論文
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Face-to-face porphyrin moieties assembled with spacing for pyrazine recognition in molecularly imprinted polymers 査読あり
Matsui, J., Sodeyama, T., Saiki, Y., Miyazawa, T., Yamada, T., Tamaki, K., Murashima, T.
Biosensors and Bioelectronics 25 ( 3 ) 635 - 639 2009年11月
共著
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Hydration of Watson-Crick base pairs and dehydration of Hoogsteen base pairs inducing structural polymorphism under molecular crowding conditions
三好大輔
J. Am. Chem. Soc. ( 131 ) 3522 - 3531 2009年11月
単著
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Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity 査読あり 国際共著
Kenji Usui, John D. Hulleman, Johan F. Paulsson, Sarah J. Siegel, Evan T. Powers, Jeffery W. Kelly
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 ( 44 ) 18563 - 18568 2009年11月
出版者・発行元：NATL ACAD SCIENCES
Accumulation of amyloid beta-peptide (A beta) and tau aggregates, possibly linked to age-associated deficiencies in protein homeostasis, appear to cause Alzheimer's disease. Schiff-base formation between A beta and the aldehyde-bearing cholesterol oxidation product 3-beta-hydroxy-5-oxo-5,6-secocholestan-6-al is known to increase A beta amyloidogenicity. Here, we synthesized A beta variants site-specifically modified with the cholesterol aldehyde at Asp-1, Lys-16, or Lys-28, rather than studying mixtures. These distinct modifications have a similar effect on the thermodynamic propensity for aggregation, enabling aggregation at low concentrations. In contrast, the modification site differentially influences the aggregation kinetics; Lys-16-modified A beta formed amorphous aggregates fastest and at the lowest concentration (within 2 h at a concentration of 20 nM), followed by the Lys-28 and Asp-1 conjugates. Also, the aggregates resulting from A beta Lys-16 cholesterol aldehyde conjugation were more toxic to primary rat cortical neurons than treatment with unmodified A beta under identical conditions and at the same concentration. Our results show that A beta modification by cholesterol derivatives, especially at Lys-16, renders it kinetically and thermodynamically competent to form neurotoxic aggregates at concentrations approaching the physiologic concentration of A beta.
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Facilitation of RNA enzyme activity in the molecular crowding media of cosolutes 査読あり
S. Nakano, H. T. Karimata, Y. Kitagawa, and N. Sugimoto
J. Am. Chem. Soc. 131 16881 - 16888 2009年10月
共著
DOI： 10.1021/ja9066628
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Biodegradable poly(l-lactide)-grafted α-cyclodextrin copolymer displaying specific dye absorption by host-guest interact 査読あり
Koji Nagahama, Keiko Shimizu, Tatsuro Ouchi, Yuichi Ohya
Reactive and Functional Polymers 69 891 2009年10月
共著
担当区分：筆頭著者
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Thermo-Sensitive Sol-Gel Transition of Poly(depsipeptide-co-lactide)-g-PEG Copolymers in Aqueous Solution 査読あり
Koji Nagahama, Yuichiro Imai, Teppei Nakayama, Junpei Ohmura, Tatsuro Ouchi, Yuichi Ohya
Polymer 50 3547 2009年10月
共著
担当区分：筆頭著者
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Polyrotaxane Composed of Poly-L-Lactide and α-Cyclodextrin Exhibiting Protease-Triggered Hydrolysis 査読あり
Yuichi Ohya, Seigo Takamido, Koji Nagahama, Tatsuro Ouchi, Ryo Katoono, Nobuhiko Yui
Biomacromolecules 10 2261 2009年10月
共著
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Accurate curve fitting procedure for UV melting analysis of highly thermostable RNA hairpins（共著）
J. Kawakami, Y. Tanaka, and K. Kishimoto
Nucleic Acids Symp. Ser. 53 227 - 228 2009年9月
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Thermal stability and hydration state of DNA G-quadruplex regulated by loop regions
T. Fujimoto, D. Miyoshi, H. Tateishi-Karimata, and N. Sugimoto
Nucleic Acids Symp Ser (Oxf) 53 237 - 238 2009年9月
共著
担当区分：筆頭著者
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DNA junction structure stabilized by molecular crowding conditions
D. Miyoshi, S. Muhuri, K. Mimura, and N. Sugimoto
Nucleic Acids Symp Ser (Oxf) 53 59 - 60 2009年9月
共著
担当区分：筆頭著者
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DNA junction structure stabilized by molecular crowding conditions
D. Miyoshi, S. Muhuri, K. Mimura, N. Sugimoto
Nucleic Acids Symp Ser (Oxf) 53 59 - 60 2009年9月
共著
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Investigations of the cation binding to nucleotides by monitoring the hairpin-duplex equilibrium of a self-complementary sequence
S. Nakano, H. Hirayama, and N. Sugimoto
Nucleic Acids Symp. Ser. 53 229 - 230 2009年9月
共著
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Porous Coordination Polymer with Pyridinium Cationic Surface, [Zn-2(tpa)(2)(Cpb)]
Higuchi Masakazu, Tanaka Daisuke, Horike Satoshi, Sakamoto Hirotoshi, Nakamura Kohei, Takashima Yohei, Hijikata Yuh, Yanai Nobuhiro, Kim Jungeun, Kato Kenichi, Kubota Yoshiki, Takata Masaki, Kitagawa Susumu
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131 ( 30 ) 10336 - + 2009年8月
共著
DOI： 10.1021/ja900373v
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Hydrophobically Modified Biodegradable Poly(ethylene glycol) Copolymers that Form Temperature-Responsive Nanogels 査読あり
Koji Nagahama, Mihoko Hashizume, Hidetoshi Yamamoto, Tatsuro Ouchi, Yuichi Ohya
Langmuir 25 9734 2009年8月
共著
担当区分：筆頭著者
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Biodegradable Shape-Memory Polymers Exhibiting Sharp Thermal Transitions and Controlled Drug Release 査読あり
Koji Nagahama, Yuichi Ueda, Tatsuro Ouchi, Yuichi Ohya
Biomacromolecules 10 1789 2009年8月
共著
担当区分：筆頭著者
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“Geometric and electronic structure differences between the type 3 copper sites of the multicopper oxidases and hemocyanin/tyrosinase” 査読あり
Jungjoo Yoon, Satoshi Fujii, Edward I. Solomon
Proc. Natl. Acad. Sci. USA 106 ( 16 ) 6585 - 6590 2009年4月
共著
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Reversible stability switching of a hairpin DNA via a photo-responsive linker unit 招待あり 査読あり
Li Wu, Kazuya Koumoto, Naoki Sugimoto
Chemical Communications 1915 - 1917 2009年4月
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ヘアピンDNAのループ部位に導入し、光異性化によってヘアピンDNA全体の安定性を制御できる新規光応答性ユニットの開発に成功した。このユニットをヘアピン部位に導入したDNAは紫外光、可視光の照射に伴って安定性が可逆的に制御することができた。
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Nuclease Resistant Methylphosphonate-DNA/LNA Chimeric Oligonucleotides 査読あり
Koji Nagahama, Rakesh Veedu, Jesper Wengel
Bioorganic and Medicinal Chemistry Letters 19 2707 2009年3月
共著
担当区分：筆頭著者
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Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification.
Kawauchi K, Araki K, Tobiume K, Tanaka N
Proceedings of the National Academy of Sciences of the United States of America 106 ( 9 ) 3431 - 3436 2009年3月
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Effects of Polydepsipeptide Side-Chain Groups on the Temperature Sensitivity of Triblock Copolymers Composed of Polydepsipeptides and Poly(ethylene glycol) 査読あり
Yuichi Ohya, Hidetoshi Yamamoto, Koji Nagahama, Tatsuro Ouchi
Journal of Polymer Science, Part A: Polymer Chemistry 47 3892 2009年2月
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