko Tetsusashi, Shintaro Tanaka, Takaaki Tsuruoka, Kensuke Akamatsu
RSC Adv. 13 7464 - 7467 2023年3月
担当区分：筆頭著者
その他リンク： https://pubs.rsc.org/en/content/articlelanding/2023/ra/d2ra08190c
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Simple and fast screening for structure-selective G-quadruplex ligands 査読あり 国際誌
Yoshiki Hashimoto, Yoshiki Imagawa, Kaho Nagano, Ryuichi Maeda, Naho Nagahama, Takeru Torii, Natsuki Kinoshita, Nagisa Takamiya, Keiko Kawauchi, Hisae Tatesishi-Karimata, Naoki Sugimoto and Daisuke Miyoshi
Chem. Commun. 59 ( 33 ) 4891 - 4894 2023年2月
担当区分：責任著者
Structural selectivity of G-quadruplex ligands is essential for cellular applications since there is an excess of nucleic acids forming duplex structures compared to G-quadruplex structures in living cells. In this study, we developed new structure-selective G-quadruplex ligands utilizing a simple and fast screening system. The affinity, selectivity, enzymatic inhibitory activity and cytotoxicity of the structure-selective G-quadruplex ligands were demonstrated along with a structural selectivity-cytotoxicity relationship of G-quadruplex ligands.
DOI： 10.1039/D3CC00556A
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Morphological Evidence for Novel Roles of Microtubules in Macrophage Phagocytosis 査読あり
Seta Y, Kawakatsu K, Degawa S, Goto T, Nishikata T
International Journal of Molecular Science 24 1373 2023年1月
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RNA 高次構造を標的とした光線力学療法の展望 招待あり
取井猛流・木下菜月・橋本佳樹・杉本渉・川内敬子・三 好大輔
38 ( 13 ) 1154 - 1156 2023年
担当区分：最終著者, 責任著者
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グアニン四重らせん構造による転移因子LINE-1の発現抑制名
月生 雅也, 李 先民, Yemima Suryani Budirahardja, 鶴田 充生, 橋本 佳樹, 高宮 渚, 木下 菜月, 建石 寿枝, 杉本 直己, 三好 大輔, 川内 敬子
日本女性科学者の会学術誌 23 48 - 48 2023年
出版者・発行元：(一社)日本女性科学者の会
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High-performance bulk Bi0.4Sb1.6Te3.0 thermoelectrics prepared from nanocrystal precursor synthesized via chemical precipitation
R. Fujiwara, Y.Takashima, T. Tsuruoka, M. Naito, J. Murai, K. Akamatsu
Journal of Solid State Chemistry 319 123777 2023年
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“Direct generation of polypyrrole-coated palladium nanoparticles inside a metal-organic framework for a semihydrogenation catalyst
Y. Takashima, S. Tetsusashi, S. Tanaka, T. Tsuruoka, K. Akamatsu
RSC Adv 13 7464 - 7467 2023年
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“Co-generation of palladium nanoparticles and phosphate supported on metal-organic frameworks as hydrogenation catalysts
Y. Takashima, S. Tetsusashi, M. Takano, S. Tanaka, Y. Murakami, T. Tsuruoka, K. Akamatsu
Dalton Trans 52 11158 - 11162 2023年
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Yohei Takashima, Seiko Tetsusashi, Shintaro Tanaka, Takaaki Tsuruoka, Kensuke Akamatsu
RSC Advances 13 ( 11 ) 7464 - 7467 2023年
出版者・発行元：Royal Society of Chemistry (RSC)
Polypyrrole-coated palladium nanoparticles could be directly generated inside a metal–organic frameworks. The resulting MOF composites exhibited higher semihydrogenation capability than the analog composite without polypyrrole coating.
DOI： 10.1039/d2ra08190c
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Yohei Takashima, Seiko Tetsusashi, Mai Takano, Shintaro Tanaka, Yui Murakami, Takaaki Tsuruoka, Kensuke Akamatsu
Dalton Transactions 52 ( 32 ) 11158 - 11162 2023年
出版者・発行元：Royal Society of Chemistry (RSC)
In this study, we demonstrated the direct synthesis of sodium dihydrogen phosphate (PA) containing palladium nanoparticles (PdNPs) supported on a metal–organic framework (MOF) for hydrogenation catalysis.
DOI： 10.1039/d2dt04109j
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Evaluation of thermal stability of DNA oligonucleotide structures embedded in hydrogels 招待あり 査読あり 国際誌
D. Yamaguchi, M. Yoshida, S. Nakano
DNA 2 ( 4 ) 302 - 313 2022年12月
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Controlling liquid-liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner. 査読あり 国際誌
Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Chemical communications (Cambridge, England) 58 ( 93 ) 12931 - 12934 2022年11月
共著
We constructed a minimum liquid-liquid phase separation model system to form liquid droplets using only G-quadruplex-forming oligonucleotides and R- and G-rich oligopeptides. We found that the G-quadruplex structure is an essential component for RNA to form droplets with the peptide. Based on this model system and our findings, droplet redissolution via structure transition from a G-quadruplex to a duplex was achieved in a sequence-specific manner.
DOI： 10.1039/d2cc04366a
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Covalent Stem Cell-Combining Injectable Materials with Enhanced Stemness and Controlled Differentiation In Vivo 査読あり
Natsumi Ueda, Shiho Sawada, Fumiya Yuasa, Karen Kato, Koji Nagahama
ACS Applied Materials & Interfaces 14 ( 47 ) 52618 - 52633 2022年11月
担当区分：最終著者, 責任著者
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ポリエチレングリコールによるアトピー性皮膚炎予防の可能性
厳原美穂、甲元一也
Fragrance Journal 50 ( 11 ) 54 - 57 2022年11月
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Controlling liquid–liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner 査読あり 国際誌
Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi-Karimata, Naoki Sugimoto and Daisuke Miyoshi
Chem. Commun. 58 ( 93 ) 12931 - 12934 2022年11月
We constructed a minimum liquid-liquid phase separation model system to form liquid droplets using only G-quadruplex-forming oligonucleotides and R- and G-rich oligopeptides. We found that the G-quadruplex structure is an essential component for RNA to form droplets with the peptide. Based on this model system and our findings, droplet redissolution via structure transition from a G-quadruplex to a duplex was achieved in a sequence-specific manner.
DOI： 10.1039/D2CC04366A
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Two-Dimensional Metal–Organic Framework-Based Cellular Scaffolds with High Protein Adsorption, Retention, and Replenishment Capabilities 査読あり
Tokitaka Katayama, Shintaro Tanaka, Takaaki Tsuruoka, and Koji Nagahama
ACS Applied Materials & Interfaces 14 ( 30 ) 34443 - 34454 2022年8月
担当区分：最終著者, 責任著者
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Two-Dimensional Metal–Organic Framework-Based Cellular Scaffolds with High Protein Adsorption, Retention, and Replenishment Capabilities 査読あり
Tokitaka Katayama, Shintaro Tanaka, Takaaki Tsuruoka, Koji Nagahama
ACS Applied Materials & Interfaces 2022年8月
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Evaluation of weak interactions of proteins and organic cations with DNA duplex structures 査読あり 国際誌
R. Morimoto, M. Horita, D. Yamaguchi, H. Nakai, and S. Nakano
Biophys. J. 121 ( 15 ) 2873 - 2881 2022年8月
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細胞内環境で安定化される核酸非構造を狙った分子標的薬の開発 招待あり
川内敬子・橋本佳樹・杉本 渉・三好大輔
バイオマテリアル = Journal of Japanese Society for Biomaterials : 生体材料 40 ( 3 ) 206 - 211 2022年7月
担当区分：責任著者
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核酸の化学修飾と構造や相分離能の相関 招待あり
鶴田 充生・取井 猛流・杉本 渉・川内 敬子・三好 大輔
月刊「細胞」（ニューサイエンス社） 53 ( 14 ) 910 - 913 2022年6月
担当区分：最終著者, 責任著者
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Exportin-inspired artificial cell nuclear-exporting nanosystems 査読あり
Mitsuo Inui , Yuta Hamada , Nana Sejima , Natsumi Ueda , Tokitaka Katayama , Kimika Ono, Koji Nagahama
Nanoscale Advances 4 2637 - 2641 2022年5月
担当区分：最終著者, 責任著者
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Significant structural change in human c-Myc promoter G-quadruplex 査読あり 国際共著
Nikita Kundu, Taniya Sharma, Sarvpreet Kaur, Mamta Singh, Vinit Kumar, Uttam Sharma, Aklank Jain, Jadala Shankaraswamy, Daisuke Miyoshi, Sarika Saxena
RSC Adv. 12 7594 - 7604 2022年4月
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Kimika Ono, Manami Sumiya, Naohiro Yoshinobu, Tatsuya Dode, Tokitaka Katayama, Natsumi Ueda, Koji Nagahama
ACS Applied Bio Materials 5 ( 2 ) 471 - 482 2022年2月
担当区分：最終著者, 責任著者
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Toshiyuki Goto, Shuhei Torii, Aoi Kondo, Kazumasa Kanda, Junji Kawakami, Yosky Kataoka, Takahito Nishikata
Journal of Developmental Biology 10 ( 1 ) 10 - 10 2022年2月
出版者・発行元：MDPI AG
In many animal species, the body axis is determined by the relocalization of maternal determinants, organelles, or unique cell populations in a cytoskeleton-dependent manner. In the ascidian first cell cycle, the myoplasm, including mitochondria, endoplasmic reticulum (ER), and maternal mRNAs, move to the future posterior side concomitantly (called ooplasmic segregation or cytoplasmic and cortical reorganization). This translocation consists of first and second phases depending on the actin and microtubule, respectively. However, the transition from first to second phase, that is, translocation of myoplasmic components from microfilaments to microtubules, has been poorly investigated. In this study, we analyzed the relationship between these cytoskeletons and myoplasmic components during the first cell cycle and their role in morphogenesis by inhibitor experiments. Owing to our improved visualization techniques, there was unexpected F-actin accumulation at the vegetal pole during this transition period. When this F-actin was depolymerized, the microtubule structure was strongly affected, the myoplasmic components, including maternal mRNA, were mislocalized, and the anteroposterior axis formation was disordered. These results suggested the importance of F-actin during the first cell cycle and the existence of interactions between microfilaments and microtubules, implying the enigmatic mechanism of ooplasmic segregation. Solving this mystery leads us to an improved understanding of ascidian early development.
DOI： 10.3390/jdb10010010
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Dynamic Changes in the Aassociation between Maternal mRNAs and Endoplasmic Reticulum during Ascidian Early Embryogenesis. 査読あり
Goto T, Torii S, Kondo A, Yagi H, Suekane M, Kataoka Y, Nishikata T
Development Genes and Evolution 232 ( 1 ) 1 - 14 2022年2月
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Actin Filament in the First Cell Cycle Contributes to the Determination of the Anteroposterior Axis in Ascidian Development. 査読あり
Goto T, Torii S, Kondo A, Kanda K, Kataoka Y, Nishikata T
Journal of Developmental Biology 10 ( 1 ) 10 - 23 2022年2月
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Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene 査読あり
Wataru Sugimoto, Natsuki Kinoshita, Minori Nakata, Tatsuya Ohyama, Hisae Minatojima-Minaminachi, Takahito Nishikata, Naoki Sugimoto, Daisuke Miyoshi, Keiko Kawauchi
Chem. Commun. 58 48 - 51 2022年1月
担当区分：責任著者
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De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide. 査読あり 国際共著 国際誌
Keisuke Shimizu, Batsaikhan Mijiddorj, Masataka Usami, Ikuro Mizoguchi, Shuhei Yoshida, Shiori Akayama, Yoshio Hamada, Akifumi Ohyama, Kenji Usui, Izuru Kawamura, Ryuji Kawano
Nature nanotechnology 17 67 - 75 2022年1月
The amino-acid sequence of a protein encodes information on its three-dimensional structure and specific functionality. De novo design has emerged as a method to manipulate the primary structure for the development of artificial proteins and peptides with desired functionality. This paper describes the de novo design of a pore-forming peptide, named SV28, that has a β-hairpin structure and assembles to form a stable nanopore in a bilayer lipid membrane. This large synthetic nanopore is an entirely artificial device for practical applications. The peptide forms multidispersely sized nanopore structures ranging from 1.7 to 6.3 nm in diameter and can detect DNAs. To form a monodispersely sized nanopore, we redesigned the SV28 by introducing a glycine-kink mutation. The resulting redesigned peptide forms a monodisperse pore with a diameter of 1.7 nm leading to detection of a single polypeptide chain. Such de novo design of a β-hairpin peptide has the potential to create artificial nanopores, which can be size adjusted to a target molecule.
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Chemical synthesis of single nanometer-sized Bi2−xSbxTe3.0 nanocrystals via direct precipitation process 査読あり
Ryosuke Fujiwara, Yohei Takashima, Takaaki Tsuruoka, Muneyuki Naito, Junya Murai, Kensuke Akamatsu
Results in Chemistry 4 100485 - 100485 2022年1月
出版者・発行元：Elsevier BV
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Wataru Sugimoto, Natsuki Kinoshita, Minori Nakata, Tatsuya Ohyama, Hisae Tateishi-Karimata, Takahito Nishikata, Naoki Sugimoto, Daisuke Miyoshi, Keiko Kawauchi
Chemical Communications 58 ( 1 ) 48 - 51 2022年
出版者・発行元：Royal Society of Chemistry (RSC)
We identified cytosine-rich regions adjacent to guanine-rich regions in the TMPRSS2 gene, which showed structural competition between a G-quadruplex and a hairpin loop. Furthermore, this competition significantly affected transcription efficiency.
DOI： 10.1039/d1cc05523b
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核酸の四重らせん構造を狙った治療薬の展望 招待あり
木下菜月、取井猛流、川内敬子、三好大輔
37 ( 4 ) 52 - 55 2022年
担当区分：責任著者
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rDNAおよびrRNAが形成する四重らせん構造による核小体機能の制御 招待あり
川内敬子、取井猛流、月生雅也、木下菜月、三好大輔
月刊細胞 54 ( 12 ) 36 - 39 2022年
担当区分：責任著者
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Rational and site-selective formation of coordination polymer consisiting of d10 coinage metal ions with thiolate ligands using metal ion-doped polymer substrate
T. Tsuruoka, Y. Miyashita, R. Yoshino, M. Fukuoka, S. Hirao, Y. Takashima, A. Demessence, K. Akamatsu
RSC Adv 12 3716 - 3720 2022年
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Chemical synthesis of single nanometer-sized Bi2-xSbxTe3.0 nanocrystals via direct precipitation process
R. Fujiwara, Y.Takashima, T. Tsuruoka, M. Naito, J. Murai, K. Akamatsu
Chemistry 4 100485 2022年
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ポリイミド基板上への選択的金属有機構造体の形成技術
福岡美海、江口慧一、髙嶋洋平、赤松謙祐、鶴岡孝章
ポリイミドの高機能設計と応用技術 6 ( 6 ) 487 - 495 2022年
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Cooperative catalysis in a metal–organic framework <i>via</i> post-synthetic immobilisation 査読あり
Yohei Takashima, Yuya Suwaki, Takaaki Tsuruoka, Kensuke Akamatsu
Dalton Transactions 51 ( 24 ) 9229 - 9232 2022年
出版者・発行元：Royal Society of Chemistry (RSC)
A Co-salen complex and a MOF were successfully hybridized by post-synthetic immobilization for a cooperative catalytic system.
DOI： 10.1039/d2dt01544g
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Takaaki Tsuruoka, Yuri Miyashita, Ryuki Yoshino, Myu Fukuoka, Shoya Hirao, Yohei Takashima, Aude Demessence, Kensuke Akamatsu
RSC Advances 12 ( 6 ) 3716 - 3720 2022年
担当区分：筆頭著者, 責任著者 出版者・発行元：Royal Society of Chemistry (RSC)
We report an interfacial approach for fabricating coordination polymer (CP) crystal films and patterns on a polymer surface using a metal ion-doped polymer substrate.
DOI： 10.1039/d2ra00269h
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ポリイミド基板上への選択的金属有機構造体の形成技術
福岡美海、江口慧一、髙嶋洋平、赤松謙祐、鶴岡孝章
ポリイミドの高機能設計と応用技術 6 ( 6 ) 487 - 495 2022年
担当区分：責任著者
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Rational and site-selective formation of coordination polymer consisiting of d10 coinage metal ions with thiolate ligands using metal ion-doped polymer substrate 査読あり 国際共著
T. Tsuruoka, Y. Miyashita, R. Yoshino, M. Fukuoka, S. Hirao, Y. Takashima, A. Demessence, K. Akamatsu
RSC Adv 12 3716 - 3720 2022年
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Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells 査読あり 国際誌
Dobrokhotov O, Sunagawa M, Torii T, Mii S, Kawauch K, Enomoto A, Sokabe M, Hirata H.
Frontiers in Cell and Developmental Biology 11 2021年11月
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Injectable Biocatalytic Nanocomposite Hydrogel Factories for Focal Enzyme-Prodrug Cancer Therapy 査読あり
Kimika Ono, Hiroyuki Hashimoto, Tokitaka Katayama, Natsumi Ueda, Koji Nagahama
Biomacromolecules 22 ( 10 ) 4217 - 4227 2021年10月
担当区分：最終著者, 責任著者
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Supercapacitor electrode with high charge density based on boron-doped porous carbon derived from covalent organic frameworks 査読あり
Shigeyuki Umezawa, Takashi Douura, Koji Yoshikawa, Yohei Takashima, Mika Yoneda, Kazuma Gotoh, Vlad Stolojan, S. Ravi P. Silva, Yasuhiko Hayashi, Daisuke Tanaka
Carbon 184 418 - 425 2021年10月
出版者・発行元：Elsevier BV
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Koji Nagahama, Seika Aoyama, Natsumi Ueda, Yuka Kimura, Tokitaka Katayama, Kimika Ono
ACS Macro Letters 10 ( 8 ) 1073 - 1079 2021年8月
担当区分：筆頭著者, 責任著者
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Involvement of Annexin A2 in Serum-MAF Dependent Phagocytic Activation of Macrophages. 査読あり
Kawakatsu K, Seta Y, Maemura M, Nishikata T.
Anticancer Research 41 ( 8 ) 4089 - 4092 2021年8月
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ウォッシャーディスインフェクターのすすぎ排水中に含まれる洗浄剤残留量の測定によるすすぎ性能評価 査読あり
三軒隼人、藤田敏、川田原瑠勇、武川公、臼井健二、原田陽滋
医療機器学 91 315 - 332 2021年8月
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Enhancement of the Catalytic Activity of Hammerhead Ribozymes by Organic Cations. 査読あり 国際誌
Shu-Ichi Nakano, Hirofumi Yamashita, Naoki Sugimoto
ChemBioChem 22 ( 17 ) 2721 - 2728 2021年7月
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Zayed, M., Iohara, K., Watanabe, H., Ishikawa, M., Tominaga, M. and Nakashima, M.
Stem Cell Res Ther. 12 ( 302 ) 2021年5月
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Detection of Intracellular Reactive Oxidative Species Using the Fluorescent Probe Hydroxyphenyl Fluorescein 招待あり 査読あり
Wataru Sugimoto, Daisuke Miyoshi, Keiko Kawauchi
Methods in Molecular Biology 2274 207 - 215 2021年5月
出版者・発行元：Humana Press Inc.
Various fluorescent probes for the detection of intracellular reactive oxidative species (ROS) have been developed because ROS levels are closely associated with cellular states. Here, we describe a method for detection of intracellular ROS in living cells using the fluorescent probe, hydroxyphenyl fluorescein (HPF), which detects hydroxyl radicals and peroxynitrite. NIH3T3 cells and p53 knockout (p53−/−) mouse embryonic fibroblasts (MEFs) were transformed by expressing oncogenic RAS using a retrovirus system. The cells were treated with HPF at 37 °C for 30 min, and subsequently, images were acquired using a confocal fluorescence microscope at an excitation wavelength of 488 nm after washing with PBS.
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がん関連RNAを破壊する分子標的型光線力学療法 招待あり 査読あり
杉本 渉・橋本 佳樹・川内 敬子・三好 大輔
BIO Clinica 36 ( 5 ) 65 - 67 2021年5月
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K. Akamatsu, S. Nakano, K. Kimura, Y. Takashima, T. Tsuruoka, H. Nawafune, Y. Sato, J. Murai, and H. Yanagimoto
ACS Appl. Mater. Interfaces 13 ( 11 ) 13896 - 13906 2021年3月
共著
出版者・発行元：ACS Publications
The development of high-performance, environmentally friendly electrodeposition processes is critical for emerging coating technologies because current technologies use highly complex baths containing metal salts, supporting electrolytes, and various kinds of organic additives, which are problematic from both environmental and cost perspectives. Here, we show that a 200 μm-thin polyelectrolyte membrane sandwiched between electrodes effectively concentrates metal ions through interfacial penetration, which increases the conductance between the electrodes to 0.30 S and realizes solid-state electrodeposition that produces no mist, sludge, or even waste effluent. Both, experimental results and theoretical calculations, reveal that electrodeposition is controlled by ion penetration at the solution/polyelectrolyte interface, providing an intrinsically different ion-transport mechanism to that of conventional diffusion-controlled electrodeposition. The setup, which includes 0.50 mol L–1 copper sulfate and no additives, delivers a maximum current density of 300 mA cm–2, which is nearly fivefold higher than that of a current commercial plating bath containing organic additives.
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核小体ストレスにより形成するrDNA G-quadruplex集合体とその機能
杉本 渉, 桑本 慎, 建石 寿枝, 岩根 敦子, 高橋 宏隆, 三好 大輔, 川内 敬子
日本薬学会年会要旨集 141年会 29V05 - am10S 2021年3月
出版者・発行元：(公社)日本薬学会
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Covalent cell-loading injectable hydrogel scaffold significantly promotes tissue regeneration in vivo compared with a conventional physical cell-loading hydrogel scaffold 査読あり
Yuka Kimura, Seika Aoyama, Natsumi Ueda, Tokitaka Katayama, Kimika Ono, Koji Nagahama
Advanced Biology 5 2000106 2021年2月
共著
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Hydrostatic pressure-regulated cellular calcium responses 査読あり 国際誌
Minami Fukuchi, Kotaro Oyama, Hiroaki Mizuno, Akihisa Miyagawa, Kazuya Koumoto, Gaku Fukuhara
Langmuir 37 ( 2 ) 820 - 826 2021年1月
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Combined Effects of Methylated Cytosine and Molecular Crowding on the Thermodynamic Stability of DNA Duplexes 招待あり 査読あり
Combined Effects of Methylated Cytosine and Molecular Crowding on the Thermodynamic Stability of DNA Duplexes
Int. J. Mol. Sci. 22 ( 2 ) 947 2021年1月
共著
DOI： 10.3390/ijms22020947
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Exploration of structural transition phenomenon in flexible metal-organic framework formed on polymer substrate
S. Hirao, R. Hamagami, T. Ohhashi, K. Eguchi, N. Kubo, Y. Takashima, K. Akamatsu, T. Tsuruoka
CrystEngComm 23 8498 - 8505 2021年
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Precisely Controlled Reproducible Synthesis of Palladium Nanoparticles inside Metal-Organic Frameworks with H2 Gas as Reductant: Effects of Framework Crystallinity and H2 Gas
Y. Takashima, Y. Sato, N.Kubo, T. Tsuruoka, K. Akamatsu
Chem. Lett 50 244 - 247 2021年
共著
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Controlling Interfacial Ion-Transport Kinetics Using Polyelectrolyte Membranes for Additive- and Effluent-free, High-Performance Electrodeposition 査読あり
Kensuke Akamatsu, Shu-ichi Nakano, Koshi Kimura, Yohei Takashima, Takaaki Tsuruoka, Hidemi Nawafune, Yuki Sato, Junya Murai, Hiroshi Yanagimoto
ACS Applied Materials&Interfaces 2021年
共著
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Ozaki, M., Yoshida, S., Tsuruoka, T., Usui, K.
Chemical Communications 57 2021年
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Ozaki, M., Imai, T., Tsuruoka, T., Sakashita, S., Tomizaki, K.-Y., Usui, K.
Communications Chemistry 4 2021年
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Shoya Hirao, Ruho Hamagami, Takashi Ohhashi, Keiichi Eguchi, Neo Kubo, Yohei Takashima, Kensuke Akamatsu, Takaaki Tsuruoka
CrystEngComm 23 ( 48 ) 8498 - 8505 2021年
担当区分：最終著者, 責任著者 出版者・発行元：Royal Society of Chemistry (RSC)
We investigate the structural transition of directly formed flexible MOF crystals on a polymer substrate.
DOI： 10.1039/d1ce01383a
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Precisely Controlled Reproducible Synthesis of Palladium Nanoparticles inside Metal-Organic Frameworks with H2 Gas as Reductant: Effects of Framework Crystallinity and H2 Gas 査読あり
Y. Takashima, Y. Sato, N.Kubo, T. Tsuruoka, K. Akamatsu
Chem. Lett 50 244 - 247 2021年
共著
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Intracellular mineralization of gold nanoparticles using gold ion-binding peptides with cell-penetrating ability 査読あり
Makoto Ozaki, Shuhei Yoshida, Takaaki Tsuruoka, Kenji Usui
Chemical Communications 2021年
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Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy 招待あり 国際誌
Keiko Kawauchi, Ryoto Urano, Natsuki Kinoshita, Shin Kuwamoto, Takeru Torii, Yoshiki Hashimoto, Shinya Taniguchi, Mitsuki Tsuruta, Daisuke Miyoshi
Genes 11 ( 11 ) 1340 2020年11月
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Precisely Controlled Reproducible Synthesis of Palladium Nanoparticles inside Metal-Organic Frameworks with H2 Gas as Reductant: Effects of Framework Crystallinity and H2 Gas Pressure 査読あり
Yohei Takashima, Yasushi Sato, Neo Kubo, Takaaki Tsuruoka, Kensuke Akamatsu
Chem. Lett. 50 ( 2 ) 244 - 247 2020年11月
担当区分：筆頭著者, 責任著者
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TakahiroYamauchi, Takafumi Kubodera, Daisuke Miyoshi, Naoki Sugimoto, Shuji Hirohata
Journal of Bioscience and Bioengineering 2020年10月
共著
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Mechanism toward turn-on of polysaccharide-porphyrin complexes for fluorescence probes and photosensitizers in photodynamic therapy in living cells 査読あり 国際誌
Shodai Hino, Rikushi Funada, Kouta Sugikawa, Riku Kawasaki, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
ChemMedChem 15 ( 1 ) 1 - 12 2020年10月
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Novel Strategy of Photodynamic Therapy Targeting RAS mRNA with G-Quadruplex Ligands for Cancer Treatment 招待あり 査読あり 国際誌
Takeru Torii, Wataru Sugimoto, Keiko Kawauchi, Daisuke Miyoshi
Journal of Data Mining in Genomics & Proteomics 11 ( 2 ) 2020年8月
共著
担当区分：責任著者
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Dermal fibroblasts internalize phosphatidylserine-exposed secretory melanosome clusters and apoptotic melanocytes. 査読あり
Hideya Ando, Satoshi Yoshimoto, Moemi Yoshida, Nene Shimoda, Ryosuke Tadokoro, Haruka Kohda, Mami Ishikawa, Takahito Nishikata, Bunpei Katayama, Toshiyuki Ozawa, Daisuke Tsuruta, Ken-Ichi Mizutani, Masayuki Yagi, Masamitsu Ichihashi
International Journal of Molecular Sciences 21 ( 16 ) 5789 2020年8月
共著
DOI： 10.3390/ijms21165789
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Modification of the release rate of curcumin from the cavity of renatured β-1,3-1,6-glucan nanoparticles by changing the molecular weight of the constituent polysaccharide chains 査読あり
Yuki Nonoguchi, Ayumu Kodama, Toshio Suzuki, Kazuya Koumoto
Chemistry Letters 49 ( 10 ) 1150 - 1153 2020年7月
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杉本 渉, 川内 敬子, 三好 大輔
Medical Science Digest 46 ( 9 ) 26 - 27 2020年7月
共著
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Competing Roles of Two Kinds of Ligand during Nonclassical Crystallization of Pillared-Layer Metal-Organic Frameworks Elucidated Using Microfluidic Systems
Yoko Tanaka, Yu Kitamura, Ryuji Kawano, Kan Shoji, Moe Hiratani, Tetsuo Honma, Hikaru Takaya, Hirofumi Yoshikawa, Takaaki Tsuruoka, Daisuke Tanaka
Chemistry - A European Journal 26 ( 41 ) 8889 - 8896 2020年7月
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim To diversify metal-organic frameworks (MOFs), multi-component MOFs constructed from more than two kinds of bridging ligand have been actively investigated due to the high degree of design freedom afforded by the combination of multiple ligands. Predicting the synthesis conditions for such MOFs requires an understanding of the crystallization mechanism, which has so far remained elusive. In this context, microflow systems are efficient tools for capturing non-equilibrium states as they facilitate precise and efficient mixing with reaction times that correspond to the distance from the mixing point, thus enabling reliable control of non-equilibrium crystallization processes. Herein, we prepared coordination polymers with pillared-layer structures and observed the intermediates in the syntheses with an in-situ measurement system that combines microflow reaction with UV/Vis and X-ray absorption fine-structure spectroscopies, thereby enabling their rapid nucleation to be monitored. Based on the results, a three-step nonclassical nucleation mechanism involving two kinds of intermediate is proposed.
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Takeru Torii, Wataru Sugimoto, Keiko Kawauchi, Daisuke Miyoshi
Journal of Data Mining in Genomics & Proteomics 2020年6月
共著
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Miho Takagi-Sato, Koji Morita, Yoshiyuki Onishi, Yuuka Watahiki, Taku Ishigaki, Tomoka Akita, Erisa Tomita, Junji Kawakami, Makoto Koizumi
Nucleosides, Nucleotides & Nucleic Acids 39 ( 6 ) 838 - 852 2020年6月
出版者・発行元：Informa UK Limited
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Comparison of macrophage activation using γ-globulin and serum-derived macrophage activating factor. 査読あり
Akamatsu M, Mashiba R, Kawakatsu K, Ishikawa M, Nishikata T.
Anticancer Research 40 ( 8 ) 4707 - 4710 2020年6月
共著
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Kazuki Kohata, Daisuke Miyoshi
Biophys. Rev. 12 669 - 676 2020年5月
共著
Living cells are highly crowded with large and small biomolecules. The total concentration of biomolecules can reach 400 mg/ml, and 40% of the cell volume is occupied by biomolecules. Droplet formation in cells via liquid-liquid phase separation may play a role in controlling biochemical reactions in this complex molecular environment. Liquid-liquid phase separation generally involves nucleic acids and proteins as anionic and cationic components, respectively. Significant characteristics of droplets, which make them different from protein aggregation or fibril formation, are reversibility of formation and responsiveness to the molecular environment. In this review, we quantitatively describe the molecular environment inside cells and droplets that participate in controlling central dogma reactions. Finally, we discuss the importance of droplets under conditions of molecular crowding within living cells.
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Miyazaki H , Hamada Y , Takaishi H , Minamino Y , Ikeda H , Mekata H , Takaishi M , Yamashita K , Usui K
Analyst 145 3211 - 3216 2020年5月
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Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA 査読あり
H. Tateishi-Karimata, D. Banerjee, T. Ohyama, S. Matsumoto, D. Miyoshi, S. Nakano, and N. Sugimoto
Biochemical and Biophysical Research Communications 525 ( 1 ) 177 - 183 2020年4月
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Coordination-Driven Self-Assembly on Polymer Surfaces for Efficient Synthesis of [Au(SPh)]<inf>n</inf> Coordination Polymer-Based Films
Takaaki Tsuruoka, Takashi Ohhashi, Jumpei Watanabe, Rikuto Yamada, Shoya Hirao, Yohei Takashima, Aude Demessence, Shefali Vaidya, Oleksandra Veselska, Alexandra Fateeva, Kensuke Akamatsu
Crystal Growth and Design 20 ( 3 ) 1961 - 1968 2020年3月
共著
出版者・発行元：American Chemical Society ({ACS})
We describe a simple bottom-up strategy to generate [Au(SPh)] (SPh: thiophenolate) coordination polymer (CP) based thin films by employing an interfacial self-assembly on a nylon substrate. This method utilizes Au ion-doped nylon film as a precursor of [Au(SPh)] CP and a support substrate to control the kinetics of the reduction of the Au ion from Au(III) to Au(I) and the complexation of Au(I) ions as well as SPh on the surface of the nylon film. The obtained CPs exhibit a fibril morphology with high crystallinity, which leads to a luminescent property. Further, we systematically study the formation mechanism of [Au(SPh)] CPs on the substrates. Amorphous CPs formed at an early stage of reaction are transformed to crystalline CPs based on the rearrangement of components during the reaction. The findings described herein offer novel and interesting openings for the synthesis of Au ion-based CPs that demonstrate desired functions for a wide range of applications. n n n
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Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA. 査読あり 国際誌
Hisae Tateishi-Karimata, Dipanwita Banerjee, Tatsuya Ohyama, Saki Matsumoto, Daisuke Miyoshi, Shu-Ich Nakano, Naoki Sugimoto
Biochemical and biophysical research communications 2020年2月
Telomeric G-quadruplex topology has the ability to regulate telomerase activity, which counteracts the shortening of telomere with successive cell divisions, thereby causing genomic longevity. However, the detailed mechanism of G-quadruplexes topologies formed by telomeric sequences requires further investigation. In this study, we quantitatively investigated the effect of cosolutes, particularly the varying number of hydroxyl groups, on the structural transition between hybrid type and parallel G-quadruplexes formed by telomeric DNA sequences. Cosolutes with one or no hydroxyl groups in the vicinal position more efficiently induced the transition to parallel G-quadruplex from hybrid G-quadruplex than those with more hydroxyl groups. We also examined the effect of cosolute structures on the hydration of G-quadruplex formation; the results indicated that cosolutes with fewer hydroxyl groups lead to the release of greater amount of water during G-quadruplex formation. Molecular dynamics results showed that the parallel G-quadruplex was more dehydrated than the hybrid type G-quadruplex. Generally, a dehydrated structure is favored under crowding condition. Thus, depending on the surrounding cosolutes, the G-quadruplex topology can be controlled by the G-quadruplex hydration state.
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Solubilization of poorly water-soluble bioactive molecules in neutral aqueous media by complexation with renatured beta-1,3-1,6-glucan nanoparticles 査読あり 国際誌
Ayumu Kodama, Akifumi Nakagawa, Yuki Nonoguchi, Haruka Sakurai, Chieko Yano, Toshio Suzuki, Kazuya Koumoto
Biopolymers 111 ( 4 ) e23349 2020年2月
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MMP24 as a Target of YAP is a Potential Prognostic Factor in Cancer Patients 査読あり 国際誌
Wataru Sugimoto, Katsuhiko Ito, Hiroaki Hirata, Yoshinori Abe, Takeru Torii, Yasumasa Mitsui, Yemima Budirahardja, Nobuyuki Tanaka, Keiko Kawauchi
Bioengineering 7 ( 18 ) 1 - 12 2020年2月
共著
担当区分：最終著者, 責任著者
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Therapeutic effect of intravenously administered autologous adipose-derived stem cells on chronic stage stroke patients. 査読あり
Masamitsu Ichihashi, Masaki Tanaka, Takashi Iizuka, Narumi Nagoe, Youko Sato, Hitomi Takahashi, Asami Ueda, Hiroko Tokura, Narumi Takanashi, Takahito Nishikata, Osamu Matsuo, Hideya Ando, and Ken-ichiMizutani
International Journal of Stem Cell Research & Therapy 7 070 2020年
共著
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Coordination-Driven Self-Assembly on Polymer Surface for Efficient Synthesis of [Au(SPh)]n Coordination Polymer-Based Films
T. Tsuruoka, T. Ohhashi, J. Watanabe, R. Yamda, S. Hirao, T. Takashima, A. Demessence, S. Vaidya, O. Veselska, A. Fateeva, K. Akamatsu
Cryst. Growth 1961 - 1968 2020年
単著
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Controlled syntheses of Ag nanoparticles inside MOFs by using amine-boranes as vapour phase reductants 査読あり
Yohei Takashima, Yasushi Sato, Takaaki Tsuruoka, Kensuke Akamatsu
Dalton Transactions 2020年
共著
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好熱性細菌および酵母菌による多段階培養発酵技術から得られた 発酵エキスの皮膚に対する有用性 査読あり
川野 大地, 廖 筝筝, 聶 菁, 伊達 朗, Eduardo Perez, Jose Fernandez, Corey Webb, Kristen Huber, Jeffry B. Stock, 川上 純司, 付 子華
日本香粧品学会誌 44 ( 3 ) 194 - 202 2020年
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Different reactivity of Sp and Rp isomers of phosphorothioate-modified oligonucleotides in a duplex structure 査読あり
Md Ariful Islam, Aki Fujisaka, Junji Kawakami, Takao Yamaguchi, Satoshi Obika
Bioorg. Med. Chem. Lett. 30 ( 14 ) 127166 - 127166 2020年
共著
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Novel purification process for amyloid beta peptide(1-40) 招待あり 査読あり
Usui, K., Yokota, S.-I., Iwata, K., Hamada, Y.
Processes 8 2020年
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Miyazaki, H., Samejima, Y., Iwata, K., Minamino, Y., Hikida, S., Ariumi, H., Ikeda, H., Hamada, Y., Yamashita, K., Usui, K.
International Journal of Molecular Sciences 21 2020年
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Miyazaki, H., Takaishi, H., Ikeda, H., Ariumi, H., Hamada, Y., Yamashita, K., Usui, K.
Processes 8 2020年
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Effect of tryptophan residues on gold mineralization by a gold reducing peptide 査読あり
Ozaki, M., Yoshida, S., Oura, M., Tsuruoka, T., Usui, K.
RSC Advances 10 2020年
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Bioinspired cell nuclear nanotransporters generated by self‐assembly of amphiphilic polysaccharide‐amino acid derivatives conjugates 査読あり
Koji Nagahama, Yoshinori Sano, Mitsuo Inui, Seika Aoyama, Tokitaka Katayama, Kimika Ono
Advanced Biosystems 4 1900189 2020年
共著
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美容医療 new horizon －幹細胞への期待－ 招待あり 査読あり
市橋正光、長濱宏治
日本香粧品学会誌 44 30 - 35 2020年
共著
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細胞移植用インジェクタブルゲルの開発 招待あり 査読あり
長濱宏治
Precision Medicine 3 724 - 728 2020年
単著
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A thin hydrogel barrier linked onto cell surface sialic acids through covalent bonds induces cancer cell death in vivo 査読あり
Kimika Ono, Yuka Sanada, Yuka Kimura, Seika Aoyama, Natsumi Ueda, Tokitaka Katayama, Koji Nagahama
Biomaterials Science 8 577 - 585 2020年
共著
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Yohei Takashima, Yasushi Sato, Takaaki Tsuruoka, Kensuke Akamatsu
Dalton Transactions 49 ( 47 ) 17169 - 17172 2020年
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Effect of tryptophan residues on gold mineralization by a gold reducing peptide
Makoto Ozaki, Shuhei Yoshida, Maho Oura, Takaaki Tsuruoka, Kenji Usui
RSC Advances 2020年
共著
DOI： 10.1039/D0RA07098J
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Flexible and luminescent fibers of a 1D Au(i)–thiophenolate coordination polymer and formation of gold nanoparticle-based composite materials for SERS
Shefali Vaidya, Oleksandra Veselska, Antonii Zhadan, Marlène Daniel, Gilles Ledoux, Alexandra Fateeva, Takaaki Tsuruoka, Aude Demessence
Journal of Materials Chemistry C 2020年
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Y. Takashima, Y. Sato, T. Tsuruoka, K. Akamatsu
Dalton Trans 49 ( 47 ) 17169 - 17172 2020年
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Improved stability and photodynamic activity of water-soluble 5,15-diazaporphyrins incorporated in beta-(1,3-1,6)-D-glucan with on-off switch 査読あり 国際誌
Shodai Hino, Shuhei Satake, Hideyuki Shinmori, Shigeki Kawabata, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Kouta Sugikawa, Riku Kawasaki, Atsushi Ikeda
Chemistry an Asian Journal 15 ( 3 ) 365 - 370 2019年12月
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Shikhar Tyagi, Sarika Saxena, Nikita Kundu, Taniya Sharma, Amlan Chakraborty, Sarvpreet Kaur, Daisuke Miyoshi, Jadala Shankaraswamy
RSC Advances 9 40255 - 40262 2019年12月
共著
We described a novel synthetic peptide in which a glutamine residue binds through hydrogen bonding to a guanine-base and a trytophan residue intercalates with K+ resulting in stabilization of a human telomeric G-quadruplex with high selectivity over its complementary c-rich strand and a double-stranded DNA and its complementary C-rich strand. This peptide offers great potential for cancer treatment by inhibiting the telomere extension by telomerase.
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Structural effect of amine N-oxides on the facilitation of alpha-glucosidase-catalyzed hydrolysis reaction 査読あり 国際誌
Takuma Aoki, Yuichi Nakagawa, Ryutaro Genjima, Kazuya Koumoto
Bioprocess Biosys. Eng. 43 ( 3 ) 541 - 548 2019年11月
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Turn-on fluorescence and photodynamic activity of beta-(1,3-1,6)-D-glucan-complexed with porhyrin derivative inside HeLa cells 査読あり 国際誌
Shodai Hino, Rikushi Funada, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
Photochem. Photobiol. Sci. 18 ( 12 ) 2854 - 2858 2019年11月
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Bulky cations greatly increase the turnover of a native hammerhead ribozyme 査読あり
S. Nakano, H. Yamashita, K. Tanabe, N. Sugimoto
RSC advances 9 35820 - 35824 2019年11月
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The RAS mRNA G-quadruplex: making undruggable cancer targets druggable
Keiko Kawauchi, Wataru Sugimoto, Daisuke Miyoshi
The Atlas of Science 2019年10月
共著
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DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death. 査読あり
Itoh K, Ebata T, Hirata H, Torii T, Sugimoto W, Onodera K, Nakajima W, Uehara I, Okuzaki D, Yamauchi S, Budirahardja Y, Nishikata T, Tanaka N, Kawauchi K.
Molecules 24 ( 17 ) E3175 2019年9月
共著
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Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity. 査読あり 国際誌
Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald FL, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y.
Science Adv. 5 2019年9月
共著
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Stabilization of DNA loop structures by large cations 査読あり
S. Nakano, T. Ayusawa, Y. Tanino, N. Sugimoto
J. Phys. Chem. B 123 7687 - 7694 2019年8月
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研究課題設定を重視した科学技術人材育成プログラムROOTのデザインと実装
伊藤 真之, 臼井 英之, 長野 寛之, 巳波 弘佳, 甲元 一也, 蛯名 邦禎
日本科学教育学会年会論文集 43 399 - 400 2019年8月
共著
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ケミカルバイオロジー2.0
三好大輔, 山東信介, 清中茂樹, 花岡健二郎, 後藤佑樹
現代化学 581 18 - 25 2019年7月
共著
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Formation of Metal-Organic Frameworks on Metal Ion-Doped Polymer Substrate: In-Depth Time-Course Analysis using Scanning Electron Microscopy 査読あり
T. Tsuruoka, M. Hata, S. Hirao, T. Ohhashi, Y. Takashima, K. Akamatsu
Langmuir 35 10390 - 10396 2019年7月
共著
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Control of the nucleation and growth processes of metal-organic frameworks using a metal ion-doped polymer substrate for the construction of continuous films 査読あり
T. Ohhashi, T. Tsuruoka, Y. Takashima, K. Akamatsu
CrystEngComm 21 4851 - 4854 2019年7月
共著
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Characteristic morphological changes and rapid actin accumulation in serum-MAF-treated macrophages. 査読あり
Kawakatsu K, Ishikawa M, Mashiba R, Tran NK, Akamatsu M, Nishikata T
Anticancer Research 39 ( 8 ) 4533 - 4537 2019年6月
共著
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A case of chronic actinic dermatitis that responded completely to treatment with oral colostrum-macrophage activating factor (colostrum-MAF). 査読あり
Ichihashi M, Nakamura Y, Muto M, Nishikata T, Inui T, Uto Y.
Photodermatol Photoimmunol Photomed 2019年5月
共著
DOI： 10.1111/phpp.12469
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細胞の分子夾雑環境における核酸構造と核酸構造リガンドの挙動 ～細胞内でも望みの機能を発現する分子の合理設計に向けて～
三好大輔
生命化学研究レター 58 ( 1 ) 17 - 21 2019年4月
単著
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Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides 査読あり
T. Shimo, K. Tachibana, Y. Kawawaki, Y. Watahiki, T. Ishigaki, Y. Nakatsuji, T. Hara, J. Kawakami and S. Obika
Chem. Commun. 55 6850 - 6853 2019年4月
共著
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Integrated Synthesis of Gold Nanoparticles Coated with Polyoxometalate Clusters 査読あり
Sergio Martin, Yohei Takashima, Chang-Gen Lin, Yu-Fei Song, Haralampos N. Miras, Leroy Cronin
Inorganic Chemistry 58 ( 7 ) 4110 - 4116 2019年3月
共著
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Massive cytoplasmic transport and microtubule organization in fertilized chordate eggs. 査読あり
Nishikata T, Goto T, Yagi H, Ishii H.
Developmental Biology 448 ( 2 ) 154 - 160 2019年2月
共著
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Non-centrosomal microtubule structures regulated by egg activation signaling contribute to cytoplasmic and cortical reorganization in the ascidian egg. 査読あり
Goto T, Kanda K, Nishikata T.
Developmental Biology 448 ( 2 ) 161 - 172 2019年2月
共著
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Osmolyte-Enhanced Protein Synthesis Activity of a Reconstituted Translation System 査読あり
Yoshiki Moriizumi, Kazuhito V. Tabata, Daisuke Miyoshi, Hiroyuki Noji
ACS Synth Biol. 8 ( 3 ) 557 - 567 2019年2月
共著
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Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells. 査読あり 国際誌
Araki K, Kawauchi K, Sugimoto W, Tsuda D, Oda H, Yoshida R, Ohtani K.
Communications Biol. 6 550 - 561 2019年1月
共著
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Formation of Metal-Organic Frameworks on Metal Ion-Doped Polymer Substrate: In-Depth Time-Course Analysis using Scanning Electron Microscopy 査読あり
T. Tsuruoka, M. Hata, S. Hirao, T. Ohhashi, T. Takashima, K. Akamatsu
Langmuir 35 10390 - 10396 2019年
共著
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Control of the nucleation and growth processes of metal-organic frameworks using a metal ion-doped polymer substrate for the construction of continuous films 査読あり
T. Ohhashi, T. Tsuruoka, T. Takashima, K. Akamatsu
CrystEngComm 21 4851 - 4854 2019年
共著
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固液界面での選択的MOF形成
鶴岡孝章、平尾翔也、髙嶋洋平、赤松謙祐
日本接着学会誌 55 301 - 307 2019年
共著
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細胞移植用スマートゲルの開発 招待あり
長濱宏治、小野公佳、木村友香、青山青海
ケミカルエンジニヤリング 64 17 - 26 2019年
共著
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Formation of Metal-Organic Frameworks on Metal Ion-Doped Polymer Substrate: In-Depth Time-Course Analysis using Scanning Electron Microscopy 査読あり
T. Tsuruoka, M. Hata, S. Hirao, T. Ohhashi, T. Takashima, K. Akamatsu
Langmuir 35 10390 - 10396 2019年
共著
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Control of the nucleation and growth processes of metal-organic frameworks using a metal ion-doped polymer substrate for the construction of continuous films 査読あり
T. Ohhashi, T. Tsuruoka, T. Takashima, K. Akamatsu
CrystEngComm 21 4851 - 4854 2019年
共著
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固液界面での選択的MOF形成
鶴岡孝章、平尾翔也、髙嶋洋平、赤松謙祐
日本接着学会誌 55 301 - 307 2019年
共著
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Metal sensitive and DNA concentration dependent structural rearrangement of short oligonucleotide into large suprastructures 査読あり
J. Shankaraswamy, Shikhar Tyagi, Anju Singh, Daisuke Miyoshi, Sarika Saxena
Journal of Biomolecular Structure and Dynamics 37 ( 9 ) 2211 - 2218 2018年12月
共著
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Wrapping Flexible Metal-Organic Framework with Organic Polymers via Site-Specific Radical Polymerization from Its Crystal Surface 招待あり 査読あり
Yohei Takashima, Kenji Fukudome, Atsuto Horikoshi, Takaaki Tsuruoka, Kensuke Akamatsu
Polyhedron 155 275 - 280 2018年11月
共著
担当区分：筆頭著者
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Yohei Takashima, Kenji Fukudome, Atsuto Horikoshi, Takaaki Tsuruoka, Kensuke Akamatsu
Polyhedron 155 275 - 280 2018年11月
共著
© 2018 Elsevier Ltd In this study, we succeeded in the crystal surface modification of metal–organic framework (MOF) with an organic polymer by site-specific radical polymerization. A MOF was selected with interpenetrated structure containing a naphthalenediimide moiety with electron accepting capability. N, N-dimethylaniline, as an electron donating guest, induced electron transfer to the napthalenediimide moiety, generating radical anions on the pore and crystal surfaces, initiating radical polymerization. The resulting composite was examined in detail with XRD, TG, TEM, ICP, IR, gas adsorption, and fluorescent measurements, demonstrating that an organic polymer was generated only on the crystal surface, preserving the original porous property. In addition, higher structural stability in response to H2O was observed after polymer wrapping.
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Anti-inflammatory effect of 5-aminolevulinic acid on macrophage in vitro. 査読あり
Ishikawa M, Mashiba R, Kawakatsu K, Nakagawa H, Kitajima Y, Ishizuka M, Nishikata T.
ALA-Porphyrin Science 7 ( 1 ) 3 - 11 2018年9月
共著
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Gold-Titania Nanocatalyst Generated by Mineralization Using Two Artificial Peptides with DNA 査読あり
Ozaki Makoto, Tomizaki Kin-Ya, Hamada Yoshio, Usui Kenji
JOURNAL OF PEPTIDE SCIENCE 24 S101 2018年9月
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Effects of platinum and palladium nanocolloid on macrophage polarization in relevance to repigmentation of vitiligo. 査読あり
Minamiyama Y, Ishikawa M, Shibata T, Tsuji G, Nishikata T, Takemura S, Ichihashi M.
J Cutan Immunol Allergy 1 139 - 146 2018年8月
共著
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巻頭言 変化は突然に ―学会参加のススメ―
三好大輔
日本化学会 生体機能関連化学部会 ニュースレター 33 ( 2 ) 2 - 3 2018年8月
単著
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Phagocytic activation of macrophages with serum MAF depends on engulfment efficiency and not migratory activity. 査読あり
Mashiba R, Ishikawa M, Sumiya YU, Kawakatsu K, Tran NK, Nishikata T.
Anticancer Res. 38 ( 7 ) 4295 - 4298 2018年7月
共著
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An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex 査読あり
Keiko Kawauchi, Wataru Sugimoto, Takatoshi Yasui, Kohei Murata, Katsuhiko Itoh, Kazuki Takagi, Takaaki Tsuruoka, Kensuke Akamatsu, Hisae Tateishi-Karimata, Naoki Sugimoto, and Daisuke Miyoshi
Nature Communicationsvolume 9 2271 2018年6月
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An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex 査読あり 国際誌
Kawauchi K, Sugimoto W, Yasui T, Murata K, Itoh K, Takagi K, Tsuruoka T, Akamatsu K, Tateishi-Karimata H, Sugimoto N, Miyoshi D.
Nature Commun. 9 2271 2018年6月
共著
担当区分：筆頭著者, 責任著者
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Living functional hydrogels generated by bioorthogonal cross-linking reactions of azide-modified cells with alkyne-modified polymers 査読あり
K. Nagahama, Y. Kimura, A. Takemoto
Nature Communications ( 9 ) 2195 2018年6月
共著
担当区分：筆頭著者
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Thermal stability and conformation of DNA and proteins under the confined condition in the matrix of hydrogels
S. Nakano, D. Yamaguchi, and N. Sugimoto
Mol. Biol. Rep. ４5 403 - 411 2018年4月
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Kenji Usui, Shin-ichiro Yokota, Makoto Ozaki, Shungo Sakashita, Takahito Imai, Kin-ya Tomizaki
Protein & Peptide Letters 25 42 - 47 2018年4月
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Yuki Tominaga, Kenji Usui, Akiyoshi Hirata, Hiro-O Ito, Kiyoshi Nokihara
Bioorganic & Medicinal Chemistry 26 3210 - 3216 2018年4月
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Peptides for Silica Precipitation: Amino Acid Sequences for Directing Mineralization 査読あり
Makoto Ozaki, Shungo Sakashita, Yoshio Hamada, Kenji Usui
Protein & Peptide Letters 25 15 - 24 2018年4月
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Editorial: Organic-Inorganic Hybrid Materials and Their Applications 査読あり
Kin-ya Tomizaki, Yoshio Hamada, Kenji Usui
Protein & Peptide Letters 25 2 - 3 2018年4月
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Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2. 査読あり 国際誌
Sugimoto W, Itoh K, Mitsui Y, Ebata T, Fujita H, Hirata H, Kawauchi K
Cell adhesion & migration 12 ( 2 ) 101 - 108 2018年3月
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Nanocomposite injectable gels capable of self-replenishing regenerative extracellular microenvironments for in vivo tissue engineering 査読あり
K. Nagahama, N. Oyama, K. Ono, A. Hotta, K. Kawauchi, T. Nishikata
Biomater Sci. 6 ( 3 ) 550 - 561 2018年2月
共著
DOI： 10.1039/c7bm01167a.
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Nanocomposite injectable gels capable of self-replenishing regenerative extracellular microenvironments for in vivo tissue engineering 査読あり 国際誌
Koji Nagahama, Naho Oyama, Kimika Ono, Atsushi Hotta, Keiko Kawauchi, Takahito Nishikata
Biomater Sci. 6 550 - 561 2018年2月
共著
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A high-throughput quantitative assay system for macrophage phagocytic activity. 査読あり
Mami Ishikawa, Riho Mashiba, Kumpei Kawakatsu, Ngoc Kiet Tran, Takahito Nishikata
macrophage 2018年2月
共著
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Nanocomposite injectable gels capable of self-replenishing regenerative extracellular microenvironments for in vivo tissue engineering 査読あり
K. Nagahama, N. Oyama, K. Ono, A. Hotta, K. Kawauchi, T. Nishikata
Biomaterials Science ( 6 ) 550 - 561 2018年2月
共著
担当区分：筆頭著者
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Destabilization of DNA G-quadruplexes by chemical environment changes during tumor progression facilitates transcription 査読あり 国際誌
Hisae Tateishi-Karimata, Keiko Kawauchi, Naoki Sugimoto
J Am Chem Soc. 140 642 - 651 2018年1月
共著
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Crystal conversion between metal-organic frameworks with different crystal topologies for efficient crystal design on two-dimensional substrates 査読あり
T. Tsuruoka, K. Inoue, A. Miyanaga, K. Tobiishi, T. Ohhashi, M. Hata, Y. Takashima, K. Akamatsu
J. Cryst. Growth 487 1 - 7 2018年
共著
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ポリイミドフィルムの表面改質と銅薄膜のダイレクトめっき技術
髙嶋洋平、鶴岡孝章、赤松謙祐
MATERIAL STAGE 18 29 - 33 2018年
共著
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Wrapping Flexible Metal-Organic Framework with Organic Polymers via Site-Specific Radical Polymerization from Its Crystal Surface
Y. Takashima, K. Fukudome, A. Horikoshi, T. Tsuruoka, K. Akamats
Polyhedron 155 275 - 280 2018年
共著
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Controlling the Orientation of Metal−Organic Framework Crystals by an Interfacial Growth Approach Using a Metal Ion-Doped Polymer Substrate
T. Ohhashi, T. Tsuruoka, S. Fujimoto, Y. Takashima, K. Akamatsu
Cryst. Growth Des 18 402 - 408 2018年
共著
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Controlling the Orientation of Metal−Organic Framework Crystals by an Interfacial Growth Approach Using a Metal Ion-Doped Polymer Substrate
T. Ohhashi, T. Tsuruoka, S. Fujimoto, Y. Takashima, K. Akamatsu
Cryst. Growth Des 18 402 - 408 2018年
共著
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ポリイミドフィルムの表面改質と銅薄膜のダイレクトめっき技術
髙嶋洋平、鶴岡孝章、赤松謙祐
MATERIAL STAGE 18 29 - 33 2018年
単著
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Wrapping Flexible Metal-Organic Framework with Organic Polymers via Site-Specific Radical Polymerization from Its Crystal Surface
Y. Takashima, K. Fukudome, A. Horikoshi, T. Tsuruoka, K. Akamatsu
Polyhedron 155 275 - 280 2018年
共著
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Design of Anti-Alzheimer's Disease Agents Focusing on a Specific Interaction with Target Biomolecules 査読あり
Yoshio Hamada, Kenji Usui
Neuromethods 132 207 - 228 2018年
共著
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Channel current analysis estimates the pore-formation and the penetration of transmembrane peptides 査読あり
Sekiya, Y., Sakashita, S., Shimizu, K., Usui, K., Kawano, R.
Analyst 143 ( 15 ) 2018年
共著
DOI： 10.1039/c8an00243f
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Crystal conversion between metal-organic frameworks with different crystal topologies for efficient crystal design on two-dimensional substrates 査読あり
T. Tsuruoka, K. Inoue, A. Miyanaga, K. Tobiishi, T. Ohhashi, M. Hata, Y. Takashima, K. Akamatsu
J. Cryst. Growth 487 1 - 7 2018年
共著
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Controlling the Orientation of Metal−Organic Framework Crystals by an Interfacial Growth Approach Using a Metal Ion-Doped Polymer Substrate 査読あり
T. Ohhashi, T. Tsuruoka, S. Fujimoto, Y. Takashima, K. Akamatsu
Cryst. Growth Des 18 402 - 408 2018年
共著
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Wrapping Flexible Metal-Organic Framework with Organic Polymers via Site-Specific Radical Polymerization from Its Crystal Surface
Y. Takashima, K. Fukudome, A. Horikoshi, T. Tsuruoka, K. Akamatsu
Polyhedron 155 275 - 280 2018年
共著
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ポリイミドフィルムの表面改質と銅薄膜のダイレクトめっき技術
髙嶋洋平、鶴岡孝章、赤松謙祐
MATERIAL STAGE 18 29 - 33 2018年
共著
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Controlling the Orientation of Metal-Organic Framework Crystals by an Interfacial Growth Approach Using a Metal Ion-Doped Polymer Substrate 査読あり
Takashi Ohhashi, Takaaki Tsuruoka, Seiya Fujimoto, Yohei Takashima, Kensuke Akamatsu
Cryst. Growth Des. 18 402 - 408 2018年
共著
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Crystal Conversion between Metal-Organic Frameworks with Different Crystal Topologies for Efficient Crystal Design on Two Dimensional Substrates 査読あり
Takaaki Tsuruoka, Kohei Inoue, Ayumi Miyanaga, Kaho Tobiishi, Takashi Ohhashi, Manami Hata, Yohei Takashima, Kensuke Akamatsu
J. Cryst. Growth 487 1 - 7 2018年
共著
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Tuning Light Emission towards White Light from a Naphthalenediimide-Based Entangled Metal-Organic Framework by Mixing Aromatic Guest Molecules 招待あり 査読あり
Rebeca Sola-Llano, Virginia Martínez-Martínez, Shuhei Furukawa, Yohei Takashima, Iñigo López-Arbeloa
Polymers 10 188 2018年
共著
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Modulation of the ribozyme and deoxyribozyme activities using tetraalkylammonium ions 査読あり
S. Nakano, T. Watabe, and N. Sugimoto
ChemPhysChem 18 ( 24 ) 3614 - 3619 2017年12月
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生体分子の挙動解析研究を目標としたマイクロ波照射システムの開発 ～ペプチドのバイオミネラリゼーションにおけるマイクロ波影響解析をモデルとして～ 査読あり
臼井健二, 富樫浩行, 圓東那津実, 尾崎誠, 有本米次郎, 裏鍛武史, 大沢隆二, 皆木幸一, 中西伸浩, 梅谷智弘
日本電磁波エネルギー応用学会論文誌 17 - 24 2017年12月
共著
担当区分：筆頭著者
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Catalytic activities of ribozymes and DNAzymes in water and mixed aqueous media 招待あり 査読あり
S. Nakano, M. Horita, M. Kobayashi, and N. Sugimoto
Catalysis 7 ( 12 ) 355 - 348 2017年11月
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DNA G-Wire Formation Using an Artificial Peptide is Controlled by Protease Activity 査読あり
Kenji Usu, Arisa Okada, Shungo Sakashita, Masayuki Shimooka, Takaaki Tsuruoka, Shu-ichi Nakano, Daisuke Miyoshi, Tsukasa Mashima, Masato Katahira and Yoshio Hamada
Molecules 22 1991 2017年11月
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Influence of intracellular environment on allosteric ribozyme activity
Misaki Kameno, Mika Sawada, Nae Sakimoto and Junji Kawakami
Proc. 44th Intl. Symp. Nucleic Acid Chemistry 178 - 179 2017年11月
共著
担当区分：筆頭著者
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Quantification of stabilization effect of co-solutes on RNA tertiary interaction
Natsumi Sasaki, Daisuke Miyoshi and Junji Kawakami
Proc. 44th Intl. Symp. Nucleic Acid Chemistry 174 - 175 2017年11月
共著
担当区分：筆頭著者
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Non-Covalent Loading of Anti-Cancer Doxorubicin by Modularizable Peptide Self-Assemblies for a Nanoscale Drug Carrier 査読あり
Kin-ya Tomizaki, Kohei Kishioka, Shunsuke Kataoka, Makoto Miyatani, Takuya Ikeda, Mami Komada, Takahito Imai, Kenji Usui
Molecules 22 ( 11 ) 1916 2017年11月
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細胞環境化学模倣実験系におけるDNAの構造とその熱力学的安定性
三好大輔
日本核酸化学会誌 1 13 - 19 2017年10月
単著
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Newly characterized interaction stabilizes DNA structure: oligoethylene glycols stabilize G-quadruplexes CH–π interactions 査読あり
H. Tateishi-Karimata, T. Ohyama, T. Muraoka, P. Podbevsek, A. M. Wawro, S. Tanaka, S. Nakano, K. Kinbara, J. Plavec, N. Sugimoto
Nucleic Acids Res. 45 7021 - 7030 2017年7月
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Fluorescent and Luminescent Fusion Proteins for Analyses of Amyloid Beta Peptide Aggregation 査読あり
Usui K, Mie M, Andou T, Mihara H, Kobatake E.
J Pept Sci. 23 ( 7-8 ) 659 - 665 2017年7月
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Quantitative relationship between chemical properties and bioactivities of anti-microRNA oligonucleotides targeted to tumor-associated microRNA-21 査読あり
Koji Nagahama, Kenta Iseda, Daichi Kawano, Junji Kawakami
BIOCHIMIE 137 124 - 131 2017年6月
共著
担当区分：最終著者, 責任著者 出版者・発行元：ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Synthetic anti-microRNA oligonucleotides (AMOs) are promising drug candidates to inactivate disease related microRNAs because of their sequence-specific binding to their targets and the variety of chemical modifications available. Over the last decade, the qualitative relationships between the chemical properties of AMOs and bioactivity (inactivation of their target miRNAs) have been studied to enhance their bioactivity. On the other hand, in real-world drug development, drugs must be designed case-by case, taking many factors into account. Thus, in order to design AMOs that target specific miRNA, understanding the quantitative relationship between the chemical properties of AMOs and inactivation of their target miRNA is necessary. Here, we aimed to find the specific quantitative relationship of AMOs targeted to tumor-associated miR-21 through direct comparison of their inactivation efficacies with systematically varied chemical properties, including sequence-specific binding affinity, nuclease resistance, and RNase H activation. As a result, we newly found the quantitative relationships; (1) sequence specific binding affinity of AMOs against miR-21 is the main determining factor for inactivation efficacy, (2) nuclease resistance of AMOs impacts their miR-21 inactivation efficacy acting cooperatively with the binding affinity, although nuclease resistance alone does not affect the miRNA inactivation efficacy, and (3) RNase H activation is unnecessary. This study also demonstrates the utility of the obtained relationship for the design of AMO-based drugs targeted to miR-21, through cell-based analyses. Thus, the obtained quantitative relationship would make it possible to predict the miR-21 inactivation efficacy of AMOs which are newly designed. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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Quantitative relationship between chemical properties and bioactivities of anti-microRNA oligonucleotides targeted to tumor-associated microRNA-21 査読あり
Koji Nagahama, Kenta Iseda, Daichi Kawano, Junji Kawakami
Biochimie 137 124 - 131 2017年6月
共著
担当区分：筆頭著者
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NF-kappaB prevents oncogenic Ras-induced b-actin cleavage in p53-deficient cells 査読あり
Wataru Sugimoto, Katsuhiko Itoh, Toshiya Kotari, Alvin K. Guo,Takahiro Ebata, Hiroaki Hirata, Keiko Kawauchi
International Journal of Cancer & Cellular Biology Research 2 ( 1 ) 15 - 18 2017年5月
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Highly Sensitive Telomerase Assay Insusceptible to Telomerase and Polymerase Chain Reaction Inhibitors for Cervical Cancer Screening Using Scraped Cells. 査読あり
Hidenobu Yaku , Yoshio Yoshida, Hidehiko Okazawa, Yasushi Kiyono, Yuko Fujita, Daisuke Miyoshi
Anal. Chem. 89 ( 13 ) 6948 - 6953 2017年5月
共著
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PEG-based nanocomposite hydrogel: Thermoresponsive sol-gel transition controlled by PLGA-PEG-PLGA molecular weight and solute concentration 査読あり
Makoto Miyazaki, Tomoki Maeda, Kenji Hirashima, Naruki Kurokawa, Koji Nagahama, Atsushi Hotta
Polymer 115 246 - 254 2017年4月
共著
担当区分：筆頭著者
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Quantitative relationship between chemical properties and bioactivities of anti-microRNA oligonucleotides targeted to tumor-associated microRNA-21 査読あり
Koji Nagahama, Kenta Iseda, Daichi Kawano, Junji Kawakami
Biochimie 137 124 - 131 2017年3月
共著
担当区分：筆頭著者
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Atsushi Ikeda, Tatsuya Iizuka, Naotake Maekubo, Kazuyuki Nobuswa, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Motofusa Akiyama
Chemistry an Asian Journal 12 ( 10 ) 1069 - 1074 2017年3月
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Development of Peptide Microarray to Detect the Protein in Saliva for Periodontal Disease Test 査読あり
Yuki Tominaga, Kenji Usui, Akiyoshi Hirata, Atsushi Kitagawa, Hiro-O Ito and Kiyoshi Nokihara
Peptide Science 2016 131 - 132 2017年3月
共著
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Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yua Kashijima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
Organic & Biomolecular Chemistry 15 ( 9 ) 1990 - 1997 2017年2月
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Cell and Molecular Mechanics in Health and Disease 招待あり 査読あり
Keiko Kawauchi, Hideaki Fujita, Daisuke Miyoshi, Evelyn K. F. Yim, and Hiroaki Hirata
BioMed Research International Article ID 2860241 2017年2月
共著
DOI： 10.1155/2017/2860241
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Nicotine-Selective Polymeric Adsorbent Obtained by Molecular Imprinting with Excess Use of Itaconic Acid 査読あり
Haruka Nogami, Yuma Nakahori, Takashi Murashima, Jun Matsui
Chromatography 38 15 - 21 2017年1月
共著
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Substrate stiffness influences doxorubicin- induced p53 activation via ROCK2 expression 査読あり
Ebata T, Mitsui Y, Sugimoto W, Maeda M, Araki K, Machiyama H, Harada I, Sawada Y, Fujita H, Hirata H, Kawauchi K
BioMed Research International 2017年1月
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Unexpected Position-Dependent Effects of Ribose G‑Quartets in G‑Quadruplexes 査読あり
J. Zhou, S. Amrane, F. Rosu, G.F. Salgado, Y. Bian, H. Tateishi-Karimata, E. Largy, D. N. Korkut, A. Bourdoncle, D. Miyoshi, J. Zhang, H. Ju, W. Wang, N. Sugimoto, V. Gabelica, and J. Mergny
J. Am. Chem. Soc. 139 7768 - 7779 2017年
共著
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Selective and Robust Stabilization of Triplex DNA Structures Using Cationic Comb-type Copolymers. 査読あり
Yamayoshi A, Miyoshi D, Zouzumi YK, Matsuyama Y, Ariyoshi J, Shimada N, Murakami A, Wada T, Maruyama A
J Phys Chem B 121 ( 16 ) 4015 - 4022 2017年
共著
担当区分：筆頭著者
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Nicotine-selective Polymeric Adsorbent Obtained by Molecular Imprinting with Excess Use of Itaconic Acid 査読あり
Haruka Nogami, Yuma Nakahori, Takashi Murashima, Jun Matsui
Chromatography 38 ( 1 ) 15 - 21 2017年
担当区分：責任著者
Currently, nicotine is mostly analyzed by chromatography with pretreatment such as solid phase extraction (SPE). One of effective pretreatment techniques would be affinity extraction; however, there is no practical biomolecular affinity media available for SPE of nicotine. Molecular imprinting has been studied as a methodology for producing nicotine-selective synthetic affinity media, which relies on the formation of complex species between a target molecule (as template) and functional monomer; therefore, the selection of functional monomer is greatly important for obtaining molecularly imprinted polymers (MIPs) with high affinity and selectivity. In this study, itaconic acid (IA), which bears two carboxyl groups, was used as functional monomer in the synthesis of nicotine selective-MIPs. Other acidic monomers, such as methacrylic acid (MA), 2-(trifluoromethyl)acrylic acid (FM) and methyl itaconate (MI) were compared with IA to evaluate their usefulness as functional monomer. In chromatographic tests, the retention factor for nicotine on a MIP synthesized with itaconic acid (IP-IA16) was 40.4, which was 3.1 times that on a non-imprinted polymer (BP-IA16), while the retention factor on MIPs with the other monomers was 21.6 or less and was 1.1 times that on corresponding non-imprint blank polymers (BPs). In the selectivity test using cotinine, 3-methylpyridine and N-methylpyrrolidine as reference compounds, IP-IA16 showed the largest retention factor for nicotine, which was more than 4.4 times that of the other compounds, suggesting that nicotine-recognition sites were formed in MIPs by the molecular imprinting using IA as functional monomer.
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Microtubule array observed in the posterior-vegetal cortex during cytoplasmic and cortical reorganization of the ascidian egg. 査読あり
Hirokazu Ishii, Toshiyuki Goto and Takahito Nishikata
Growth and Differentiation 59 648 - 656 2017年
共著
DOI： 10.1111/dgd.12405
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An integrated function system using metal nanoparticle@mesoporous silica@metal-organic framework hybrids 査読あり
T. Ohhashi, T. Tsuruoka*, K. Inoue, Y. Takashima, S. Horike, K. Akamatsu
Micropor. Mesopor. Mater 245 104 - 108 2017年
共著
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Rational composition control of mixed-lanthanide metal-organic frameworks by an interfacial reaction with metal ion-doped polymer substrates 査読あり
T. Tsuruoka*, A. Miyanaga, T. Ohhashi, M. Hata, Y. Takashima, K. Akamatsu
J. Solid State Chem 253 43 - 46 2017年
共著
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An Integrated Function System Using Metal Nanoparticle@Mesoporous Silica@Metal-Organic Framework Hybrids
T. Ohhashi, T. Tsuruoka, K. Inoue, Y. Takashima, S. Horike, K. Akamatsu
Micropor. Mesopor. Mater 245 104 - 108 2017年
共著
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Rational composition control of mixed-lanthanide metal-organic frameworks by an interfacial reaction with metal ion-doped polymer substrates
T. Tsuruoka, A. Miyanaga, T. Ohhashi, M. Hata, Y. Takashima, K. Akamatsu
J. Solid State Chem 253 43 - 46 2017年
共著
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Ionic liquid/metal-organic framework hybrid generated by ion-exchange reaction: Synthesis and unique catalytic activity
Y. Takashima, M. Yokoyama, A. Horikoshi, Y. Sato, T. Tsuruoka, K. Akamatsu
New J. Chem 41 14409 - 14413 2017年
共著
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In situ generation and immobilization of an activated Rh complex catalyst in a metal-organic framework for hydrogenation under low H2 pressure
Y. Takashima, Y. Fukuhara, Y. Sato, T. Tsuruoka, K. Akamatsu
Eur. J. Inorg. Chem 45 5344 - 5349 2017年
共著
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Influence of intracellular environment on allosteric ribozyme activity
M. Kameno, M. Sawada, N. Sakimoto, J. Kawakami
Proc. 44th Intl. Symp. Nucleic Acid Chemistry 178 - 179 2017年
共著
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Quantification of stabilization effect of co-solutes on RNA tertiary interaction
N. Sasaki, D. Miyoshi, J. Kawakami
Proc. 44th Intl. Symp. Nucleic Acid Chemistry 174 - 175 2017年
共著
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An integrated function system using metal nanoparticle@mesoporous silica@metal-organic framework hybrids 査読あり
T. Ohhashi, T. Tsuruoka*, K. Inoue, Y. Takashima, S. Horike, K. Akamatsu
Micropor. Mesopor. Mater 245 104 - 108 2017年
共著
-
Rational composition control of mixed-lanthanide metal-organic frameworks by an interfacial reaction with metal ion-doped polymer substrates 査読あり
T. Tsuruoka*, A. Miyanaga, T. Ohhashi, M. Hata, Y. Takashima, K. Akamatsu
J. Solid State Chem 253 43 - 46 2017年
共著
担当区分：筆頭著者
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An integrated function system using metal nanoparticle@mesoporous silica@metal-organic framework hybrids 査読あり
T. Ohhashi, T. Tsuruoka*, K. Inoue, Y. Takashima, S. Horike, K. Akamatsu
Micropor. Mesopor. Mater 245 104 - 108 2017年
共著
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Ionic Liquid/Metal-Organic Framework Hybrid Generated by Ion-Exchange Reaction: Synthesis and Unique Catalytic Activity 査読あり
Yohei Takashima*, Mai Yokoyama, Atsuto Horikoshi, Yasushi Sato, Takaaki Tsuruoka, Kensuke Akamatsu
New J. Chem. 41 14409 - 14413 2017年
共著
担当区分：筆頭著者
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In Situ Generation and Immobilization of an Activated Rh Complex Catalyst in a Metal-Organic Framework for Hydrogenation at Low H2 Pressure 査読あり
Yohei Takashima*, Yoshimasa Fukuhara, Yasushi Sato, Takaaki Tsuruoka, Kensuke Akamatsu
Eur. J. Inorg. Chem 45 5344 - 5349 2017年
共著
担当区分：筆頭著者
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Rational composition control of mixed-lanthanide metal-organic frameworks by an interfacial reaction with metal ion-doped polymer substrates 査読あり
T. Tsuruoka*, A. Miyanaga, T. Ohhashi, M. Hata, Y. Takashima, K. Akamatsu
J. Solid State Chem 253 43 - 46 2017年
共著
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Model studies of the effects of intracellular crowding on nucleic acid interactions 招待あり 査読あり
S. Nakano and N. Sugimoto
Mol. BioSyst. 13 32 - 41 2016年12月
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Elucidation of a “Signal-ON” Mechanism of Aggregation-Induced Emission Dye-Labelled DNA/DNA Duplexes and Application of a Repeat DNA Detection Method 査読あり
Takashi Murashima, Koji Kawamura, Ai Matsumoto
Medicinal Chemistry 6 704 - 709 2016年12月
共著
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Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase 査読あり
Seiya Watanabe, Kunihiko Tajima, Satoshi Fujii, Fumiyasu Fukumori, Ryotaro Hara, Rio Fukuda, Mao Miyazaki, Kuniki Kino, Yasuo Watanabe
Scientific Reports 6 1 - 12 2016年12月
共著
DOI： 10.1038/srep38720
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Unusual Colorimetric Change for Alkane Solvents with a Porous Coordination Framework
Takashima Yohei, Sato Yasushi, Tsuruoka Takaaki, Akamatsu Kensuke
INORGANIC CHEMISTRY 55 ( 22 ) 11617 - 11620 2016年11月
共著
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Effects of trimethylamine N-oxide and urea on DNA duplex and G-quadruplex 査読あり
Y. Ueda, Y. Zouzumi, A. Maruyama, S. Nakano, N. Sugimoto, and D. Miyoshi
Sci. Tech. Adv. Mat. 17 753 - 759 2016年11月
共著
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細胞核DDSのためのナノトランスポーターの設計 招待あり 査読あり
長濱宏治
Drug Delivery System 31 482 - 483 2016年11月
単著
担当区分：筆頭著者
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Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy 査読あり 国際誌
Masafumi Ueda, Kengo Ashizawa, Kouta Sugikawa, Kazuya Koumoto, Takeshi Nagasaki, Atsushi Ikeda
Organic & Biomolecular Chemistry 15 ( 7 ) 1565 - 1569 2016年10月
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Thermal stability of RNA structures with bulky cations in mixed aqueous solutions 査読あり
S. Nakano, Y. Tanino, H. Hirayama, and N. Sugimoto
Biophys. J. 111 1350 - 1360 2016年10月
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MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility. 査読あり
Hirata H, Ku WC, Yip AK, Ursekar CP, Kawauchi K, Roy A, Guo AK, Vedula SR, Harada I, Chiam KH, Ishihama Y, Lim CT, Sawada Y, Sokabe M
Journal of Cell Science 129 ( 19 ) 3574 - 3582 2016年10月
共著
DOI： 10.1242/jcs.189415
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A Systematic Study on Molecular Mechanism of Pore-Forming Peptides for Discovering Antimicrobial Medicine
Y. Sekiya, H. Watanabe, K. Usui, R. Kawano
Proceedings of MicroTAS 2016 595 - 596 2016年10月
共著
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Increased yield of β-glucosidase-catalyzed hydrolysis reactions in the presence of betaine-type metabolite analog 査読あり 国際誌
Shiro Sehata, Ryojun Suzuki, Kazuya Koumoto
Bioprocess Biosystem Engineering 40 ( 1 ) 153 - 159 2016年9月
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Local thermodynamics of the water molecules around single- and double-stranded DNA studied by grid inhomogeneous solvation theory 査読あり
M. Nakano, H. Tateishi-Karimata, S. Tanaka, F. Tamab, O. Miyashita, S. Nakano, and N. Sugimoto
Chem. Phys. Lett. 660 ( 1 ) 250 - 255 2016年9月
共著
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Characterization of functional RNA to perform self-cleavage reaction under low pH condition
N. Sakimoto, M. Kameno, N. Sasaki, J. Kawakami
Proc. 43rd Intl. Symp. Nucleic Acid Chemistry 284 - 285 2016年9月
共著
担当区分：筆頭著者
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Discovery of a new function of curcumin which enhances its anticancer therapeutic potency 査読あり
Koji Nagahama, Tomoya Utsumi, Takayuki Kumano, Saeko Maekawa, Naho Oyama, Junji Kawakami
Scientific Reports 6 30962 2016年8月
共著
DOI： 10.1038/srep30962
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Curcumisome nanovesicles generated by self-assembly of curcumin amphiphiles toward cancer theranostics 査読あり
K. Nagahama, T. Utsumi, T. Kumano, S. Maekawa, N. Oyama, J. Kawakami
Scientific Reports 6 30962 2016年8月
共著
担当区分：筆頭著者
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Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors. 査読あり
Sumiya Y.U., Inoue T., Ishikawa M., Inui T., Kuchiike D., Kubo K., Uto Y., Nishikata T.
Anticancer Res. 36 ( 7 ) 3619 - 3623 2016年7月
共著
担当区分：筆頭著者
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Case Report: GcMAF Treatment in a Patient with Multiple Sclerosis. 査読あり
Inui T., Katsuura G., Kubo K., Kuchiike D., Chenery L., Uto Y., Nishikata T., Mette M.
Anticancer Res. 36 ( 7 ) 3771 - 3774 2016年7月
共著
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Case Report: A Non-small Cell Lung Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Tumor Treating Fields. 査読あり
Inui T., Amitani H., Kubo K., Kuchiike D., Uto Y., Nishikata T., Mette M.
Anticancer Res. 36 ( 7 ) 3767 - 6770 2016年7月
共著
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Use of a ureido-substituted deoxycytidine module for DNA assemblies 招待あり 査読あり
S. Nakano, H. Oka, M. Fujii, and N. Sugimoto
Nucleosides, Nucleotides and Nucleic Acids 35 ( 7 ) 370 - 378 2016年5月
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A reversible B-A transition of DNA duplexes induced by synthetic cationic copolymers 招待あり 査読あり
M. Yamaguchi, Y. Zouzumi, N. Shimada, S. Nakano, N. Sugimoto, A. Maruyama, and D. Miyoshi
Chem. Commun. 52 7446 - 7449 2016年4月
共著
DOI： 10.1039/C6CC02237E
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Site-Specific Control of Silica Mineralization on DNA Using a Designed Peptide 査読あり
M. Ozaki, K. Nagai, H. Nishiyama, T. Tsuruoka, S. Fujii, T. Endoh, T. Imai, K.-y. Tomizaki, K. Usui
Chem. Commun. 52 4010 - 4013 2016年3月
共著
担当区分：筆頭著者
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Site-specific control of silica mineralization on DNA using a designed peptide 査読あり
Makoto Ozaki, Kazuma Nagai, Hiroto Nishiyama, Takaaki Tsuruoka, Satoshi Fujii, Tamaki Endoh, Takahito Imai, Kin-ya Tomizaki, Kenji Usui
Chemical Communications 52 ( 21 ) 4010 - 4013 2016年3月
共著
DOI： 10.1039/C5CC07870A
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Development of Designed Peptides with Secondary Structure for Use in Nanobiotechnology 招待あり 査読あり
K.Usui
Peptide Science 2015 5 - 8 2016年3月
単著
担当区分：筆頭著者
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The structural stability and catalytic activity of DNA and RNA oligonucleotides in the presence of organic solvents 招待あり 査読あり
S. Nakano and N. Sugimoto
Biophys. Rev. 8 ( 1 ) 11 - 23 2016年1月
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Reevaluation of the stability of G-quadruplex structures under crowding conditions 査読あり
Jun Zhou, Hisae Tateishi-Karimata, Jean-Louis Mergny, Mingpan Cheng, Zhaochi Feng, Daisuke Miyoshi, Naoki Sugimoto, Can Li
Biochimie 121 204 - 208 2016年
共著
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A reversible B-A transition of DNA duplexes induced by synthetic cationic copolymers 査読あり
Nonoka Yamaguchi, Yu-ki Zouzumi, Naohiko Shimada, Shuichi Nakano, Naoki Sugimoto, Atsushi Maruyama, Daisuke Miyoshi
Chem. Commun. 52 7446 - 7449 2016年
共著
担当区分：筆頭著者
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In situ synthesis of Cu/Ni alloy nanoparticles embedded in thin polymer layers 査読あり
R. Shimizu, T. Kawakami, Y. Takashima, T. Tsuruoka, K. Akamatsu
RSC Adv 6 18895 - 18898 2016年
共著
-
Morphology Control of Metal-Organic Frameworks Based on Paddle-Wheel Units on Ion-Doped Polymer Substrate Using An Interfacial Growth Approach 査読あり
T. Tsuruoka*, K. Mantani, A. Miyanaga, T. Matsuyama, T. Ohhashi, Y. Takashima, K. Akamatsu
Langmuir 32 6068 - 6073 2016年
共著
-
Interfacial Synthetic Approach for Constructing Metal-Organic Framework Crystals Using Metal Ion-Doped Polymer Substrate 査読あり
T. Tsuruoka*, M. Kumano, K. Mantani, T. Matsuyama, A. Miyanaga, T. Ohhashi, Y. Takashima, H. Minami, T. Suzuki, K. Imagawa, K. Akamatsu
Cryst. Growth Des 16 2472 - 2476 2016年
共著
-
Highly Sensitive Plasmonic Optical Sensors Based on Gold Core-Satellite Nanostructures Immobilized on Glass Substrates 査読あり
K. Ode, M. Honjo, Y. Takashima, T. Tsuruoka, K. Akamatsu
ACS Appl. Mater. Interfaces 8 20522 - 20526 2016年
共著
-
Unusual Colorimetric Change for Alkane Solvents with Porous Coordination Framework 査読あり
Y. Takashima, Y. Sato, T. Tsuruoka, K. Akamatsu
Inorg. Chem 55 11617 - 11620 2016年
共著
-
Site-selective growth of metal-organic frameworks using an interfacial growth approach combined with VUV photolithography 査読あり
T. Tsuruoka*, T. Matsuyama, A. Miyanga, T. Ohhashi, Y. Takashima, K. Akamatsu
RSC Adv 6 77297 - 77300 2016年
共著
-
Highly Sensitive Plasmonic Optical Sensors Based on Gold Core−Satellite Nanostructures Immobilized on Glass Substrates
K. Ode, M. Honjo, Y. Takashima, T. Tsuruoka, K. Akamatsu
ACS Appli. Mater. Interfaces 8 20522 - 20526 2016年
共著
-
Unusual Colorimetric Change for Alkane Solvents with a PorousCoordination Framework
Y. Takashima, Y. Sato, T. Tsuruoka, K. Akamatsu
Inorg. Chem 55 11617 - 11620 2016年
共著
-
Site-Selective Growth of Metal–Organic Frameworks Using An Interfacial Growth Approach Combined with VUV Photolithography
T. Tsuruoka, T. Matsuyama, A. Miyanaga, T. Ohhashi, Y. Takashima, K. Akamatsu
RSC Advances 6 77297 - 77300 2016年
共著
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Morphology Control of Metal-Organic Frameworks Based on Paddle-Wheel Units on Ion-Doped Polymer Substrate Using An Interfacial Growth Approach
T. Tsuruoka, K. Mantani, A. Miyanaga, T. Matsuyama, T. Ohhashi, Y. Takashima, K. Akamatsu
Langmuir 32 6068 - 6073 2016年
共著
-
Interfacial Synthetic Approach for Constructing Metal-Organic Framework Crystals Using Metal Ion-Doped Polymer Substrate
T. Tsuruoka, M. Kumano, K. Mantani, T. Matsuyama, A. Miyanaga, T. Ohhashi, Y. Takashima, H. Minami, T. Suzuki, K. Imagawa, K. Akamatsu
Cryst. Growth Des 16 2472 - 2476 2016年
共著
-
In Situ Synthesis of Cu/Ni Alloy Nanoparticles Embedded in Thin Polymer Layers
R. Shimizu, T. Kawakami, Y. Takashima, T. Tsuruoka, K. Akamatsu
RSC Advances 6 18895 - 18898 2016年
共著
-
Characterization of functional RNA to perform self-cleavage reaction under low pH condition
N. Sakimoto, M. Kameno, N. Sasaki, J. Kawakami
Proc. 43rd Intl. Symp. Nucleic Acid Chemistry 284 - 285 2016年
共著
-
Discovery of a new function of curcumin which enhances its anticancer therapeutic potency
K. Nagahama, T. Utsumi, T. Kumano, S. Maekawa, N. Oyama, J. Kawakami
Scientific Reports 6 30962 2016年
共著
-
A Cell Microarray Format: A Peptide Release System Using a Photo-Cleavable Linker for Cell Toxicity and Cell Uptake Analysis. 査読あり
Usui K, Tomizaki KY, Mihara H
Methods in molecular biology (Clifton, N.J.) 1352 199 - 210 2016年
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Site-specific control of silica mineralization on DNA using a designed peptide 査読あり
Makoto Ozaki, Kazuma Nagai, Hiroto Nishiyama, Takaaki Tsuruoka, Satoshi Fujii, Tamaki Endoh, Takahito Imai, Kin-ya Tomizaki, Kenji Usui
CHEMICAL COMMUNICATIONS 52 ( 21 ) 4010 - 4013 2016年
出版者・発行元：ROYAL SOC CHEMISTRY
We developed a site-specific method for precipitating inorganic compounds using organic compounds, DNA, and designed peptides with peptide nucleic acids (PNAs). Such a system for site-specific precipitation represents a powerful tool for use in nanobiochemistry and materials chemistry.
DOI： 10.1039/c5cc07870a
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Site-specific control of multiple mineralizations using a designed peptide and DNA 査読あり
Kenji Usui, Makoto Ozaki, Aoi Yamada, Yoshio Hamada, Takaaki Tsuruoka, Takahito Imai, Kin-ya Tomizaki
NANOSCALE 8 ( 39 ) 17081 - 17084 2016年
出版者・発行元：ROYAL SOC CHEMISTRY
We have developed a site-specific method for precipitating multiple inorganic compounds using target DNA and a designed peptide consisting of a peptide nucleic acid (PNA) sequence and an inorganic compound-precipitating sequence. This system for controlled site-specific precipitation represents a powerful tool for use in nanobiotechnology and materials science.
DOI： 10.1039/c6nr03468c
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Site-specific control of silica mineralization on DNA using a designed peptide 査読あり
M. Ozaki, K. Nagai, H. Nishiyama, T. Tsuruoka, S. Fujii, T. Endoh, T. Imai, K. Tomizaki, K. Usui
Chem. Commun 52 4010 - 4010 2016年
共著
-
Morphology Control of Metal-Organic Frameworks Based on Paddle-Wheel Units on Ion-Doped Polymer Substrate Using An Interfacial Growth Approach 査読あり
T. Tsuruoka*, K. Mantani, A. Miyanaga, T. Matsuyama, T. Ohhashi, Y. Takashima, K. Akamatsu
Langmuir 32 6068 - 6073 2016年
共著
担当区分：筆頭著者
-
Interfacial Synthetic Approach for Constructing Metal-Organic Framework Crystals Using Metal Ion-Doped Polymer Substrate 査読あり
T. Tsuruoka, M. Kumano, K. Mantani, T. Matsuyama, A. Miyanaga, T. Ohhashi, Y. Takashima, H. Minami, T. Suzuki, K. Imagawa, K. Akamatsu
Cryst. Growth Des 16 2472 - 2476 2016年
共著
担当区分：筆頭著者
-
In situ synthesis of Cu/Ni alloy nanoparticles embedded in thin polymer layers 査読あり
R. Shimizu, T. Kawakami, Y. Takashima, T. Tsuruoka, K. Akamatsu
RSC Adv 6 18895 - 18898 2016年
共著
-
Unusual Colorimetric Change for Alkane Solvents with Porous Coordination Framework 査読あり
Y.Takashima, Y.Sato,
Inorg.Chem 55 11617 - 11620 2016年
単著
-
Site-specific control of multiple mineralizations using a designed peptide and DNA 査読あり
K. Usui, M. Ozaki, A. Yamada, Y. Hamada, T. Tsuruoka, T. Imai, K. Tomizaki
Nanoscale 8 17081 - 17084 2016年
共著
-
Site-selective growth of metal-organic frameworks using an interfacial growth approach combined with VUV photolithography 査読あり
T. Tsuruoka*, T. Matsuyama, A. Miyanga, T. Ohhashi, Y. Takashima, K. Akamatsu
RSC Adv. 6 77297 - 77300 2016年
共著
担当区分：筆頭著者
-
Highly Sensitive Plasmonic Optical Sensors Based on Gold Core-Satellite Nanostructures Immobilized on Glass Substrates 査読あり
K. Ode, M. Honjo, Y. Takashima, T. Tsuruoka, K. Akamatsu
ACS Appl. Mater.Interfaces 8 20522 - 20526 2016年
共著
-
Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling.
Ebata T, Hirata H, Kawauchi K
BioMed research international 2016 9231057 2016年
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In situ synthesis of Cu/Ni alloy nanoparticles embedded in thin polymer layers 査読あり
R. Shimizu, T. Kawakami, Y. Takashima, T. Tsuruoka, K. Akamatsu
RSC Adv 6 18895 - 18898 2016年
共著
-
Shrink Wrapping Redox-Active Crystals of Polyoxometalate Open Frameworks with Organic Polymers via Crystal Induced Polymerisation 査読あり
Yohei Takashima, Haralampos N Miras, Stefan Glatzel, Leroy Cronin
Chem. Commun 52 7794 - 7797 2016年
共著
-
Interfacial Synthetic Approach for Constructing Metal-Organic Framework Crystals Using Metal Ion-Doped Polymer Substrate 査読あり
T. Tsuruoka*, M. Kumano, K. Mantani, T. Matsuyama, A. Miyanaga, T. Ohhashi, Y. Takashima, H. Minami, T. Suzuki, K. Imagawa, K. Akamatsu
Cryst. Growth Des 16 2472 - 2476 2016年
共著
-
Morphology Control of Metal-Organic Frameworks Based on Paddle-Wheel Units on Ion-Doped Polymer Substrate Using An Interfacial Growth Approach 査読あり
T. Tsuruoka*, K. Mantani, A. Miyanaga, T. Matsuyama, T. Ohhashi, Y. Takashima, K. Akamatsu
Langmuir 32 6068 - 6073 2016年
共著
-
Highly Sensitive Plasmonic Optical Sensors Based on Gold Core-Satellite Nanostructures Immobilized on Glass Substrates 査読あり
K. Ode, M. Honjo, Y. Takashima, T. Tsuruoka, K. Akamatsu
ACS Appl. Mater. Interfaces 8 20522 - 20526 2016年
共著
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Unusual Colorimetric Change for Alkane Solvents with Porous Coordination Framework 査読あり
Y. Takashima, Y. Sato, T. Tsuruoka, K. Akamatsu
Inorg. Chem 55 11617 - 11620 2016年
共著
担当区分：筆頭著者
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Site-selective growth of metal-organic frameworks using an interfacial growth approach combined with VUV photolithography 査読あり
T. Tsuruoka*, T. Matsuyama, A. Miyanga, T. Ohhashi, Y. Takashima, K. Akamatsu
RSC Adv 6 77297 - 77300 2016年
共著
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Electrochemical quantification of the Alzheimer's disease amyloid-β(1-40) using amyloid-β fibrillization promoting peptide 査読あり
Satoshi Fujii, Daiki Sono, Kaoru Matsubara, Hitoshi Abe
Sensing and Bio-Sensing Research 6 7 - 12 2015年12月
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Facile Quantification of Alzheimer's Disease Amyloid-β Based on Aggregation-Induced Emission 査読あり
Koji Kawamura, Runa Nakayama, Ai Matsumoto, Satoshi Fujii, Takashi Murashima
Journal of Pharmaceutical and Medicinal Research 1 ( 1 ) 27 - 30 2015年12月
共著
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ATP-Binding Peptide-Hydrogel Composite Synthesized by Molecular Imprinting on Beads 査読あり
Ayana Takata, Kenji Usui, Jun Matsui
Molecular Imprinting 3 65 - 70 2015年12月
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Facile Quantification of Alzheimer’s Disease Amyloid-β Based On Aggregation-Induced Emission
Koji Kawamura, Runa Nakayama, Ai Matsumoto, Satoshi Fujii, Takashi Murashima
Journal of Pharmaceutical and Medicinal Research 1 ( 1 ) 27 - 30 2015年11月
共著
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Thermodynamic properties of water molecules in the presence of cosolute depend on DNA structure: a study using grid inhomogeneous solvation theory 査読あり
M. Nakano, H. Tateishi-Karimata, S. Tanaka, F. Tama, O. Miyashita, S. Nakano, and N. Sugimoto
Nucleic Acids Res. 43 10114 - 10125 2015年11月
共著
DOI： 10.1093/nar/gkv1133
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A Cell Microarray Format: A Peptide Release System Using a Photo-Cleavable Linker for Cell Toxicity and Cell Uptake Analysis 査読あり
K. Usui, K.-y. Tomizaki, H. Mihara
Methods. Mol. Biol. 1352 199 - 210 2015年11月
共著
担当区分：筆頭著者
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p53 regulates cytoskeleton remodeling to suppress tumor progression.
Araki K, Ebata T, Guo AK, Tobiume K, Wolf SJ, Kawauchi K
Cellular and molecular life sciences : CMLS 72 ( 21 ) 4077 - 4094 2015年11月
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Facile DNA Detection Based on Fluorescence Switching of A Hydrophobic AIE Dye-Labeled Peptide Nucleic Acid Probe by Aggregation/Disaggregation 査読あり
K. Kawamura, A. Matsumoto, T. Murashima
International Journal of Medical Nano Research 2 ( 2 ) 2015年9月
共著
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Cryoprotective ability of betaine-type metabolite analogs during freezing denaturation of enzymes 国際誌
Yuichi Nakagawa, Masahiro Sota, Kazuya Koumoto
BIOTECHNOLOGY LETTERS 37 ( 8 ) 1607 - 1613 2015年8月
出版者・発行元：SPRINGER
To evaluate an analog library of betaine-type cellular metabolites, which are naturally found in polar fish for survival in subzero temperatures, for preventing denaturation of enzymes during freezing.Comparison of the cryoprotective ability of reported cryoprotectants, such as dimethylsulfoxide, glycerol, ectoine, hydroxyectoine, and trehalose, with betaine-type analogs using alpha-glucosidase revealed that analogs introducing C-3-C-6 alkyl chains into an ammonium cation retained 20 % higher activity than the control cryoprotectants at the same concentration. In particular, the analog possessing triplicate n-butyl chains showed a profound effect. It allowed retention of enzyme activity to 95 % even after 100 freeze-thaw cycles, while addition of the control cryoprotectants decreased the activity to 10-20 %. The cryoprotective ability of betaine-type analogs can be applied not only to alpha-glucosidase but also other enzymes such as beta-glucosidase, alkaline phosphatase, lactose dehydrogenase, sulfatase, and horseradish peroxidase.Synthetic betaine-type metabolite analogs possess practicable cryoprotective ability for various enzymes, and are considerably superior to previously reported cryoprotectants.
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Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size 査読あり 国際誌
Koji Nagahama, Takayuki Kumano, Yuichi Nakagawa, Naho Oyama, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, Jun Matsui
BIOCONJUGATE CHEMISTRY 26 ( 8 ) 1775 - 1781 2015年8月
出版者・発行元：AMER CHEMICAL SOC
The design and synthesis of materials capable of activating the immune system in a safe manner is of great interest in immunology and related fields. Lactobacilli activate the innate immune system of a host when acting as probiotics. Here, we constructed lactobacilli-mimicking materials in which polysaccharide peptidoglycan complexes (PS PGs) derived from lactobacilli were covalently conjugated to the surfaces of polymeric microparticles with a wide variety of sizes, ranging from 200 nm to 3 mu m. The artificial lactobacilli successfully stimulated macrophages without cytotoxicity. Importantly, we found that the size of artificial lactobacilli strongly influenced their immunostimulating activities, and that artificial lactobacilli of 1 mu m exhibited 10-fold higher activity than natural lactobacilli. One major advantage of the artificial lactobacilli is facile control of size, which cannot be changed in natural lactobacilli. These findings provide new insights into the design of materials for immunology as well as the molecular biology of lactobacillus.
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Establishment of a macrophage-activating factor (MAF) assay system using human-monocytic cell line, THP-1. 査読あり
Inoue T., Ishikawa M., Sumiya Y., Kohda H, Inui T., Kuchiike D., Kubo K., Uto Y and Nishikata T.
Anticancer Research 35 4441 - 4445 2015年8月
共著
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Oral Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue Syndrome: Three Case Reports. 査読あり
Inui T., Kubo K., Kuchiike D., Uto Y., Nishikata T., Sakamoto N., Mette M.
Anticancer Research 35 ( 8 ) 4545 - 4549 2015年8月
共著
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Macrophage Activation Mechanisms in Human Monocytic Cell Line-derived Macrophages. 査読あり
Sumiya Y, Ishikawa M, Inoue T, Inui T, Kuchiike D, Kubo K, Uto Y, Nishikata T
Anticancer research 35 ( 8 ) 4447 - 4451 2015年8月
共著
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Establishment of a Macrophage-activating Factor Assay System Using the Human Monocytic Cell Line THP-1 査読あり
Takahiro Inoue, Mami Ishikawa, Yu Sumiya, Haruka Kohda, Toshio Inui, Daisuke Kuchiike, Kentaro Kubo, Yoshihiro Uto, Takahito Nishikata
ANTICANCER RESEARCH 35 ( 8 ) 4441 - 4445 2015年8月
共著
出版者・発行元：INT INST ANTICANCER RESEARCH
Background: As the mechanism of macrophage activation is not well-understood, standardization of an assay system for measuring phagocytic activities of macrophages will be useful for research on macrophages. Previously, we established a novel standardized macrophage-activating factor (MAF) assay system using U937. Materials and Methods: Using the human monocytic cell line THP-1, another standardized MAF assay system was established. Characteristic gene expression of U937- and THP-1-derived macrophages was compared by gene expression microarray analysis. Results: Both U937- and THP-1-derived macrophages showed obvious phagocytic activities with unique characteristics and, therefore, could not be assigned to a single sub-type. Conclusion: Activation of macrophages is an intricate cellular process. Comparison of our two novel assay systems provides new insights into macrophage activation mechanisms.
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Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size 査読あり
Koji Nagahama, Takayuki Kumano, Yuichi Nakagawa, Naho Oyama, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, and Jun Matsui
Bioconjugate Chemistry 26 1775 - 1781 2015年8月
共著
担当区分：筆頭著者
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Effects of background anionic compounds on the activity of the hammerhead ribozyme in Mg2+-unsaturated solutions 査読あり
S. Nakano, Y. Kitagawa, D. Miyoshi, and N. Sugimoto
J. Biol. Inorg. Chem 20 ( 6 ) 1049 - 1058 2015年7月
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Effects of cosolvents on the folding and catalytic activities of the hammerhead ribozyme 査読あり
S. Nakano, Y. Kitagawa, H. Yamashita, D. Miyoshi, and N. Sugimoto
ChemBioChem 16 ( 12 ) 1803 - 1810 2015年7月
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生命分子－合成高分子ハイブリッドの開発とナノバイオマテリアル，その可能性 招待あり
長濱宏治
Materials Stage 7 18 - 21 2015年7月
単著
担当区分：筆頭著者
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Anticancer drug-based multifunctional nanogels through self-assembly of dextran-curcumin conjugates toward cancer theranostics 査読あり
Koji Nagahama, Yoshinori Sano, Takayuki Kumano
Bioorganic & Medical Chemistry Letters 25 2519 - 2522 2015年6月
共著
担当区分：筆頭著者
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Effects of four-week feed restriction on toxicological parameters in beagle dogs. 査読あり
Takamatsu K., Yamashita H., Satake S., Kazusa K., Tabata H., and Nishikata T.
Experimental Animals 64 269 - 280 2015年5月
共著
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A mRNA-responsive G-quadruplex-based drug release system 査読あり
H. Yaku, T. Murashima, D. Miyoshi, N. Sugimoto
Sensors 15 ( 4 ) 9388 - 9403 2015年4月
共著
DOI： 10.3390/s150409388
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Label and Label-Free Detection Techniques for Protein Microarrays 査読あり 国際共著
Amir Syahir, Kenji Usui, Kin-ya Tomizaki, Kotaro Kajikawa, Hisakazu Mihara
Microarrays 4 ( 4 ) 228 - 244 2015年4月
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DNA G-quadruplex detection system employing a protein fibril ligand 査読あり
R. Maeda, H. Yaku, T. Nakabayashi, T. Murashima, N. Sugimoto, D. Miyoshi
Telomere and Telomerase 2 2015年3月
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Mechanistic study of unusual enzyme activation caused by addition of inert betaine-type metabolite and the analogs
Yuichi Nakagawa, Kazuya Koumoto
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 249 2015年3月
出版者・発行元：AMER CHEMICAL SOC
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Self-Assembling Polymer Micelle/Clay Nanodisk/Doxorubicin Hybrid Injectable Gels for Safe and Efficient Focal Treatment of Cancer 査読あり
Koji Nagahama, Daichi Kawano, Naho Oyama, Ayaka Takemoto, Takayuki Kumano, Junji Kawakami
BIOMACROMOLECULES 16 ( 3 ) 880 - 889 2015年3月
共著
出版者・発行元：AMER CHEMICAL SOC
The purpose of this study was to fabricate a safe and effective doxorubicin (DOX)-delivery system for focal cancer chemotherapy. A novel biodegradable injectable gel was developed through self-assembly of poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer micelles, clay nanodisks (CNDs), and DOX. We discovered that DOX loaded in the hybrid gels acts as an anticancer drug and as a building block to organize new gel networks. Accordingly, long-term sustained release of DOX from hybrid injectable gels without initial burst release was achieved. Moreover, it was revealed that the DOX incorporated into gel networks controls its own release profile. This hybrid injectable gel is a self-controlled drug release system, which is a novel concept in controlled drug release. Importantly, a single injection of PLGA-PEG-PLGA/CND/DOX hybrid gel provides long-term sustained antitumor activity in vivo against human xenograft tumors in mice, suggesting the potential of hybrid gels as a valuable local DOX-delivery platform for cancer focal therapy.
DOI： 10.1021/bm5017805
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Site-Specific Mineralization of Silica and Calcium on DNAs Using a Designed Peptide 査読あり
K. Usui, H. Nishiyama, A. Yamada, M. Ozaki, T. Tsuruoka, K.-y. Tomizaki
Peptide science 2014 325 - 326 2015年3月
共著
担当区分：筆頭著者
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Self-Assembling Polymer Micelle/Clay Nanodisk/Doxorubicin Hybrid Injectable Gels for Safe and Efficient Focal Treatment of Cancer 査読あり
Koji Nagahama, Daichi Kawano, Naho Oyama, Ayaka Takemoto, Takayuki Kumano, Junji Kawakami
Biomacromolecules 16 880 - 889 2015年3月
共著
担当区分：筆頭著者
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Synthesis and lmmunestimulating Activity of Lactobacilli-Originated Polysaccharide-Polymeric Microparticle Conjugates 査読あり 国際誌
Koji Nagahama, Takayuki Kumano, Tsubasa Nakata, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, Jun Matsui
LANGMUIR 31 ( 4 ) 1489 - 1495 2015年2月
出版者・発行元：AMER CHEMICAL SOC
The design and synthesis of biomaterials capable of activating the immune system are of interest in immunology-related fields because of their ability to tune up the immune defenses of the host. Lactobacilli are a major constituent of normal human indigenous flora, and some specific strains are known to activate the immune system of the host as probiotics. In this study, we first fabricated novel biohybrid materials in which lactobacilli (L. casei strain Shirota, LcS)-originated polysaccharide-peptidoglycan complexes (PS-PGs) are conjugated with polymeric microparticles (MPs). PS-PGs conjugated onto polymeric MPs surfaces bound its specific antibody, suggesting that PS-PGs kept their original molecular recognition ability. The PS-PGs-based hybrid MPs with an appropriate density of conjugated PS-PGs effectively induced high levels of IL-12 production from macrophages without cytotoxicity. These results suggest that LcS-originated PS-PGs could be available bio-originated materials for developing novel biomaterials capable of activating the immune system in a safe manner.
DOI： 10.1021/la5041757
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Synthesis and Immunestimulating Activity of Lactobacilli-Originated Polysaccharide-Polymeric Microparticle Conjugates 査読あり
Koji Nagahama, Takayuki Kumano, Tsubasa Nakata, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, and Jun Matsui
Langmuir 31 1489 - 1495 2015年1月
共著
担当区分：筆頭著者
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Synthesis and Immunestimulating Activity of Lactobacilli-Originated Polysaccharide-Polymeric Microparticle Conjugates 査読あり
Koji Nagahama, Takayuki Kumano, Tsubasa Nakata, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, Jun Matsui
Langmuir 31 1489 - 1495 2015年
共著
担当区分：筆頭著者
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Cryoprotective ability of betaine-type metabolite analogs during freezing denaturation of enzymes 査読あり
Yuichi Nakagawa, Masahiro Sota, Kazuya Koumoto
Biotechnology Letters 37 1607 - 1613 2015年
共著
担当区分：筆頭著者
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化学修飾技術を利用した乳酸菌模倣粒子による免疫賦活 招待あり
甲元一也、長濱宏治、松井淳
バイオインダストリー 32 ( 9 ) 42 - 47 2015年
共著
担当区分：筆頭著者
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Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size 査読あり
Koji Nagahama, Takayuki Kumano, Yuichi Nakagawa, Naho Oyama, Hirokazu Tsuji, Kaoru moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, Jun Matsui
Bioconjugate Chemistry 26 ( 8 ) 1775 - 1781 2015年
共著
担当区分：筆頭著者
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Significance of anionic functional group in betaine-type metabolite analogs on the facilitation of enzyme reactions 国際誌
Yuichi Nakagawa, Kotomi Takagi, Ryutaro Genjima, Kazuya Koumoto
Bioprocess and Biosystems Engineering 38 ( 9 ) 1811 - 1817 2015年
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Enhanced Chromogenic Sensitivity of Horseradish Peroxidase-catalyzed Oxidative Reactions in the Presence of Betaine-type Metabolite Analogs 査読あり
Kotomi Takagi, Yasuhiro Kashima, Satoshi Fujii, Kazuya Koumoto
Bulletin of the Chemical Society of Japan 88 ( 8 ) 1074 - 1082 2015年
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DNA structures under molecular crowding conditions with a phosphorylcholine derivative (MPC) 査読あり
Yu-mi Ueda, Tomohiro Konno, Kazuhiko Ishihara, Naoki Sugimoto, Daisuke Miyoshi
Transact. Mat. Res. Soc. Japan 40 99 - 102 2015年
共著
担当区分：筆頭著者
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Effects of background anionic compounds on the activity of the hammerhead ribozyme in Mg2+-unsaturated solutions 査読あり
Shu-ichi Nakano, Yuichi Kitagawa, Daisuke Miyoshi, Naoki Sugimoto
J. Biol. Inorg. Chem. 20 1049 - 1058 2015年
共著
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Stabilization of DNA Structures With Poly(ethylene sodium phosphate) 査読あり
R. Moriyama, Y. Iwasaki, D. Miyoshi
J. Phys. Chem. B 119 11969 - 11977 2015年
共著
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Effects of cosolvents on the folding and catalytic activities of the hammerhead ribozyme 査読あり
S. Nakano, Y. Kitagawa, H. Yamashita, D. Miyoshi, N. Sugimoto
ChemBioChem 16 1803 - 1810 2015年
共著
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A mRNA-responsive G-quadruplex-based drug release system 招待あり 査読あり
Hidenobu Yaku, Takashi Murashima, Daisuke Miyoshi, and Naoki Sugimoto
Sensors 15 ( 4 ) 9388 - 9403 2015年
共著
担当区分：筆頭著者
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DNA G-quadruplex detection system employing a protein fibril ligand 招待あり 査読あり
Ryuichi Maeda, Hidenobu Yaku, Takakazu Nakabayashi, Takashi Murashima, Naoki Sugimoto, Daisuke Miyoshi
Telomere and Telomerase 2 e691 2015年
共著
担当区分：筆頭著者
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DNA structures under molecular crowding conditions with a phosphorylcholine derivative (MPC)
Yu-mi Ueda, Tomohiro Konno, Kazuhiko Ishihara, Naoki Sugimoto, Daisuke Miyoshi
Transact. Mat. Res. Soc. Japan 40 99 - 102 2015年
共著
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Stabilization of DNA Structures With Poly(ethylene sodium phosphate)
R. Moriyama, Y. Iwasaki, D. Miyoshi
J. Phys. Chem. B 119 11969 - 11977 2015年
共著
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Metal nanocrystal/metal-organic framework core/shell nanostructure from selective self-assembly induced by localization of metal ion precursors on nanocrystal surface 査読あり
T. Ohhashi, T. Tsuruoka*, T. Matsuyama, Y. Takashima, H. Nawafune, H. Minami, K. Akamatsu
J. Colloid Interface Sci 451 212 - 215 2015年
共著
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Metal nanocrystal/metal-organic framework core/shell nanostructure from selective self-assembly induced by localization of metal ion precursors on nanocrystal surface 査読あり
T. Ohhashi, T. Tsuruoka*, T. Matsuyama, Y. Takashima, H. Nawafune, H. Minami, K. Akamatsu
J. Colloid Interface Sci 451 212 - 215 2015年
共著
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Metal Nanocrystal/Metal Organic Framework Core/Shgell Nanostructure From Selective Self-Assembly Induced By Localization of Metal Ion Precursors on Nanocrystal Surface
T. Ohhashi, T. Tsuruoka, T. Matsuyama, Y. Takashima, H. Nawafune, H. Minami, K. Akamatsu
J. Colloid Interface Sci 451 212 - 215 2015年
共著
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Comparison of Kinetic and Thermodynamic Analyses for Duplex Formation
E. Tomita, M. Sumimoto, S. Itoh, M. Takashima, and J. Kawakami
Proc. 42nd Intl. Symp. Nucleic Acid Chemistry 142 - 143 2015年
共著
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Curcumisome nanovesicles generated by self-assembly of curcumin amphiphiles toward cancer theranostics
Koji Nagahama, Takayuki Kumano, Naho Oyama, Junji Kawakami
BIOMATERIALS SCIENCE 3 ( 12 ) 1566 - 1578 2015年
共著
出版者・発行元：ROYAL SOC CHEMISTRY
Curcumin (CCM) is an important molecule for achieving cancer theranostics because CCM is a naturally-occurring biocompatible material that exhibits both anticancer activity and strong fluorescence property that can be used for bio-imaging. However, CCM has never been utilized in clinical trials due to its extremely low water solubility, its rapid hydrolysis in aqueous conditions at neutral pH, and its low cellular uptake into cancer cells. Taking advantage of the strong hydrophobicity, p-conjugated frameworks, and ketone and enol groups that generate hydrogen bonds in CCM, we herein fabricated novel CCM-based biodegradable nanovesicles, which we termed as "curcumisome", through the self-assembly of amphiphilic CCM-poly(ethylene glycol) conjugates in aqueous media to develop multifunctional nanobiomaterials for use in cancer theranostics. A high CCM loading content in the curcumisomes was achieved, and the curcumisomes showed high water dispersibility with improved hydrolysis resistance. Importantly, the curcumisomes were effectively internalized into cancer cells and exhibited strong fluorescence for a long period, which is favorable for cancer cell imaging, although only a small amount of the curcumisomes penetrated into normal cells and showed very weak fluorescence. Moreover, curcumisomes effectively induced apoptosis of cancer cells. Thus, curcumisomes may act as multifunctional nanobiomaterials for the development of CCM-based cancer theranostics.
DOI： 10.1039/c5bm00212e
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Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide 査読あり
Kenji Usui, Arisa Okada, Keita Kobayashi, Naoki Sugimoto
ORGANIC & BIOMOLECULAR CHEMISTRY 13 ( 7 ) 2022 - 2025 2015年
出版者・発行元：ROYAL SOC CHEMISTRY
We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadruplex-related important biological events.
DOI： 10.1039/c4ob02535k
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Metal nanocrystal/metal-organic framework core/shell nanostructure from selective self-assembly induced by localization of metal ion precursors on nanocrystal surface 査読あり
T. Ohhashi, T. Tsuruoka*, T. Matsuyama, Y. Takashima, H. Nawafune, H. Minami, K. Akamatsu
J. Colloid Interface Sci. 451 212 - 215 2015年
共著
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Site-Specific Mineralization of Silica and Calcium on DNAs Using a Designed Peptide 査読あり
K. Usui, H. Nishiyama, A. Yamada, M. Ozaki, T. Tsuruoka, K.-y. Tomizaki
Peptide Science 325 - 326 2015年
共著
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Metal nanocrystal/metal-organic framework core/shell nanostructure from selective self-assembly induced by localization of metal ion precursors on nanocrystal surface 査読あり
T. Ohhashi, T. Tsuruoka*, T. Matsuyama, Y. Takashima, H. Nawafune, H. Minami, K. Akamatsu
J. Colloid Interface Sci 451 212 - 215 2015年
共著
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Direct Fabrication of Metal Patterns on Resin Substrate by Combining Imprint and Electrochemical Lithography 査読あり
Yusuke Kimura, Ryosuke Fujiwara, Takaaki Tsuruoka, Yohei Takashima, Hidemi Nawafune, Hiroshi Yanagimoto, Kensuke Akamatsu
J. Surf. Finish. Soc. Jpn 66 18 - 19 2015年
共著
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Dependence of Crystal Size on the Catalytic Performance of a Porous Coordination Polymer 査読あり
Tomokazu Kiyonaga, Masakazu Higuchi, Takashi Kajiwara, Yohei Takashima, Jingui Duan, Kazuro Nagashima, Susumu Kitagawa
Chem. Commun 51 2728 - 2730 2015年
共著
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Preparation of hydrogels for the study of the effects of spatial confinement on DNA 査読あり
S. Nakano, M. Yoshida, D. Yamaguchi, and N. Sugimoto
Trans. Mat. Res. Soc. Jpn. 39 435 - 438 2014年12月
共著
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A novel ribozyme core to perform self-cleavage reaction
S. Tanaka, N. Sakimoto, M. Kameno, N. Sasaki, and J. Kawakami
Proc. 41st Intl. Symp. Nucleic Acid Chemistry 340 - 341 2014年11月
共著
担当区分：筆頭著者
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Thermodynamic Features Provided by an ENA Introduction to Nucleic Acid Drugs
E. Tomita, M. Sumimoto, and J. Kawakami
Proc. 41st Intl. Symp. Nucleic Acid Chemistry 188 - 189 2014年11月
共著
担当区分：筆頭著者
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Effects of oligonucleotide length and locked nucleic acid content on splice-switching oligonucleotide activity
T. Shimo, K. Tachibana, K. Saito, T. Yoshida, E. Tomita, R. Waki, T. Yamamoto, T. Doi, T. Inoue, J. Kawakami, and S. Obika
Proc. 41st Intl. Symp. Nucleic Acid Chemistry 332 - 333 2014年11月
共著
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Understanding p53: new insights into tumor suppression.
Kawauchi K, Wolf SJ
Expert review of anticancer therapy 14 ( 10 ) 1101 - 1103 2014年10月
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Mechanistic study on the facilitation of enzymatic hydrolysis by alpha-glucosidase in the presence of betaine-type metabolite analogs 査読あり
Yuichi Nakagawa, Shiro Sehata, Satoshi Fujii, Hiroaki Yamamoto, Akihiko Tsuda, Kazuya Koumoto
TETRAHEDRON 70 ( 35 ) 5895 - 5903 2014年9月
出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD
Recently we reported that betaine-type metabolite analogs structure-dependently facilitate enzymatic hydrolysis reaction for alpha-glucosidases, beta-glucosidases, and alkaliphosphatases. To understand the facilitation mechanism for enzymes, in this study we expanded the analog library and measured the properties of analog solutions. The structural investigation on alpha-glucosidase-mediated hydrolysis reaction indicated that suitable structures to facilitate the enzyme reaction efficiently should have the ammonium cation in the betaine structure possess triplicate aliphatic chains from Cl to C7 without any polar functional groups. Analyses of the solution properties revealed that such analogs possess a large hydration layer with low water density. Such a specific hydration environment is generated by the characteristic structure of the betaine-type metabolite analogs. The characteristic hydration indirectly regulates enzyme activity and stability. These findings not only increase our understanding enzyme activation by betaine-type metabolite analogs, but also will contribute to the molecular design of enzyme regulators. (C) 2014 Elsevier Ltd. All rights reserved.
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Refinement and verification of test conditions for colony-forming unit assay in dog bone marrow cells with preservable colony specimens. 査読あり
Takamatsu K., Wakata A., Hirota R., Tabata H., and Nishikata T.
Comparative Clinical Pathology 23 ( 5 ) 1133 - 1139 2014年9月
共著
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Cellular differentiation assessments by measuring the degree of cellular internalization and membrane adsorption using designed peptides 査読あり
Kenji Usui, Takuya Kikuchi, Kunio Kikuchi, Masayasu Mie, Eiry Kobatake, Hisakazu Mihara
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24 ( 17 ) 4129 - 4131 2014年9月
出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD
We demonstrate examples of cellular differentiation assessments, including cellular neurite outgrowth and fat cell maturation, by measuring the degree of membrane adsorption or cellular internalization using designed peptides. Because changes in the cellular membrane and cytosol during differentiation were shown to influence membrane adsorption and cellular internalization, we could successfully evaluate the extent of differentiation simply like stain indicators. (C) 2014 Elsevier Ltd. All rights reserved.
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Roles of the amino group of purine bases in the thermodynamic stability of DNA base pairing 査読あり
S. Nakano and N. Sugimoto
Molecules 19 ( 8 ) 11613 - 11627 2014年8月
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Case Report: A Breast Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Hormone Therapy. 査読あり
Inui T, Makita K, Miura H, Matsuda A. Kuchiike D, Kubo K, Mette M, Uto Y, Nishikata T, Hori H, and Sakamoto N.
Anticancer Research 34 ( 8 ) 4589 - 4593 2014年8月
共著
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Dangling ends perturb the stability of RNA duplexes responsive to surrounding conditions 査読あり
H. Tateishi-Karimata, S. Pramanik, S. Nakano, D. Miyoshi, and N. Sugimoto
ChemMedChem 9 ( 9 ) 2150 - 2155 2014年7月
共著
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Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds 査読あり
S. Nakano, Y. Kitagawa, D. Miyoshi, N. Sugimoto
FEBS Open Bio 4 643 - 650 2014年7月
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Drastic stabilization of parallel DNA hybridizations by a polylysine comb-type copolymer with hydrophilic graft chain 査読あり
D. Miyoshi, Y. Ueda, N. Shimada, S. Nakano, N. Sugimoto, and A. Maruyama
ChemMedChem 9 ( 9 ) 2156 - 2163 2014年7月
共著
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A Designed Small Protein For Controlling Site-Specific Mineralization Of Silica And Calcium On Dnas 査読あり
Kenji Usui, Kazuma Nagai, Hiroto Nishiyama, Aoi Yamada, Makoto Ozaki, Takaaki Tsuruoka, Kin-ya Tomizaki
PROTEIN SCIENCE 23 143 - 143 2014年7月
共著
出版者・発行元：WILEY-BLACKWELL
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Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro 査読あり
T. Shimo, K. Tachibana, K. Saito, T. Yoshida, E. Tomita, R. Waki, T. Yamamoto, T. Doi, T. Inoue, J. Kawakami and S. Obika
Nucleic Acids Res. 42 8174 - 8187 2014年6月
共著
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A nanocomposite approach to develop biodegradable thermogels exhibiting excellent cell-compatibility for injectable cell delivery 査読あり
N. Oyama, H. Minami, D. Kawano, M. Miyazaki, T. Maeda, K. Toma, A. Hotta, K. Nagahama
Biomaterials Science 2 ( 8 ) 1057 - 1062 2014年6月
共著
担当区分：筆頭著者
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Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers.
Higuchi S, Watanabe TM, Kawauchi K, Ichimura T, Fujita H
Journal of bioscience and bioengineering 117 ( 6 ) 749 - 755 2014年6月
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Refinement and verification of test conditions for colony-forming unit assay in rat bone marrow cells with preservable colony specimens 査読あり
Takamatsu K., Wakata A., Tabata H., and Nishikata T.
Comparative Clinical Pathology 23 ( 3 ) 569 - 575 2014年5月
共著
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In vitro assays predictive of telomerase inhibitory effect of G-quadruplex ligands in cell nuclei 査読あり
H. Yaku, T. Murashima, D. Miyoshi, N. Sugimoto
The Journal of Physical Chemistry B 118 ( 10 ) 2605 - 2614 2014年3月
共著
DOI： 10.1021/jp410669t
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Effects of molecular crowding on the structures, interactions, and functions of nucleic acids 査読あり
S. Nakano, D. Miyoshi, and N. Sugimoto
Chem. Rev. 114 2733 - 2758 2014年3月
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Site-Specific Control of Silica Mineralization on DNA Using Designed Peptides 査読あり
K. Usui, K. Nagai, H. Nishiyama, A. yamada, T. Tsuruoka, S. Fujii, K.-y. Tomizaki
Peptide Science 2013 2415 - 2416 2014年3月
共著
担当区分：筆頭著者
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A simple "add and measure" FRET-based telomeric tandem repeat sequence detection and telomerase assay method 査読あり
K. Kawamura, H. Yaku, D. Miyoshi, T. Murashima
Organic & Biomolecular Chemistry 12 ( 6 ) 936 - 941 2014年2月
共著
DOI： 10.1039/c3ob42092b
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Peptides targeting G-quadruplex structures 査読あり
Kenji Usui, Arisa Okada
Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications 459 - 475 2014年1月
出版者・発行元：Springer Berlin Heidelberg
Research in recent decades has revealed that some DNA and RNA secondary structures modulate a variety of cellular events. One secondary structure, the Guanine(G)-quadruplex, also regulates various cellular events that are mostly related to serious diseases. Systems capable of controlling DNA and RNA G-quadruplex structures would therefore be useful for the modulation of various cellular events to produce biological effects. Because of their biological importance, many G-quadruplex-targeting compounds have been described. However, the next generation of targeting molecules should exhibit increased G-quadruplex sequence specificity, a higher structure-inducing or -collapsing ability, and a greater degree of functionality, including on–off switches of binding ability and cellular penetration. Peptides might be good candidates for these next-generation Gquadruplex- targeting molecules due to the following advantages: (1) their easy design and synthesis, (2) their ability to mimic protein–G–quadruplex interactions, (3) the possibility of employing artificial amino acids in addition to naturally occurring amino acids, and (4) the ability to combine G-quadruplex-binding sequences with other functional sequences. Accordingly, several peptide-based compounds, such as furan-based cyclic peptides, PNA-conjugated peptides, and small molecule-peptide conjugates, have been developed. In this chapter, we introduce all these peptide ligands and describe most of the approaches for targeting G-quadruplex structures. We then conclude that peptides are among the most promising functional ligands for G-quadruplexes to control various biological events in next-generation approaches.
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Mechanistic study on the facilitation of enzymatic hydrolysis by α-glucosidase in the presence of betaine-type metabolite analogs 査読あり
Yuichi Nakagawa, Shiro Sehata, Satoshi Fujii, Hiroaki Yamamoto, Akihiko Tsuda, Kazuya Koumoto
Tetrahedron 70 5895 - 5903 2014年
共著
担当区分：筆頭著者
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Reduced Graphene Oxide Upconversion Nanoparticle Hybrid for Electrochemiluminescent Sensing of a Prognostic Indicator in Early-Stage Cancer 査読あり
Li Wu, Jiasi Wang, Meili Yin, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto, Xiaogang Qu
Small 10 330 - 336 2014年
共著
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A fluorescent probe for detection of an intracellular prognostic indicator in early-stage cancer (10.1039/c4cc08789e 査読あり
Haiwei Ji, Yijia Guan, L Wu, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto Xiaogang Qu
Chem. Commun. 51 1479 - 1482 2014年
共著
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Preparation of hydrogels for the study of the effects of spatial confinement on DNA 査読あり
Shu-ichi Nakano, Masatoshi Yoshida, Daisuke Yamaguchi, Naoki Sugimoto
Transact. Mat. Res. Soc. Japan 39 435 - 438 2014年
共著
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Dangling ends perturb the stability of RNA duplex responsive to surrounding condition 招待あり 査読あり
H. Tateishi-Karimata, S. Pramanik, S. Nakano, D. Miyoshi and N. Sugimoto
ChemMedChem 9 ( 9 ) 2150 - 2155 2014年
共著
-
Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds 査読あり
Shu-ichi Nakano, Yuichi Kitagawa, Daisuke Miyoshi, Naoki Sugimoto
FEBS Open Bio 4 643 - 650 2014年
共著
-
Drastic stabilization of parallel DNA hybridizations by a polylysine comb-type copolymer with hydrophilic graft chain 査読あり
Daisuke Miyoshi, Yu-mi Ueda, Naohiko Shimada, Shu-ichi Nakano, Naoki Sugimoto, Atsushi Maruyama
ChemMedChem 9 ( 9 ) 2156 - 2163 2014年
共著
担当区分：筆頭著者
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グラフェンと生体分子を用いたバイオセンサー 招待あり 査読あり
三好大輔、上田侑美
バイオサイエンスとインダストリー 72 ( 2 ) 117 - 120 2014年
共著
担当区分：筆頭著者
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measure” FRET-based telomeric tandem repeat sequence detection and telomerase assay method 査読あり
Koji Kawamura, Hidenobu Yaku, Daisuke Miyoshi, Takashi Murashima
Org. Biomol. Chem. 12 934 - 941 2014年
共著
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Effects of Molecular Crowding on the Structures, Interactions, and Functions of Nucleic Acids 査読あり
Shu-ichi Nakano, Daisuke Miyoshi, Naoki Sugimoto
Chem. Rev. 114 ( 5 ) 2733 - 2758 2014年
共著
担当区分：筆頭著者
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In Vitro Assays Predicting of Telomerase Inhibitory Effect of G-Quadruplex Ligands in Cell Nuclei 査読あり
Hidenobu Yaku, Takashi Murashima, Daisuke Miyoshi, Naoki Sugimoto
J. Phys. Chem. B 118 2605 - 2614 2014年
共著
担当区分：筆頭著者
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Preparation of hydrogels for the study of the effects of spatial confinement on DNA
Shu-ichi Nakano, Masatoshi Yoshida, Daisuke Yamaguchi, Naoki Sugimoto
Transact. Mat. Res. Soc. Japan 39 435 - 438 2014年
共著
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グラフェンと生体分子を用いたバイオセンサー
三好大輔, 上田侑美
バイオサイエンスとインダストリー 72 ( 2 ) 117 - 120 2014年
共著
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Synthesis and Chromatographic Evaluation of PFOS-selective Polymer by Molecular Imprinting
Rei Sakamoto, Keito Yuasa, Jun Matsui
Chromatography 35 ( Supplement1 ) 81 - 82 2014年
共著
担当区分：筆頭著者
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In Situ Synthesis of Metal/Polymer Nanocomposite Thin Films on Glass Substrates by using Highly Cross-Linked Polymer Matrices with Tailorable Ion Exchange Capabilities 招待あり
Isao Toda, Takaaki Tsuruoka, Jun Matsui, Takashi Murashima, Hidemi Nawafune, Kensuke Akamatsu
RSC Advances 4 4723 - 4726 2014年
共著
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Synthesis and Chromatographic Evaluation of Affinity Polymer Having Zinc Porphyrin Moieties
Kota Matsuo, Yuki Minetoki, Jun Matsui
Chromatography 35 ( Supplement1 ) 79 - 80 2014年
共著
担当区分：筆頭著者
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Mitochondrial inhibitor sodium azide inhibits the reorganization of mitochondria-rich cytoplasm and the establishment of the anteroposterior axis in ascidian embryo 査読あり
Ishii H., Shirai T., Makino C. and Nishikata T
Devl. Growth Differ. 56 175 - 188 2014年
共著
DOI： 10.1111/dgd.12117
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A Novel Assay System for Macrophage Activating Factor Activity Using a Human U937 Cell Line. 査読あり
Ishikawa M, Inoue T, Inui T, Kuchiike D, Kubo K, Uto Y, and Nishikata T,
Anticancer Research 34 ( 8 ) 4577 - 4581 2014年
共著
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Simultaneous Expression of Cancer Stem Cell-like Properties and Cancer-associated Fibroblast-like Properties in a Primary Culture of Breast Cancer Cells 査読あり
Ishikawa M, Inoue T, Shirai T, Takamatsu K, Kunihiro S, Ishii H, and Nishikata T
Cancers 6 1570 - 1578 2014年
共著
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A Facile Template Synthesis of Asymmetric Gold Silica Heteronanoparticles 査読あり
R. Miyanohata, T. Matsushita, T. Tsuruoka, H. Nawafune, K. Akamatsu
J. Colloid Interface Sci 416 147 - 150 2014年
共著
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Electroless nickel plating on polymer particles 査読あり
S. Fujii, H. Hamasaki, H. Takeoka, T. Tsuruoka, K. Akamatsu, Y. Nakamura
J. Colloid Interface Sci 430 47 - 55 2014年
共著
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Direct fabrication of metal patterns on resin substrate by combining imprint and electrochemical lithography 査読あり
Y. Kimura, R. Fujiwara, T. Tsuruoka, Y. Takashima, H. Nawafune, H. Yanagimoto, K. Akamatsu
Journal of The Surface Finishing Society of Japan 66 18 - 19 2014年
共著
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Electroless Deposition of Tin Using Contact with Zinc Powder in the Bath 査読あり
E. Uchida, K. Tanaka, A. Kawabata, S. Nabeshima, T. Tsuruoka, K. Akamatsu, H. Nawafune
Journal of The Surface Finishing Society of Japan 65 453 - 457 2014年
共著
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Fluorescence Enhancement of Immobilized CdTe Nanocrystals on Metal Nanocrystals-Modified Substrate by Dipole Coupling 査読あり
T. Tsuruoka, M. Yamashita, M. Kumano, K. Uwajima, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn. 39 481 - 484 2014年
共著
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Gold nanoparticle satellite nanostructures on glass substrate for dual-responsive optical sensing of organic liquids 査読あり
Y. Tanaka, A. Matsumoto, T. Tsuruoka, H. Nawafune, K. Akamatsu
Chem. Lett 43 1084 - 1085 2014年
共著
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Electroless nickel plating on polymer particles 査読あり
S. Fujii, H. Hamasaki, H. Takeoka, T. Tsuruoka, K. Akamatsu, Y. Nakamura
J. Colloid Interface Sci 430 47 - 55 2014年
共著
-
Direct fabrication of metal patterns on resin substrate by combining imprint and electrochemical lithography 査読あり
Y. Kimura, R. Fujiwara, T. Tsuruoka, Y. Takashima, H. Nawafune, H. Yanagimoto, K. Akamatsu
Journal of The Surface Finishing Society of Japan 66 18 - 19 2014年
共著
-
Electroless Deposition of Tin Using Contact with Zinc Powder in the Bath 査読あり
E. Uchida, K. Tanaka, A. Kawabata, S. Nabeshima, T. Tsuruoka, K. Akamatsu, H. Nawafune
Journal of The Surface Finishing Society of Japan 65 453 - 457 2014年
共著
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Fluorescence Enhancement of Immobilized CdTe Nanocrystals on Metal Nanocrystals-Modified Substrate by Dipole Coupling 査読あり
T. Tsuruoka, M. Yamashita, M. Kumano, K. Uwajima, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn. 39 481 - 484 2014年
共著
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Gold nanoparticle satellite nanostructures on glass substrate for dual-responsive optical sensing of organic liquids 査読あり
Y. Tanaka, A. Matsumoto, T. Tsuruoka, H. Nawafune, K. Akamatsu
Chem. Lett 43 1084 - 1085 2014年
共著
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Controlled Synthesis of Metal-Organic Framework Films on Metal Nanoparticles by the Versatile Layer-by-Layer Assembly Approach 査読あり
T. Ohhashi, T. Tsuruoka, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn 39 153 - 156 2014年
共著
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All‐Inorganic Water-Dispersible Silicon Quantum Dots: Highly Efficient Near-Infrared Luminescence in a Wide pH range
H. Sugimoto, M. Fujii, Y. Fukuda, K. Imakita, K. Akamatsu
Nanoscale 6 122 - 126 2014年
共著
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Electroless Bismuth Plating as a Peripheral Technology for SiC Power Devices 査読あり
E. Uchida, K. Tanaka, M. Okada, T. Tsuruoka, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn 39 47 - 51 2014年
共著
-
In Situ Synthesis of Metal/Polymer Nanocomposite Thin Films on Glass Substrates by using Highly Cross-Linked Polymer Matrices with Tailorable ion exchange capabilities 査読あり
I. Toda, T. Tsuruoka, J. Matsui, T. Murashima, H. Nawafune, K. Akamatsu
RSC Advances 4 4723 - 4726 2014年
共著
-
A Facile Template Synthesis of Asymmetric Gold Silica Heteronanoparticles
R. Miyanohata, T. Matsushita, T. Tsuruoka, H. Nawafune, K. Akamatsu
J. Colloid Interface Sci 416 147 - 150 2014年
共著
-
In situ Synthesis of Metal/Polymer Nanocomposite Thin Films on Glass Substrates by using Highly Cross-linked Polymer Matrices with Tailorable Ion Exchange Capabilities
I. Toda, T. Tsuruoka, J. Matsui, T. Murashima, H. Nawafune, K. Akamatsu
RSC Advances 3 16243 - 16246 2014年
共著
-
Gold nanoparticle satellite nanostructures on glass substrate for dual-responsive optical sensing of organic liquids
Y. Tanaka, A. Matsumoto, T. Tsuruoka, H. Nawafune, K. Akamatsu
Chem. Lett 43 1084 - 1085 2014年
共著
-
Fluorescence Enhancement of Immobilized CdTe Nanocrystals on Metal-Nanocrystals-Modified Substrate by Dipole Coupling
T. Tsuruoka, M. Yamashita, M. Kumano, K, Uwajima, Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn 39 481 - 484 2014年
共著
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Electroless Bismuth Plating as a Peripheral Technology for SiC Power Devices
E. Uchida, K. Tanaka, M. Okada, T. Tsuruoka, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn 39 47 - 51 2014年
共著
-
Controlled Synthesis of Metal-Organic Framework Films on Metal Nanoparticles by the Versatile Layer-by-Layer Assembly Approach
T. Ohhashi, T. Tsuruoka, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn 39 153 - 156 2014年
共著
-
All-Inorganic Water-Dispersible Silicon Quantum Dots: Highly Efficient Near-Infrared Luminescence in a Wide pH range
H. Sugimoto, M. Fujii, Y. Fukuda, K. Imakita, K. Akamatsu
Nanoscale 6 122 - 126 2014年
共著
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Thermodynamic Features Provided by an ENA Introduction to Nucleic Acid Drugs
E. Tomita, M. Sumimoto, J. Kawakami
Proc. 41st Intl. Symp. Nucleic Acid Chemistry 188 - 189 2014年
共著
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Mechanistic study on the facilitation of enzymatic hydrolysis by alpha-glucosidase in the presence of betaine-type metabolic analogs 査読あり
Yuichi Nakagawa, Shiro Sehata, Satoshi Fujii, Hiroaki Yamamoto, Akihiko Tsuda, Kazuya Koumoto
Tetrahedron 70 5895 - 5903 2014年
共著
-
Site-Specific Control of Silica Mineralization on DNA Using Designed Peptides 査読あり
K. Usui, K. Nagai, H. Nishiyama, A. Yamada, T. Tsuruoka, S. Fujii, K-y. Tomizaki
Peptide Science 2415 - 2416 2014年
共著
-
Electroless nickel plating on polymer particles 査読あり
S. Fujii, H. Hamasaki, H. Takeoka, T. Tsuruoka, K. Akamatsu, Y. Nakamura
J. Colloid Interface Sci. 430 47 - 55 2014年
共著
-
Direct fabrication of metal patterns on resin substrate by combining imprint and electrochemical lithography 査読あり
Y. Kimura, R. Fujiwara, T. Tsuruoka, Y. Takashima, H. Nawafune, H. Yanagimoto, K. Akamatsu
Journal of The Surface Finishing Society of Japan 66 18 - 19 2014年
共著
-
Electroless Deposition of Tin Using Contact with Zinc Powder in the Bath 査読あり
E. Uchida, K. Tanaka, A. Kawabata, S. Nabeshima, T. Tsuruoka, K. Akamatsu, H. Nawafune
Journal of The Surface Finishing Society of Japan 65 453 - 457 2014年
共著
-
Fluorescence Enhancement of Immobilized CdTe Nanocrystals on Metal Nanocrystals-Modified Substrate by Dipole Coupling 査読あり
T. Tsuruoka, M. Yamashita, M. Kumano, K. Uwajima, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc.Jpn 39 481 - 484 2014年
共著
-
Gold nanoparticle satellite nanostructures on glass substrate for dual-responsive optical sensing of organic liquids 査読あり
Y. Tanaka, A. Matsumoto, T. Tsuruoka, H. Nawafune, K. Akamatsu
Chem. Lett 43 1084 - 1085 2014年
共著
-
Controlled Synthesis of Metal-Organic Framework Films on Metal Nanoparticles by the Versatile Layer-by-Layer Assembly Approach 査読あり
T.Ohhashi, T. Tsuruoka, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc.Jpn 39 153 - 156 2014年
共著
-
Electroless Bismuth Plating as a Peripheral Technology for SiC Power Devices 査読あり
E. Uchida, K. Tanaka, M. Okada, T. Tsuruoka, K. Akamatsu H. Nawafune
Trans. Mater. Res. Soc.Jpn 39 47 - 51 2014年
共著
-
In Situ Synthesis of Metal/Polymer Nanocomposite Thin Films on Glass Substrates by using Highly Cross-Linked Polymer Matrices with Tailorable ion exchange capabilities 査読あり
I.Toda, T.Tsuruoka, J. Matsui, T. Murashima, H. Nawafune, K. Akamatsu
RSC Adovances 4 4723 - 4726 2014年
共著
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A Facile Template Synthesis of Asymmetric Gold Silica Heteronanoparticles 査読あり
R. Miyanohata, T. Mstsushita, T. Tsuruoka, H. Nawafune, K. Akamatsu
J. Colloid Interface Sci. 416 147 - 150 2014年
共著
-
Towards Imaging Electron Density inside Metal-Organic Framework Structures 査読あり
Yohei Takashima, De-Liang Long, Leroy Cronin
Chem. Commun 50 2271 - 2274 2014年
共著
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Enhanced Phosphorescence Emission by Incorporating Aromatic Halides into an Entangled Coordination Framework Based on Naphthalenediimide 査読あり
Virginia Mart?nez-Mart?nez, Rebeca Sola Llano, Shuhei Furukawa, Yohei Takashima, I?igo L?pez Arbeloa, Susumu Kitagawa
ChemPhysChem 15 2517 - 2521 2014年
共著
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In situ synthesis of metal/polymer nanocomposite thin films on glass substrates by using highly cross-linked polymer matrices with tailorable ion exchange capabilities 査読あり
I. Toda, T. Tsuruoka, J. Matsui, T. Murashima, H. Nawafune, K. Akamatsu
RSC Advances 4 4723 - 4726 2013年12月
共著
DOI： 10.1039/C3RA46166A
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Control of Site-Specific Silica Precipitation Using PNA Peptides and DNAs 査読あり
K. Usui, H. Nishiyama, K. Nagai, T. Tsuruoka, S. Fujii, K.-y. Tomizaki
Peptides 2013 162 - 163 2013年12月
共著
担当区分：筆頭著者
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Designed Peptide Libraries for Cell Analyzing Microarrays 査読あり
H. Mihara, K. Usui, H. Tsutsumi, K. Nokihara
Peptides 2013 22 - 23 2013年12月
共著
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Peptide-DNA Hybrid G-Quadruplex Structures for Regulation of Protein Expression Depending on Protease Activity 査読あり
A. Okada, M. Taniguchi, K. Usui, N. Sugimoto
Peptides 2013 180 - 181 2013年12月
共著
担当区分：筆頭著者
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Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization.
Araki K, Kawauchi K, Hirata H, Yamamoto M, Taya Y
eLife 2 e01228 2013年12月
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Positional Effect of 2',4'-BNA/LNA Introduction into DNA/RNA Duplexes on Thermodynamic Parameters
S. Tahara, E. Tomita, H. Nagai, S. Obika, and J. Kawakami
Proc. 40th Intl. Symp. Nucleic Acid Chemistry 190 - 191 2013年11月
共著
担当区分：筆頭著者
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A highly sensitive telomerase activity assay that eliminates false-negative results caused by PCR inhibitors 査読あり
H. Yaku, T. Murashima, D. Miyoshi, N. Sugimoto
Molecules 18 ( 10 ) 11751 - 11767 2013年9月
共著
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Multiple and cooperative binding of fluorescence light-up probe thioflavin t with human telomere DNA G-quadruplex 査読あり
V. Gabelica, R. Maeda, T. Fujimoto, H. Yaku, T. Murashima, N. Sugimoto, D. Miyoshi
Biochemistry 52 ( 33 ) 5620 - 5628 2013年7月
共著
DOI： 10.1021/bi4006072
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Conformational changes of the phenyl and naphthyl isocyanate-DNA adducts during DNA replication and by minor groove binding molecules 査読あり
S. Nakano, Y. Uotani, Y. Sato, H. Oka, M. Fujii, and N. Sugimoto
Nucleic Acids Res. 41 8581 - 8590 2013年7月
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In situ template synthesis of one-dimensional gold nanoparticle arrays in organic nanowires 査読あり
T. Matsushita, Y. Fukumoto, T. Kawakami, T. Tsuruoka, T. Murashima, T. Yanagishita, H. Masuda, H. Nawafune, K. Akamatsu
RSC Advances 3 16243 - 16246 2013年7月
共著
DOI： 10.1039/C3RA42727G
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Quantitative analyses of nucleic Acid stability under the molecular crowding condition induced by cosolutes 招待あり 査読あり
Tateishi-Karimata H, Nakano S, Sugimoto N.
Curr Protoc Nucleic Acid Chem. Chapter 7 Unit7.19 2013年6月
共著
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Systematic screening of the cellular uptake of designed alpha-helix peptides 査読あり
Kenji Usui, Takuya Kikuchi, Masayasu Mie, Eiry Kobatake, Hisakazu Mihara
BIOORGANIC & MEDICINAL CHEMISTRY 21 ( 9 ) 2560 - 2567 2013年5月
出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD
The cellular penetration (CP) activity of functional molecules has attracted significant attention as one of the most promising new approaches for drug delivery. In particular, cell-penetrating peptides (CPPs) have been studied extensively in cellular engineering. Because there have been few large-scale systematic studies to identify peptide sequences with optimal CP activity or that are suitable for further applications in cell engineering, such as cell-specific penetration and cell-selective culture, we screened and compared the cellular uptake (CU) activity of 54 systematically designed a-helical peptides in HeLa cells. Furthermore, the CU activity of 24 designed peptides was examined in four cell lines using a cell fingerprinting technique and statistical approaches. The CU activities in various cells depended on amino acid residues of peptide sequences as well as charge, a-helical content and hydrophobicity of the peptides. Notably, the mutation of a single residue significantly altered the CU ability of a peptide, highlighting the variability of cell uptake mechanisms. Moreover, these results demonstrated the feasibility of cell-selective culture by conducting cell-selective permeation and death in cultures containing two cell types. These studies may lead to further peptide library design and screening for new classes of CPPs with useful functions. (C) 2013 Elsevier Ltd. All rights reserved.
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T. Kakiyama, K. Usui, K.-y. Tomizaki, M. Mie, E. Kobatake, H. Mihara
Polym. J. 45 ( 5 ) 525 - 539 2013年5月
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Biodegradable polymers exhibiting temperature-responsive sol-gel transition as injectable biomedical materials 査読あり
Koji Nagahama, Akihiro Takahashi, Yuichi Ohya
Reactive and Functional Polymers ( 73 ) 979 - 985 2013年5月
共著
担当区分：筆頭著者
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Study on effects of molecular crowding on G-quadruplex-ligand binding and ligand-mediated telomerase inhibition 査読あり
H. Yaku, T. Murashima, H. Tateishi-Karimata, S. –I. Nakano, D. Miyoshi, N. Sugimoto
Methods 64 ( 1 ) 19 - 27 2013年4月
共著
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A PNA Peptide for the Control of Site-Specific Silica Precipitation on DNA 査読あり
Kenji Usui, Kazuma Nagai, Hiroto Nishiyama, Takaaki Tsuruoka, Satoshi Fujii
Peptide Science 2012 375 - 376 2013年3月
共著
担当区分：筆頭著者
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Construction of Artificial Peptides for Control of DNA G-quadruplex Structures Depending on Protease Activity toward Regulation of Protein Expression 査読あり
Arisa Okada, Kenji Usui, Mai Taniguchi, Keita Kobayashi, Naoki Sugimoto
Peptide Science 2012 285 - 286 2013年3月
共著
担当区分：筆頭著者
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Enhanced stereocomplex formation of enantiomeric polylactides grafted on a polyrotaxane platform 査読あり
Koji Nagahama, Rie Aoki, Toshifumi Saito, Tatsuro Ouchi, Yuichi Ohya and Nobuhiko Yui
Polymer Chemistry ( 4 ) 1769 - 1773 2013年3月
共著
担当区分：筆頭著者
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Design of Biodegradable Injectable Polymers Exhibiting Temperature-Responsive Sol-Gel Transition 査読あり
Y. Ohya, H. Suzuki, K. Nagahama, A. Takahashi, T. Ouchi, A. Kuzuya
Advances in Science and Technology ( 86 ) 9 - 16 2013年3月
共著
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Thermodynamics - Hydration Relationships within Loops that Affect G-Quadruplexes under Molecular Crowding Conditions 査読あり
Takeshi Fujimoto, Shu-ichi Nakano, Naoki Sugimoto, Daisuke Miyoshi
J. Phys. Chem. B 117 963 - 972 2013年1月
共著
担当区分：筆頭著者
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Thermodynamics-hydration relationships within loops that affect G-quadruplexes under molecular crowding conditions 査読あり
T. Fujimoto, S. Nakano, N. Sugimoto, and D. Miyoshi
J. Phys. Chem. B 117 ( 4 ) 963 - 972 2013年1月
共著
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Biochemical purification of mitochondrial HSP60 and ATPsynthase from ascidian eggs: Implications for antibody specificity 査読あり
Janet Chenevert, Gerard Pruliere, Hirokazu Ishii, Christian Sardet, Takahito Nishikata
PLoS One 8 ( 1 ) e52996 2013年1月
共著
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Multiple and cooperative binding of fluorescence light-up probe Thioflavin T with human telomere DNA G-quadruplex 査読あり
Valerie Gabelica, Ryuichi Maeda, Takeshi Fujimoto, Hidenobu Yaku, Takashi Murashima, Naoki Sugimoto, and Daisuke Miyoshi
Biochemistry 52 5620 - 5628 2013年
共著
担当区分：筆頭著者
-
A Highly Sensitive Telomerase Activity Assay that Eliminates False-Negative Results Caused by PCR Inhibitors 査読あり
Hidenobu Yaku, Takashi Murashima, Daisuke Miyoshi, and Naoki Sugimoto
Molecules 18 ( 10 ) 11751 - 11767 2013年
共著
担当区分：筆頭著者
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Sequence and Solvent Effects on Telomeric DNA Bimolecular G-Quadruplex Folding Kinetics 査読あり
Adrien Marchand, Ruben Ferreira, Hisae Tateishi-Karimata, Daisuke Miyoshi, Naoki Sugimoto, Valerie Gabelica
J. Phys. Chem. B 117 ( 41 ) 12391 - 12401 2013年
共著
-
Recognition of Perfluorooctanoic Acid (PFOA) by Fluorous Molecularly Imprinted Polymer
Jun Matsui, Megumi Takayose
Chromatography 34 ( Supplement1 ) 21 - 22 2013年
共著
担当区分：筆頭著者
-
Application of a Reflectometric Interference Spectroscopic Device (RIfS) with a Polymer-gel Coated SiN Chip to an HPLC Detector
Yuma Nakahori, Yusuke Sugahara, Jun Matsui
Chromatography 34 ( Supplement1 ) 51 - 52 2013年
共著
担当区分：筆頭著者
-
Primary culture of breast cancer: A model system for epithelial-mesenchymal transition and cancer stem cells 査読あり
Nishikata T., Ishikawa M., Matsuyama T., Takamatsu K., Fukuhara T., and Konishi Y.
Anticancer Research 33 2867 - 2874 2013年
共著
担当区分：筆頭著者
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Purification of mitochondrial proteins HSP60 and ATP synthase from ascidian eggs: implications for antibody specificity. 査読あり
Chenevert J, Pruliere G, Ishii H, Sardet C, Nishikata T
PloS one 8 ( 1 ) e52996 2013年
-
Phosphorus and Boron Codoped Colloidal Silicon Nanocrystals with Inorganic Atomic Ligandas 査読あり
H.Sugimoto, M.Fujii, K.Imakita, S.Hayashi, K.Akamatsu
J.Phys Chem.C. 117 6807 - 6813 2013年
共著
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Synthesis of Polystyrene-based Nanocomposite Thin Films with Domain Structure Consisting of Au Nanoparticles 査読あり
T. Tsuruoka, S. Kumazaki, I. Osaka, H. Nawafune, K. Akamatsu
Journal of Physics: Conference Series 417 012020 - 012020 2013年
共著
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In Situ Template Synthesis of One-dimensional Gold Nanoparticle Arrays in Organic Nanowires 査読あり
T. Matsushita, Y. Fukumoto, T. Kawakami, T. Tsuruoka, T. Murashima, T. Yanagishita, H. Masuda, H. Nawafune, K. Akamatsu
RSC Advances 3 16243 - 16246 2013年
共著
-
Codoping n- and p-type impurities in colloidal silicon nanocrystals:controlling luminescence energy from below bulk band gap to visible range
H. Sugimoto, M. Fujii, K. Imakita, S. Hayashi, K Akamatsu
J. Phys. Chem C.117(22) 11850 - 11857 2013年
共著
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Shape Memory Nanopores Induced in Coordination Frameworks by Crystal Downsizing
Y. Sakata, S. Furukawa, M. Kondo, K. Hirai, N. Horike, Y.Takashima, H. Uehara, N. Louvain, M. Meilikhov, T. Tsuruoka, S. Isoda, W. Kosaka, O. Sakata, S. Kitagawa
Science 339 193 - 196 2013年
共著
-
Phosphorus and Boron Codoped Colloidal Silicon Nanocrystals with Inorganic Atomic Ligands
H. Sugimoto, M. Fujii, K. Imakita, S. Hayashi, K Akamatsu
J. Phys. Chem C.117(13) 6807 - 6813 2013年
共著
-
In Situ Template Synthesis of One-dimensional Gold Nanoparticle Arrays in Organic Nanowires
T. Matsushita, Y. Fukumoto, T. Kawakami, T. Tsuruoka, T. Murashima, T. Yanagishita, H. Masuda, H. Nawafune, K. Akamatsu
RSC Advances 3 16243 - 16246 2013年
共著
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Specific recognition of cytosine by hypoxanthine in pyrrolidinyl peptide nucleic acid 査読あり
C. Vilaivan, W. Srinarang, N. Yotapan, W. Mansawat, C. Boonlua, J. Kawakami, Y. Yamaguchi, Y. Tanaka, and T. Vilaivan
Org. Biomol. Chem. 11 2310 - 2317 2013年
共著
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Control of Site-Specific Silica Precipitation Using PNA Peptides and DNAs 査読あり
Kenji Usui, Hiroto Nishiyama, Kazuma Nagai, Takaaki Tsuruoka, Satoshi Fujii, Kin-ya Tomizaki
Peptide Science 162 - 163 2013年
共著
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A novel array format for monitoring cellular uptake using a photo-cleavable linker for peptide release 査読あり
Kenji Usui, Takuya Kikuchi, Kin-ya Tomizaki, Takashi Kakiyama, Hisakazu Mihara
CHEMICAL COMMUNICATIONS 49 ( 57 ) 6394 - 6396 2013年
出版者・発行元：ROYAL SOC CHEMISTRY
We developed a novel peptide array format incorporating a photo-cleavable linker for monitoring cellular uptake. Model peptides were successfully immobilised via the photo-cleavable linker onto conventional plates and could be released spatiotemporally using UV irradiation. Incorporation of confocal microscopy allowed for detailed real-time monitoring of cellular internalisation of peptides.
DOI： 10.1039/c3cc41632a
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Shape Memory Nanopores Induced in Coordination Frameworks by Crystal Downsizing 査読あり
Y.Sakata, S. Fukumoto, M. Kondo, K. Hirai, N. Horike, Y. Takashima, H.Uehara, N. Louvain, M.Meilikhov, T.Tsuruoka, S.Isoda, W.Kosaka, O.Sakata, S.Kitagawa
Science 339 193 - 196 2013年
共著
-
A PNA Peptide for the Control of Site-Specific Silica Precipitation on DNA 査読あり
K. Usui, K. Nagai, H. Nishiyama, T. Tsuruoka, Satoshi Fujii
Peptide Science 375 - 376 2013年
共著
-
Control of Site-Specific Silica Precipitation Using PNA Peptides and DNAs 査読あり
K. Usui, H. Nishiyama, K. Nagai, T. Tsuruoka, S. Fujii K-y. Tomizaki
Peptide 162 - 162 2013年
共著
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Shape Memory Nanopores Induced in Coordination Frameworks by Crystal Downsizing 査読あり
Yoko Sakata, Shuhei Furukawa, Mio Kondo, Kenji Hirai, Nao Horike, Yohei Takashima, Hiromitsu Uehara, Nicolas Louvain, Mikhail Meilikhov, Takaaki Tsuruoka, Seiji Isoda, Wataru Kosaka, Osami Sakata, Susumu Kitagawa
Science 339 193 - 196 2013年
共著
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Base-pairing selectivity of a ureido-linked phenyl-2'-deoxycytidine derivative 査読あり
Nakano S, Oka H, Yamaguchi D, Fujii M, Sugimoto N.
Org Biomol Chem 10 ( 48 ) 9664 - 9670 2012年12月
-
The beads-on-a-string structure of long telomeric DNAs under molecular crowding conditions 査読あり
Haiqing Yu, Gu Xiaobo Gu, Shu-ichi Nakano, Daisuke Miyoshi, Naoki Sugimoto
J. Am. Chem. Soc. (Higthlighted as the cover and introduced in the Spotslights on Recent JACS Publications) 134 20060 - 20069 2012年12月
共著
担当区分：筆頭著者
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The beads-on-a-string structure of long telomeric DNAs under molecular crowding conditions 査読あり
Yu H, Gu X, Nakano S, Miyoshi D, Sugimoto N.
J Am Chem Soc. 134 ( 49 ) 20060 - 20069 2012年12月
共著
DOI： 10.1021/ja305384c
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Aptamer carbon nanodot sandwich used for fluorescent detection of protein 査読あり
Bailu Xu, Chuanqi Zhao, Weili Wei, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto, and Xiaogang Qu
Analyst 137 5483 - 5486 2012年12月
共著
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Cytosolic subunits of ATP synthase are localized to the cortical endoplasmic reticulum-rich domain of the ascidian egg myoplasm. 査読あり
Hirokazu Ishii, Shiori Kunihiro, Manabu Tanaka, Kyoko Hatano and Takahito Nishikata
Devlopment, Growth and Differentiation 54 753 - 766 2012年12月
共著
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Construction of a trans-acting system of a L-histidine dependent ribozyme based on the secondary structure
S. Tanaka, Y. Yamaguchi, R. Takamine, and J. Kawakami
Proc. 39th Intl. Symp. Nucleic Acid Chemistry 234 - 235 2012年11月
共著
担当区分：筆頭著者
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Myosin II-dependent exclusion of CD45 from the site of Fcγ receptor activation during phagocytosis.
Yamauchi S, Kawauchi K, Sawada Y
FEBS letters 586 ( 19 ) 3229 - 3235 2012年9月
-
Mechanistic Study on Microstructural Tuning of Metal Nanoparticle/ Polymer Composite Thin Layers: Hydrogenation and Decomposition of Polyimide Matrices Catalyzed by Embedded Nickel Nanoparticles 査読あり
Kensuke Akamatsu , Maki Fujii , Takaaki Tsuruoka , Shu-ichi Nakano , Takashi Murashima , and Hidemi Nawafune
The Journal of Physical Chemistry C 116 ( 33 ) 17947 - 17954 2012年8月
共著
DOI： 10.1021/jp304702b
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Mechanistic study on microstructural tuning of metal nanoparticle/polymer composite thin layers: Hydrogenation and decomposition of polyimide matrices catalyzed by embedded nickel nanoparticles. 査読あり
K. Akamatsu, M. Fujii, T. Tsuruoka, S. Nakano, T. Murashima, and H. Nawafune
J. Phys. Chem. C 116 17947 - 17954 2012年8月
共著
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Specific Binding of Anionic Porphyrin and Phthalocyanine to the G-quadruplex 招待あり 査読あり
Hidenobu Yaku, Takashi Murashima, Daisuke Miyoshi, Naoki
Molecules 17 10586 - 10613 2012年8月
共著
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p130Cas-dependent actin remodelling regulates myogenic differentiation.
Kawauchi K, Tan WW, Araki K, Abu Bakar FB, Kim M, Fujita H, Hirata H, Sawada Y
The Biochemical journal 445 ( 3 ) 323 - 332 2012年8月
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Dimerization of nucleic acid hairpins in the conditions caused by neutral cosolutes 査読あり
S. Nakano, H. Hirayama, D. Miyoshi, and N. Sugimoto
J. Phys. Chem. B 116 ( 25 ) 7406 - 7415 2012年6月
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Monodispersed Moleculary Imprinted Polymer Beads with Enhanced Atranzine Retention Ability Synthesized with Polymeric Diluents
Tsuyoshi Nagata, Shou Goji, Kensuke Akamatsu, Hidemi Nawafune, Jun Matsui
Analytical Letters 9 572 - 578 2012年6月
共著
-
Colorimetric Detection of Perfluorooctanoic Acid (PFOA) Utilizing Polystyrene-Modified Gold Nanoparticles 査読あり
M. Takayose, K. Akamatsu, H. Nawafune, T. Murashima, J. Matsui
Analytical Letters 45 ( 18 ) 2856 - 2864 2012年5月
共著
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Hydration changes upon DNA folding studied by osmotic stress experiments 査読あり
S. Nakano, D. Yamaguchi, H. Tateishi-Karimata, D. Miyoshi, and N. Sugimoto
Biophys. J. 102 ( 12 ) 2808 - 2817 2012年5月
-
Biodegradable Stereocomplex Materials of Polylactide-grafted Dextran Exhibiting Soft and Tough Properties in Dry and Wet States 査読あり
K. Nagahama, K. Shimizu, S. Ichimura, A. Takahashi, T. Ouchi, Y. Ohya
Journal of Polymer Science Part A: Polymer Chemistry ( 50 ) 2669 - 2676 2012年5月
共著
担当区分：筆頭著者
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Biodegradable Polymeric Assemblies for Biomedical Materials 招待あり 査読あり
Y. Ohya, A. Takahashi, K. Nagahama
Advances in Polymer Science ( 247 ) 65 - 114 2012年4月
共著
担当区分：筆頭著者
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Screening of Designed Peptides for Binders to a DNA G-Quadruplex Structure 査読あり
N. Matsui, K. Kobayashi, K. Usui
Peptide Science 2011 2011 315 - 316 2012年3月
共著
担当区分：筆頭著者
-
Development of PNA-Peptides Controlling DNA G-Quadruplex Structures Depending on Protease Activity 査読あり
K. Usui, K. Kobayashi, N. Sugimoto
Peptide Science 2011 2012 315 - 316 2012年3月
共著
担当区分：筆頭著者
-
De Novo Designed Nitric Oxide Sensor Protein consisted of Iron Complex-Peptide Conjugate 査読あり
H. Miyazaki, K. Usui, S. Fujii
Peptide Science 2011 2011 303 - 304 2012年3月
共著
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Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts.
Watanabe TM, Higuchi S, Kawauchi K, Tsukasaki Y, Ichimura T, Fujita H
Biochemical and biophysical research communications 418 ( 4 ) 742 - 747 2012年2月
-
Detection of a Prognostic Indicator in Early-Stage Cancer Using Functionalized Graphene-Based Peptide Sensors 査読あり
Lingyan Feng, Li Wu, Jiasi Wang, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto, Xiaogang Qu
Advanced Materials 24 ( 1 ) 125 - 131 2012年1月
共著
-
Colorimetric Detection of Perfluorooctanoic Acid (PFOA) Utilizing Polystyrene-Modified Gold Nanoparticles 査読あり
Megumi Takayose, Kensuke Akamatsu, Hidemi Nawafune, Takashi Murashima, Jun Matsui
Analytical Letters 2012年
共著
担当区分：筆頭著者
-
A fluorous synthetic receptor that recognizes perfluorooctanoic acid (PFOA) via fluorous interaction obtained by molecular imprinting 査読あり
Megumi Takayose, Kenji Nishimoto, Jun Matsui
Analyst 2012年
共著
担当区分：筆頭著者
-
Monodispersed Molecularly Imprinted Polymer Beads with Enhanced Atrazine Retention Ability Synthesized with Polymeric Diluents 査読あり
Tsuyoshi Nagata, Shou Goji, Kensuke Akamatsu, Hidemi Nawafune, Jun Matsui
Analytical Letters 2012年
共著
担当区分：筆頭著者
-
ポリイミド樹脂/金属間におけるナノ構造界面の構築と樹脂上への金属パターン形成
福本ユリナ、谷山智紀、鶴岡孝章、縄舟秀美、赤松謙祐
エレクトロニクス実装学会誌 15 534 - 540 2012年
共著
-
Mechanistic Study on Microstructural Tuning of Metal Nanoparticle/Polymer Composite Thin Layers:Hydrogenation and Decomposition of Polyimide Matrices Ctalyzed By Embedded Nickel Nanoparticles
K. Akamatsu, M. Fujii, T. Tsuruoka, S. Nakano, T. Murashima, H. Nawafune
J. Phys. Chem. C 116 1794 - 1795 2012年
共著
-
In situ synehesis of composite nanowires consisting of metal nanoparticles in ion-exchangeable polymer matrix using porous alumina tenplates 査読あり
Y.Fukumoto, T.Tsuruoka, T.Yangishita, H.Masuda, H.Nawafune, K. Akamatsu
Ttrans.Mater.Res.Soc.Jpn 37 185 - 188 2012年
共著
-
Synthesis of Au Nanocrustals/Porous Coordination Polymer Composites by Preferential Self-Assembly of Frameworks 査読あり
H.Kawasaki, M.Kumano, M. Yamashita, T. Tsuruoka, H.Nawafune, K.Akamatsu
Trans. Mater. Res. Soc. Jpn 37 181 - 184 2012年
共著
-
Enhancement of upconversion luminescence of AI2O3, Er3+thin films by small assemblies of Au nanorods 査読あり
T.Nakano, M. Fujii, K. Imakita, S. Hayashi, T.Tsuruoka, K. Akamatsu
Trans. Mater. Res. Soc. Jpn 38 449 - 452 2012年
共著
-
Colorimetric Detection of Perfluorooctanoic Acid (PHOA) Utilizing Polystyrene-Modified Gold Nanoparticles
Megumi Takayose, Kensuke Akamatsu, Hidemi Nawafune, Takashi Murashima, Jun Matsui
Analytical Letters 18 2856 - 2864 2012年
共著
-
All‐Inorganic Near-Infrared Luminescent Colloidal Silicon Nanocrystals:High Dispersibility in Polar liquid by Phosphorus and Boron Codoping
H. Sugimoto, M. Fujii, K. Imakita, S. Hayashi, K. Akamatsu
J. Phys. Chem. C 116 17969 - 17974 2012年
共著
-
All-Inorganic Near-Infrared Luminescent Colloidal Silicon Nanocrystals:High Dispersibility in Polar Liquid by Phosphorus and Boron Codoping
Fujii, K. Imakita, S. Hayashi, K. Akamatsu
J. Phys. Chem C.116(33) 17969 - 17974 2012年
共著
-
ポリイミド樹脂/金属間におけるナノ構造界面の構築と樹脂上への金属パターン形成
福本ユリナ、谷山智紀、鶴岡孝章、縄舟秀美、赤松謙祐
エレクトロニクス実装学会誌 15 534 - 540 2012年
単著
-
Synthesis of Polystyrene-based Nanocomposite Thin Films with Domain Structure Consisting of Au Nano
T. Tsuruoka, S. Kumazaki, I. Osaka, H. Nawafune, K. Akamatsu
Journal of Physics 2012年
共著
-
Synthesis of Au Nanocrystals/Porous Coordination Polymer Composites by Preferential Self-Assembly of Frameworks
H. Kawasaki, M. Kumano, M. Yamashita, T. Tsuruoka, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn 37 181 - 184 2012年
共著
-
Monodispersed Molecularly Imprinted Polymer Beads with Enhanced Atranzine Retention Ability Synthesized with Polymeric Diluents
Tsuyoshi Nagata, Shou Goji, Kensuke Akamatsu, Hidemi Nawafune, Jun Matsui
Anal. Lett 9 572 - 578 2012年
共著
-
Mechanistic Study on Microstructural Tuning of Metal Nanoparticle/Polymer Composite Thin Layers: Hydrogenation and Decomposition of Polyimide Matrices Ctalyzed By Embedded Nickel Nanoparticles
K. Akamatsu, M. Fujii, T. Tsuruoka, S. Nakano, T. Murashima, H. Nawafune
J. Phys. Chem C.116 1794 - 1795 2012年
共著
-
In situ synthesis of composite nanowires consisting of metal nanoparticles in ion-exchangeable polymer matrix using porous alumina tenplates
Y. Fukumoto, T. Tsuruoka, T. Yangishita, H. Masuda, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn 37 185 - 188 2012年
共著
-
Enhancement of upconversion Iuminescence of Al2O3 : Er3+, Yb3+ thin films by small assemblies of Au nanorods
T.Nakano, M.Fujii, K. Imakita, S. Hayashi, T. Tsuruoka, K. Akamatsu
Trans. Mater. Res. Soc. Jpn 38 449 - 452 2012年
共著
-
Colorimetric Detection of Perfluorooctanoic Acid (PFOA)Utilizing Polystyrene-Modified Gold Nanoparticles
Megumi Takayose, Kensuke Akamatsu, HIdemi Nawafune, Takashi Murashima, Jun Matsui
Anal. Lett 18 2856 - 2864 2012年
共著
-
Phthalocyanines: A new class of G-quadruplex-ligands with many potential applications（共著） 査読あり
Yaku, H., Fujimoto, T., Murashima, T., Miyoshi, D., Sugimoto, N.
Chemical Communications 48 ( 50 ) 6203 - 6216 2012年
共著
-
Specific binding of anionic porphyrin and phthalocyanine to the G-quadruplex with a variety of in Vitro and in Vivo applications 査読あり
H. Yaku, T. Murashima, D. Miyoshi, N. Sugimoto
Molecules 17 10586 - 10613 2012年
共著
-
Mechanistic Study on Microstructural Tuning of Metal Nanoparticle/Polymer Composite Thin Layers:Hydrogenation and Decomposition of Polyimide Matrices Ctalyzed By Embedded Nickel Nanopoarticles 査読あり
K. Akamatsu, M. Fujii, T. Tsuruoka, S. Nakano, T. Murashima, H. Nawafune
J. Phys. Chem. C 2012年
共著
-
Synthesis of Polystyrene-based Nanocomposite Thin Films with Domain Structure Consisting if Au Nanoparticles 査読あり
T. Tsuruoka, S. Kumazaki, I. Osaka, H. Nawafune, K.Akamatsu
J. Physics 2012年
共著
-
ポリイミド樹脂/金属間におけるナノ構造界面の構造と樹脂上への金属パターン形成 査読あり
福本ユリナ、谷山智紀、鶴岡孝章、縄舟秀美、赤松謙祐
エレクトロニクス実装学会誌 15 534 - 540 2012年
共著
-
Charge Transfer and Exciplex Emissions from a Naphthalenediimide Entangled Coordination Framework accommodating Various Aromatic Guests 査読あり
Virginia Mart?nez-Mart?nez, Shuhei Furukawa, Yohei Takashima, I?igo L?pez Arbeloa, Susumu Kitagawa
J. Phys. Chem 116 26084 - 26090 2012年
共著
-
細胞内環境因子に応答する核酸デバイスの開発 招待あり
三好大輔
化学と工業（日本化学会） 64 ( 12 ) 956 - 956 2011年12月
単著
担当区分：筆頭著者
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Effects of protein binding on DNA G-quadruplex structures 招待あり
S. Nagatoishi, D. Miyoshi and N. Sugimoto
Int. Rev. Biophys. Chem. 2 129 - 134 2011年12月
共著
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Synthesis and Application of Functional Nucleic Acids 招待あり
Daisuke Miyoshi, Friedrich C. Simmel, Souvik Maiti, and Luis A. Marky
Journal of Nucleic Acids 2011 547245 2011年12月
共著
担当区分：筆頭著者
-
細胞内環境因子に応答する核酸デバイスの開発
三好大輔
化学と工業（日本化学会） 64 ( 12 ) 956 - 956 2011年12月
単著
-
Effect of Nickeｌ(II) ion on Copper Electrodeposition from Ethylenediamine Complex Bath
H. Arimura, T. Shigematsu, T. Tsuruoka, K. Akamatsu, H. Nawafune
Journal of The Surface Finishing Society of Japan 62 708 - 711 2011年12月
共著
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Effect of Nickel(Ⅱ）ion on Copper Electrodeposition from Ethylenediamine Complex Bath
H. Arimura, T. Shigematsu, T. Tsuruoka, K. Akamatsu
Journal of The Surface Finishing Society of Japan 62 708 - 711 2011年12月
共著
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Rational design of a new IMP aptamer based on a TPP riboswitch and a hypoxanthine aptamer 査読あり
Misato Tokui, Takahiro Yamauchi, Daisuke Miyoshi, Hisaya Kamiya, Akira Nishimura, Naoki Sugimoto
Chemistry Letters 40 ( 11 ) 1313 - 1314 2011年11月
共著
担当区分：筆頭著者
-
Measurements of the binding of a large protein using a substrate density-controlled DNA chip 査読あり
S. Nakano, T. Kanzaki, M. Nakano, D. Miyoshi, N. Sugimoto
Analytical Chemistry 83 6368 - 6372 2011年11月
共著
-
Structure-function relationship of a histidine dependent ribozyme
Y. Yamaguchi, Y. Ishibashi, S. Tanaka, A. Tanigawa, I. Matsunaga, and J. Kawakami
Proc. 38th Intl. Symp. Nucleic Acids Chemistry 194 - 195 2011年11月
共著
担当区分：筆頭著者
-
Cell fingerprint patterns using designed α-helical peptides to screen for cell-specific toxicity. 査読あり
Usui K, Kakiyama T, Tomizaki KY, Mie M, Kobatake E, Mihara H
Bioorganic & medicinal chemistry letters 21 ( 21 ) 6281 - 6284 2011年11月
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Triplet analysis that identifies unpaired regions of functional RNAs（共著） 査読あり
J. Kawakami, Y. Yamaguchi, and N. Sugimoto
Journal of Nucleic Acids 2011 doi:10.4061/2011/471843 2011年10月
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The effects of molecular crowding on the structure and stability of G-quadruplexes with an abasic site 招待あり 査読あり
T. Fujimoto, S. Nakano, D. Miyoshi, and N. Sugimoto
Journal of Nucleic Acids (Hindawl Publishing Corporation) 2011 ( 857149 ) 857149 2011年9月
共著
DOI： 10.4061/2011/857149
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A Novel Nitric Oxide Sensor Using Fluorescenct Peptides Attached to Iron Complexes
Hiroshi Miyazaki, Kenji Usui, Satoshi Fujii
Peptides: Building Bridges. Proceeding of the Twenty-Second American Peptide Symposium 224 - 225 2011年9月
共著
-
グラフェンを用いたバイオセンサー 招待あり
三好大輔、杉本直己
化学 66 ( 8 ) 30 - 35 2011年9月
共著
担当区分：筆頭著者
-
The effects of molecular crowding on the structure and stability of G-quadruplexes with an abasic site 査読あり
Takeshi Fujimoto, Shu Ichi Nakano, Daisuke Miyoshi, and Naoki Sugimoto
J. Nucleic Acids 2011 857149 2011年9月
共著
担当区分：筆頭著者
-
グラフェンを用いたバイオセンサー
三好大輔, 杉本直己
化学 66 ( 8 ) 30 - 35 2011年9月
共著
-
Fabrication of Silver Patterns on Polyimide Films Based on Solid-Phase Electrochemical Constructive Lithography Using Ion-Exchangeable Precursor Layers
K. Akamatsu, Y. Fukumoto, T. Taniyama, T. Tsuruoka, H. Yanagimoto, H. Nawafune
Langmuir 27 11761 - 11766 2011年9月
共著
-
Contlloed Self-Assembly of Metal-Organic Frameworks on Metal Nanoparticles for Efficient Synthesis of Hybrid Nanostructures
T. Tsuruoka, H. Kawasaki, H. Nawafune, K. Akamatsu
Contlloed Self-Assembly of Metal-Organic Frameworks on Metal Nanoparticles for Efficient Synthesis of Hybrid Nanostructures 3 3788 - 3791 2011年9月
共著
-
Contlloed Self-Assembly of Metaｌ-Organic Frameworks on Metal Nanoparticle for Efficient Synthesis of Hybrid Nanostructures 査読あり
T.Tsuruoka, H.Kawasaki, H. Nawafune, K. Akamatsu
ACS Appl. Mater. Interfaces 3 3788 - 3791 2011年9月
共著
-
Fabrication of Silver Patterns on Polyimide Films Based on Solid-Phase Electrochemical Constructive Lithography Using Ion-Exchangeable Precursor Layers
K. Akamatsu, Y. Fukumoto, T. Taniyama, T. Tsuruoka, H.Yanagimoto, H. Nawafune
Langmuir 27 11761 - 11766 2011年9月
共著
-
Measurements of the binding of a large protein using a substrate density-controlled DNA chip 査読あり
S. Nakano, T. Kanzaki, M. Nakano, D. Miyoshi, and N. Sugimoto
Anal. Chem. 83 ( 16 ) 6768 - 6372 2011年8月
-
Effect of locked nucleic acid modifications on the thermal stability of noncanonical DNA structure 査読あり
J. Bhattacharyya, S. Maiti, S. Muhuri, S. Nakano, D. Miyoshi, and N. Sugimoto
Biochemistry 50 ( 34 ) 7414 - 7425 2011年8月
共著
DOI： 10.1021/bi200477g
-
Label-free colorimetric and quantitative detection of cancer marker protein using noncrosslinking aggregation of Au/Ag nanoparticles induced by target-specific peptide probe 査読あり
Xiaohui Wang, Li Wu, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto, and Xiaogang Qu
Biosensors and Bioelectronics 26 4804 - 4809 2011年8月
共著
-
In situ generation of silver nanoparticles in ion-exchangeable polymer photonic crystals
T. Tsuruoka, S. Kumazaki, H. Nawafune, K. Akamatsu
Chem. Lett. 40 1233 - 1234 2011年8月
共著
-
In situ generation of silver nanoparticles in ion-exchangeable polymer photonic crystals 査読あり
T.Tsuruoka, S.Kumazaki, H. Nawafune, K. Akamatsu
Chem. Lett. 40 1233 - 1234 2011年8月
共著
-
Use of nucleic acid analogs for the study of nucleic acid interactions 招待あり 査読あり
S. Nakano, M. Fujii, and N. Sugimoto
Journal of Nucleic Acids 2011 ( 967098 ) 967098 2011年7月
共著
DOI： 10.4061/2011/967098
-
Monolayer-Functionalized CｄTe Nanocrystals with Controlled Fluorescent Properties Based on Chemical Surface Modification
T.Tsuruoka, M.Sugiyama, R.Takahashi, H. Nawafune, K.Akamatsu
Trans.Mater.Res.Soc.Jpn 36 183 - 186 2011年6月
共著
-
Cellular zwitterionic metabolite analogs simultaneously enhance reaction rate, thermostability, salt tolerance, and substrate specificity of alpha-glucosidase 査読あり
Eisuke Deguchi, Kazuya Koumoto
Bioorganic and Medicinal Chemistry 19 3128 - 3134 2011年4月
共著
担当区分：筆頭著者
天然の代謝産物を模倣し、化学的に合成した代謝産物アナログがα−グルコシダーゼ、β−グルコシダーゼ、アルカリフォスファターゼといった加水分解酵素の活性（反応速度、耐熱性、耐塩性、基質選択性等）を溶液に共存させるだけで向上させることを明らかとした。
-
Thermodynamic stability of Hoogsteen and Watson-Crick base pairs in the presence of histone H3-mimicking peptide 査読あり
S. Pramanik, K. Nakamura, K. Usui, S. Nakano, S. Saxena, J. Matsui, D. Miyoshi and N. Sugimoto
Chem. Commun. 47 ( 10 ) 2790 - 2792 2011年2月
共著
DOI： 10.1039/C0CC05776B
-
Thermodynamic Stability of Hoogsteen and Watson-Crick Base Pairs in the Presence of Histone H3-Mimicking Peptide 査読あり
Smritimoy Pramanik, Kaori Nakamura, Kenji Usui, Shu-ichi Nakano, Sarika Saxena, Jun Matsuia, Daisuke Miyoshi, Naoki Sugimoto
Chem. Commun. 47 2790 - 2792 2011年2月
共著
担当区分：筆頭著者
-
Biodegradable Nano-aggregates of Star-Shaped 8-arm PEG-PLLA Block Co-polymers for Encapsulation of Water-Soluble Macromolecules 査読あり
K. Nagahama, T. Saito, T. Ouchi, Y. Ohya
Journal of Biomaterials Science, Polymer Edition 22 407 2011年1月
共著
担当区分：筆頭著者
-
Thermodynamic Stability of Hoogsteen and Watson-Crick Base Pairs in the Presence of Histone H3-Mimicking Peptide 査読あり
Smritimoy Pramanik, Kaori Nakamura, Kenji Usui, Shu-ichi Nakano, Sarika Saxena, Jun Matsui, Daisuke Miyoshi, Naoki Sugimoto
Chemical Communications 2011年
共著
-
Direct Detection of Thrombin Binding to 8-Bromodeoxyguanosine-Modified Aptamer: Effects of Modification on Affinity and Kinetics 査読あり
S. Goji, J. Matsui
Journal of Nucleic Acids 2011年
共著
担当区分：筆頭著者
-
Monolayer-Functionalized CdTe Nanocrystals with Controlled Fluorescent Properties Based on Chemical Surface Modification
T. Tsuruoka, M. Sugiyama, R. Takahashi, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn 36 183 - 186 2011年
共著
-
Synthesis of Au Nanocrystals/Porous Coordination Polymer Compoosites by Preferential Self-Assembly of Frameworks
H. Kawasaki, M. Kumano, M. Yamashita, T. Tsuruoka, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn. 37 181 - 184 2011年
共著
-
In situ synthesis of comosite nanowires consisting of metal nanoparticles in ion-exchangeable polymer matrix using porous alumina tenplates
Y. Fukumoto, T. Tsuruoka, T.Yanagishita, H. Masuda, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn. 37 185 - 188 2011年
共著
-
Contlloed Self-Assembly of Metal-Organic Frameworks on Metal Nanoparticles for Efficient Synthesis of Hybrid Nanostructures
T. Tsuruoka, H. Kawasaki, H. Nawafune, K. Akamatsu
ACS Appl. Mater. Interfaces 3 3788 - 3791 2011年
共著
-
Morphology Design of Porous Coordination Polymer Crystals by Coordination Modulation
A. Umemura, S. Diring, S. Furukawa, H. Uehara, T. Tsuruoka, S. Kitagawa
J. Am.Chem.Soc 133 15506 - 15513 2011年
共著
-
Monolayer-Functionalized CdTe Nanocrystals with Controlled Fluorescent Properties Based on Chemical Surface Modification
T. Tsuruoka, M. Sugiyama, R. Takahashi, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn 36 183 - 186 2011年
共著
-
In situ generation of silver nanoparticles in ion-exchangeable polymer photonic crystals
T. Tsuruoka, S. Kumazaki, H. Nawafune, K. Akamatsu
Chem. Lett 40 1233 - 1234 2011年
共著
-
Fabrication of Silver Patterns on Polyimide Films Based on Solid-Phase Electrochemical Constructive Lithography Using Ion-Exchangeable Precursor Layers
K. Akamatsu, Y. Fukumoto, T. Taniyama, T. Tsuruoka, H. Yanagimoto, H. Nawafune
Langmuir 27 11761 - 11766 2011年
共著
-
Effect of Nickeｌ(II) ion on Copper Electrodeposition from Ethylenediamine Complex Bath
H. Arimura, T. Shigematsu, T. Tsuruoka, K. Akamatsu, H. Nawafune
Journal of The Surface Finishing Society of Japan 62 708 - 711 2011年
共著
-
Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone - A conformationally constrained PNA with unusual hybridization properties
C. Vilaivan, C. Srisuwannaket, C. Ananthanawat, C. Suparpprom, J. Kawakami, Y. Yamaguchi, Y. Tanaka, T. Vilaivan
Artificial DNA: PNA & XNA 2 11 2011年
-
Thermodynamic stability of Hoogsteen and Watson-Crick base pairs in the presence of histone H3-mimicking peptide 査読あり 国際共著
Smritimoy Pramanik, Kaori Nakamura, Kenji Usui, Shu-ichi Nakano, Sarika Saxena, Jun Matsui, Daisuke Miyoshi, Naoki Sugimoto
CHEMICAL COMMUNICATIONS 47 ( 10 ) 2790 - 2792 2011年
出版者・発行元：ROYAL SOC CHEMISTRY
We found that Hoogsteen base pairs were stabilized by molecular crowding and a histone H3-mimicking peptide, which was not observed for Watson-Crick base pairs. Our findings demonstrate that the type of DNA base pair is critical for the interaction between DNA and histones.
DOI： 10.1039/c0cc05776b
-
Use of a designed peptide library to screen for binders to a particular DNA G-quadruplex sequence 査読あり
Keita Kobayashi, Noriko Matsui, Kenji Usui
Journal of Nucleic Acids 2011 572873 2011年
We demonstrated a method to screen for binders to a particular G-quadruplex sequence using easily designed short peptides consisting of naturally occurring amino acids and mining of binding data using statistical methods such as hierarchical clustering analysis (HCA). Despite the small size of the library used in this study, candidates of specific binders were identified. In addition, a selected peptide stabilized the G-quadruplex structure of a DNA oligonucleotide derived from the promoter region of the protooncogene c-MYC. This study illustrates how a peptide library can be designed and presents a screening guideline for construction of G-quadruplex binders. Such G-quadruplex peptide binders could be functionally modified to enable switching, cellular penetration, and organelle-targeting for cell and tissue engineering. © 2011 Keita Kobayashi et al.
DOI： 10.4061/2011/572873
-
PNA-Peptide Conjugates for Regulation of DNA and RNA G-Quadruplex Structures Depending on a Particular Protease Concentration 査読あり
Kenji Usui, Keita Kobayashi, Naoki Sugimoto
Peptides 2010 2010 608 - 609 2011年
共著
担当区分：筆頭著者
-
Nanomolar aggregation of amyloid-beta peptides covalently and site-specifically modified by cholesterol oxidation products 査読あり 国際共著
Kenji Usui, Evan T. Powers, Johan F. Paulsson, Sarah J. Siegel & Jeffery W. Kelly
Peptides 2008 2008 588 - 589 2011年
共著
担当区分：筆頭著者
-
Fluorescent and Luminescent Fusion Proteins for Detection of Amyloid Beta Peptide Localization and Aggregation 査読あり
Kenji Usui, Masayasu Mie, Takashi Andou, Naoki Sugimoto, Hisakazu Mihara, Eiry Kobatake
Peptides 2010 2010 488 - 489 2011年
共著
担当区分：筆頭著者
-
Designed Peptide Libraries for Protein and Cell analyses 査読あり
K. Kikuchi, K. Usui, K.-Y. Tomizaki, T. Takahashi, H. Mihara
Peptide Science 2010 2010 21 - 21 2011年
共著
-
A Novel Nitric Oxide Sensor Using Fluorescent Peptides Attached to Iron Complexes 査読あり
Hiroshi Miyazaki, Kenji Usui, Satoshi Fujii
Peptides 2011 2011 224 - 255 2011年
共著
-
A PNA Peptide Inducing DNAs to Form G-Quadruplex Structures Depending on a Protease Activity 査読あり
Kenji Usui, Keita Kobayashi, Naoki Sugimoto
Peptides 2011 2011 152 - 153 2011年
共著
担当区分：筆頭著者
-
Nanomolar Aggregation and Neurotoxicity of Amyloid beta Peptides with Site-Specific Modification of Oxidized Cholesterol 査読あり 国際共著
K. Usui, J. D. Hulleman, J. F. Paulsson, S. J. Siegel, E. T. Powers, J. W. Kelly
Peptide Science 2010 2010 169 - 169 2011年
共著
担当区分：筆頭著者
-
Synthesis of Au Nanocrystals/Porous Coordination Polymer Compoosites by Perferential Self-Assembly of Frameworks 査読あり
H. Kawasaki, M. Kumano, M. Yamashita, T. Tsuruoka, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn. 37 181 - 184 2011年
共著
-
In situ synthesis of comosite nanowires consisting of metal nanoparticles in ion-exchangeable polymer matrix using porous alumina tenplates
Y. Fukumoto, T. Tsuruoka, T.Yanagishita, H. Masuda, H. Nawafune, K. Akamatsu
Trans. Mater. Res. Soc. Jpn. 37 185 - 188 2011年
共著
-
Molecular Decoding using Luminescence from an Entangled Porous Framework 査読あり
Yohei Takashima, Virginia Mart?nez Mart?nez, Shuhei Furukawa, Mio Kondo, Satoru Shimomura, Hiromitsu Uehara, Masashi Nakahama, Kunihisa Sugimoto, Susumu Kitagawa
Nature Commun 2 168 - 168 2011年
共著
-
Thermodynamically controlled coordination-engineering of novel 2D cadmium thiolate coordination polymers 査読あり
Nicolas Louvain, Yohei Takashima, Susumu Kitagawa, Shuhei Furukawa
New J. Chem. 35 1265 - 1269 2011年
共著
-
Control of the Charge-Transfer Interaction between a Flexible Porous Coordination Host and Aromatic Guests by Framework Isomerism 査読あり
Yohei Takashima, Shuhei Furukawa, Susumu Kitagawa
CrystEngComm 13 3360 - 3363 2011年
共著
-
Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes 査読あり
Xiaohui Wang, Chunyan Wang, Konggang Qu, Yujun Song, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto, and Xiaogang Qu
Advanced Functional Materials 20 3967 - 3971 2010年12月
共著
-
Comparative thermodynamic analysis of RNA-protein interaction on surface and in solution（共著）
Y. Tanaka, K. Ishidate, K. Kishimoto, N. Sugimoto, and J. Kawakami
Proc. 37th Intl. Symp. Nucleic Acids Chemistry 276 - 277 2010年11月
共著
担当区分：筆頭著者
-
A rapid and sensitive "add-mix-measure" assay for multiple proteinases based on one goldnanoparticle-peptide-fluorophore conjugate 査読あり
X.Wang, J.Geng, D.Miyoshi, J.Ren, N.Sugimoto, and X.Qu
Biosens. Bioelectron. 26 743 - 747 2010年11月
共著
-
Stacking interaction in the middle and at the end of a DNA helix studied with non-natural nucleotides 査読あり
S. Nakano, H. Oka, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Mol. BioSyst. 6 2023 - 2029 2010年10月
共著
DOI： 10.1039/C0MB00002G
-
Sole and stable RNA duplexes of G-rich sequences located in the 5'-untranslated region of protooncogenes 査読あり
Sarika Saxena, Daisuke Miyoshi, Naoki Sugimoto
Biochemistry 49 7190 - 7201 2010年9月
共著
担当区分：筆頭著者
-
Development of new functional nanostructures consisting of both DNA duplex and quadruplex 査読あり
Kakoli Dutta, Takeshi Fujimoto, Mamiko Inoue, Daisuke Miyoshi, and Naoki Sugimoto
Chem. Commun 46 7772 - 7774 2010年9月
共著
担当区分：筆頭著者
-
Controlled Multiscale Synthesis of Porous Coordination Polymer in Nano/Micro Regimes
Diring Stephane, Furukawa Shuhei, Takashima Yohei, Tsuruoka Takaaki, Kitagawa Susumu
CHEMISTRY OF MATERIALS 22 ( 16 ) 4531 - 4538 2010年8月
共著
DOI： 10.1021/cm101778g
-
Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes 査読あり
Yaku, H., Murashima, T., Miyoshi, D., Sugimoto, N.
Chemical Communications 46 ( 31 ) 5740 - 5742 2010年8月
共著
-
Anionic Phthalocyanines Targeting G-quadruplexes and Inhibiting Telomerase Activity in the Presence of Excessive DNA Duplexes 査読あり
Hidenobu Yaku, Takashi Murashima, Daisuke Miyoshi, Naoki Sugimoto
Chem. Commun 46 5740 - 5742 2010年8月
共著
担当区分：筆頭著者
-
“生きたバイオマテリアル”としての機能性細胞 招待あり 査読あり
長濱宏治
バイオマテリアル 28 193 2010年8月
単著
担当区分：筆頭著者
-
Monomorphic RNA G-quadruplex and polymorphic DNA G-quadruplex structures responding to cellular environmental factors 査読あり
Dong-Hao Zhang, Takeshi Fujimoto, Sarika Saxena, Hai-Qing Yu, Daisuke Miyoshi, and Naoki Sugimoto
Biochemisry 49 4554 - 4563 2010年7月
共著
担当区分：筆頭著者
-
Preparation of Nanoaggregates through Self-assembly of Amphiphilic Polyrotaxane Composed of PLLA–PEG–PLLA Triblock Copolymer and α-Cyclodextrins 査読あり
Koji Nagahama, Junpei Ohmura, Hiromi Sakaue, Tatsuro Ouchi, Yuichi Ohya and Nobuhiko Yui
Chemistry Letters 39 250 2010年4月
共著
担当区分：筆頭著者
-
Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3.
Ando M, Uehara I, Kogure K, Asano Y, Nakajima W, Abe Y, Kawauchi K, Tanaka N
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 77 ( 2 ) 97 - 105 2010年4月
共著
-
Utilization of salmon milt DNA against UV damage 査読あり
Yoshiharu Sasaki, Daisuke Miyoshi, and Naoki Sugimoto
Applied Biochem. Biotech. 160 2458 - 2466 2010年2月
共著
-
Upstream regulatory sequences required for specific gene expression in the ascidian neural tube. 査読あり
Shimai K, Kitaura Y, Tamari Y, Nishikata T
Zoological science 27 ( 2 ) 76 - 83 2010年2月
-
The molecular mechanism of glucose metabolism hampered by p53 tumor suppressor protein.
Kawauchi K
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 77 ( 1 ) 48 - 49 2010年2月
単著
-
Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH 査読あり
A. Rajendran, S. Nakano, and N. Sugimoto
Chem. Commun. 46 1299 - 1301 2010年1月
共著
DOI： 10.1039/B922050J
-
The upstream regulatory sequences required for specific gene expression in the ascidian neural tube. 査読あり
Shimai K., Kitaura Y., Tamari Y., and Nishikata T.
Zoological Science 27 76 - 83 2010年
共著
-
Fabrication of copper damascene patterns on polyimide using direct metallization of trench templates generated by imprint lithography
T. Matsumura, Y. Enomoto, T. Tsuruoka, K. Akamatsu, H. Nawafune
Langmuir 26 12448 2010年
共著
-
Synthesis of pH-responsive nanocomposite microgels with size-controlled gold nanoparticles from ion-doped, lightly cross-linked poly(vinylpyridine)
K. Akamatsu, M. Shimada, T. Tsuruoka, H. Nawafune, S. Fujii, Y. Nakamura
Langmuir 26 1254 2010年
共著
-
Synthesis and characterization of polypyrrole-palladium nanocomposite-coated latex particles and their use as a catalyst for Suzuki coupling reaction in aqueous media
S. Fujii, S. Matsuzawa, Y. Nakamura, A. Ohtaka, T. Teratani, K. Akamatsu, T, Tsuruoka, H. Nawafune
Langmuir 26 6230 2010年
共著
-
Facile one-step route to polyaniline-silver nanocomposite particles and their application as a colored particulate emulsifier
S. Fujii, Y. Nishimura, A. Aichi, S. Matsuzawa, Y. Nakamura, K. Akamatsu, H. Nawafune
Synthetic Metals 160 1322 2010年
共著
-
Electron Magnetic Resonance in Interacting Ferromagnetic-Metal Nanoparticle Systems: Experiment and Numerical Simulation
C. Mitsumata, S. Tomita, S. Hagiwara, and K. Akamatsu
J. Phys. Cond. Mater. 22 ( 016005 ) 2010年
共著
-
Controlled Multiscale Synthesis of Porous Coordination Polymer in Nano/Micro Regimes
S. Diring, S. Furukawa, Y. Takashima, T. Tsuruoka, S. Kitagawa
Chem. Mater 22 4531 - 4538 2010年
共著
-
「光化学還元法によるガラス基板上への銅のダイレクトパターニング」
有村英俊、中道良太、木村明寛、鶴岡孝章、赤松謙祐、縄舟秀美
エレクトロニクス実装学会誌 13 46 - 51 2010年
単著
-
Synthesis of pH-responsive nanocomposite microgels with size-controlled gold nanoparticles from ion-doped, lightly cross-linked poly(vinylpyridine)
K. Akamatsu, M. Shimada, T. Tsuruoka, H. Nawafune, S. Fujii, Y. Nakamura
Langmuir 26 1254 - 1259 2010年
共著
-
Synthesis and characterization of polypyrrole-palladium nanocomposite-coated latex particles and their use as a catalyst for Suzuki coupling reaction in aqueous media
S. Fujii, S. Matsuzawa, Y. Nakamura, A. Ohtaka, T. Teratani, K. Akamatsu, T, Tsuruoka, H. Nawafune
Langmuir 26 6230 - 6230 2010年
共著
-
Facile one-step route to polyaniline-silver nanocomposite particles and their application as a colored particulate emulsifier
S. Fujii, Y. Nishimura, A. Aichi, S. Matsuzawa, Y. Nakamura, K. Akamatsu, H. Nawafune
Synthetic Metals 160 1322 - 1322 2010年
共著
-
Fabrication of copper damascene patterns on polyimide using direct metallization of trench templates generated by imprint lithography
Y. Matsumura, Y. Enomoto, T. Tsuruoka, K. Akamatsu, H. Nawafune
Langmuir 26 12448 - 12454 2010年
共著
-
Electron Magnetic Resonance in Interacting Ferromagnetic-Metal Nanoparticle Systems: Experiment and Numerical Simulation
C. Mitsumata, S. Tomita, S. Hagiwara, and K. Akamatsu
J. Phys. Cond. Mater 22 016005 - 016005 2010年
共著
-
Construction of Detection System for Amyloid beta Peptide Localization and Aggregation Using Fluorescent and Luminescent Fusion Proteins 査読あり
Kenji Usui, Masayasu Mie, Takashi Andou, Naoki Sugimoto, Hisakazu Mihara, Eiry Kobatake
Peptide Science 2009 2009 111 - 112 2010年
共著
担当区分：筆頭著者
-
Controlled Multiscale Synthesis of Porous Coordination Polymer in Nano/Micro Regimes 査読あり
S. Diring, S. Furukawa, Y. Takashima, T. Tsuruoka, S. Kitagawa
Chem. Mater. 22 4531 - 4538 2010年
共著
-
光化学還元法によるガラス基板上への銅のダイレクトパターニング
有村英俊、中道良太、木村明寛、鶴岡孝章、赤松謙祐、縄舟秀美
エレクトロニクス実装学会誌 13 46 - 51 2010年
共著
-
Synthesis of pH-Responsive Nanocomposite Microgels with Size-Controlled Gold Nanoparticles from Ion-Doped, Lightly Cross-Linked Poly(vinylpyridine) 査読あり
K. Akamatsu, M. Shimada, T. Tsuruoka, H. Nawafune, S. Fujii, Y. Nakamura
Langmuir 26 1254 - 1259 2010年
共著
-
Synthesis and Characterization of Polypyrrole-Palladium Nanocomposite-coated Latex Particles and Their Use as a Catalyst for Suzuki Coupling Reaction in Aqueous Media 査読あり
S. Fujii, S. Matsuzawa, Y. Nakamura, A. Ohtaka, T. Teratani, K. Akamatsu, T. Tsuruoka, H. Nawafune
Langmuir 26 6230 - 6239 2010年
共著
-
Fabrication of Copper Damascene Patterns on Polyimide Using Direct Metallization on Trench Templates Generated by Imprint Lithography 査読あり
Y. Matsumura, Y. Enomoto, T. Tsuruoka, K. Akamatsu, H. Nawafune
Langmuir 26 12448 - 12454 2010年
共著
-
Periodic Molecular Boxes in Entangled Enantiomorphic lcy Nets 査読あり
Yohei Takashima, Charlotte Bonneau, Shuhei Furukawa, Mio Kondo, Ryotaro Matsuda, Susumu Kitagawa
Chem. Commun 46 4142 - 4144 2010年
共著
-
Controlled Multiscale Synthesis of Porous Coordination Polymers in Nano/Micro Regimes 査読あり
St?phane Diring, Shuhei Furukawa, Yohei Takashima, Takaaki Tsuruoka, Susumu Kitagawa
Chem. Mater. 22 4531 - 4538 2010年
共著
-
Control over the Nucleation Process determines the Framework Topology of Porous Coordination Polymers 査読あり
Mio Kondo, Yohei Takashima, Joobeom Seo, Susumu Kitagawa, Shuhei Furukawa
CrystEngComm 12 2350 - 2353 2010年
共著
-
Stabilization of Three-Way Junctions of DNA under Molecular Crowding Conditions 査読あり
Sanjukta Muhuri, Kenta Mimura, Daisuke Miyoshi, and Naoki Sugimoto
J. Am. Chem. Soc. 131 9268 - 9280 2009年12月
共著
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Neuronal differentiation of neural progenitor cells by intracellular delivery of synthetic oligopeptide derived from von Hippel-Lindau protein 査読あり
H. Kanno, S. Nakano, A. Kubo, T. Mimura, N. Tajima, and N. Sugimoto
Protein & Peptide Letters 16 1291 - 1296 2009年12月
共著
-
Dynamics and energetics of the base flipping conformation studied with base pair-mimic nucleosides 査読あり
S. Nakano, H. Oka, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Biochemistry 48 11304 - 11311 2009年12月
共著
DOI： 10.1021/bi901496q
-
Face-to-face porphyrin moieties assembled with spacing for pyrazine recognition in molecularly imprinted polymers 査読あり
Matsui, J., Sodeyama, T., Saiki, Y., Miyazawa, T., Yamada, T., Tamaki, K., Murashima, T.
Biosensors and Bioelectronics 25 ( 3 ) 635 - 639 2009年11月
共著
-
Hydration of Watson-Crick base pairs and dehydration of Hoogsteen base pairs inducing structural polymorphism under molecular crowding conditions
三好大輔
J. Am. Chem. Soc. ( 131 ) 3522 - 3531 2009年11月
単著
-
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity 査読あり 国際共著
Kenji Usui, John D. Hulleman, Johan F. Paulsson, Sarah J. Siegel, Evan T. Powers, Jeffery W. Kelly
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 ( 44 ) 18563 - 18568 2009年11月
出版者・発行元：NATL ACAD SCIENCES
Accumulation of amyloid beta-peptide (A beta) and tau aggregates, possibly linked to age-associated deficiencies in protein homeostasis, appear to cause Alzheimer's disease. Schiff-base formation between A beta and the aldehyde-bearing cholesterol oxidation product 3-beta-hydroxy-5-oxo-5,6-secocholestan-6-al is known to increase A beta amyloidogenicity. Here, we synthesized A beta variants site-specifically modified with the cholesterol aldehyde at Asp-1, Lys-16, or Lys-28, rather than studying mixtures. These distinct modifications have a similar effect on the thermodynamic propensity for aggregation, enabling aggregation at low concentrations. In contrast, the modification site differentially influences the aggregation kinetics; Lys-16-modified A beta formed amorphous aggregates fastest and at the lowest concentration (within 2 h at a concentration of 20 nM), followed by the Lys-28 and Asp-1 conjugates. Also, the aggregates resulting from A beta Lys-16 cholesterol aldehyde conjugation were more toxic to primary rat cortical neurons than treatment with unmodified A beta under identical conditions and at the same concentration. Our results show that A beta modification by cholesterol derivatives, especially at Lys-16, renders it kinetically and thermodynamically competent to form neurotoxic aggregates at concentrations approaching the physiologic concentration of A beta.
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Facilitation of RNA enzyme activity in the molecular crowding media of cosolutes 査読あり
S. Nakano, H. T. Karimata, Y. Kitagawa, and N. Sugimoto
J. Am. Chem. Soc. 131 16881 - 16888 2009年10月
共著
DOI： 10.1021/ja9066628
-
Biodegradable poly(l-lactide)-grafted α-cyclodextrin copolymer displaying specific dye absorption by host-guest interact 査読あり
Koji Nagahama, Keiko Shimizu, Tatsuro Ouchi, Yuichi Ohya
Reactive and Functional Polymers 69 891 2009年10月
共著
担当区分：筆頭著者
-
Thermo-Sensitive Sol-Gel Transition of Poly(depsipeptide-co-lactide)-g-PEG Copolymers in Aqueous Solution 査読あり
Koji Nagahama, Yuichiro Imai, Teppei Nakayama, Junpei Ohmura, Tatsuro Ouchi, Yuichi Ohya
Polymer 50 3547 2009年10月
共著
担当区分：筆頭著者
-
Polyrotaxane Composed of Poly-L-Lactide and α-Cyclodextrin Exhibiting Protease-Triggered Hydrolysis 査読あり
Yuichi Ohya, Seigo Takamido, Koji Nagahama, Tatsuro Ouchi, Ryo Katoono, Nobuhiko Yui
Biomacromolecules 10 2261 2009年10月
共著
-
Accurate curve fitting procedure for UV melting analysis of highly thermostable RNA hairpins（共著）
J. Kawakami, Y. Tanaka, and K. Kishimoto
Nucleic Acids Symp. Ser. 53 227 - 228 2009年9月
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Thermal stability and hydration state of DNA G-quadruplex regulated by loop regions
T. Fujimoto, D. Miyoshi, H. Tateishi-Karimata, and N. Sugimoto
Nucleic Acids Symp Ser (Oxf) 53 237 - 238 2009年9月
共著
担当区分：筆頭著者
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DNA junction structure stabilized by molecular crowding conditions
D. Miyoshi, S. Muhuri, K. Mimura, and N. Sugimoto
Nucleic Acids Symp Ser (Oxf) 53 59 - 60 2009年9月
共著
担当区分：筆頭著者
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DNA junction structure stabilized by molecular crowding conditions
D. Miyoshi, S. Muhuri, K. Mimura, N. Sugimoto
Nucleic Acids Symp Ser (Oxf) 53 59 - 60 2009年9月
共著
-
Investigations of the cation binding to nucleotides by monitoring the hairpin-duplex equilibrium of a self-complementary sequence
S. Nakano, H. Hirayama, and N. Sugimoto
Nucleic Acids Symp. Ser. 53 229 - 230 2009年9月
共著
-
Porous Coordination Polymer with Pyridinium Cationic Surface, [Zn-2(tpa)(2)(Cpb)]
Higuchi Masakazu, Tanaka Daisuke, Horike Satoshi, Sakamoto Hirotoshi, Nakamura Kohei, Takashima Yohei, Hijikata Yuh, Yanai Nobuhiro, Kim Jungeun, Kato Kenichi, Kubota Yoshiki, Takata Masaki, Kitagawa Susumu
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131 ( 30 ) 10336 - + 2009年8月
共著
DOI： 10.1021/ja900373v
-
Hydrophobically Modified Biodegradable Poly(ethylene glycol) Copolymers that Form Temperature-Responsive Nanogels 査読あり
Koji Nagahama, Mihoko Hashizume, Hidetoshi Yamamoto, Tatsuro Ouchi, Yuichi Ohya
Langmuir 25 9734 2009年8月
共著
担当区分：筆頭著者
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Biodegradable Shape-Memory Polymers Exhibiting Sharp Thermal Transitions and Controlled Drug Release 査読あり
Koji Nagahama, Yuichi Ueda, Tatsuro Ouchi, Yuichi Ohya
Biomacromolecules 10 1789 2009年8月
共著
担当区分：筆頭著者
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“Geometric and electronic structure differences between the type 3 copper sites of the multicopper oxidases and hemocyanin/tyrosinase” 査読あり
Jungjoo Yoon, Satoshi Fujii, Edward I. Solomon
Proc. Natl. Acad. Sci. USA 106 ( 16 ) 6585 - 6590 2009年4月
共著
-
Reversible stability switching of a hairpin DNA via a photo-responsive linker unit 招待あり 査読あり
Li Wu, Kazuya Koumoto, Naoki Sugimoto
Chemical Communications 1915 - 1917 2009年4月
共著
ヘアピンDNAのループ部位に導入し、光異性化によってヘアピンDNA全体の安定性を制御できる新規光応答性ユニットの開発に成功した。このユニットをヘアピン部位に導入したDNAは紫外光、可視光の照射に伴って安定性が可逆的に制御することができた。
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Nuclease Resistant Methylphosphonate-DNA/LNA Chimeric Oligonucleotides 査読あり
Koji Nagahama, Rakesh Veedu, Jesper Wengel
Bioorganic and Medicinal Chemistry Letters 19 2707 2009年3月
共著
担当区分：筆頭著者
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Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification.
Kawauchi K, Araki K, Tobiume K, Tanaka N
Proceedings of the National Academy of Sciences of the United States of America 106 ( 9 ) 3431 - 3436 2009年3月
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Effects of Polydepsipeptide Side-Chain Groups on the Temperature Sensitivity of Triblock Copolymers Composed of Polydepsipeptides and Poly(ethylene glycol) 査読あり
Yuichi Ohya, Hidetoshi Yamamoto, Koji Nagahama, Tatsuro Ouchi
Journal of Polymer Science, Part A: Polymer Chemistry 47 3892 2009年2月
共著
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DNAは細胞内で三重らせん・四重らせん構造を形成しているのか？ 招待あり
三好大輔、杉本直己
化学と生物 7 449 - 451 2009年1月
共著
-
Cu(II) ion inhibits early stages of amyloid β fibril formation in vitro
T. Fujimoto, D. Miyoshi, H. Tateishi-Karimata, and N. Sugimoto
J. Biol. Inorg. Chem., Suppl. 1 S118 2009年1月
共著
-
An Approach to Peptide-based ATP Receptors by a Combination of Random Selection, Rational Design, and Molecular Imprinting 査読あり
J. Matsui, J. Nagano, D. Miyoshi, K. Tamaki, N. Sugimoto
Biosens. Bioelectron. 25 563 - 567 2009年1月
共著
-
Cu(II) ion inhibits early stages of amyloid β fibril formation in vitro
T. Fujimoto, D. Miyoshi, H. Tateishi-Karimata, N. Sugimoto
J. Biol. Inorg. Chem., Suppl. 1 S118 2009年1月
共著
-
DNAは細胞内で三重らせん・四重らせん構造を形成しているのか？
三好大輔, 杉本直己
化学と生物 7 449 - 451 2009年1月
共著
-
Molecularly Imprinted Nanocomposites for Highly Sensitive SPR Detection of a Non-aqueous Atrazine Sample 査読あり
J. Matsui, M. Takayose, K. Akamatsu, H. Nawafune, K. Tamaki, N. Sugimoto
Analyst 2009年
共著
担当区分：筆頭著者
-
Face-to-face Porphyrin Moieties Assembled with Spacing for Pyrazine Recognition in Molecularly Imprinted Polymers 査読あり
J. Matsui, T. Sodeyama, Y. Saiki, T. Miyazawa, T. Yamada, K. Tamaki, T. Murashima
Biosensors and Bioelectronics 2009年
共著
担当区分：筆頭著者
-
An Approach to Peptide-based ATP Receptors by a Combination of Random Selection, Rational Design, and Molecular Imprinting 査読あり
J. Matsui, J. Nagano, D. Miyoshi, K. Tamaki, N. Sugimoto
Biosensors and Bioelectronics 2009年
共著
担当区分：筆頭著者
-
ホヤ卵形成過程における付属細胞と卵母細胞との関わり
島井光太郎,石井宏和,西方敬人
甲南大学理工学部紀要 56 31 - 41 2009年
共著
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ベンゾトリアゾール誘導体のマイクロコンタクトプリンティングを利用するULSI銅微細配線の形成
有村英俊、尾山祐斗、鶴岡孝章、赤松謙祐、縄舟秀美
表面技術 60 598 - 602 2009年
共著
-
Enhancement of photoluminescence from silicon nanocrystals by metal nanostructures made by nanosphere lithography
Y. Mochizuki, M. Fujii, S. Hayashi, T. Tsuruoka, K. Akamatsu
J. Appl. Phys. 106 013517 2009年
共著
-
Site-selective direct nickel metallization on precursor polyimide using microcontact printing
Y. Matsumura, Y. Enomoto, K. Akamatsu, H. Nawafune
J. Surf, Finish, Soc. Jpn. 60 61 - 62 2009年
共著
-
Molecularly imprinted nanocomposites for highly sensitive SPR detection of an non-aqueous atrazine sample
J. Matui, M. Takayose, K. Akamatsu, H. Nawafune, K. Tamaki, K. Sugimoto
Analyst 134 80 - 86 2009年
共著
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A designed peptide chip: Protein fingerprinting technology with a dry peptide array and statistical data mining 査読あり
Kenji Usui, Kin-Ya Tomizaki, Hisakazu Mihara
Methods in Molecular Biology 570 273 - 284 2009年
There has recently been increased interest in the potential for microarray technologies to study protein networks in a whole cell system within a single experiment. Protein-detecting microarrays are composed of numerous agents immobilized within a tiny area on solid surfaces to capture targeted proteins and to detect interactions in a high-throughput fashion. In this chapter, in order to extend the usability of peptide microarrays, we describe a novel dry peptide microarray format to obtain protein fingerprint (PFP) data sets and a statistical PFP data manipulation technique to quantitatively analyze targeted proteins. © 2009 Humana Press, a part of Springer Science+Business Media, LLC.
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Nanoporous Nanorods Fabricated by Coordination Modulation and Oriented Attachment Growth 査読あり
T. Tsuruoka, S. Furukawa, Y. Takashima, K. Yoshida, S. Isoda, S. Kitagawa
Angew. Chem. Int. Ed. 48 4739 - 4743 2009年
共著
印刷中
-
Heterogeneously Hybridized Porous Coordination Polymer Crystals: Fabrication of Heterometallic Core–Shell Single Crystals with an In-Plane Rotational Epitaxial Relationship 査読あり
S. Furukawa, K. Hirai, K. Nakagawa, Y. Takashima, R. Matsuda, T. Tsuruoka, M. Kondo, R. Haruki, D. Tanaka, H. Sakamoto, S. Shimomura, O. Sakata, S. Kitagawa
Angew. Chem. Int. Ed. 48 1766 - 1770 2009年
共著
-
A Block PCP Crystal: Anisotropic Hybridization of Porous Coordination Polymers by Face-Selective Epitaxial Growth 査読あり
S. Furukawa, K. Hirai, Y. Takashima, K. Nakagawa, M. Kondo, T. Tsuruoka, O. Sakata, S. Kitagawa
Chem. Commun. 5097 - 5099 2009年
共著
-
ベンゾトリアゾール誘導体のマイクロコンタクトプリンティングを利用するULSI銅微細配線の形成 査読あり
有村英俊、尾山祐斗、鶴岡孝章、赤松謙祐、縄舟秀美
表面技術 60 598 - 602 2009年
共著
-
Enhancement of Photoluminescence from silicon nanocrystals by metal nanostructures made by nanosphere lithography 査読あり
Y. Mochizuki, M. Fujii, S. Hayashi, T. Tsuruoka, K. Akamatsu
J. Appl. Phys. 106 013517 2009年
共著
-
Heterogeneously Hybridized Porous Coordination Polymer Crystals: Fabrication of Heterometallic Core-Shell Single Crystals with an In-Plane Rotational Epitaxial Relationship 査読あり
Shuhei Furukawa, Kenji Hirai, Keiji Nakagawa, Yohei Takashima, Ryotaro Matsuda, Takaaki Tsuruoka, Mio Kondo, Rie Haruki, Daisuke Tanaka, Hirotoshi Sakamoto, Satoru Shimomura, Osami Sakata and Susumu Kitagawa
Angew. Chem. Int. Ed 48 1766 - 1770 2009年
共著
-
A Block PCP Crystal: Anisotropic Hybridization of Porous Coordination Polymers by Face-Selective Epitaxial Growth 査読あり
Shuhei Furukawa, Kenji Hirai, Yohei Takashima, Keiji Nakagawa, Mio Kondo, Takaaki Tsuruoka, Osami Sakata, Susumu Kitagawa
Chem. Commun 5097 - 5099 2009年
共著
-
Porous Coordination Polymer with Pyridinium Cationic Surface, [Zn2(tpa)2(cpb)] 査読あり
Masakazu Higuchi, Daisuke Tanaka, Satoshi Horike, Hirotoshi Sakamoto, Kohei Nakamura, Yohei Takashima, Yuh Hijikata, Nobuhiro Yanai, Jungeun Kim, Kenichi Kato, Yoshiki Kubota, Masaki Takata, Susumu Kitagawa
J. Am. Chem. Soc 131 10336 - 10337 2009年
共著
-
Nanoporous Nanorods Fabricated by Coordination Modulation and Oriented Attachment Growth 査読あり
Takaaki Tsuruoka, Shuhei Furukawa, Yohei Takashima, Kaname Yoshida, Seiji Isoda and Susumu Kitagawa
Angew. Chem. Int. Ed 48 4739 - 4743 2009年
共著
-
Design of allele-specific primers and detection of the human ABO genotyping to avoid the pseudopositive problem 査読あり
H. Yaku, T. Yukimasa, S. Nakano, N. Sugimoto, and H. Oka
Electrophoresis, 29 4130 - 4140 2008年12月
共著
-
Structural effect of synthetic zwitterionic cosolutes on the stability of DNA duplexes 査読あり
甲元一也
Tetrahedron ( 64 ) 168 - 174 2008年11月
共著
担当区分：筆頭著者
-
Small-molecule-directed assembly of DNA: a gold-nanoparticle-based strategy for screening of a DNA duplex binders
三好大輔
Adv. Mat ( 20 ) 706 - 710 2008年11月
単著
-
Telomerase activity regulated by thermodynamic stability of DNA・RNA hybrid
三好大輔
Angew. Chem. Int. Ed., ( 47 ) 9034 - 9038 2008年11月
単著
-
Temperature-Induced Hydrogel through Self-Assembly of Cholesterol-substituted Star PEG-b-PLLA Copolymers as an Injectable Scaffold for Tissue Engineering 査読あり
K. Nagahama, T. Ouchi, Y. Ohya,
Adv. Funct. Mater. 18 ( 8 ) 1220 - 1231 2008年11月
共著
担当区分：筆頭著者
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Biodegradable Nanogels Prepared by Self-Assembly of Poly(L-Lactide)-Grafted Dextran: Entrapment and Release of Protein 査読あり
K. Nagahama, T. Ouchi, Y. Ohya,
Macromol. Biosci. 8 ( 11 ) 1044 - 1952 2008年11月
共著
担当区分：筆頭著者
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Irreversible Temperature-Responsive Formation of High-strength Hydrogel from an Enantiomeric Mixture of Starburst Triblock Copolymers Consisting of 8-arm PEG and PLLA or PDLA 査読あり
K. Nagahama, K. Fujiura, S. Enami, T. Ouchi, Y. Ohya,
J. Polym. Sci. Part A Polym. Chem., 46 ( 18 ) 6317 - 6332 2008年11月
共著
-
Resolution of secondary alcohols via Carica papaya lipase-catalyzed enantioselective acylation 査読あり
Miyazawa, T., Houhashi, M., Inoue, Y., Murashima, T., Yamada, T.
Biotechnology Letters 30 ( 10 ) 1783 - 1787 2008年10月
共著
-
Peptide synthesis using carbamoylmethyl esters as acyl donors mediated by Bacillus amyloliquefaciens protease 査読あり
Miyazawa, T., Shindo, T., Murashima, T., Yamada, T.
Protein and Peptide Letters 15 ( 10 ) 1050 - 1054 2008年10月
共著
-
Molecular crowding effect on metal ion binding properties of the hammerhead ribozyme
S. Nakano, Y. Kitagawa, H. T. Karimata, and N. Sugimoto
Nucleic Acids Symp. Ser. 52 519 - 520 2008年9月
共著
-
IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors. 査読あり
Araki K, Kawauchi K, Tanaka N
Oncogene 27 ( 43 ) 5696 - 5705 2008年9月
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Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation.
Kawauchi K, Araki K, Tobiume K, Tanaka N
Biochemical and biophysical research communications 372 ( 1 ) 137 - 141 2008年7月
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Conformation and the sodium ion condensation on DNA and RNA structures in the presence of a neutral cosloute as a mimic of the intracellular media 査読あり
Shuichi Nakano, Lei Wu, Hirohito Oka, Hisae Tateishi-Karimata, Toshimasa Kirihata, Yuichi Sato, Satoshi Fujii, Hiroshi Sakai, Masayuki Kuwahara, Hiroaki Sawai, and Naoki Sugimoto
Mol. BioSys. 4 579 - 588 2008年6月
共著
-
Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibition-induced apoptosis in PC12 cells.
Kawauchi K, Tobiume K, Iwashita K, Inagaki H, Morikawa T, Shibukawa Y, Moriyama Y, Hirata H, Kamata H
Bioscience, biotechnology, and biochemistry 72 ( 6 ) 1564 - 1570 2008年6月
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Cationic Porphyrin Induced a Telomeric DNA to G-Quadruplex Form in Water. 査読あり
Murashima, T., Sakiyama, D., Miyoshi, D., Kuriyama, M., Yamada, T., Miyazawa, T., Sugimoto, N.
Bioinorganic Chemistry and Applications 2008年5月
共著
担当区分：筆頭著者
Bioinorg. Chem. Appl. （学術雑誌、2008） 2008, Article ID 294756,
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p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
Kawauchi K, Araki K, Tobiume K, Tanaka N
Nature cell biology 10 ( 5 ) 611 - 618 2008年5月
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“Reaction of iron(III)-polyaminocarboxylate complexes with hydrogen peroxide: Correlation between ligand structure and reactivity.” 査読あり
Satoshi Fujii, Chiyo Tsueda, Kunio Yamabe, Kohsuke Nakajima, and Hiroshi Sakai
Inorg. Chim. Acta 361 1207 - 1211 2008年3月
共著
-
Design of Polylactide-Based Hydrogels as Biodegradable Soft-Biomaterials
Koji NAGAHAMA
2008年3月
単著
-
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.
Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N
Proceedings of the National Academy of Sciences of the United States of America 105 ( 12 ) 4838 - 4843 2008年3月
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Capture of cationic ligands bound diffusely to base pairs during the DNA refolding
S. Nakano, T. Kirihata, and N. Sugimoto
Chem. Commun. ( 6 ) 700 - 702 2008年2月
-
Conformation and the sodium ion condensation on DNA and RNA structures in the presence of a neutral cosolute as a mimic of the intracellular media 招待あり 査読あり
S. Nakano, L. Wu, H. Oka, H. T. Karimata, T. Kirihata, Y. Sato, S. Fujii, H. Sakai, M. Kuwahara, H. Sawai, and N. Sugimoto
Mol. BioSyst. 4 579 - 588 2008年2月
共著
DOI： 10.1039/B718806D
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Recognition of a flipped base in a hairpinloop DNA by a small peptide （共著） 査読あり
J. Kawakami, S. Okabe, Y. Tanabe, and N. Sugimoto
Nucleoside, Nucleotides and Nucleic Acids 27 292 - 308 2008年2月
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Riboswitches for enhancing target gene expression in eukaryotes 査読あり
T. Yamauchi, D. Miyoshi, T. Kubodera, M. Ban, A. Nishimura, and N. Sugimoto
ChemBioChem 9 1040 - 1043 2008年1月
共著
-
外部刺激に応答する機能性核酸 －核酸ならではの機能を活用したナノバイオマテリアルの設計－ 招待あり
三好大輔、杉本直己
化学工業 （化学工業社） 59 ( 11 ) 21 - 27 2008年1月
共著
-
Thermodynamics of DNA structures under molecular crowding conditions with neutral and positive charged cosolutes
D. Miyoshi, K. Nakamura, S. Muhuri, H. T. Karimata, N. Sugimoto
Nucleic Acids Symp. Ser. 52 413 - 414 2008年1月
共著
-
Cationic porphyrin induced a telomeric DNA to g-quadruplex form in water 査読あり
T. Murashima, D. Sakiyama, D. Miyoshi, M. Kuriyama, T. Yamada, T. Miyazawa, N. Sugimoto
Bioinorg Chem Appl. 294756 2008年1月
共著
-
Molecular crowding effects on structure and stability of DNA 招待あり 査読あり
D. Miyoshi and N. Sugimoto
Biochimie 90 1040 - 1051 2008年1月
共著
-
外部刺激に応答する機能性核酸 －核酸ならではの機能を活用したナノバイオマテリアルの設計－
三好大輔, 杉本直己
化学工業 （化学工業社） 59 ( 11 ) 21 - 27 2008年1月
共著
-
Highly regioselective propanoylation of dihydroxybenzenes mediated by Candida antarctica lipase B in organic solvents 査読あり
Miyazawa, T., Hamada, M., Morimoto, R., Murashima, T., Yamada, T.
Tetrahedron Letters 49 ( 1 ) 175 - 178 2008年1月
共著
-
“Spectroscopic Studies of Perturbed T1 Cu Sites in the Multicopper Oxidases Saccharomyces cerevisiae Fet3p and Rhus vernicifera Laccase: Allosteric Coupling between the T1 and Trinuclear Cu Sites” 査読あり
Anthony J. Augustine, Mads Emil Kragh, Ritimukta Sarangi, Satoshi Fujii, Barry D. Liboiron, Christopher S. Stoj, Daniel J. Kosman, Keith O. Hodgson, Britt Hedman, and Edward I. Solomon
Biochemistry 47 ( 7 ) 2036 - 2045 2008年1月
共著
-
Preparation and Characterization of Au Nanoparticle/Polymer composite Photonic Crystals
T. Tsuruoka, S. Samitsu, T. Aokata, J. Matsui, T. Murashima, K. Akamatsu, H. Nawafune
Trans.MRS-Japan 717 - 720 2008年
共著
-
Novel ubiquitous promoters and expression-vector optimization in ascidian embryos.
西方敬人
Invertebrate Reproduction & Development ( 51 ) 103 - 110 2008年
単著
-
Multimodal pathways during UVB-induced apoptosis in HL-60.
西方敬人
Proceedings of the 14th Biennial Congress of the International Society for Free Radical Research, Beijing, China 2008年
単著
-
Nanocomposite polymeric microspheres containing Ni nanoparticles with controlled microstructures
K. Akamatsu, S. Adachi, T. Tsuruoka, S. Ikeda, S. Tomita, H. Nawafune
Chem. Mater. 20 3042 - 3047 2008年
共著
-
Immobilization and Assembly of Mixed Monolayer-Protected Au Nanoparticles on Glass substrate via Covalent Bond Interconnection
T. Tsuruoka, A. Fujimoto, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn. 33 157 - 160 2008年
共著
-
Highly luminescent mono- and multilayers of immobilized CdTe nanocrystals: controlling optical properties through post chemical surface modification
T. Tsuruoka, R. Takahashi, T. Nakamura, M. Fujii, K. Akamatsu, and H. Nawafune
Chem. Commun. 1641 - 1643 2008年
共著
-
Control of the optical properties of CdTe nanocrystals by selective exchange of Te with thiolate: effect of organic ligands on the formation of core-shell structures
T. Tsuruoka, R. Takahashi, K. Akamatsu, H. Nawafune
Phys. Chem. Chem. Phys. 10 2221 - 2226 2008年
共著
-
Direct metallization of nickel on polymeric template patterns for fabrication of copper circuits on glass substrates
Y. Matsumura, Y. Enomoto, M. Sugiyama, K. Akamatsu, H. Nawafune
J. Mater. Chem. 18 5058 - 5082 2008年
共著
-
Fabrication of conductive thin films on precursor polyimide via chemical reduction of nickel (II) complex
Y. Matsumura, Y. Enomoto, T. Jyo, K. Akamatsu, H. Nawafune
J. Surf, Finish, Soc. Jpn. 59 562 - 564 2008年
共著
-
Formation of metal thin film nanocomposite layer from precursor polyimide containing metal complex
M. Matsumura, Y. Enomoto, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn. 33 1333 - 1336 2008年
共著
-
Molecular crowding effect on metal ion binding properties of the hammerhead ribozyme
S. Nakano, Y. Kitagawa, H. T. Karimata, and N. Sugimoto
Nucleic Acids Symp. Ser. 52 519 - 520 2008年
共著
-
Nanocomposite Polymeric Microspheres Containing Ni Nanoparticles with Controlled Microstructures 査読あり
K. Akamatsu, S. Adachi, T. Tsuruoka, S. Ikeda, S. Tomita, H. Nawafune
Chem. Mater. 20 3042 - 3047 2008年
共著
-
Highly Luminescent Mono- and Multilayers of Immobilized CdTe Nanocrystals: Controlling Optical Properties Through Post Chemical Surface Modification 査読あり
T. Tsuruoka, R. Takahashi, T. Nakamura, M. Fujii, K. Akamatsu, H. Nawafune
Chem. Commun. 1641 - 1643 2008年
共著
-
Control of the Optical Properties of CdTe Nanocrystals by Selective Exchange of Te with Thiolate: Effect of Organic Ligands on the Formation of Core-Shell Structures 査読あり
T. Tsuruoka, R. Takahashi, K. Akamatsu, H. Nawafune
Phys. Chem. Chem. Phys. 10 2221 - 2226 2008年
共著
-
Immobilization and Assembly of Mixed Monolayer-Protected Au Nanoparticles on Glass Substrate via Covalent Bond Interconnection 査読あり
T. Tsuruoka, A. Fujimoto, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn. 33 157 - 160 2008年
共著
-
Preparation and Characterization of Au Nanoparticles/Polymer Composite Photonic Crystals 査読あり
T. Tsuruoka, S. Samitsu, T. Aokata, J. Matui, T. Murashima, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn. 33 717 - 720 2008年
共著
-
Influence of cationic molecules on the hairpin to duplex equilibria of self-complementary DNA and RNA oligonucleotides 査読あり
S. Nakano, T. Kirihata, S. Fujii, H. Sakai, M. Kuwahara, H. Sawai, and N. Sugimoto
Nucleic Acids Research 35 486 - 494 2007年12月
共著
DOI： 10.1093/nar/gkl1073
-
Synthesis, structure and thermal stability of fully hydrophobic porphyrin-DNA conjugates.
Murashima, T., Hayata, K., Saiki, Y., Matsui, J., Miyoshi, D., Yamada, T., Miyazawa, T., Sugimoto, N.
Tetrahedron Lett., 48 ( 48 ) 8514 - 8517 2007年11月
共著
担当区分：筆頭著者
Tetrahedron Lett., （学術雑誌、2007）48, 8514-8517.
-
Secondary alcohols act as better nucleophiles than primary alcohols in the lipase-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxyls.
Miyazawa, T., Hamada, M., Morimoto, R., Murashima, T., Yamada, T.
Tetrahedron Lett., 48 ( 47 ) 8334 - 8337 2007年11月
共著
Tetrahedron Lett., （学術雑誌、2007）48, 8334-8337.
-
Artificial G-wire Switch with 2,2’-Bipyridine Units Responsive to Divalent Metal Ions
甲元一也
J. Am. Chem. Soc ( 129 ) 5919 - 5925 2007年11月
単著
-
５）天然高分子 核酸 エネルギーデータベースに基づく核酸医薬の設計
甲元一也
絵で見てわかるナノDDS 遺伝子医学MOOK別冊（メディカルドゥ） 63 - 69 2007年11月
単著
-
Conformational switch of a functional nanowire based on the DNA G-quadruplex
甲元一也
Nucleic Acids Symp. Ser. ( 51 ) 251 - 252 2007年11月
単著
-
Delivery of antisense oligonucleotides to nuclear telomere RNA by use of a complex between polysaccharide and polynucleotide
甲元一也
Bull. Chem. Soc. Jpn ( 80 ) 1091 - 1098 2007年11月
単著
-
Molecular Imprinting Under Molecular Crowding Conditions: an Aid to the synthesis of a High-capacity Polymeric Sorbent for Triazine Herbicides
三好大輔
Anal. Chem ( 79 ) 1749 - 1757 2007年11月
単著
-
DNAを用いたバイオ計測 －センシング核酸の開発と新展開－
三好大輔
未来材料, 7 ( 6 ) 10 - 18 2007年11月
単著
-
Regulation of DNA nucleases by molecular crowding
三好大輔
Nucleic Acids Res ( 35 ) 4086 - 4093 2007年11月
単著
-
Artificial G-wire Switch with 2,2’-Bipyridine Units Responsive to Divalent Metal Ions
三好大輔
J. Am. Chem. Soc ( 129 ) 5919 - 5925 2007年11月
単著
-
DNAデザイン －機能性分子開発への道しるべ－
三好大輔
化学 62 ( 9 ) 28 - 32 2007年11月
単著
-
DNA四重らせん構造を細胞内環境因子で制御する
三好大輔
生体機能関連化学部会 News Letter, 22 ( 3 ) 14 - 17 2007年11月
単著
-
Synthesis, structure and thermal stability of fully hydrophobic porphyrin-DNA conjugates
三好大輔
Tetrahedron Lett ( 48 ) 8514 - 8517 2007年11月
単著
-
Effects of cosolutes on the thermodynamic stability of parallel DNA duplex and triplex
三好大輔
Nucleic Acids Symp. Ser. (Oxf), ( 51 ) 167 - 168 2007年11月
単著
-
Conformational switch of a functional nanowire based on the DNA G-quadruplex
三好大輔
Nucleic Acids Symp. Ser. (Oxf), ( 51 ) 167 - 168 2007年11月
単著
-
DNA四重らせん構造を細胞内環境因子で制御する
三好大輔
生体機能関連化学部会 News Letter, 22 ( 3 ) 14 - 17 2007年11月
単著
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Effects of polyethylene glycol on a DNA duplex stability differed by the NaCl concentration 査読あり
H. Karimata, S. Nakano, and N. Sugimoto
Bull. Chem. Soc. Jpn. 80 1987 - 1994 2007年11月
共著
-
The base-pairing ability of the base pair-mimic nucleosides
S. Nakano, K. Uenishi, M. Fujii, and N. Sugimoto
Nucleic Acids Symp. Ser. 51 71 - 72 2007年11月
単著
-
Impacts of Stereoregularity and Stereocomplex Formation on Physicochemical, Protein Adsorption and Cell Adhesion Behaviors of Star-Shaped 8-Arms Poly(ethylene glycol)-Poly(lactide) Block Copolymer Films 査読あり
K. Nagahama, Y. Nishimura, Y. Ohya,
Polymer, 48 ( 9 ) 2649 - 2658 2007年11月
共著
担当区分：筆頭著者
-
Exhibition of Soft and Tenacious Characters Based on Liquid Crystal Formation by Introduction of Cholesterol Groups on Biodegradable Lactide Copolymer 査読あり
K. Nagahama, Y. Ueda, T. Ouchi, Y. Ohya
Biomacromolecules, 8 ( 12 ) 3938 - 3943 2007年11月
共著
担当区分：筆頭著者
-
Molecular “Screw and Nut”: α-Cyclodextrin Recognizes Polylactide Chirality 査読あり
Y. Ohya, S. Takamido, K. Nagahama, T. Ouchi, T. Ooya, R. Katoono, N. Yui
Macromolecules, 40 ( 18 ) 6441 - 6444 2007年11月
共著
-
Biodegradable Nanogel Formation of Polylactide-Grafted Dextran Copolymer in Dilute Aqueous Solution and Enhancement of Its Stability by Stereocomplexation, 査読あり
K. Nagahama, Y. Mori Y. Ohya, T. Ouchi
Biomacromolecules 8 ( 7 ) 2135 - 2141 2007年11月
共著
担当区分：筆頭著者
-
Functionalization of DNA by the base pair-mimic nucleosides
H. Oka, S. Nakano, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Nucleic Acids Symp. Ser. 51 151 - 152 2007年11月
共著
-
Suppression of AP-1 activity by cycloprodigiosin hydrochloride.
Kawauchi K, Tobiume K, Kaneko S, Kaneshiro K, Okamoto S, Ueda E, Kamata H, Moriyama Y, Hirata H
Biological & pharmaceutical bulletin 30 ( 9 ) 1792 - 1795 2007年9月
共著
-
Schizophyllan, beta-1,3-glucan,-oligoamine conjugates as non-viral vector 査読あり
Takeshi Nagasaki, Atsushi Uno, Kazuya Koumoto, Kazuo Sakurai, Seiji Shinkai
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 234 2007年8月
出版者・発行元：AMER CHEMICAL SOC
-
Consecutive GC base pairs determine the energy barrier of DNA duplex formation under molecularly crowded conditions 査読あり
X. Gu, S. Nakano, and N. Sugimoto
Chem. Commun. 2750 - 2752 2007年4月
共著
DOI： 10.1039/B702865B
-
Mechanistic characterization of the HDV genomic ribozyme: A mutant of the C41 motif provides insight into positioning and thermodynamic linkage of metal ions and protons 査読あり
S. Nakano and P. C. Bevilacqua
Biochemistry 46 3001 - 3012 2007年2月
共著
DOI： 10.1021/bi061732s
-
Molecular Imprinting Under Molecular Crowding Conditions: an Aid to the synthesis of a High-capacity Polymeric Sorbent for Triazine Herbicides.
Matsui, J., Goji, S., Murashima, T., Miyoshi, D., Komai, S., Shigeyasu, A., Kushida, T
Anal. Chem., 79 ( 4 ) 1749 - 1757 2007年2月
共著
Anal. Chem., （学術雑誌、2007）79, 1749-1757.
-
Hydration regulates thermodynamic stability of DNA structures under molecular crowding conditions 査読あり
D. Miyoshi, H. Karimata, and N. Sugimoto
Nucleosides, Nucleotides and Nucleic Acids 26 589 - 595 2007年1月
共著
-
“Modulation of the DNA and RNA Secondary Structure by Cationic Molecule” 査読あり
Shu-ichi Nakano, Toshimasa Kirihata, Satoshi Fujii, Hiroshi Sakai, Masayuki Kuwahara, Hiroaki Sawai, and Naoki Sugimoto
Nucleic Acids Res 35 ( 2 ) 486 - 494 2007年1月
共著
-
Screening of alpha-helical peptide ligands controlling a calcineurin-phosphatase activity 査読あり
Kenji Usui, Kin-ya Tomizaki, Hisakazu Mihara
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 ( 1 ) 167 - 171 2007年1月
出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD
In this paper, we describe an application of 202-membered fluorescently labeled peptide library designed to take an alpha-helix secondary structure. As a proof-of-concept experiment, a calmodulin (CaM)/calcineurin (Cn) pair was chosen to screen alpha-helical peptide ligands that tightly bind to CaM and also control enzymatic functions of Cn. Three peptides were successfully selected from the library by assaying Cn-phosphatase activities and peptide-CaM interactions (dual check process). The strategy using a designed peptide. library shows real promise as a peptide-based high-throughput screening system. (c) 2006 Elsevier Ltd. All rights reserved.
-
Molecular Imprinting Under Molecular Crowding Conditions: an Aid to the synthesis of a High-capacity Polymeric Sorbent for Triazine Herbicides
J. Matsui, S. Goji, T. Murashima, D. Miyoshi, S. Komai, A. Shigeyasu, T. Kushida, T. Miyazawa, T. Yamada, K. Tamaki, N. Sugimoto
Anal. Chem. 2007年
共著
担当区分：筆頭著者
-
Synthesis, structure and thermal stability of fully hydrophobic porphyrin-DNA conjugates 査読あり
T. Murashima, K. Hayata, Y. Saiki, J. Matsui, D. Miyoshi, T., Yamada, T. Miyazawa, and N. Sugimoto
Tetrahedron Letters 2007年
共著
-
Neural-tube specific paralogous genes and their upstream regulatory sequences
西方敬人
Mem. Konan Univ., Sci. Eng. Ser ( 54 ) 75 - 88 2007年
単著
-
Controlled magnetic properties of Ni nanoparticles embedded in polyimide films
S. Tomita, P. E. Jonsson, K. Akamatsu, H. Nawafune, H. Takayama
Phys. Rev. B ( 174432 ) 1 - 6 2007年
共著
-
ポリエチレングリコール誘導体の予備吸着を利用する銅電析プロセスによるULSI微細配線の形成
尾山祐斗、有村英俊、赤松謙祐、縄舟秀美
表面技術 58 425 - 429 2007年
共著
-
Copper/polyimide heterojunction: controlling interfacial structures through an additive-based, all-wet chemical process using ion-doped precursors
S. Ikeda, H. Yanagimoto, K. Akamatsu, H. Nawafune
Adv. Funct. Mater. 17 889 - 897 2007年
共著
-
One-step synthesis of polypyrrole-coated silver nanocomposite particles and their application as a coloured particulate emulsifier
S. Fujii, A. Aichi, K. Akamatsu, H. Nawafune and Y. Nakamura
J. Mater. Chem. 17 3777 - 3779 2007年
共著
-
Atomic Beam-Induced Fluorination of Polyimide and Its Application to Site-Selective Cu Metallization
M. Tagawa, K. Maeda, T. Kajita, K. Yokota, K. Akamatsu, H. Nawafune
Langmuir 23 11351 - 11354 2007年
共著
-
Photosensitization of oxygen molecules by surface-modified hydrophilic porus Si
M. Fujii, N. Nishimura, H. Fumon, S. Hayashi, K. Akamatsu, T. Tsuruoka, M. Shimada, H. Katayama, D. Kovalev, B. Goller
Euro. Phys. J. D 43 193 - 196 2007年
共著
-
Interactions between Peptides Containing Nucleobase Amino Acids and T7 Phages Displaying S. Cerevisiae Proteins 査読あり
S. Watanabe, K.-Y. Tomizaki, T. Takahashi, K. Usui, K. Kajikawa and H. Mihara
Biopolymers 88 ( 2 ) 131 - 140 2007年
-
Photosensitization of Oxygen Molecules by Surface-Modified Hydrophilic Porus Si 査読あり
M. Fujii, N. Nishimura, H. Fumon, S. Hayashi, K. Akamatsu, T. Tsuruoka, M. Shimada, H. Katayama, D. Kovalev, B. Goller
Euro. Phys. J. D 43 193 - 196 2007年
共著
-
Functional role of the cofactor on activation process of L-histidine dependent ribozyme（共著）
J. Kawakami, C. Maiya, and N. Sugimoto
Nucleic Acids Symp. Ser. 50 241 - 242 2006年11月
共著
担当区分：筆頭著者
-
Galactose-PEG Dual Conjugation of b-(1→3)-D-glucan schizophyllan for antisense oligonucleotide delivery to enhance cellular uptake
甲元一也
Biomaterials, ( 27 ) 1626 - 1635 2006年11月
単著
-
CpG DNA/zymosan complex to enhance cytokine secretion owing to the cocktail effect
甲元一也
Bioorg. Med. Chem. Lett ( 16 ) 1301 - 1304 2006年11月
単著
-
A DNA duplex with Extremely Enhanced Thermal Stability Based on Controlled Immobilization on Gold Nanoparticles.
三好大輔
Nano Lett., ( 6 ) 491 - 495 2006年11月
単著
-
Development of molecular logic gates using the structural switch of telomere DNAs
三好大輔
Nucleic Acids Symp. Ser. ( 50 ) 315 - 316 2006年11月
単著
-
Molecularly Imprinting within a Single Peptide Molecule for Synthesizing a Water-soluble ATP Receptor
三好大輔
Proceedings of the International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting 396 - 397 2006年11月
単著
-
Properties of long telomeric DNAs under cell-mimicking conditions
三好大輔
Nucleic Acids Symp. Ser. ( 50 ) 207 - 208 2006年11月
単著
-
Factors regulating thermodynamic stability of DNA structures under molecular crowding conditions
三好大輔
Nucleic Acids Symp. Ser ( 50 ) 203 - 204 2006年11月
単著
-
Characterization of Structure and Stability of Long Telomeric DNA G-Quadruplexes
三好大輔
J. Am. Chem. Soc., ( 128 ) 15461 - 15468 2006年11月
単著
-
DNA Logic Gates Based on Structural Polymorphism of Telomere DNA Molecules Responding to Chemical Input Signals
三好大輔
Angew. Chem. Int. Ed., ( 45 ) 7716 - 7719 2006年11月
単著
-
Hydration regulates thermodynamics of G-quadruplex formation under molecular crowding conditions
三好大輔
J. Am. Chem. Soc ( 128 ) 7957 - 7963 2006年11月
単著
-
生命を制御するのは遺伝子か環境か－細胞内環境に左右される遺伝子の構造と機能－
三好大輔
高分子 55 ( 5 ) 322 - 325 2006年11月
単著
-
Effect of molecular crowding on DNA polymerase activity
三好大輔
Biotech. J., ( 1 ) 440 - 446 2006年11月
単著
-
Properties of long telomeric DNAs under cell-mimicking conditions
三好大輔
Nucleic Acids Symp. Ser. ( 50 ) 207 - 208 2006年11月
単著
-
The Suppression of Cell and Platelet Adhesion to Star-Shaped Poly(ethylene glycol)-Poly(L-lacitde) Block Copolymer Film, 査読あり
K. Nagahama, Y. Ohya, T. Ouchi,
Macromol. Biosci. 6 ( 6 ) 412 - 419 2006年11月
共著
担当区分：筆頭著者
-
Synthesis of Star-Shaped 8arms Poly(ethylene glycol)-Poly(L-lacitde) Block Copolymer and Physical Properties of Its Solution Cast Film as Soft Biomaterial 査読あり
K. Nagahama, Y. Ohya, T. Ouchi,
Polym. J., 38 ( 8 ) 852 - 860 2006年11月
共著
担当区分：筆頭著者
-
The roles of cosolutes on the hammerhead ribozyme activity
中野 修一
Nucleic Acids Symp. Ser. 50 81 - 82 2006年11月
共著
-
The effect of the structure of cosolutes on the DNA duplex formation
中野 修一
Nucleic Acids Symp. Ser. 50 205 - 206 2006年11月
共著
-
Recognition of the base pair-mimic nucleosides by DNA polymerases
中野 修一
Nucleic Acids Symp. Ser. 50 201 - 202 2006年11月
共著
-
Protein-fingerprint data mining of a designed alpha-helical peptide array 査読あり
Kenji Usui, Kin-ya Tomizaki, Hisakazu Mihara
MOLECULAR BIOSYSTEMS 2 ( 9 ) 417 - 420 2006年9月
出版者・発行元：ROYAL SOC CHEMISTRY
The data generated from protein fingerprints with an a-helical peptide array were analyzed using several statistical methods such as hierarchical clustering analysis and principal component analysis to discriminate target proteins. The data generated from protein fingerprints with an a-helical peptide array were analyzed using several statistical methods such as hierarchical clustering analysis and principal component analysis to discriminate target proteins.
DOI： 10.1039/b608875a
-
A novel stable RNA pentaloop that interacts specifically with a motif peptide of lambda-N protein（共著） 査読あり
J. Kawakami, H. Tokitoh, Y. Tanabe, and N. Sugimoto
Nucleoside, Nucleotides and Nucleic Acids 25 397 - 416 2006年4月
-
The negative regulation of p53 by hedgehog signaling 査読あり
Abe Yoshinori, Oda-Sato Eri, Tobiume Kei, Kawauchi Keiko, Okamoto Koji, Taya Yoichi, Tanaka Nobuyuki
CANCER RESEARCH 66 ( 8 ) 2006年4月
共著
-
A novel peptide microarray for protein detection and analysis utilizing a dry peptide array system 査読あり
K Usui, K Tomizaki, T Ohyama, K Nokihara, H Mihara
MOLECULAR BIOSYSTEMS 2 ( 2 ) 113 - 121 2006年2月
出版者・発行元：ROYAL SOC CHEMISTRY
A novel dry peptide microarray system has been constructed that affords a practical solution for protein detection and analysis. This system is an array preparation and assay procedure tinder dry conditions that uses designed peptides as non-immobilized capture agents for the detection of proteins. The system has several advantages that include its portability and ease-Of-Use, as well as the fact that vaporization of sample solutions need not be considered. In this study, various proteins have been characterized with an a-helical peptide mini-library. When proteins were added to the peptide library array, the fluorescent peptides showed different fluorescent intensities depending on their sequences. The patterns of these responses could be regarded as protein fingerprints' (PFPs), which are sufficient to establish the identities of the target proteins. Furthermore, statistical analysis of the resulting PFPs was performed using cluster analysis. The PFPs of the proteins were clustered successfully depending on their families and binding properties. Additionally, the target protein was characterized using a nanolitre system and could be detected down to 1.2 fmol. These Studies imply that the dry peptide array system is a promising too] for detecting and analyzing target proteins. The dry peptide array will play a role in development of high-throughput protein-detecting nano/micro arrays for proteomics and ligand screening studies.
DOI： 10.1039/b514263r
-
A PNA-DNA hybridization chip approach for the detection of beta-secretase activity 査読あり
S Sano, KY Tomizaki, K Usui, H Mihara
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16 ( 3 ) 503 - 506 2006年2月
出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD
Developed was the addressable chip technology based on the PNA-DNA complementary hybridization equipped with short seven-mer PNA-encoded peptides that can be a versatile scaffold to monitor on-chip immunoassays. We also developed and validated a methodology to perform beta-secretase enzyme assay with a highly sensitive fashion, resulting that a peptide substrate tethering dual fluorescent probes allowed us to detect beta-secretase activity 10 times more sensitively than assays in solution. (c) 2005 Elsevier Ltd. All rights reserved.
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A DNA duplex with extremely enhanced thermal stability based on controlled immobilization on gold nanoparticles 査読あり
K. Akamatsu, M. Kimura, Y. Shibata, S. Nakano, D. Miyoshi, H. Nawafune, and N. Sugimoto
Nano Lett. 3 491 - 495 2006年1月
共著
DOI： 10.1021/nl0524748
-
Use of the polymorphic nature of high-order DNA structures for the design of dynamic and functional nanodevices 招待あり 査読あり
D. Miyoshi, N. Sugimoto
Recent Devel. Nucleic Acids Res. 2 49 - 70 2006年1月
共著
-
Use of the polymorphic nature of high-order DNA structures for the design of dynamic and functional nanodevices
D. Miyoshi, N. Sugimoto
Recent Devel. Nucleic Acids Res. 2 49 - 70 2006年1月
共著
-
Photodimerization of Anthryl Moieties in a Poly(methacrylic acid) Derivative as Reversible Cross-linking Step in Molecular Imprinting
J. Matsui, Y. Ochi, K. Tamaki
Chem. Lett. 80 - 81 2006年
共著
担当区分：筆頭著者
-
Molecularly-Imprinted Polymeric Logic Gates Selective for Predetermined Chemical Input Species
松井淳
Chem. Comm. 3217 - 3219 2006年
単著
-
Dynamic redistribution of vasa homolog and exclusion of somatic cell determinants during germ cell specification in Ciona intestinalis.
西方敬人
Development ( 133 ) 2683 - 2693 2006年
単著
-
UV-irradiated cells as a screening system for the antioxidants.
西方敬人
Proceedings of the 13th Biennial Congress of the International Society for Free Radical Research -SFRR 253 - 256 2006年
単著
-
A DNA duplex with Extremely Enhanced Thermal Stability Based on Controlled Immobilization on Gold Nanoparticles
K. Akamatsu, M. Kimura, Y. Shibata, S. Nakano, D. Miyoshi, H. Nawafune, N. Sugimoto
Nano Lett. 6 491 - 495 2006年
共著
-
金属イオンレドックス系無電解めっき浴の安定性
赤松謙祐、増田昭仁、尾山祐斗、縄舟秀美
表面技術 57 799 - 801 2006年
共著
-
Fabrication of fluorescent multilayers consisting of CdTe nanocrystals
T. Tsuruoka, R. Takahashi, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn. 31 425 - 428 2006年
共著
-
Designed peptide microarrays for protein detection and characterization 査読あり
Kenji Usui, Kin-ya Tomizaki, Kiyoshi Nokihara, Hisakazu Mihara
UNDERSTANDING BIOLOGY USING PEPTIDES 731 - + 2006年
出版者・発行元：SPRINGER
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High throughput preparation of peptide arrays containing two fluorescent byes focusing on practical protein detection systems 査読あり
Kiyoshi Nokihara, Takafumi Ohyama, Koichi Yonemura, Yasuo Oka, Kenji Usui, Hisakazu Mihara
UNDERSTANDING BIOLOGY USING PEPTIDES 738 - + 2006年
共著
出版者・発行元：SPRINGER
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Site-Selective Integration of Monolayer-Protected Inorganic Nanoparticles onto Surface Monolayer Templates by a Solvent-Induced Lift-Off Process 査読あり
K. Akamatsu, S. Samitsu, T. Tsuruoka, J. Hasegawa, H. Nawafune
Small 2 1130 - 1133 2006年
共著
-
Fabrication of Fluorescent Multilayers Consisting of CdTe Nanocrystals 査読あり
T. Tsuruoka, R. Takahashi, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn. 31 425 - 428 2006年
共著
-
DNA base flipping by a base pair-mimic nucleoside 査読あり
S. Nakano, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Nucleic Acids Research, 33 7111 - 7119 2005年12月
単著
DOI： 10.1093/nar/gki1018
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Anomalous reflection of gold applicable for a practical protein-detecting chip platform 査読あり
S Watanabe, K Usui, K Tomizaki, K Kajikawa, H Mihara
MOLECULAR BIOSYSTEMS 1 ( 5-6 ) 363 - 365 2005年12月
出版者・発行元：ROYAL SOC CHEMISTRY
A simple, convenient and label-free fiber optic detection system based on the characteristic property, 'anomalous reflection (AR)' of gold was developed and preliminary experiments showed that the AR signals were sensitive enough to monitor protein-peptide interactions on solid surfaces.
DOI： 10.1039/b513075c
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Amino Acid Ester Salt Recognition by Ferrocene-based Ditopic Receptor Bearing Oligoethylene Glycol with Pendant Bipy Subunits: CV, UV-vis and ESR Studies. 査読あり
Murashima, T., Tsukiyama, S., Fujii, S., Hayata, K., Sakai, H., Miyazawa, T., Yamada, T.
Org. Biomol. Chem., 3 ( 22 ) 4060 - 4064 2005年11月
共著
担当区分：筆頭著者
Org. Biomol. Chem., （学術雑誌、2005）3, 4060-4064.
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“Amino acid ester salt recognition by ferrocene-based ditopic receptor bearing oligoethylene glycol with pendant bipy subunits: CV, UV-vis and ESR Studies” 査読あり
Takashi Murashima, Sayo Tsukiyama, Satoshi Fujii, Kazuyuki Hayata, Hiroshi Sakai, Toshifumi Miyazawa, and Takashi Yamada
Org. Biomol. Chem 3 4060 - 4064 2005年11月
共著
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In situ monitoring of polysaccharide-polynucleotide interaction using a schizophyllan-immobilized QCM device
甲元一也
Sensors & Actuators B: Chemicals ( 105 ) 490 - 494 2005年11月
単著
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Transferrin-appended b-(1→3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake
甲元一也
J. Contr. Rel. ( 108 ) 529 - 539 2005年11月
単著
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Transferrin-appended b-(1→3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake
甲元一也
e-J. Surface Sci. Nanotech ( 3 ) 195 - 202 2005年11月
単著
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Cholesterol-appended b-(1,3)-D-glucan schizophyllan for antisense oligonucleotide delivery to enhance cellular uptake
甲元一也
Bull. Chem. Soc. Jpn. ( 78 ) 1821 - 1830 2005年11月
単著
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Parallel vs. anti-parallel orientation in a curdlan/oligo(dA) complex as estimated by a FRET technique
甲元一也
Org. Biomol. Chem., ( 3 ) 2255 - 2261 2005年11月
単著
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Competition between Polysaccharide/Polynucleotide Complexation vs. Polynucleotide Hybridization; Salt Concentration Dependence of the Reaction Direction
甲元一也
e-J. Surface Sci. Nanotech. ( 3 ) 30 - 37 2005年11月
単著
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PEG-appended b-(1→3)-D-glucan schizophyllan to deliver antisense-oligonucleotides with avoiding lysosomal degradational of New Modification Technique for Linear Double-Stranded DNAs Using the Polysaccharide Schizophyllan
甲元一也
Biomaterials ( 26 ) 4866 - 4873 2005年11月
単著
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Schizophyllan-Poly(N-isopropylacrylamide) Conjugate for Selective Recovery of Polynucleotides by Precipitation
甲元一也
Polym. J., ( 37 ) 177 - 185 2005年11月
単著
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Thermodynamic and Kinetic Analysis of Nucleic Acid Structures toward Pharmacogenomics.
三好大輔
Current Pharmacogenomics, ( 3 ) 217 - 236 2005年11月
単著
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Structural switch of telomere DNA by pH and monovalent cation.
三好大輔
Nucleic Acids Symp. Ser ( 49 ) 243 - 244 2005年11月
単著
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Structure and stability of DNA quadruplexes under molecular crowding conditions.
三好大輔
Nucleic Acids Symp. Ser ( 49 ) 239 - 240 2005年11月
単著
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DNA nanowire sensitive to the surrounding condition.
三好大輔
Nucleic Acids Symp. Ser. ( 49 ) 43 - 44 2005年11月
単著
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DNA-Based Biosensor for Monitoring pH in Vitro and in Living Cells.
三好大輔
Biochemistry ( 44 ) 7125 - 7130 2005年11月
単著
-
Roles of Mg2+ in TPP-dependent riboswitch.
三好大輔
FEBS Lett. ( 579 ) 2583 - 2588 2005年11月
単著
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Drastic Effect of a Single Base Difference between Human and Tetrahymena Telomere Sequences on Their Structures under Molecular Crowding Conditions.
三好大輔
Angew. Chem. Int. Ed. Engl ( 44 ) 3740 - 3744 2005年11月
単著
-
SPR sensor chip for detection of small molecules using molecularly imprinted polymer with embedded gold nanoparticles.
三好大輔
Anal Chem ( 77 ) 4282 - 4285 2005年11月
単著
-
Roles of Mg2+ in TPP-dependent riboswitch.
三好大輔
FEBS Lett ( 579 ) 2583 - 2588 2005年11月
単著
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Thermodynamic and Kinetic Analysis of Nucleic Acid Structures toward Pharmacogenomics
三好大輔
Current Pharmacogenomics ( 3 ) 217 - 236 2005年11月
単著
-
Drastic effect of a single base difference between human and tetrahymena telomere sequences on their structures under molecular crowding conditions.
三好大輔
Angew Chem Int Ed Engl. ( 44 ) 3740 - 3744 2005年11月
単著
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SPR Sensor Chip for Detection of Small Molecules Using Molecularly Imprinted Polymer with Embedded Gold Nanoparticles Anal. Chem.
松井淳
（学術雑誌、 2005 ）77, 4282-4285 4282 - 4285 2005年11月
単著
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Synthesis of Water-soluble Porphyrin and the Corresponding Highly Planar Benzoporphyrin without meso-Substituents.
村嶋 貴之
Tetrahedron Lett., 2005年11月
単著
Tetrahedron Lett., （学術雑誌、2005）46, 113-116.
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Resolution of Non-protein Amino Acids via Carica papaya Lipase-catalyzed Enantioselective Transesterification.
村嶋 貴之
Tetrahedron: Asymmetry, 2005年11月
単著
Tetrahedron: Asymmetry, （学術雑誌、2005）16, 2569-2573.
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Enzymatic Resolution of 2-Aryloxy-1-propanols via Lipase-catalyzed Enantioselective Acylation Using Acid Anhydrides as Acyl Donors.
村嶋 貴之
J. Mol. Cat., B, 2005年11月
単著
J. Mol. Cat., B, （学術雑誌、2005）37, 63-67.
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Studies on intramolecular hydrogen bonding between the pyridine nitrogen and the amide hydrogen of the peptide: synthesis and conformational analysis of tripeptides containing novel amino acids with a pyridine ring.
村嶋 貴之
J. Peptide Sci., 2005年11月
単著
J. Peptide Sci., （学術雑誌、2005）11, 491-498.
-
Conformational switch of oligonucleotides induced by spermine
中野 修一
Nucleic Acids Symp. Ser. 49 241 - 242 2005年11月
単著
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Linkage between proton binding and folding in RNA: implications for RNA catalysis
中野 修一
Biochem. Soc. Trans. 33 466 - 470 2005年11月
単著
-
Kenji Usui, Tetsunori Ojima, Kin-Ya Tomizaki, Hisakazu Mihara
Nanobiotechnology 1 ( 2 ) 191 - 199 2005年11月
For the realization of a practical high-throughput protein detection and analysis system, a novel peptide array has been constructed using a designed glycopeptide model library with an α-helical secondary structure. This study will contribute the increment of the diversity of such an array system and the application to focused proteomics and ligand screening by effective detection of sugar-binding proteins. Fluorescent glycopeptides with an α-helix, a β-strand, or a loop structure were designed initially to select a suitable scaffold for the detection of a model protein. After selection of the α-helical structure as the best scaffold, a small model library with various saccharides was constructed to have charge and hydrophobicity variations in the peptide sequences. When various sugar-binding proteins were added to the peptide library array, the fluorescent peptides showed different responses in fluorescence intensities depending on their sequences as well as saccharides. The patterns of these responses could be regarded as "protein fingerprints" (PFPs), which are able to establish the identities of the target proteins. The resulting PFPs reflected the recognition properties of the proteins. Furthermore, statistical data analysis from obtained PFPs was performed using a cluster analysis. The PFPs of sugar-binding proteins were clustered successfully depending on their families and binding properties. These studies demonstrate that arrays with glycopeptide libraries based on designed structures can be promising tools to detect and analyze the target proteins. Designed peptides with functional groups such as sugars will play roles as the capturing agents of high-throughput protein nano/micro arrays for focused proteomics and ligand screening studies. Copyright © 2005 Humana Press Inc. All rights of any nature whatsoever are reserved.
DOI： 10.1385/NBT:1:2:191
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Difference in self-assembling morphology of peptide nanorings 査読あり
H Okamoto, T Yamada, H Miyazaki, T Nakanishi, K Takeda, K Usui, Obataya, I, H Mihara, H Azehara, W Mizutani, K Hashimoto, H Yamaguchi, Y Hirayama
JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS 44 ( 11 ) 8240 - 8248 2005年11月
出版者・発行元：JAPAN SOC APPLIED PHYSICS
We synthesized the peptide nanorings of cyclo[-(D-Ala-L-Gln)(3)], cyclo[-(D-CyS-L-Gln)(3)], CyC10[-D-Cys-L-HiS-D-Ala-L-Asn-Gly-L-Gln-1 and Cyc1o[-(L-Gln)(5)], and studied the way in which the difference in the type and/or number of component amino acid residues changes the self-assembling morphology of the nanorings on gold substrates by atomic force microscopy. The study revealed that CyClo[-(D-Ala-L-Gln)(3)] formed nanotube bundles through inter-ring hydrogen bonds, while the nanorings of CyC10[-(D-CyS-L-Gln)3] adhered to the gold surface directly due to the high affinity of thiol to gold. In contrast, a random amino acid sequence of cyclo[-D-CyS-L-HiS-D-Ala-L-Asn-GlY-L-Gln-] resulted in many isolated nanotubes, which were first observed in the present study. While the D,L-peptide nanotubes have very straight forms, the homo-L-peptide of cyclo[-(L-Gln)(5)] formed interesting randomly branching nanotubes that were entwined and grew on the substrate. Scanning tunneling microscopy was also performed and high-resolution images of both the peptide nanotubes and the nanotube bundles were obtained.
DOI： 10.1143/JJAP.44.8240
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IR study on stacking manner of peptide nanorings in peptide nanotubes 査読あり
Y Nagai, T Nakanishi, H Okamoto, K Takeda, Y Furukawa, K Usui, H Mihara
JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS 44 ( 10 ) 7654 - 7661 2005年10月
出版者・発行元：JAPAN SOC APPLIED PHYSICS
We here report our theoretical as well as experimental studies on the stacking manner of peptide nanorings (PNRs) in peptide nanotubes (PNTs). We focus on the molecular vibrations of N-H and C=O stretching modes and discuss this subject via their infrared (IR) spectroscopy, because PNTs are formed by the inter-ring H bonds between the adjacent PNRs via -N-H(...)O=C-. Symmetry analysis based on group theory reveals that parallel stacking causes two IR active modes in these molecular vibrations while three modes are active in the antiparallel stacking. This difference in the number of IR active modes is determined only by the stacking manner and not by the number of amino acid residues composing the PNRs. By using two typical PNRs Of cyclo[-((L)-Gln-D-Ala)(3)] and cyclo[-((L)-Gln-(D)-Ala)(4)], we further studied the favorable stacking manners of PNRs via IR observation. Our IR experiments as well as the ab initio energetics show that the former PNRs create a PNT by stacking themselves in parallel while the latter PNRs do so by stacking themselves in an antiparallel manner.
DOI： 10.1143/JJAP.44.7654
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Specific recognition of the basic N peptide by an RNA（共著）
J. Kawakami, H. Tokitoh, Y. Tanabe, and N. Sugimoto
Nucleic Acids Symposium Series 49 353 - 354 2005年9月
共著
担当区分：筆頭著者
-
Central dogma for a molecular design based on DNA: DNB (databasing/designable nanobio) -> ENB (engineering nanobio) -> FNB (functional nanobio) 査読あり
S. Nakano and N. Sugimoto
Chemistry Letters 34 1206 - 1211 2005年7月
単著
DOI： 10.1246/cl.2005.1206
-
Protein-Detecting Microarrays: Current Accomplishments and Requirements 査読あり
Kin-ya Tomizaki, Kenji Usui, Hisakazu Mihara
ChemBioChem 6 ( 6 ) 782 - 799 2005年5月
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Studies on Fluorescent Dyes and Surface Chemistry focusing on Practical Peptide Array Preparation 査読あり
NOKIHARA Kiyoshi, USUI Kenji, YONEMURA Koichi, OHYAMA Takafumi, OKA Yasuo, TOMIZAKI Kin‐ya, MIHARA Hisakazu
Pept Sci 2004 145 - 148 2005年3月
共著
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Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.
Qu X, Kawauchi-Kamata K, Miah SM, Hatani T, Yamamura H, Sada K
Biochemistry 44 ( 10 ) 3891 - 3898 2005年3月
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Thermodynamic analysis of duplex formation of the heterochiral DNA with L-deoxyadenosine（共著） 査読あり
J. Kawakami, K. Tsujita, and N. Sugimoto
Analytical Sciences 21 ( 2 ) 77 - 82 2005年2月
共著
担当区分：筆頭著者
-
Site-selective RNA cleavage by DNA bearing a base pair-mimic nucleoside 査読あり
S. Nakano, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
J. Am. Chem. Soc. 127 518 - 519 2005年1月
単著
DOI： 10.1021/ja045445s
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Nucleic acid with guanidinium modification exhibits efficient cellular uptake.
西方敬人
Angew. Chem. Int. Ed. Engl ( 44 ) 6682 - 6685 2005年
単著
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Site-Selective Deposition of Gold on Glass Substrates Using Monolayer-Protected Gold Nanoparticles
K. Akamatsu, H. Terahata, J. Hasegawa, H. Nawafune
J. Surf, Finish, Soc. Jpn 56 427 - 428 2005年
共著
（学術雑誌、2005）56, 427-428
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Fabrication and Structural Control of Fe/Ti Oxide Thin Films with Graded Compositional Profiles by Liquid Phase Deposition
S. Deki, S. Iizuka, K. Akamatsu, M. Mizuhata and A. Kajinami
J. Ame. Ceram. Soc. 88 731 - 736 2005年
共著
（学術雑誌、2005) 88, 731-736
-
Selective Electroless Copper Deposition on Aluminum Nitride Substrate with Patterned Copper Seed Layer
H. Yanagimoto, S. Deki, K. Akamatsu, and K. Gotoh
Thin Solid Films 491 18 - 22 2005年
共著
（学術雑誌、2005) 491, 18-22
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A novel fabrication technique for interacting ferromagnetic-metal nanoparticle systems:fine-tuning of particle dimeter and interparticle spacing
S. Tomita, K. Akamatsu, H. Shinkai, S. Ikeda, H. Nawafune, C. Mitsumata, T. Kashiwagi, M. Hagiwara
Mater. Res. Soc. Proceedings 853E I5.10.1 - I5.10.6 2005年
共著
（学術雑誌、2005） 853E. I5.10.1-I5.10.6
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Site-Selective Deposition of Gold on Glass Substrates Using Monolayer-Protected Gold Nanoparticles
K. Akamatsu, H. Terahata, J. Hasegawa, H. Nawafune
J. Surf. Finish. Soc. Jpn 56 427 - 428 2005年
共著
（学術雑誌、2005）56. 427-428
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Band Gap Engineering of CdTe nanocrystals Through Chemical Surface Modification
K. Akamatsu, T. Tsuruoka, H. Nawafune
J. Am. Chem. Soc. 127 1634 - 1635 2005年
共著
（学術雑誌、2005） 127. 1634-1635
-
Stereocontrolled Synthesis and Optical Properties of All-cis Poly(phenylene vinylene)s (PPVs): A Method for Direct Patterning of PPVs
H. Katayama, M. Nagao, T. Nishimura, Y. Matsui, K. Umeda, K. Akamatsu, T. Tsuruoka, H. Nawafune, F. Ozawa
J. Am. Chem. Soc. 127 4350 - 4353 2005年
共著
（学術雑誌、2005） 127. 4350-4353
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An SPR Sensor Chip for Sensitive Detection of Small Molecules Using Molecularly Imprinted Polymer with Embedded Gold Nanoparticle
J. Matsui, K. Akamatsu, N. Hara, D. Miyoshi, H. Nawafune, K. Tamaki, N. Sugimoto
Anal. Chem. 77 4282 - 4285 2005年
共著
（学術雑誌、2005） 77. 4282-4285
-
Controlling Interparticle Spacing Among Metal Nanoparticles Through Metal-Catalyzed Decomposition of Surrounding Polymer Matrix
K. Akamatsu, H. Shinkai, S. Ikeda, S. Adachi, H. Nawafune, S. Tomita
J. Am. Chem. Soc. 127 7980 - 7981 2005年
共著
（学術雑誌、2005） 127. 7980-7981
-
Tuning magnetic interactions in ferromagnetic-metal nanoparticle systems
S. Tomita, K. Akamatsu, H. Shinkai, S. Ikeda, H. Nawafune, C. Mitsumata, T. Kashiwagi, and M, Hagiwara
Phys. Rev. B 71 180414(R)1 - 4 2005年
共著
（学術雑誌、2005） 71. 180414(R)1-4
-
Surface Functionalization of Mixed Monolayer-Protected Semiconductor Nanocrystals
T. Tsuruoka, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc 30 1227 - 1230 2005年
共著
（学術雑誌、2005） 30, 1227-1230
-
Synthesis and Structural Control of Metal-Containing Polyimide Nanocomposite
H. Shinkai, S. Ikeda, K. Akamatsu, H. Nawafune, S. Tomita
Trans. Mater. Res. Soc. Jpn. 30 1223 - 1226 2005年
共著
（学術雑誌、2005）30, pp. 1223-1226
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Site-Selective Direct Photochemical Deposition of Copper on Glass Substrates Using TiO2 Nanocrystals
K. Akamatsu, A. Kimura, H. Matsubara, S. Ikeda, H. Nawafune
Langmuir 21 8099 - 8102 2005年
共著
（学術雑誌、2005）21, 8099-8102
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Protein-detection microarrays using structure-based designed peptide libraries 査読あり
Kenji Usui, Tetsunori Ojima, Masato Suzuki, Sin-ya Watanabe, Kin-ya Tomizaki, Kiyoshi Nokihara, Hisakazu Mihara
Peptides 2004, Proceedings 401 - 402 2005年
共著
出版者・発行元：KENES INT
-
Optimization of peptide arrays on chip as novel practical protein characterization system 査読あり
Kiyoshi Nokihara, Takafumi Ohyama, Koichi Yonemura, Kenji Usui, Kin-ya Tomizaki, Hisakazu Mihara
Peptides 2004, Proceedings 176 - 177 2005年
共著
出版者・発行元：KENES INT
-
Band Gap Engineering of CdTe Nanocrystals Through Chemical Surface Modification 査読あり
K. Akamatsu, T. Tsuruoka, H. Nawafune
J. Am. Chem. Soc. 127 1634 - 1635 2005年
共著
-
Stereocontrolled Synthesis and Optical Properties of All-cis Poly(phenylene vinylene)s (PPVs): A Method for Direct Patterning of PPVs 査読あり
H. Katayama, M. Nagao, T. Nishimura, Y. Matsui, K. Umeda, K. Akamatsu, T. Tsuruoka, H. Nawafune, F. Ozawa
J. Am. Chem. Soc. 127 4350 - 4353 2005年
共著
-
Surface Functionalization of Mixed Monolayer-Protected Semiconductor Nanocrystals 査読あり
T. Tsuruoka, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn. 30 1227 - 1230 2005年
共著
-
Nickel- and Palladium-Catalyzed Cross-Coupling Reaction of Polyfluorinated Arenes and Alkenes with Grignard Reagents 査読あり
Tomoyuki Saeki, Yohei Takashima, Kohei Tamao
Synlett 11 1771 - 1774 2005年
共著
-
Duplex dissociation of telomere DNAs induced by molecular crowding. 査読あり
D. Miyoshi, S. Matsumura, S. Nakano, and N. Sugimoto
J. Am. Chem. Soc. 128 165 - 169 2004年12月
単著
DOI： 10.1021/ja036721q
-
Introduction of peptide function into DNA by Nucleic Acid Peptides, NAPs（共著）
J. Kawakami, Z.-M. Wang, H. Fujiki, S. Izumi, and N. Sugimoto
Chemistry Letters 33 ( 12 ) 1554 - 1555 2004年12月
-
多糖・核酸複合体を用いた機能性高分子コンジュゲート −核酸医薬デリバリーへの挑戦−
甲元一也
高分子加工 ( 53 ) 561 - 568 2004年11月
単著
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A Polysaccharide Carrier for Immunostimulatory CpG DNAs to Enhance Cytokine Secretion
甲元一也
J. Am. Chem. Soc. ( 126 ) 8372 - 8373 2004年11月
単著
-
Removal of the side-chain glucose groups from schizophyllan improves the thermal stability of the polycytidylic acid complex under the physiological conditions
甲元一也
Biopolymers ( 75 ) 403 - 411 2004年11月
単著
-
Schizophyllans carrying oligosaccharide appendages as potential candidates for cell-targeted antisense carrier
甲元一也
Org. Biomol. Chem ( 2 ) 3091 - 3098 2004年11月
単著
-
Proposal of New Modification Technique for Linear Double-Stranded DNAs Using the Polysaccharide Schizophyllan
甲元一也
Bioorg. Med. Chem. Lett ( 14 ) 5655 - 5659 2004年11月
単著
-
Molecular weight control of curdlan (b-1,3-glucan polysaccharide) provides unique polynucleotide binding properties
甲元一也
Polym. J. ( 36 ) 380 - 385 2004年11月
単著
-
Low Mw sulfated curdlan with improved water-solubility forms macromolecular complexes with polycytidylic acid
甲元一也
Carbohydr. Res ( 339 ) 161 - 167 2004年11月
単著
-
Chemically modified polysaccharide schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake efficiency
甲元一也
Biochim. Biophys. Acta ( 1670 ) 91 - 104 2004年11月
単著
-
Lactose-appended schizophyllan as a potential candidate for hepatocyte-targetted antisense carrier
甲元一也
Chem. Commun 382 - 383 2004年11月
単著
-
Protection of polynucleotides against nuclease-mediated hydrolysis by complexation with schizophyllan
甲元一也
Biomaterials ( 25 ) 3109 - 3116 2004年11月
単著
-
Antisense oligonucleotides bound in the polysaccharide complex and the enhanced antisense effect due to the low hydrolysis
甲元一也
Biomaterials ( 25 ) 3117 - 3123 2004年11月
単著
-
Long-Term Expression with Cationic Polymer Derived from a Natural Polysaccharide: Schizophyllan
甲元一也
Bioconjugate Chem ( 15 ) 249 - 259 2004年11月
単著
-
Polysaccharide/Polynucleotide Complexes Part 6: Complementary-Strand-Induced Release of Single-stranded DNA Bound in the Schizophyllan Complex
甲元一也
Chemistry & Biodiversity ( 1 ) 520 - 529 2004年11月
単著
-
Enhancement of antisense effect by reducing interactions between proteins and ODNs
甲元一也
Bull. Chem. Soc. Jpn. ( 77 ) 1101 - 1110 2004年11月
単著
-
First observation by Fluorescence Polarization of Complexation between mRNA and the Natural Polysaccharide Schizophyllan
甲元一也
Chemistry & Biodiversity ( 1 ) 634 - 639 2004年11月
単著
-
Duplex Dissociation of Telomere DNA Induced by Molecular Crowding.
三好大輔
J. Am. Chem. Soc. ( 126 ) 165 - 169 2004年11月
単著
-
生命分子を用いたサブナノデバイスの創製
三好大輔
未来材料(NTS) ( 4 ) 26 - 33 2004年11月
単著
-
Composite of Au Nanoparticles and molecularly imprinted polymer as a sensing material
三好大輔
Anal. Chem ( 76 ) 1310 - 1315 2004年11月
単著
-
Synthetic Cinchonidine Receptors Obtained by Cross-linking Linear Poly(Methacrylic Acid) Derivatives as an Alternative Molecular Imprinting Technique J. Chromatogr., B
松井淳
（学術雑誌、 2004 ）804, 223-229 223 - 229 2004年11月
単著
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Atrazine Tranformation Using Synthetic Enzymes Prepared by Molecular Imprinting Org. Biomol. Chem.
松井淳
（学術雑誌、 2004 ）2, 2563-2566 2563 - 2566 2004年11月
単著
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Composite of Au Nanoparticles and molecularly imprinted polymer as a sensing material Anal. Chem.
松井淳
（学術雑誌、 2004 ）76, 1310-1315 1310 - 1315 2004年11月
単著
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Synthesis of Tripeptides Containing a Very Crowded a,a-Disubstituted Glycine with Pyridine Rings by Solid-Phase Ugi Reaction.
村嶋 貴之
Tetrahedron Lett, 2004年11月
単著
Tetrahedron Lett, （学術雑誌、 2004 ）45, 8871-8874.
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A novel intramolecular hydrogen bonding between a side-chain pyridine ring and an amide hydrogen of the peptide backbone in tripeptides containing the new amino acid, a,a-di(2-pyridyl)glycine.
村嶋 貴之
Org. Biomol. Chem., 2004年11月
単著
Org. Biomol. Chem., （学術雑誌、 2004 ） 2, 2335-2339 .
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Conformational change of a nucleotide by a base-pair mimic nucleoside in the complementary DNA strand
中野 修一
Nucleic Acids Symp. Ser. 48 259 - 260 2004年11月
単著
-
Secondary structure change of oligonucleotides induced by salts
中野 修一
Nucleic Acids Symp. Ser. 48 109 - 110 2004年11月
単著
-
Stabilization of a DNA duplex under molecular crowding conditions of PEG
中野 修一
Nucleic Acids Symp. Ser. 48 107 - 108 2004年11月
単著
-
Peptide Arrays with Designed Secondary Structures for Protein Characterization Using Fluorescent Fingerprint Patterns. 査読あり
臼井健二
Biopolymers ( 76 ) 129 - 139 2004年11月
単著
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Stabilization of a DNA duplex under molecular crowding conditions of PEG （共著）
H. Karimata, S. Nakano, T. Ohmichi, J. Kawakami, and N. Sugimoto
Nucleic Acids Symp. Ser. 48 107 - 108 2004年11月
共著
-
Analysis of the secondary structure of a ribozyme that requires His as a cofactor（共著）
J. Kawakami, C. Maiya, and N. Sugimoto
Nucleic Acids Symp. Ser. 48 203 - 204 2004年11月
共著
担当区分：筆頭著者
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The effect of molecular crowding with nucleotide length and cosolute structure on DNA duplex stability（共著） 査読あり
S. Nakano, H. Karimata, T. Ohmichi, J. Kawakami, and N. Sugimoto
Journal of American Chemical Society 126 14330 - 14331 2004年10月
共著
DOI： 10.1021/ja0463029
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"Spinnokinetic Analyses of Blood Disposition and Biliary Excretion of Nitric Oxide (NO)-Fe(II)-N-(Dithiocarboxy)sarcosine Complex in Rats: BCM-ESR and BEM-ESR Studies" 査読あり
Hiroyuki Yasui, Satoshi Fujii, Tetsuhiko Yoshimura, and Hiromu Sakurai
Free Radic. Res 38 ( 10 ) 1061 - 1072 2004年10月
共著
-
Peptide arrays with designed alpha-helical structures for characterization of proteins from FRET fingerprint patterns 査読あり
Kenji Usui, Mizuki Takahashi, Kiyoshi Nokihara, Hisakazu Mihara
MOLECULAR DIVERSITY 8 ( 3 ) 209 - 218 2004年9月
出版者・発行元：SPRINGER
A practical high-throughput protein detection system is described, based on synthetic peptide arrays consisting of designed alpha-helical peptides, detected by fluorescence resonance energy transfer (FRET). Initially a model alpha-helical peptide known to interact with a structured protein, calmodulin, was selected to establish the strategy for high-throughput detection. In comparison to peptides with a single probe, a much higher FRET response has been observed with two fluorescent probes (7-diethylaminocoumarin-3-carboxylic acid and 5(6)-carboxy-fluorescein) at both termini of the synthetic peptides. To establish a reproducible high-throughput detection system, peptides were also immobilized onto a solid surface for detection of the target proteins. A small library of 112 different peptides was constructed, based on a model of the alpha-helical peptide with systematic replacement of residues carrying specific charges and/or hydrophobicities. The library was used to effectively characterize various proteins, giving their own 'protein fingerprint' patterns. The resulting 'protein fingerprints' correlate with the recognition properties of the proteins. The present microarray with designed synthetic peptides as the capturing agents is promising for the development of protein detection chips.
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Cycloprodigiosin up-regulates inducible nitric oxide synthase gene expression in hepatocytes stimulated by interleukin-1beta.
Teshima S, Nakanishi H, Kamata K, Kaibori M, Kwon AH, Kamiyama Y, Nishizawa M, Ito S, Okumura T
Nitric oxide : biology and chemistry 11 ( 1 ) 9 - 16 2004年8月
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Influences of ribonucleotide on a duplex conformation and its thermal stability: Study with the chimeric RNA-DNA strands. 査読あり
S. Nakano, T. Kanzaki, and N. Sugimoto
J. Am. Chem. Soc. 126 1088 - 1095 2004年1月
単著
DOI： 10.1021/ja037314h
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Catalytic roles for proton transfer and protonation in ribozymes: Current understanding and future possibilities. 査読あり
P. C. Bevilacqua, T. S. Brown, S. Nakano, and R. Yajima
Biopolymers 73 90 - 109 2004年1月
単著
DOI： 10.1002/bip.10519
-
Fluorescent in situ hybridization to ascidian chromosomes.
西方敬人
Zool. Sci. ( 21 ) 153 - 157 2004年
単著
-
A role of Ecdysteroid-phosphates during early embryonic development in silkworm Bombyx mori.
西方敬人
Mem. Konan Univ., Sci. Ser ( 51 ) 1 - 16 2004年
単著
-
CiYB1 is a major component of storage mRNPs in ascidian oocytes: implications in translational regulation of localized mRNAs
西方敬人
Developmental Biology ( 272 ) 217 - 230 2004年
単著
-
Synthesis, Surface Modification and Multilayer Construction of Mixed Monolayer-Protected CdS Nanoparticles
T. Tsuruoka, K. Akamatsu, H. Nawafune
Langmuir 20 11169 - 11174 2004年
共著
（学術雑誌、2004）3. 11169-11174
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Electroless Copper Plating Using Sn(II) Complex as a Reducing Agent for ULSI Metallization
H. Nawafune, Y. Kobata, K. Akamatsu, S. Mizumoto, Y. Murakami
Mem. Konan Univ., Sci. Eng.Ser. 51 29 - 38 2004年
共著
（大学・研究所紀要、2004）51, 29-38
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Preparation of transparent alumina film and fiber from a composite of aluminum polynuclear complex/methyl cellulose
Y. Gotoh, K. Fujimura, Y. Ohkoshi, M. Nagura, K. Akamatsu, and S. Deki
Mater. Chem. Phys. 83 54 - 59 2004年
共著
（学術雑誌、2004）83, 54-59
-
Aqueous solution-based synthesis of rare earth-doped metal oxide thin films
S. Deki, K. Kuratani, M. Uemura, K. Akamatsu, M. Mizuhata, and A. Kajinami
Thin Solid Films 460 83 - 86 2004年
共著
（学術雑誌、2004）460, 83-86
-
Polyaddition of 2,7-diethyl-9,9-dioctylfluorene using regio- and stereoselective alkyne dimerization catalysts
H. Katayama, M. Nakayama, T. Nakano, C. Wada, K. Akamatsu and F. Ozawa
Macromolecules 37 13 - 17 2004年
共著
（学術雑誌、2004）37, 13-17
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Composite of Au nanoparticles and molecularly imprinted polymer as a sensing material
J. Matsui, K. Akamatsu, S. Nishiguchi, D. Miyoshi, H. Nawafune, K. Tamaki and N. Sugimoto
Anal. Chem. 76 1310 - 1315 2004年
共著
（学術雑誌、2004）76, 1310-1315
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Direct Patterning of Copper on Polyimide Using Ion Exchangeable Surface Templates Generated by Site-Selective Surface Modification
K. Akamatsu, S. Ikeda, H. Nawafune, H. Yanagimoto
J. Am. Chem. Soc 126 10822 - 10823 2004年
共著
.（学術雑誌、2004）126, 10822-10823
-
Formation and Growth of Copper Nanoparticles from Ion-Doped Precursor Polyimide Layers
S. Ikeda, K. Akamatsu, H. Nawafune, T. Nishino, S. Deki
J. Phys. Chem. B. 108 15599 - 15607 2004年
共著
（学術雑誌、2004）108, 15599-15607
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Development of a practical protein-chip using designed synthetic peptide-arrays 査読あり
K Nokihara, T Ohyama, K Usui, K Yonemura, K Tomizaki, H Mihara
KOBUNSHI RONBUNSHU 61 ( 10 ) 523 - 532 2004年
出版者・発行元：SOC POLYMER SCIENCE JAPAN
Novel high-throughput technologies, which can replace conventional electrophoresis and mass spectroscopic analyses, are in great demand for understanding the structure-function relationships of proteins. For a practical protein-detection system, arrays with immobilized designed synthetic peptides have been constructed. Peptides were labeled with fluorescent dyes in order to achieve high sensitivity. Two different types of prototype-arrayer have been constructed: one has a micro-dispensing system and the other a spot-printing system. Combinatorial peptide libraries, which consisted of beta-loop, beta-strand and alpha-helical peptides, were constructed by improved highly efficient solid-phase synthesis. Labeled peptides were covalently immobilized on solid supports such as precision glass plates. Various proteins were characterized with these peptide-arrays using a fluorescent scanner to give the "protein fingerprint" which is characteristic of the individual proteins. The results of the present prototype system demonstrate the practicality of protein-chips as a new generation of biochips.
-
Peptide arrays with designed secondary structures for protein characterization using fluorescent fingerprint patterns 査読あり
K Usui, T Ojima, M Takahashi, K Nokihara, H Mihara
BIOPOLYMERS 76 ( 2 ) 129 - 139 2004年
出版者・発行元：JOHN WILEY & SONS INC
To realize a practical high-throughput protein-detection system, novel peptide arrays have been constructed using designed peptide libraries with loop, a-helix, or P-strand structures. Here, we describe the overview of the reported deigned peptide arrays with loop and a-helix structures and the new results of those with beta-strand structures. Initially, several model peptides known to interact with model structured proteins were selected to establish the present strategy for high-throughput detection of proteins. The fluorescent probes and suitable scaffolds of peptides were examined for the effective detection of proteins. The detection methods were established in solution and in an immobilized manner using the model systems. In the case of a-helix peptide, the response of a peptide with fluorescent resonance energy tran, fer between two probes at both termini was several times higher than that of a peptide with a single probe. In the cases of peptides with other structures, however, proteins were effectively detectable even by the fluorescent change of one probe. Furthermore, structurally focused libraries consisting of a total of ca. 250 different peptides based on the model pcptides with secondary and/or tertiary structures were constructed with systematic replacement of residues. Using these libraries, various proteins were characterized effectively to give their own fluorescent "protein fingerprint" patterns. The resulting protein fingerprints correlated with the recognition properties of the proteins. These studies demonstrate that arrays with peptide libraries based on designed structures can be promising tools for detecting the target proteins. Designed synthetic peptides play roles as the capturing agents to be developed for practical protein chips. (C) 2004 Wiley Periodicals, Inc.
DOI： 10.1002/bip.10568
-
Development of Peptide-Chips Focusing on a High Throughput Protein-Detection System 査読あり
Kiyoshi Nokihara, Takafumi Ohyama, Kenji Usui, Koichi. Yoneyama, Mizuki Takahashi, Hisakazu Mihara
Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries 83 - 88 2004年
-
Peptide microarrays using structure-based peptide libraries for protein chips 査読あり
Kenji Usui, Mizuki Takahashi, Tetsunori Ojima, Masato Suzuki, Kiyoshi Nokihara, Eiichi Tamiya, Hisakazu Mihara
Peptide Revolution: Genomics, Proteomics & Therapeutics 258 - 259 2004年
共著
出版者・発行元：AMER CHEMICAL SOC
-
Synthesis, Surface Modification and Multilayer Construction of Mixed Monolayer-Protected CdS Nanoparticles 査読あり
T. Tsuruoka, K. Akamatsu, H. Nawafune
Langmuir 20 11169 - 11174 2004年
共著
-
Microanalysis of Nucleic Acids Using the Limulus G Test
甲元一也
Anal. Sci ( 19 ) 1567 - 1568 2003年11月
単著
-
アンチセンス治療に向けた多糖系遺伝子キャリアー
甲元一也
月刊BIOINDUSTRY 20 ( 10 ) 30 - 37 2003年11月
単著
-
Polysaccharide-Polynucleotide Complexes Part 7. Hydrogen-ion and Salt Concentration Dependence of Complexation between Schizophyllan and Single-Stranded Homo RNAs
甲元一也
Bioorg. Chem ( 31 ) 216 - 226 2003年11月
単著
-
Supramolecular structure of a sugar-appended organogelator explored with synchrotron X-ray small angle scattering
甲元一也
Langmuir, ( 19 ) 8211 - 8217 2003年11月
単著
-
Polysaccharide-polynucleotide complexes Part 17. Solvent effects on conformational-transition of polydeoxyadenylic acid in the complex with schizophyllan
甲元一也
Polym. J. ( 35 ) 714 - 720 2003年11月
単著
-
Polysaccharide-polynucleotide Complexes (15): Thermal Stability of Schizophyllan(SPG)/Poly(C) Triple Strands is Controllable by the a-Amino Acid Modification
甲元一也
Bioorg. Chem ( 31 ) 163 - 171 2003年11月
単著
-
Structural Ttransition from Antiparallel to Parallel G-Quadruplex of d(G4T4G4) Induced by Ca2+.
三好大輔
Nucleic Acids Res ( 31 ) 1156 - 1163 2003年11月
単著
-
バイオインフォマティクスを活用した未来型生体内・外センシングシステム
三好大輔
科学と工業, ( 77 ) 413 - 419 2003年11月
単著
-
Novel biomaterials derived from deoxyribozyme and NAPzyme
三好大輔
Macromol. Chem. Phys. Macromol. Symp. ( 201 ) 245 - 252 2003年11月
単著
-
Effect of Putrescine and PEG on a Structural Transition of DNA G-Quadruplex.
三好大輔
Nucleosides, Nucleotides, and Nucleic Acids ( 22 ) 1591 - 1594 2003年11月
単著
-
Structural Competition Involving G-Quadruplex DNA and Its Complement.
三好大輔
Biochemistry ( 42 ) 11736 - 11744 2003年11月
単著
-
Structural Polymorphism of Telomeric DNA Regulated by pH and Divalent Cation.
三好大輔
Nucleosides, Nucleotides, and Nucleic Acids ( 22 ) 203 - 221 2003年11月
単著
-
Facile One-Pot Synthesis of Aromatic and Heteroaromatic Sulfonamides.
村嶋 貴之
J. Org. Chem., 2003年11月
単著
J. Org. Chem., （学術雑誌、 2003）68, 8274-8276.
-
A new synthesis of functional dyes from 2-acenaphtho[1,2-c]pyrrole.
村嶋 貴之
Heterocycles, 2003年11月
単著
Heterocycles, （学術雑誌、 2003） 61, 433-447 .
-
Utilization of proteases from Aspergillus species for peptide synthesis via the kinetically controlled approach.
村嶋 貴之
Biocatal. Biotrans., 2003年11月
単著
Biocatal. Biotrans., （学術雑誌、 2003） 21, 93-100 .
-
Novel biomaterials derived from deoxyribozyme and napzyme.
中野 修一
Macromol. Symp. 201 245 - 252 2003年11月
単著
-
An oligopeptide containing the C-terminal sequence of RNase A inhibits an RNA hydrolysis by RNase A.
S. Nakano, A. L. Cerrone, and P. C. Bevilacqua
First International Symposium on Biomolecular Chemistry 240 - 241 2003年11月
単著
-
Large stacking stability of a base pair-mimic nucleotide on the DNA duplex.
中野 修一
Nucleic Acids Res. Supple. 3 79 - 80 2003年11月
単著
-
Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation.
Kyo S, Sada K, Qu X, Maeno K, Miah SM, Kawauchi-Kamata K, Yamamura H
Genes to cells : devoted to molecular & cellular mechanisms 8 ( 10 ) 825 - 836 2003年10月
共著
-
Structural competition involving G-quadruplex DNA and its complement. 査読あり
W. Li, D. Miyoshi, S. Nakano, and N. Sugimoto
Biochemistry, 42 11736 - 11744 2003年9月
単著
DOI： 10.1021/bi034168j
-
“Pentacoordinated iron complexes with carboxamido nitrogens and thiolate sulfurs: As models for Fe-containing nitrile hydratase”
Satoshi Fujii, Takeshi Ogura, Shozo Kitamura and Hiroshi Sakai
J. Inorg. Biochem 96 134 2003年7月
共著
担当区分：筆頭著者
-
Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase.
Maeno K, Sada K, Kyo S, Miah SM, Kawauchi-Kamata K, Qu X, Shi Y, Yamamura H
The Journal of biological chemistry 278 ( 27 ) 24912 - 24920 2003年7月
-
An Oligopeptide containing the C-terminal sequence of RNase A has a potent RNase A binding property. 査読あり
S. Nakano and N. Sugimoto
J. Am. Chem. Soc. 125 8728 - 8729 2003年6月
単著
DOI： 10.1021/ja034659r
-
Large stabilization of a DNA duplex by the deoxyadenosine derivatives tethering an aromatic hydrocarbon group. 査読あり
S. Nakano, Y. Uotani, S. Nakashima, Y. Anno, M. Fujii, and N. Sugimoto
J. Am. Chem. Soc. 125 8086 - 8087 2003年6月
単著
DOI： 10.1021/ja034465b
-
核酸の長鎖ダングリングエンドと四重鎖の構造形成に関する熱力学的研究
三好大輔
2003年3月
単著
-
Mechanistic chracterization of the HDV genomic ribozyme: Classifying the catalitic and structural metal ion sites within a multichannel mechanism. 査読あり
中野 修一
Biochemistry 42 2982 - 2994 2003年2月
単著
DOI： 10.1021/bi026815x
-
Site-selective direct silver metallization on surface-modified polyimide layers
K. Akamatsu, S. Ikeda, H. Nawafune
Langmuir 19 10366 - 10371 2003年
共著
（学術雑誌、2003）19, 10366-10371
-
低温鉛フリーはんだ接合を目的としたスズー亜鉛共晶合金の電析および亜鉛の共析機構
縄舟秀美、中谷敏雄、赤松謙祐、内田衛、小幡恵吾
エレクトロニクス実装学会誌 6 222 - 227 2003年
共著
（学術雑誌、2003）6, 222-227
-
Fabrication and structural characterization of nanocomposites consisting of Ni nanoparticles dispersed in polyimide films
K. Akamatsu, K. Nakahashi, S. Ikeda, H. Nawafune
Eur. Phys. J. D 24 377 - 380 2003年
共著
（学術雑誌、2003）24, 377-380
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Fabrication of copper film on aluminum nitride by novel electroless plating
H. Yanagimoto, K. Akamatsu, S. Deki, K. Gotoh
J. Electrochem. Soc. 150 260 - 265 2003年
共著
（学術雑誌、2003）150, 260-265
-
Covalent bond-mediated network fabrication of carboxylic anhydride-protected gold nanoparticles
K. Akamatsu, J. Hasegawa, H. Nawafune, H. Katayama, F. Ozawa
Trans. Mater. Res. Soc. Jpn. 28 927 - 930 2003年
共著
（学術雑誌、2003）28, 927-930
-
ULSI銅微細配線の形成を目的とした中性無電解銅めっきにおけるビアフィリング特性の改善
縄舟秀美、樋口晋吾、赤松謙祐、内田衛
表面技術 54 683 - 688 2003年
共著
（学術雑誌、2003）54, 683-688
-
Preparation and characterization of Au/Co nano-alloys
H. Nabika, M. Mizuhata, K. Kajinami, S. Deki, K. Akamatsu
J. Electroanal. Chem. 559 99 - 102 2003年
共著
（学術雑誌、2003）559, 99-102
-
Introduction of Ag and Ag2S nanoparticles into nylon 6 film and fiber
Y. Gotoh, T. Kanno, Y. Fujimori, Y. Ohkoshi, M. Nagura, K. Akamatsu, S. Deki
Polymer Journal 35 960 - 964 2003年
共著
（学術雑誌、2003）35, 960-964
-
Synthesis of metallized polyimide films by surface chemical modification
S. Ikeda, K. Akamatsu, H. Nawafune
Trans. Mater. Res. Soc. Jpn 28 1267 - 1270 2003年
共著
.（学術雑誌、2003）28, 1267-1270
-
Ring-opening methathesis polymerization using alkenyl sulfides as chain-transfer agents: efficient routes to unsymmetrical poly(norbornen)-based macroinitiators bearing a terminal hydroxy group
H. Katayama, Y. Fukuse, Y. Nobuto, K. Akamatsu, F. Ozawa
Macromolecules 36 7020 - 7026 2003年
共著
（学術雑誌、2003）36, 7020-7026
-
NH2-terminated poly(ethylene oxide) containing nano-sized NiO particles: synthesis, characterization and structural considerations
S. Deki, H. Yanagimoto, S. Hiraoka, K. Akamatsu, K. Gotoh
Chem. Mater. 15 4916 - 4922 2003年
共著
（学術雑誌、2003）15, 4916-4922
-
Surface modification-based synthesis and microstructural tuning of nanocomposite layers: monodispersed copper nanoparticles in polyimide resins
K. Akamatsu, S. Ikeda, H. Nawafune, S. Deki
Chem. Mater. 15 1488 - 2491 2003年
共著
（学術雑誌、2003）15, 1488-2491
-
Novel biomaterials derived from deoxyribozyme and NAPzyme 査読あり
Y. Okumoto, H. Fujiki, J. Kawakami, S. Nakashima, S. Nakano, T. Ohmichi, D. Miyoshi and N. Sugimoto
Macromol. Chem. Phys., Macromol. Symp. 201 245 - 252 2003年
-
Important effects of non-Watson-Crick interactions and cation binding on nucleic acid structures.
中野 修一
Recent research development in nucleosides＆nucleotides （Transworld Research Networks）, Vol. 1, 59-80 2003年
単著
-
Temparature dependence of themodynamic properties for DNA/DNA and RNA/DNA duplex formation. 査読あり
P. Wu, S. Nakano, and N. Sugimoto
Eur. J. Biochem. 269 2821 - 2830 2002年11月
単著
-
Molecular Design of “Super” Hydrogelators: Understanding the Gelation process of Azobenzene-Based Sugar Derivatives in Water
甲元一也
Org. Lett., ( 4 ) 1423 - 1426 2002年11月
単著
-
Chemical modification of curdlan: Characteristic complexation with polynucleotides by control of the molecular weight
甲元一也
Polym. Prep 43 ( 2 ) 721 - 723 2002年11月
単著
-
Novel DNA-polysaccharide triple helix and its application to a gene carrier
甲元一也
Polym. Prep 43 ( 2 ) 691 - 692 2002年11月
単著
-
Polysaccharide-polynucleotide Interaction (XI); Novel Separation System of RNAs by Using Schizophyllan-appended Column
甲元一也
Chem. Lett. 1240 - 1241 2002年11月
単著
-
Polysaccharide-Polynucleotide Complexes Part 12: Enhanced affinity for various polynucleotide chains by site-specific chemical modification of schizophyllan
甲元一也
Perkin Trans. 1 2477 - 2484 2002年11月
単著
-
Sol-gel phase transition induced by fiber-vesicle structural changes in sugar-based bolaamphiphiles
甲元一也
Perkin Trans 2 1930 - 1936 2002年11月
単著
-
Gel formation properties of a uracil-appended cholesterol gelator and cooperative effects of the complementary nucleobases
甲元一也
Tetrahedron ( 58 ) 8863 - 8873 2002年11月
単著
-
Polysaccharide-Polynucleotide Complexes Part 8. Cation Induced Complex Formation between Polyuridylic Acid and Schizophyllan
甲元一也
Biopolymers ( 65 ) 1 - 9 2002年11月
単著
-
Long RNA Dangling End Has Large Energetic Contribution to Duplex Stability.
三好大輔
J. Am. Chem. Soc. ( 124 ) 10367 - 10372 2002年11月
単著
-
シリーズ「生命を化学する」—モレキュラークラウディングとin cell Chemistry—
三好大輔
化学（化学同人） 57 ( 12 ) 50 - 56 2002年11月
単著
-
超タンパク質材料—タンパク質活用最前線—
三好大輔
未来材料（NTS） ( 5 ) 29 - 35 2002年11月
単著
-
Molecular Crowding Regulates the Structural Switch of the DNA G-quadruplex.
三好大輔
Biochemistry, ( 41 ) 15017 - 15024 2002年11月
単著
-
Molecular Imprinting in Alcohols: utility of a pre-polymer based strategy for synthesizing stereoselective artificial receptor polymers in media hydrophilic Anal.Chim.Acta
松井淳
（学術雑誌、 2002 ） 466, 11-15 11 - 15 2002年11月
単著
-
コンビナトリアル・モレキュラーインプリンティングで目指す水系での分子認識
松井淳
化学（学術雑誌、 2002 ）57, 33-38 33 - 38 2002年11月
単著
-
Preparation of Novel Heteroisoindoles from Nitro Pyridines and Nitro Pyridones.
村嶋 貴之
Heterocycles, 2002年11月
単著
Heterocycles, （学術雑誌、 2002） 58, 301-310 .
-
Aspergillus melleus protease-catalyzed peptide synthesis using the carbamoylmethyl ester as an acyl donor in 1,1,1,3,3,3-hexafluoro-2-propanol/N,N-dimethylformamide.
村嶋 貴之
Biotechnol. Lett., 2002年11月
単著
Biotechnol. Lett., （学術雑誌、 2002） 24, 1945-1949.
-
Bacillus licheniformis protease-catalyzed peptides synthesis via the kinetically controlled approach using the carbamoylmethyl ester as an acyl donor in anhydrous acetonitrile.
村嶋 貴之
Lett. Pept. Sci., 2002年11月
単著
Lett. Pept. Sci., （学術雑誌、 2002） 9, 173-177 .
-
Role of 2'-OH on Thermodynamic Stability and Structure of Chimeric Oligonucleotides
中野 修一
Nucleic Acids Res. Supple. 2 189 - 190 2002年11月
単著
-
Long RNA Dangling end Has Large Energetic Contribution to Duplex Stability. 査読あり
T. Ohmichi, S. Nakano, D. Miyoshi, and N. Sugimoto
J. Am. Chem. Soc. 124 10367 - 10372 2002年8月
単著
DOI： 10.1021/ja0255406
-
Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops.
Kamata H, Manabe T, Oka Si, Kamata K, Hirata H
FEBS letters 519 ( 1-3 ) 231 - 237 2002年5月
共著
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“Comparison of Nitric Oxide Production in Response to Carbachol Between Macrovascular and Microvascular Cardiac Endothelial Cells” 査読あり
Takehiko Miyashita, Yasuchika Takeishi, Hiroki Takahashi, Takuya Miyamoto, Satoshi Fujii, Tetsuhiko Yoshimura, Hitonobu Tomoike, Shuichi Kato, and Isao Kubota
Circulation Journal, 66 ( 5 ) 511 - 515 2002年4月
共著
-
「アルツハイマー病とNO・金属イオンの化学」
藤井 敏司,杉本直己
化学 57 ( 4 ) 43 - 47 2002年4月
共著
担当区分：筆頭著者
-
「狂牛病・プリオン病と金属イオンの化学」
藤井 敏司,杉本直己
化学 57 ( 3 ) 30 - 34 2002年3月
共著
担当区分：筆頭著者
-
"In Vivo Nitric Oxide Transfer of a Physiological NO Carrier, Dinitrosyl Dithiolato Iron Complex, to Target Complex" 査読あり
Takaharu Ueno, Yasuhiro Suzuki, Satoshi Fujii, Anatoly F. Vanin, and Tetsuhiko Yoshimura
Biochem. Pharmacol. 63 ( 3 ) 485 - 493 2002年2月
共著
-
Ciona intestinalis cDNA projects: expressed sequence tag analyses and gene expression profiles during embryogenesis
西方敬人
Gene ( 287 ) 83 - 96 2002年
単著
-
Novel G-protein-coupled receptor gene expressed specifically in the entire neural tube of the ascidian Ciona intestinalis
西方敬人
Development, Genes and Evolution ( 212 ) 447 - 451 2002年
単著
-
Highly reactive intermediate-functionalized gold clusters: Synthesis and immobilization on silica supports through amide-forming coupling
K. Akamatsu, J. Hasegawa, H. Nawafune, H. Katayama, F. Ozawa
J. Mater. Chem. 12 2862 - 2865 2002年
共著
（学術雑誌、2002）12, 2862-2865
-
鉛フリーはんだ接合を目的としたスルホコハク酸浴からのSn-0.7Cu-0.3Ag３元合金の電析
縄舟秀美、芝一博、赤松謙祐、水本省三、内田衛、小幡恵吾
エレクトロニクス実装学会誌 5 146 - 151 2002年
共著
（学術雑誌、2002）5, 146-151
-
フリップチップ実装を目的としたスルホコハク酸浴からのスズ−インジウム共晶合金の電析
縄舟秀美、中谷敏雄、赤松謙祐、水本省三、小幡恵吾、内田衛
エレクトロニクス実装学会誌 5 349 - 352 2002年
共著
（学術雑誌、2002）5, 349-352
-
Fabrication and characterization of PAN-derived carbon thin films containing Au nanoparticles
S. Deki, H. Nabika, K. Akamatsu, M. Mizuhata, A. Kajinami, S. Tomita, M. Fujii, S. Hayashi
Thin Solid Films 408 59 - 63 2002年
共著
（学術雑誌、2002）408, 59-63
-
Novel copper electroless plating process on ceramic substrate using copper oxide
H. Yanagimoto, K. Akamatsu, S. Deki, K. Gotoh
Electrochem. Solid State Lett. 5 C87 - C89 2002年
共著
（学術雑誌、2002）5, C87-C89
-
Growth of metal oxide thin films from aqueous solution by liquid phase deposition, LPD, method
S. Deki, N. Yoshida, Y. Hiroe, K. Akamatsu, M. Mizuhata, A. Kajinami
Solid State Ionics 151 1 - 9 2002年
共著
（学術雑誌、2002）151, 1-9
-
Microstructure and electron transport properties of AuxCo1-x nano-alloys embedded in polyacrylonitrile thin films
H. Nabika, K. Akamatsu, M. Mizuhata, A. Kajinami, S. Deki
J. Mater. Chem. 12 2408 - 2411 2002年
共著
（学術雑誌、2002）12, 2408-2411
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Effect of composition and structure of gold/copper bimetallic nanoparticles on dispersion in polymer thin films
K. Akamatsu, T. Kawamura, H. Nabika, S. Deki, T. Strunskus, F. Faupel
J. Mater. Chem. 12 3610 - 3614 2002年
共著
（学術雑誌、2002）12, 3610-3614
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Synergistic effects induced by cycloprodigiosin hydrochloride and epirubicin on human breast cancer cellsYamamoto D 査読あり
Tanaka K, Nakai K, Baden T, Inoue K, Yamamoto C, Takemoto H, Kamata K, Hirata H, Morikawa S, Inubushi T, Hioki K
Breast Cancer Research and Treatment 72 2002年
-
分子転写法による新素材の開発 –生体分子を超える分子認識材料開発を目指して-
甲元一也
未来材料 1 ( 5 ) 35 - 41 2001年11月
単著
-
Application of schizophyllan as a novel gene carrier
甲元一也
Nucleic Acids Res. Supplement ( 1 ) 223 - 224 2001年11月
単著
-
A novel technique to specifically separate RNAs by Schizophyllan
甲元一也
Nucleic Acids Res. Supplement ( 1 ) 283 - 284 2001年11月
単著
-
Chemical Modification of Curdlan to Induce an Interaction with Poly(C)
甲元一也
Chem. Lett 908 - 909 2001年11月
単著
-
Chemical modification of schizophyllan by introduction of a cationic charge into the side chain which enhances the thermal stability of schizophyllan/poly(C) complexes
甲元一也
Chem. Commun 1962 - 1963 2001年11月
単著
-
Organization of Nucleosides Supported by Boronic-Acid-Appended poly(L-Lysine): Creation of a Novel RNA Mimic
甲元一也
Bull. Chem. Soc. Jpn ( 74 ) 1311 - 1317 2001年11月
単著
-
Polysaccharide-Polynucleotide Complexes (IV): Anti-hydrolysis effect of the schizophyllan/poly(C) complex and the complex dissociation induced by amines
甲元一也
Bioorg. Chem., ( 29 ) 178 - 185 2001年11月
単著
-
Thermally induced conformational–transition of polydeoxyadenosine in the complex with schizophyllan and the base-length dependence of its stability
甲元一也
Chem. Commun. 429 - 430 2001年11月
単著
-
A Stable DNA tetraloop and Its Structural Tolerance for Modification.
三好大輔
Chem. Lett 258 - 259 2001年11月
単著
-
Structural transition of d(G4T4G4) from antiparallel to parallel G-quartet induced by divalent cations
三好大輔
Nucleic Acids Res. Supple ( 1 ) 259 - 260 2001年11月
単著
-
Effect of Divalent Cations on Antiparallel G-Quartet Structure of d(G4T4G4).
三好大輔
FEBS Lett ( 496 ) 128 - 133 2001年11月
単著
-
Molecularly Imprinted Polymers with Metalloporphyrin-Based Molecular Recognition Sites Coassembled with Methacrylic Acid Anal.Chem.
松井淳
（学術雑誌、 2001 ） 73, 3869-3874 3869 - 3874 2001年11月
単著
-
Molecularly Imprinted Polymer Library on a Microtiter Plate: High-throughput Synthesis and Assessment of Cinchona Alkaloid-imprinted Polymer Receptors Instrumentation Sci. & Technologyvol.
松井淳
（学術雑誌、2001）29, 1-9 1 - 9 2001年11月
単著
-
Combinatorial Molecular Imprinting for Formation of Atrazine Decomposing Polymers Chem.Lett.
松井淳
（学術雑誌、 2001 ） 530-531 530 - 531 2001年11月
単著
-
Synthesis and optical properties of a new class of pyrromethene-BF2-complexes fised with rigid bicyclo rings and benzo derivatives.
村嶋 貴之
Tetrahedron Lett., 2001年11月
単著
Tetrahedron Lett., （学術雑誌、 2001） 6711-6713.
-
Synthesis of benzoporphyrins functionalized with octaester groups.
村嶋 貴之
Tetrahedron Lett., 2001年11月
単著
Tetrahedron Lett.,（学術雑誌、2001） 42, 45-47.
-
Synthesis and properties of polypyrrole annelated with bicyclo[2.2.2]octene units.
村嶋 貴之
Tetrahedron Lett., 2001年11月
単著
Tetrahedron Lett.,（学術雑誌、2001） 42, 707-710.
-
Preparation of meso-unsubstituted porphyrins substituted with mono- and tetraformyl and other electron-withdrawing groups.
村嶋 貴之
Heterocycles, 2001年11月
単著
Heterocycles,（学術雑誌、2001） 54, 705-720.
-
Synthesis of b,b'-(phenylene)diporphyrins.
村嶋 貴之
Synthesis, 2001年11月
単著
Synthesis, （学術雑誌、2001） 399-402.
-
Synthesis of oligo(thienylenevinylenes) substituted with alkoxy groups.
村嶋 貴之
Heteroatom Chemistry, 2001年11月
単著
Heteroatom Chemistry, （学術雑誌、 2001） 12, 414-417.
-
“Spin trapping agent, phenyl N-tert-butylnitrone, reduces nitric oxide production in the rat brain during experimental meningitis”
藤井 敏司
Free Radic Res ( 35 ) 583 - 591 2001年11月
単著
-
Proton Inventory of the Genomic HDV Ribozyme in Mg2+-Containing Solutions. 査読あり
S. Nakano and P. C. Bevilacqua
J. Am. Chem. Soc. 123 11333 - 11334 2001年10月
単著
DOI： 10.1021/ja0166850
-
Mechanistic Characterization of the HDV Genomic Ribozyme: Assessing the Catalytic and Structural Contributions of Divalent Metal Ions within a Multichannel Reaction Mechanism. 査読あり
S. Nakano, D. J. Proctor, and P. C. Bevilacqua
Biochemistry 40 12022 - 12038 2001年9月
単著
DOI： 10.1021/bi011253n
-
Stabilization Factors Affecting Duplex Formation fo Peptide Nucleic Acid with DNA. 査読あり
N. Sugimoto, N. Satoh, K. Yasuda, and S. Nakano
Biochemistry 40 8444 - 8451 2001年6月
単著
DOI： 10.1021/bi010480m
-
A Stable DNA Tetraloop and Its Structural Tolerance for Modification
KAWAKAMI Junji, YONEYAMA Mari, MIYOSHI Daisuke, SUGIMOTO Naoki
Chemistry letters 2001 ( 3 ) 258 - 259 2001年3月
出版者・発行元：The Chemical Society of Japan
Structural features of a stable hairpin DNA with a tetraloop, dAGGC(TTCG)GCCT (CORE), and its six abasic mutants were investigated by the melting behavior of the UV absorption and circular dichroism spectra. The CORE and an abasic mutant at the second position of the loop exhibit considerable thermodynamic stability and have similar structural features suggesting the same folding with an identical base orientation of the two hairpin DNAs except for the second base in the loop.
DOI： 10.1246/cl.2001.258
-
Maternal genetic information stored in fertilized eggs of the ascidian, Halocynthia roretzi.
西方敬人
in Biology of Ascidian Springer-Verlag 165 - 177 2001年
単著
-
Profiles of maternally expressed genes in fertilized eggs of Ciona intestinalis
西方敬人
Developmental Biology ( 238 ) 315 - 331 2001年
単著
-
Large-scale cDNA analysis of the maternal genetic information in the egg of Halocynthia roretzi for a gene expression catalog of ascidian development.
西方敬人
Development ( 128 ) 2555 - 2567 2001年
単著
-
Utilization of ribozymes for loss-of-function analyses of the early development of the ascidian Ciona intestinalis.
西方敬人
Mem. Konan Univ., Sci. Ser. ( 48 ) 11 - 20 2001年
単著
-
Functional analysis of Ciona intestinalis Y-box protein.
西方敬人
in Biology of Ascidian Springer-Verlag 186 - 192 2001年
単著
-
RNA-binding proteins in ascidian development.
西方敬人
RNA-binding proteins in ascidian development. 178 - 185 2001年
単著
-
Utilization of ribozymes for loss-of-function analyses of the early development of the ascidian Ciona intestinalis.
Katano, M., Yamada, A., Tanaka, K. J., Murakami, A., Taira, K., Kawakami, J. Sugimoto, N., and Nishikata, T.
Mem. Konan Univ. Sci. Ser. 48 11 - 20 2001年
単著
-
Improved antigen detection on Western-blots 査読あり
Matsugu, H., Nishikata, T.
Technical Tips Online 6 ( 1 ) 34 - 36 2001年
-
Direct photochemical formation of Cu patterns on surface modified polyimide resin
S. Ikeda, K. Akamatsu, H. Nawafune
J. Mater. Chem. 11 2919 - 1921 2001年
共著
（学術雑誌、2001）11, 2919-1921
-
Formation of copper nanoparticles in surface modified polyimide resin
K. Akamatsu, S. Ikeda, H. Nawafune, S. Dek
Proc. of the 7th International Symposium on Advanced Physical Fields 2001 392 - 395 2001年
共著
（学術雑誌、2001）, 392-395
-
Single-electron tunneling effects in nylon 11 thin films containing nanoparticles
M. Fujii, Y. Inoue, S. Hayashi, K. Akamatsu, S. Deki
Jpn. J. Appl. Phys. 40 1911 - 1914 2001年
共著
（学術雑誌、2001）40, 1911-1914
-
Preparation and characterization of metal nanoparticles dispersed in polyacrylonitrile thin film
S. Deki. H. Nabika, K. Akamatsu, M. Mizuhata, A. Kajinami
Scripta Mater. 44 1879 - 1882 2001年
共著
（学術雑誌、2001）44, 1879-1882
-
Formation process and characterization of copper oxide nanoparticles dispersed in polymer thin films
K. Akamatsu, S. Deki
Scripta Mater. 44 2149 - 2152 2001年
共著
（学術雑誌、2001）44, 2149-2152
-
ポリイミド樹脂の表面改質および熱圧着を利用する銅のDirect Metallization
池田慎吾、赤松謙祐、縄舟秀美、水本省三、清田優
エレクトロニクス実装学会誌 4 603 - 606 2001年
共著
（学術雑誌、2001）4, 603-606
-
添加剤の予備吸着を利用する銅電析プロセスによるULSI微細配線の形成
縄舟秀美、粟野まいこ、赤松謙祐、水本省三、内田衛、細田勉
表面技術 53 59 - 64 2001年
共著
（学術雑誌、2001）53, 59-64
-
Synthesis of titanium carbide from a composite of TiO2 nanoparticles/methyl cellulose by carbothermal reduction
Y. Gotoh, K. Fujimura, M. Koike, Y. Ohkoshi, M. Nagura, K. Akamatsu, S. Deki
Mater. Res. Bull. 36 2263 - 2275 2001年
共著
（学術雑誌、2001）36, 2263-2275
-
Preparation of Cu2O nanoparticles dispersed in NH2-terminated polyethylene oxide matrix
H. Yanagimoto, K. Akamatsu, K. Goto, S. Deki
Eur. Phys. J. D 16 313 - 316 2001年
共著
（学術雑誌、2001）16, 313-316
-
Synthesis and microstructure of metal oxide thin films containing metal nanoparticles by liquid phase deposition (LPD) method
S. Deki, Hin Yu Yu Ko, T. Fujita, K. Akamatsu, M. Mizuhata, A. Kajinami
Eur. Phys. J. D 16 325 - 328 2001年
共著
（学術雑誌、2001）16, 325-328
-
Composition dependence on dispersion of Au/Cu bimetallic nanoparticles in nylon 11 thin films
K. Akamatsu, T. Kawamura, S. Deki
Eur. Phys. J. D 16 305 - 308 2001年
共著
（学術雑誌、2001）16, 325-328
-
Novel fabrication method for Si1-xTixO2 thin films with garaded composition profiles by liquid phase deposition
S. Deki, S. Iizuka, K. Akamatsu, M. Mizuhata, A. Kajinami
J. Mater. Chem. 11 984 - 986 2001年
共著
（学術雑誌、2001）11, 984-986
-
Synthesis and characterization of Cu2O nanoparticles dispersed in NH2-terminated poly(ethylene oxide)
H. Yanagimoto, K. Akamatsu, K. Gotoh, S. Deki
J. Mater. Chem. 11 2387 - 2389 2001年
共著
（学術雑誌、2001）11, 2387-2389
-
Utilization of ribozymes for loss-of-function analyses of the early development of the ascidian Ciona intestinalis
M. Katano, A. Yamada, K. J. Tanaka, A. Murakami, K. Taira, J. Kawakami, N. Sugimoto and T. Nishikata
Mem. Konan Univ., Sci. Eng. Ser. 48 11 - 20 2001年
-
Thermodynamic stability of base pairs between 2-hydroxyadenine and incoming nucleotides as a determinant of nucleotide incorporation specificity during replication 査読あり
J. Kawakami, H. Kamiya, K. Yasuda, H. Fujiki, H. Kasai and N. Sugimoto
Nucleic Acids Research 29 3289 - 3296 2001年
-
Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB 査読あり
Kamata K, Okamoto S, Oka S, Kamata H, Yagisawa H, Hirata H
FEBS Letters 507 2001年
担当区分：筆頭著者
-
Cycloprodigiosin hydrochloride, a H+/Cl- symporter, induces apoptosis in human colon cancer cell lines in vitro
Yamamoto C, Takemoto H, Kuno K, Yamamoto D, Nakai K, Baden T, Kamata K, Hirata H, Watanabe T, Inoue K
Oncology Reports 8 2001年
-
Colorimetric Sugar Sensing Method Useful in “Neutral” Aqueous Media
甲元一也
Chem. Lett., 856 - 857 2000年11月
単著
-
TEM and SEM observations of super-structures constructed in organogel systems from a combination of boronic-acid-appended bola-amphiphiles with chiral diols
甲元一也
Nanotechnology, ( 12 ) 25 - 31 2000年11月
単著
-
Polysaccharide-Polynucleotide Complex (III): A novel interaction between the b-1,3-Glucan Family and the Single-Strand RNA: Poly(C)
甲元一也
Chem. Lett 1242 - 1243 2000年11月
単著
-
The First Example of Positive Allosterism in an Aqueous Saccharide-Binding System Designed on a Ce(IV) Bis(porphyrinate) Double Decker Scaffold
甲元一也
Tetrahedron ( 56 ) 4717 - 4723 2000年11月
単著
-
Development of Small Peptides Recognizing a Monosaccharide by Combinatorial Chemistry.
三好大輔
Chem. Commun 2295 - 2296 2000年11月
単著
-
ゲノム化学は今3 SNPs解析と次世代の生命化学 —「ニューセントラルドグマ」の構築に向けて.
三好大輔
化学（化学同人） ( 55 ) 20 - 25 2000年11月
単著
-
ゲノム化学は今2 DNAチップとバイオインフォマティクス —遺伝子の定量的解析に向けて.
三好大輔
化学（化学同人） ( 55 ) 14 - 18 2000年11月
単著
-
Molecularly Imprinted 9-Ethyladenine Receptor Having Porphyrin-based Recognition Center J. Am. Chem. Soc
松井淳
.（学術雑誌、2000）122, 5218-5219 5218 - 5219 2000年11月
単著
-
Solid - phase Extraction with a Dibutylmelamine-imprinted Polymer as Triazine Herbicide - selective Sorbent
松井淳
J. Chromatogr., A（学術雑誌、2000）889, 25-31 25 - 31 2000年11月
単著
-
Miniaturized Molecularly Imprinted Contiunous Polymer Rods J. High Resolution Chromatogr.
松井淳
J. High Resolution Chromatogr.（学術雑誌、2000）23, 44-46 44 - 46 2000年11月
単著
-
Molecularly Imprinted Fluorescent-shift Receptors Prepared Using 2-(Trifluoromethyl)acrylic Acid Anal. Chem.
松井淳
（学術雑誌、2000）72, 3286-3290 3286 - 3290 2000年11月
単著
-
Atrazine-selective Polymers Prepared by Molecular Imprinting of Trialkylmelamines as Dummy Template Species of Atrazine Anal. Chem.
松井淳
（学術雑誌、2000）72, 1810-1813 1810 - 1813 2000年11月
単著
-
Synthesis and coplanarity-dependent HOMO-LUMO separation of conjugated dimers.
村嶋 貴之
J. Chem. Soc., Perkin Trans. 1, 2000年11月
単著
J. Chem. Soc., Perkin Trans. 1,（学術雑誌、2000） 2671-2675.
-
A new synthesis of benzoporphyrins using 4,7-dihydro-4,7-ethano-2H-isoindole as an isoindole equivalent.
村嶋 貴之
Heterocycles, 2000年11月
単著
Heterocycles,（学術雑誌、2000） 52, 399-411.
-
A new synthesis of [2,3]naphthoporphyrins.
村嶋 貴之
Chem. Commun., 2000年11月
単著
Chem. Commun.,（学術雑誌、2000） 893-894.
-
Synthesis and structures of pyrroles fused with rigid bicyclic ring systems at b-positions.
村嶋 貴之
J. Chem. Soc., Perkin Trans. 1, 2000年11月
単著
J. Chem. Soc., Perkin Trans. 1,（学術雑誌、2000） 4347-4355.
-
Synthesis and X䀭ray structure of stable 2H-isoindoles.
村嶋 貴之
J. Chem. Soc., Perkin Trans. 1 2000年11月
単著
J. Chem. Soc., Perkin Trans. 1,（学術雑誌、2000） 995-998.
-
“Nitric Oxide Enhances Expression and Shedding of Tumor Necrosis Factor Receptor I (p55) in Endothelial Cells”
藤井 敏司
Arterioscler Thromb Vasc Biol. ( 20 ) 1506 - 1511 2000年11月
単著
-
“Detection and Imaging of Endogenously Produced Nitric Oxide with Electron Paramagnetic Resonance Spectroscopy”
藤井 敏司
Antiox. Redox Signal ( 2 ) 879 - 901 2000年11月
単著
-
"A New Trend in Iron-Dithiocarbamate Complexes: As an Endogenous NO Trapping Agent."
藤井 敏司
Coord. Chem. Rev ( 198 ) 89 - 99 2000年11月
単著
-
"Reaction of Nitric Oxide with the Iron(III) Complex of N-(dithiocarboxy)sarcosine: A New Type of Reductive Nitrosylation Involving Iron(IV) as an Intermediate”
藤井 敏司
J. Chem. Soc. Dalton Trans 3310 - 3315 2000年11月
単著
-
Thermodynamics-Structure Relationship of Single Mismatches in RNA/DNA Duplexes. 査読あり
N. Sugimoto, M. Nakano, and S. Nakano
Biochemistry 39 11270 - 11281 2000年8月
単著
DOI： 10.1021/bi000819p
-
A Role for Upstream RNA Structure in Facilitating the Catalytic Fold of the Genomic Hepatitis Delta Virus Ribozyme. 査読あり
D. M. Chadalavada, S. M. Knudsen, S. Nakano, and P. C. Bevilacqua
J. Mol. Biol. 301 349 - 367 2000年3月
単著
-
Expression patterns of musashi homologs of the ascidians, Halocynthia roretzi and Ciona intestinalis 査読あり
T Kawashima, AR Murakami, M Ogasawara, KJ Tanaka, R Isoda, Y Sasakura, T Nishikata, H Okano, KW Makabe
DEVELOPMENT GENES AND EVOLUTION 210 ( 3 ) 162 - 165 2000年3月
共著
出版者・発行元：SPRINGER VERLAG
The gene family encoding RNA-binding proteins includes important regulators involved in the neurogenesis in both protostomes and deuterostomes. We isolated cDNAs of the ascidian homolog of one of the RNA-binding proteins, MUSASHI, from Halocynthia roretzi and Ciona intestinalis. The predicted amino acid sequences contained two RNA-recognition and RNA-binding motifs in the N-terminus and an ascidian-specific YG-rich domain in the C-terminus. Maternal transcripts of musashi were ubiquitous in early cleavage-stage embryos. Ascidian musashi had three domains of zygotic expression: the brain, nerve cord, and mesenchyma. The temporal order of the onset in these domains was highly divergent between the two species of ascidian examined.
-
General Acid-Base Catalysis in the Mechanism of a Hepatitis Delta Virus Ribozyme. 査読あり
S. Nakano, D. M. Chadalavada, and P. C. Bevilacqua
Science 287 1493 - 1497 2000年2月
単著
-
Expression patterns of musashi homologus of the ascidians, Halocynthia roretzi and Ciona intestinalis.
西方敬人
Devl. Genes Evol ( 210 ) 162 - 165 2000年
単著
-
Zoospore-specific antigen as a useful marker for molecular analysis of net formation in Hydrodictyon reticulatum (Chlorococcales, Chlorophyceae).
西方敬人
Phycol. Res ( 48 ) 143 - 148 2000年
単著
-
Improved antigen detection on Western-blots.
西方敬人
Tech. Tips Online http://www.elsevier.com/locate/tto/ T02043 2000年
単著
-
The transcript coding for an RNA-binding protein is localized in the anterior side of the ascidian 2-cell stage embryo.
西方敬人
Devl. Gene Evol. ( 210 ) 464 - 466 2000年
単著
-
An ascidian glycine-rich RNA-binding protein is not induced by temperature-stress but is expressed under a genetic program during embryogenesis.
西方敬人
Gene ( 243 ) 207 - 214 2000年
単著
-
Zoospore-specific antigen as a useful marker for molecular analysis of net formation in Hydrodictyon reticulatum(Chlorococcales, Chlorophyceae) 査読あり
Hatano, K., Yamamoto, M., Yamada, Y., Nishikata, T.
Phycol Res 48 143 - 148 2000年
共著
-
The transcript coding for an RNA-binding protein is localized in the anterior side of the ascidian 2-cell stage embryo 査読あり
Tanaka, K. J., Kawamura, H., Nishikata, T.
Devl. Gene Evol. 210 464 - 466 2000年
共著
-
Expression patterns of musashi homologus of the ascidians, Halocynthia roretzi and Ciona intestinalis 査読あり
Kawashima, T., Murakami, A. R., Ogasawara, M., Tanaka, K. J., Isoda, R., Sasakura, Y., Nishikata, T., Okano, H., Makabe, K. W.
Devl. Genes Evol. 210 162 - 165 2000年
共著
-
An ascidian glycine-rich RNA-binding protein is not induced by temperature-stress but is expressed under a genetic program during embryogenesis 査読あり
Tanaka, K. J., Kawamura, H., Matsugu, H., Nishikata, T.
Gene 243 207 - 214 2000年
共著
-
In situ spectroscopic and microscopic study on dispersion of Ag nanoparticles in polymer thin films
K. Akamatsu, N. Tsuboi, Y. Hatakenaka, S. Deki
J. Phys. Chem. B 104 10168 - 10173 2000年
共著
（学術雑誌、2000）104, 10168-10173
-
Au超微粒子を埋め込んだナイロン11蒸着膜の構造と物性
赤松謙祐、出来成人、井上翼、藤井稔、林真至
信学技報 OME 200-99 1 - 6 2000年
共著
（学術雑誌、2000）OME 200-99, 1-6
-
Preparation and characterization of polymer thin films containing silver and silver sulfide nanoparticles
K. Akamatsu, S. Takei, M. Mizuhata, A. Kajinami, S. Deki, S. Takeoka, M. Fujii, S. Hayashi, K. Yamamoto
Thin Solid Films 359 55 - 60 2000年
共著
（学術雑誌、2000）359, 55-60
-
Single-electron tunneling effects in thin nylon 11 films containing gold nanoparticles
Y. Inoue, M. Fujii, M. Inata, S. Hayashi, K. Yamamoto, K. Akamatsu, S. Deki
Thin Solid Films 372 169 - 172 2000年
共著
（学術雑誌、2000）372, 169-172
-
Formation of Co filled carbon nanocapsules by metal-template graphitization of diamond nanoparticles
S. Tomita, M. Hikita, M. Fujii, S. Hayashi, K. Akamatsu, S. Deki, H. Yasuda
J. Appl. Phys. 88 5452 - 5456 2000年
共著
（学術雑誌、2000）88, 5452-5456
-
Preparation and structure of copper nanoparticles/poly(acrylic acid) composite films
Y. Gotoh, R. Igarashi, Y. Ohkoshi, M. Nagura, K. Akamatsu, S. Deki
J. Mater. Chem. 10 2548 - 2552 2000年
共著
（学術雑誌、2000）10, 2548-2552
-
In vitro selection of aptamers that act with Zn2+ 査読あり
J. Kawakami, H. Imanaka, Y. Yokota and N. Sugimoto
J. Inorg. Biochem. 82 197 - 206 2000年
-
Analysis for peptide binding to porphyrin using surface plasmon resonance
C. Nakamura, Y. Inuyama, K. Shirai, S. Nakano, N. Sugimoto, and J. Miyake
Synthetic Metals 117 127 - 129 2000年
共著
-
"A New Trend in Iron-Dithiocarbamate Complexes : As an Endogenous NO Trapping Agent. " 招待あり 査読あり
FUJII Satoshi
Coord. Chem. Rev. 198 89 - 99 2000年
単著
-
Cycloprodigiosin hydrochloride, H(+)/CL(-) symporter, induces apoptosis and differentiation in HL-60 cells 査読あり
Yamamoto D, Uemura Y, Tanaka K, Nakai K, Yamamoto C, Takemoto H, Kamata K, Hirata H, Hioki K
International Journal of Cancer 88 2000年
-
N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases 査読あり
Oka S, Kamata H, Kamata K, Yagisawa H, Hirata H
FEBS Letters 2000年
-
Demonstration of Cl- requirement for inhibition of vacuolar acidification by cycloprodigiosin in situ 査読あり
Nakayasu T, Kawauchi K, Hirata H, Shimmen T
Plant & Cell Physiol 41 2000年
-
A Novel Screening Method for Combinatorial Chemistry for Low Affinity Interactions.
三好大輔
Chem. Commun. 677 - 678 1999年11月
単著
-
Selection of peptides that recognize tryptophan by combinatorial chemistry
三好大輔
Peptide Science 281 - 284 1999年11月
単著
-
a-b Structural Transition of Short Oligopeptides by Water/Organic Solvent Titration.
三好大輔
Chem. Lett 637 - 638 1999年11月
単著
-
"四塩化炭素肝障害にて発生した一酸化窒素のジチオカルボキシサルコシン鉄錯体による捕捉"
藤井 敏司
磁気共鳴と医学(日本医学館) ( 10 ) 16 - 20 1999年11月
単著
-
"In vivo Distribution and Behavior of Paramagnetic Dinitrosyl Dithiolato Iron Complex in the Abdomen of Mouse"
藤井 敏司
Free Radic. Res. ( 31 ) 525 - 534 1999年11月
単著
-
"Direct Evidence of In Vivo Nitric Oxide Production and Inducible Nitric Oxide Synthase mRNA Expression in the Rat Brain of Living Rat During Experimental Meningitis"
藤井 敏司
J. Cereb. Blood Flow Metab ( 19 ) 1175 - 1178 1999年11月
単著
-
"内因性NOドナー(NOチオレート鉄錯体)のマウス腹部における分布,動態に関する研究"
藤井 敏司
G.I.Research ( 7 ) 85 1999年11月
単著
-
"内因性一酸化窒素のジチオカルバメート誘導体鉄錯体による捕捉検出～検出法の基礎的検討～"
藤井 敏司
磁気共鳴と医学(日本医学館) ( 10 ) 21 - 25 1999年11月
単著
-
Nucleic Acid Duplex Stability : Influence of Base Composition on Cation Effects. 査読あり
S. Nakano, M. Fujimoto, H. Hara, and N. Sugimoto
Nucleic Acids Res. 27 2957 - 2965 1999年7月
単著
-
Generation and characterization of a monoclonal antibody, mH1, raised against mitotic HeLa cells.
西方敬人
Devl. Growth Differ ( 41 ) 381 - 389 1999年
単著
-
A non-radioactive gel shift protocol enables recovery of RNA-binding proteins.
西方敬人
Tech. Tips Online http://www.elsevier.com/locate/tto/T01794 1999年
単著
-
Chracterization of MTR1: A novel protein correlated with the myoplasmic movement during ascidian ooplasmic segregation.
西方敬人
Mem. Konan Univ., Sci. Ser. ( 46 ) 25 - 33 1999年
単著
-
The CAB (Centrosome-Attracting Body), microtubule system and posterior egg cytoplasm are involved in positioning of cleavage planes in the ascidian embryo.
西方敬人
Devl. Biol ( 209 ) 72 - 85 1999年
単著
-
The expression of the protochordate homologue of the proteasome regulatory subunit Rpn12 is transcriptionally , and post-translationally regulated during cleavage stage.
西方敬人
Zool. Sci. ( 16 ) 125 - 129 1999年
単著
-
Interactions between cytoskeletal components during ooplasmic segregation in the myoplasm of ascidian eggs.
西方敬人
Devl. Growth Differ. ( 41 ) 265 - 272 1999年
単著
-
The expression of the protochordate homologue of the proteasome regulatory subunit Rpn12 is transcriptionally and post-translationally regulated during cleavage stage.(共著) 査読あり
NISHIKATA Takahito
Zool. Sci. 16, 125-129 1999年
単著
DOI： 10.2108/zsj.16.125
-
Generation and characterization of a monoclonal antibody, mH1, raised against mitotic HeLa cells.(共著) 査読あり
NISHIKATA Takahito
Devl. Growth Differ. 41, 381-389 1999年
単著
-
Interactions between cytoskeletal components during ooplasmic segregation in the myoplasm of ascidian eggs.(共著) 査読あり
NISHIKATA Takahito
Devl. Growth Differ. 41, 265-272 1999年
-
The CAB(Centrosome-Attracting Body), microtubule system, and posterior egg cytoplasm are involved in positioning of cleavage planes in the ascidian embryo.(共著) 査読あり
NISHIKATA Takahito
Devl. Biol. 209, 72-85 1999年
単著
-
A non-radioactive gel shift protocol enables recovery of RNA-binding proteins 査読あり
Tanaka, K. J., Nishikata, T.
Tech. Tips Online 4 ( 1 ) 70 - 72 1999年
-
Characterization of MTR1: A novel protein correlated with the myoplasmic movement during ascidian ooplasmic segregation.
西方 敬人
Memoirs of Konan University, Science and Engineering Series. 46 25 - 33 1999年
単著
-
Characterization of MTR1 : A novel protein correlated with the myoplasmic movement during ascidian ooplasmic segregation.(共著)
NISHIKATA Takahito
Mem. Konan Univ. Sci. Ser 46, 25-33 1999年
単著
-
TEM investigation and electron diffraction study on dispersion of gold nanoparticles into nylon 11 thin film during heat treatment
K. Akamatsu, S. Deki
J. Colloid Interface Sci. 214 353 - 361 1999年
共著
（学術雑誌、1999）214, 353-361
-
Novel preparation method of nano-sized gold particles by using NH2-terminated polyehtylenoxide
S. Deki, K. Sayo, A. Yamada, K. Akamatsu, S. Hayashi
J. Colloid Interface Sci. 214 123 - 125 1999年
共著
（学術雑誌、1999）214, 123-125
-
Synthesis and characterization of gold-palladium bimetallic particles dispersed in polymer thin film matrix
S. Deki, K. Akamatsu, Y. Hatakenaka, M. Mizuhata, A. Kajinami
Nanostruct. Mater. 11 59 - 65 1999年
共著
（学術雑誌、1999）11, 59-65
-
Preparation, characterization and optical properties of nano-sized bimetallic particles dispersed in polymer thin films
K. Akamatsu, Y. Hatakenaka, M. Mizuhata, A. Kajinami, S. Deki
Trans. Mater. Res. Soc. Jpn. 24 109 - 112 1999年
共著
（学術雑誌、1999）24, 109-112
-
A selection of short peptides that interact with a porphyrin as a small target by immobilized phage display 査読あり
J. Kawakami, T. Kitano and N. Sugimoto
Chem. Commun. 1765 - 1766 1999年
-
Development of New Biotechnology for the 21st Century ((]G0002[))-Structural and thermodynamic studies of PNA/DNA hybrids containing single bulge nucleotides-
Junji Kawakami
Mem, Konan Univ., Sci. Ser. 46 61 1999年
単著
-
"Direct Evidence of In Vivo Nitric Oxide Production and Inducible Nitric Oxide Synthase mRNA Expression in the Rat Brain of Living Rat During Experimental Meningitis" 査読あり
FUJII Satoshi
J. Cereb. Blood Flow Metab. 19 1175 - 1178 1999年
単著
-
Cycloprodigiosin hydrochloride, a new H(+)/Cl(-) symporter, induces apoptosis in human and rat hepatocellular cancer cell lines in vitro and inhibits the growth of hepatocellular carcinoma xenografts in nude mice 査読あり
Yamamoto C, Takemoto H, Kuno K, Yamamoto D, Tsubura A, Kamata K, Hirata H, Yamamoto A, Kano H, Seki T, Inoue K
Hepatology 1999年
-
Cycloprodigiosin hydrochloride inhibits acidification of plant vacuole 査読あり
Nakayasu T, Kawauchi K, Hirata H, Shimmen T
Plant & Cell Physiol 40 1999年
-
Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent 査読あり
Kim HS, Hayashi M, Shibata Y, Wataya Y, Mitamura T, Horii T, Kawauchi K, Hirata H, Tsuboi S, Moriyama Y
Biol. Pharm. Bull 22 1999年
-
Cycloprodigiosin uncouples H+-pyrophosphatase of plant vacuolar membranes in the presence of chloride ionMaeshima 査読あり
M, Nakayasu, T, Kawauchi, K, Hirata, H, Shimmen, T
Plant & Cell Physiol 1999年
-
Single-Stranded DNA Recognition of a 24 mer Peptide Derived from RecA Protein. 査読あり
S. Nakano and N. Sugimoto
Bull. Chem. Soc. Jpn. 71 2205 - 2210 1998年11月
単著
-
Effect of Cation Concentration on Duplex Stability of Nucleic Acids with Unnatural Base Pairs.
中野 修一
Nucleic Acids Symp. Ser. 39 121 - 122 1998年11月
単著
-
Synthesis and Applications of Molecularly Imprinted Artificial Receptors
Jun Matsui
1998年3月
単著
-
Isolation and characterization of cDNA clones for epidermis-specific and musclespecific benes in Ciona savignyi embryos. 査読あり
NISHIKATA Takahito
Zoological Science 15 ( 2 ) 239 - 246 1998年
-
An alternatively spliced gene encoding a Y-box protein showing maternal expression and tissue-specific zygotic expression in the ascidian embryos.(共著) 査読あり
NISHIKATA Takahito
Development, Growth and Differentiation 40 ( 6 ) 631 - 640 1998年
-
Centrosome-attracting body : A novel structure closely related to unequal cleavages in the ascidian embryo. 査読あり
NISHIKATA Takahito
Development, Growth & Differentiation 40 ( 1 ) 85 - 95 1998年
-
Dispersion of gold nanoparticles into a nylon 11 thin film during heat treatment : in situ optical transmission study
K. Akamatsu, S. Deki
J. Mater. Chem. 8 637 - 640 1998年
共著
-
Preparation and characterization of copper(I) oxide nanoparticles dispersed in polymer matrix
S. Deki, K. Akamatsu, T. Yano, M. Mizuhata, and A. Kajinami
J. Mater. Chem. 8 1865 - 1868 1998年
共著
-
Stability of DNA duplexes containing mirror-image DNA
J. Kawakami, K. Tsujita and N. Sugimoto
Nucleic Acids Symp. Ser. 39 55 - 56 1998年
-
ニューバイオテクノロジー:ファージディスプレイ、インビトロセレクション及びコンビナトリアルケミストリー
川上 純司
化学 53 74 1998年
単著
-
Minimization of genomic human hepatitis delta virus ribozyme 査読あり
H. Fauzi, A. Chiba, F. Nishikawa, M. Roy, J. Kawakami and S. Nishikawa
Anal. Chim. Acta 365 309 - 317 1998年
-
In vitro selection of aptamers that recognize a monosaccharide
J. Kawakami, Y. Kawase and N. Sugimoto
Anal. Chim. Acta 365 95 - 100 1998年
-
生命関連分子の微視的相互作用(3)-RNA鎖を切断するデオキシリボザイムと金属イオンの関係-
川上 純司
甲南大学紀要,理学編 45 125 1998年
単著
-
生命関連分子の微視的相互作用(4)-ミスマッチを含むRNA/DNAハイブリッドの安定性に及ぼすミスマッチの隣接塩基対の影響-
川上 純司
甲南大学紀要,理学編 45 135 1998年
単著
-
"Electron Paramagnetic Resonance Detection of Nitric Oxide in the Brain During Sepsis and Meningitis"
FUJII Satoshi
In"The Proceedings of the 2nd International Conference on Bioradicals" 146 - 148 1998年
単著
-
A 24 mer Peptide Derived from RecA Protein can Discriminate a Single-Stranded DNA from a Double-Stranded DNA. 査読あり
N. Sugimoto and S. Nakano
Chem. Commun. 2125 - 2126 1997年11月
単著
DOI： 10.1039/A705575G
-
A 24 mer Peptide with Activity of a Nucleic Acid Discrimination and Its Recombination.
中野 修一
First International Peptide Symp. ( P-108 ) 1997年11月
単著
-
Experimental Quantitation of Cation Effect on Nucleic Acid Stability.
中野 修一
Nucleic Acids Symp. Ser. 37 147 - 148 1997年11月
単著
-
Sandwiching Interaction of Peptides with a Porphyrin. 査読あり
N. Sugimoto and S. Nakano
Chem. Lett. 939 - 949 1997年11月
単著
-
Cloning of the ascidian Y-box protein gene with a convenient and reliable amplification protocol of 3' ends of mRNAs.
NISHIKATA Takahito
Memoirs of Konan University, Science Series 44 ( 2 ) 45 - 51 1997年
単著
-
Nanoscale metal particles dispersed in polymer matrix
K. Akamatsu, S. Deki
Nanostruct. Mater. 8 1121 - 1129 1997年
共著
-
Characterization and optical properties of gold nanoparticles dispersed in nylon 11 thin films
K. Akamatsu, S. Deki
J. Mater. Chem. 7 1773 - 1777 1997年
共著
-
Evolution of a phosphorothioate RNA library during in vitro selection
J. Kawakami and N. Sugimoto
Nucleic Acids Symp. Ser. 37 201 - 202 1997年
-
生命関連分子の微視的相互作用(II)-ペプチドの分子内α-ヘリックスと分子間β-シートの構造遷移-
川上 純司
甲南大学紀要,理学編 44 17 1997年
単著
-
Analysis of the cleavage reaction of a trans-acting human hepatitis delta virus ribozyme 査読あり
H. Fauzi, J. Kawakami, F. Nishikawa and S. Nishikawa
Nucleic Acids Research 25 3124 - 3130 1997年
-
A possible immunosuppressant, cycloprodigiosin hydrochloride, obtained from Pseudoalteromonas denitrificans 査読あり
Kawauchi K, Shibutani K, Yagisawa H, Kamata H, Nakatsuji S, Anzai H, Yokoyama Y, Ikegami Y, Moriyama Y, Hirata H
Biochem. Biophys. Res. Commun, 237 1997年
担当区分：筆頭著者
-
Development of New SPR Chip with an Oligopeptide Recognizing a Single-Stranded DNA.
中野 修一
Nucleic Acids Symp. Ser. 35 303 - 304 1996年11月
単著
-
Improved Thermodynamic Parameters and Helix Initiation Factor to Predict Stability of DNA Duplexes. 査読あり
N. Sugimoto, S. Nakano, M. Yoneyama, and K. Honda
Nucleic Acids Res. 24 4501 - 4505 1996年11月
単著
-
Interactions of 5-(1-pyrenyl)-10,15,20,-tris(4-methyl-pyridinium)porphine with Double-Helix and Triple-Helix Nucleic Acids. 査読あり
N. Sugimoto, S. Nakano, M. Katoh, M. Sasaki, and S. Kugimiya
Nucleosides & Nucleotides 15 743 - 747 1996年8月
単著
-
Two distinct cell types identified in the ascidian notochord. 査読あり
NISHIKATA Takahito
Zoological Science 13 725 - 730 1996年
単著
-
Molecalar characterization of myoplasmin-Cl : a cytoskeletal component localized in the myoplasm of the ascidian egg 査読あり
NISHIKATA Takahito, WADA Michiko
Development, Genes and Evolution 206 72 - 79 1996年
共著
-
Preparation and characterization of Au-dispersed TiO2 thin films by a liquid-phase deposition method
S. Deki, Y. Aoi, H. Yanagimoto, H. Ishii, K. Akamatsu, M. Mizuhata, A. Kajinami
J. Mater. Chem. 6 1879 - 1882 1996年
共著
-
Selection in vitro of trans-acting genomic human hepatitis delta virus (HDV) ribozymes 査読あり
F. Nishikawa, J. Kawakami, A. Chiba, K. Yuda, M. Shirai, P.K.R. Kumar and S. Nishikawa
Eur. J. Biochem. 327 712 - 718 1996年
-
生命関連分子の微視的相互作用(I)-バルジを含むDNA二重らせんの熱力学的安定性に及ぼすイノシン置換の影響-
川上 純司
甲南大学紀要,理学編 43 37 - 47 1996年
単著
-
Constructing an efficient trans-acting genomic HDV ribozyme 査読あり
J. Kawakami, K. Yuda, Y.-A. Suh, P.K.R. Kumar, F. Nishikawa, H. Maeda, K. Taira, E. Ohtsuka and S. Nishikawa
FEBS Lett. 394 132 - 136 1996年
-
Thermodynamic Parameters to Predict Stability of RNA/DNA Hybrid Duplexes.
中野 修一
J. Biomol. Struct. Dyn. 12 ( a233 ) 1995年11月
単著
-
Interaction of Oligonuleotides with a Single Stranded DNA Binding Site of RecA Protein.
中野 修一
Nucleic Acids Symp. Ser. 34 61 - 62 1995年11月
単著
-
Thermodynamic stability of RNA/DNA hybrids. 査読あり
N. Sugimoto, S. Nakano, M. Katoh, A. Matsumura, H. Nakamuta, T. Ohmichi, M. Yoneyama, and M. Sasaki
Biochemistry 34 11211 - 11216 1995年9月
単著
DOI： 10.1021/bi00035a029
-
ANALYSIS OF FUNCTIONAL STRUCTURE OF HDV RIBOZYME BY MODIFICATION INTERFERENCE AND IN-VITRO SELECTION-STRATEGIES
S NISHIKAWA, YH JEOUNG, P KUMAR, J KAWAKAMI, F NISHIKAWA, A CHIBA, K YUDA, P VILLJANEN, K TAIRA
JOURNAL OF CELLULAR BIOCHEMISTRY 19A 227 - 227 1995年1月
共著
出版者・発行元：WILEY-LISS
-
Designing of HDV ribozyme by in vitro selection 査読あり
S. Nishikawa, F. Nishikawa, J. Kawakami, A. Chiba, K. Yuda, Y.-H. Jeoung, P.K.R. Kumar and K. Taira
Antisense Research and Development 54 104 - 105 1995年
-
Thermodynamic Parameters to Predict the Stability of RNA/DNA Hybrids in Antisense Interaction.
中野 修一
First International Antisence Conference of Japan ( P1-05 ) 1994年11月
単著
-
RNA/DNA Hybrid Duplexes with Identical Nearest-Neighbor Base-Pairs Have Identical Stability. 査読あり
N. Sugimoto, M. Katoh, S. Nakano, T. Ohmichi, and M. Sasaki
FEBS Lett. 354 74 - 78 1994年10月
単著
-
ヒトδ型肝炎ウイルス（HDV）リボザイムの構造活性相関に関する研究
川上純司
1994年3月
単著
-
Specification in the primary lineage of ascidian muscle cells analyzed with a specific monoclonal antibody
NISHIKATA Takahito
Memoirs of Konan University Science Series 41 ( 2 ) 89 - 97 1994年
単著
-
Monoclonal antibodies with affinity to self-complementary left-handed DNA containing cyclonucleosides with high anti conformation 査読あり
J. Kawakami, S. Uesugi, M. Ikehara, T. Itoh, K. Miura and E. Ohtsuka
Nucleosides & Nucleotides 13 421 - 427 1994年
-
The accumulation of vanadium and manifestation of an antigen recognized by a monoclonal antibody specific to vanadocytes during embryo genesis in vanadium-rich ascidian, ┣DBAsidia(/)-┫DB ┣DBSydneieusis(/)-┫DB ┣DBsamea(/)-┫DB. 査読あり
NISHIKATA Takahito
Journal of Experimental Zoology 265,29-34 1993年
単著
-
Systematic substitution of individual bases in two important single-stranded regions of the HDV ribozyme for evaluation of the role of specific bases 査読あり
Y.-A. Suh, P.K.R. Kumar, J. Kawakami, F. Nishikawa, K. Taira, and S. Nishikawa
FEBS Lett. 326 158 - 162 1993年
-
Chemical probing studies of the hepatitis delta virus (HDV) genomic ribozyme
S. Nishikawa, P.K.R. Kumar, Y.-H. Jeong, J. Kawakami, F. Nishikawa, Y.-A. Suh, E. Ohtsuka and K. Taira
Nucleic Acids Symp. Ser. 29 119 - 120 1993年
-
Identification of important bases in a single-stranded region (SSrC) of the hepatitis delta ribozyme 査読あり
J. Kawakami, P.K.R. Kumar, Y.-A. Suh, F. Nishikawa, K. Kawakami, K. Taira, E. Ohtsuka and S. Nishikawa
Eur. J. Biochem. 217 29 - 36 1993年
-
Initial stages of tunic morphogenesis in the ascidian ┣DBHalocythia(/)-┫DB : a fine structural study. 査読あり
NISHIKATA Takahito
Tissue and Cell 24 1992年
単著
-
Random mutations to evaluate the role of bases at two important single-stranded regions of genomic HDV ribozyme 査読あり
P.K.R. Kumar, Y.-A. Suh, H. Miyashiro, F. Nishikawa, J. Kawakami, K. Taira and S. Nishikawa
Nucleic Acids Research 20 3919 - 3924 1992年
-
Ribozymes as molecular scissors for suppressing AIDS virus 査読あり
J. Ohkawa, T. Shimayama, N. Yuyama, S. Sawata, Y. Takagi, A. Wada, K. Yasuda, J. Kawakami, P.K.R. Kumar, Y.-A. Suh, F. Nishikawa, M. Oda, S. Shinshi, M. Uebayashi, T. Uchimaru, K. Furukawa, S. Nishikawa and K. Taira
Now & Future 8 8 - 12 1992年
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Identification of important bases for the self-cleavage activity at two single-stranded regions of genomic HDV ribozyme
Junji Kawakami
Nucleic Acids Symposium Series 27 41 1992年
単著
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Monoclonal antibody specific to signet ring cells, the vanadocytes of the tunicate, ┣DBAscidia(/)-┫DB ┣DBsydneiensis(/)-┫DB ┣DBsamea(/)-┫DB. 査読あり
NISHIKATA Takahito
Journal of Experimental Zoology 259 1991年
単著
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Characterization of antigenic polypeptides recognized by monoclonal antibodies specific to the myoplasm of eggs of the ascidian ┣DBCiona(/)-┫DB ┣DBinterstinalis(/)-┫DB. 査読あり
NISHIKATA Takahito
Development, Growth and Differentiation 33 1991年
単著
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Expression of an antigen specific for trunk-lateral cells in quarter embryos of the ascidian, ┣DBHalocynthia(/)-┫DB ┣DBroretzi(/)-┫DB. 査読あり
NISHIKATA Takahito
Journal of Experimental Zoology 258 1991年
単著
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Specification of notochord cells in the ascidian embryo analysed with a specific monoclonal antibody. 査読あり
NISHIKATA Takahito
Cell Differentiation and Development 30 1990年
単著
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Cellular and molecular mechanisms of muscle cell differentiation in the ascidian embryos. 査読あり
NISHIKATA Takahito
International Review of Cytology 122 1990年
単著
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Egg cytoplasmic components responsible for larval muscle cell differentiation in ascidian embryos.
NISHIKATA Takahito
Developmental Biology UCLA Symposia 125 1990年
単著
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ホヤ卵における筋肉細胞分化決定因子の分子的実体の解析
西方敬人
1989年3月
単著
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A monoclonal antibody specific to embryoie trunk-lateral cells of the ascidian ┣DBHalocynthia(/)-┫DB ┣DBroretzi(/)-┫DB stains coelomic cells of juvenile and adult basophilic blood cells. 査読あり
NISHIKATA Takahito
Development, Growth and Differentiation 31 ( 6 ) 595 - 600 1989年
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Differentiation expression in blastomeres of cleavagearrested embryos of the ascidian ┣DBHalocynthia(/)-┫DB ┣DBroretzi(/)-┫DB. 査読あり
NISHIKATA Takahito
Development, Growth and Differentiation 30 ( 4 ) 1988年
単著
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Muscle cell differentiation in ascidian embryos analysed with a tissue-specific monoclonal antibody. 査読あり
NISHIKATA Takahito
Development 99 ( 2 ) 1987年
単著
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Monoclonal antibodies against components of the myoplasm of eggs of the ascidian ┣DBCiona(/)-┫DB ┣DBintestinalis(/)-┫DB partially block the development of muscle-specific acetylcholinesterase. 査読あり
NISHIKATA Takahito
Development 100 ( 2 ) 1987年
単著
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Cell-and tissue-specific monoclonal antibodies in eggs and embryos of the ascidian ┣DBHalocynthia(/)-┫DB ┣DBroretzi(/)-┫DB. 査読あり
NISHIKATA Takahito
Development 99 ( 2 ) 1987年
単著
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Expression of epidermis-specific antigens during embryogenesis of the ascidian, ┣DBHalocynthia(/)-┫DB ┣DBroretzi(/)-┫DB. 査読あり
NISHIKATA Takahito
Developmental Biology 121 ( 2 ) 408 - 416 1987年