論文
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Dangling ends perturb the stability of RNA duplexes responsive to surrounding conditions 査読あり
H. Tateishi-Karimata, S. Pramanik, S. Nakano, D. Miyoshi, and N. Sugimoto
ChemMedChem 9 ( 9 ) 2150 - 2155 2014年7月
共著
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Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds 査読あり
S. Nakano, Y. Kitagawa, D. Miyoshi, N. Sugimoto
FEBS Open Bio 4 643 - 650 2014年7月
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Drastic stabilization of parallel DNA hybridizations by a polylysine comb-type copolymer with hydrophilic graft chain 査読あり
D. Miyoshi, Y. Ueda, N. Shimada, S. Nakano, N. Sugimoto, and A. Maruyama
ChemMedChem 9 ( 9 ) 2156 - 2163 2014年7月
共著
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A Designed Small Protein For Controlling Site-Specific Mineralization Of Silica And Calcium On Dnas 査読あり
Kenji Usui, Kazuma Nagai, Hiroto Nishiyama, Aoi Yamada, Makoto Ozaki, Takaaki Tsuruoka, Kin-ya Tomizaki
PROTEIN SCIENCE 23 143 - 143 2014年7月
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出版者・発行元：WILEY-BLACKWELL
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Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro 査読あり
T. Shimo, K. Tachibana, K. Saito, T. Yoshida, E. Tomita, R. Waki, T. Yamamoto, T. Doi, T. Inoue, J. Kawakami and S. Obika
Nucleic Acids Res. 42 8174 - 8187 2014年6月
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A nanocomposite approach to develop biodegradable thermogels exhibiting excellent cell-compatibility for injectable cell delivery 査読あり
N. Oyama, H. Minami, D. Kawano, M. Miyazaki, T. Maeda, K. Toma, A. Hotta, K. Nagahama
Biomaterials Science 2 ( 8 ) 1057 - 1062 2014年6月
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担当区分：筆頭著者
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Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers.
Higuchi S, Watanabe TM, Kawauchi K, Ichimura T, Fujita H
Journal of bioscience and bioengineering 117 ( 6 ) 749 - 755 2014年6月
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Refinement and verification of test conditions for colony-forming unit assay in rat bone marrow cells with preservable colony specimens 査読あり
Takamatsu K., Wakata A., Tabata H., and Nishikata T.
Comparative Clinical Pathology 23 ( 3 ) 569 - 575 2014年5月
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In vitro assays predictive of telomerase inhibitory effect of G-quadruplex ligands in cell nuclei 査読あり
H. Yaku, T. Murashima, D. Miyoshi, N. Sugimoto
The Journal of Physical Chemistry B 118 ( 10 ) 2605 - 2614 2014年3月
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DOI： 10.1021/jp410669t
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Effects of molecular crowding on the structures, interactions, and functions of nucleic acids 査読あり
S. Nakano, D. Miyoshi, and N. Sugimoto
Chem. Rev. 114 2733 - 2758 2014年3月
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Site-Specific Control of Silica Mineralization on DNA Using Designed Peptides 査読あり
K. Usui, K. Nagai, H. Nishiyama, A. yamada, T. Tsuruoka, S. Fujii, K.-y. Tomizaki
Peptide Science 2013 2415 - 2416 2014年3月
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担当区分：筆頭著者
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A simple "add and measure" FRET-based telomeric tandem repeat sequence detection and telomerase assay method 査読あり
K. Kawamura, H. Yaku, D. Miyoshi, T. Murashima
Organic & Biomolecular Chemistry 12 ( 6 ) 936 - 941 2014年2月
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DOI： 10.1039/c3ob42092b
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Peptides targeting G-quadruplex structures 査読あり
Kenji Usui, Arisa Okada
Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications 459 - 475 2014年1月
出版者・発行元：Springer Berlin Heidelberg
Research in recent decades has revealed that some DNA and RNA secondary structures modulate a variety of cellular events. One secondary structure, the Guanine(G)-quadruplex, also regulates various cellular events that are mostly related to serious diseases. Systems capable of controlling DNA and RNA G-quadruplex structures would therefore be useful for the modulation of various cellular events to produce biological effects. Because of their biological importance, many G-quadruplex-targeting compounds have been described. However, the next generation of targeting molecules should exhibit increased G-quadruplex sequence specificity, a higher structure-inducing or -collapsing ability, and a greater degree of functionality, including on–off switches of binding ability and cellular penetration. Peptides might be good candidates for these next-generation Gquadruplex- targeting molecules due to the following advantages: (1) their easy design and synthesis, (2) their ability to mimic protein–G–quadruplex interactions, (3) the possibility of employing artificial amino acids in addition to naturally occurring amino acids, and (4) the ability to combine G-quadruplex-binding sequences with other functional sequences. Accordingly, several peptide-based compounds, such as furan-based cyclic peptides, PNA-conjugated peptides, and small molecule-peptide conjugates, have been developed. In this chapter, we introduce all these peptide ligands and describe most of the approaches for targeting G-quadruplex structures. We then conclude that peptides are among the most promising functional ligands for G-quadruplexes to control various biological events in next-generation approaches.
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Mechanistic study on the facilitation of enzymatic hydrolysis by α-glucosidase in the presence of betaine-type metabolite analogs 査読あり
Yuichi Nakagawa, Shiro Sehata, Satoshi Fujii, Hiroaki Yamamoto, Akihiko Tsuda, Kazuya Koumoto
Tetrahedron 70 5895 - 5903 2014年
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担当区分：筆頭著者
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Reduced Graphene Oxide Upconversion Nanoparticle Hybrid for Electrochemiluminescent Sensing of a Prognostic Indicator in Early-Stage Cancer 査読あり
Li Wu, Jiasi Wang, Meili Yin, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto, Xiaogang Qu
Small 10 330 - 336 2014年
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A fluorescent probe for detection of an intracellular prognostic indicator in early-stage cancer (10.1039/c4cc08789e 査読あり
Haiwei Ji, Yijia Guan, L Wu, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto Xiaogang Qu
Chem. Commun. 51 1479 - 1482 2014年
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Preparation of hydrogels for the study of the effects of spatial confinement on DNA 査読あり
Shu-ichi Nakano, Masatoshi Yoshida, Daisuke Yamaguchi, Naoki Sugimoto
Transact. Mat. Res. Soc. Japan 39 435 - 438 2014年
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Dangling ends perturb the stability of RNA duplex responsive to surrounding condition 招待あり 査読あり
H. Tateishi-Karimata, S. Pramanik, S. Nakano, D. Miyoshi and N. Sugimoto
ChemMedChem 9 ( 9 ) 2150 - 2155 2014年
共著
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Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds 査読あり
Shu-ichi Nakano, Yuichi Kitagawa, Daisuke Miyoshi, Naoki Sugimoto
FEBS Open Bio 4 643 - 650 2014年
共著
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Drastic stabilization of parallel DNA hybridizations by a polylysine comb-type copolymer with hydrophilic graft chain 査読あり
Daisuke Miyoshi, Yu-mi Ueda, Naohiko Shimada, Shu-ichi Nakano, Naoki Sugimoto, Atsushi Maruyama
ChemMedChem 9 ( 9 ) 2156 - 2163 2014年
共著
担当区分：筆頭著者