論文
-
Synthesis of pH-responsive nanocomposite microgels with size-controlled gold nanoparticles from ion-doped, lightly cross-linked poly(vinylpyridine)
K. Akamatsu, M. Shimada, T. Tsuruoka, H. Nawafune, S. Fujii, Y. Nakamura
Langmuir 26 1254 - 1259 2010年
共著
-
Synthesis and characterization of polypyrrole-palladium nanocomposite-coated latex particles and their use as a catalyst for Suzuki coupling reaction in aqueous media
S. Fujii, S. Matsuzawa, Y. Nakamura, A. Ohtaka, T. Teratani, K. Akamatsu, T, Tsuruoka, H. Nawafune
Langmuir 26 6230 - 6230 2010年
共著
-
Facile one-step route to polyaniline-silver nanocomposite particles and their application as a colored particulate emulsifier
S. Fujii, Y. Nishimura, A. Aichi, S. Matsuzawa, Y. Nakamura, K. Akamatsu, H. Nawafune
Synthetic Metals 160 1322 - 1322 2010年
共著
-
Fabrication of copper damascene patterns on polyimide using direct metallization of trench templates generated by imprint lithography
Y. Matsumura, Y. Enomoto, T. Tsuruoka, K. Akamatsu, H. Nawafune
Langmuir 26 12448 - 12454 2010年
共著
-
Electron Magnetic Resonance in Interacting Ferromagnetic-Metal Nanoparticle Systems: Experiment and Numerical Simulation
C. Mitsumata, S. Tomita, S. Hagiwara, and K. Akamatsu
J. Phys. Cond. Mater 22 016005 - 016005 2010年
共著
-
Construction of Detection System for Amyloid beta Peptide Localization and Aggregation Using Fluorescent and Luminescent Fusion Proteins 査読あり
Kenji Usui, Masayasu Mie, Takashi Andou, Naoki Sugimoto, Hisakazu Mihara, Eiry Kobatake
Peptide Science 2009 2009 111 - 112 2010年
共著
担当区分：筆頭著者
-
Controlled Multiscale Synthesis of Porous Coordination Polymer in Nano/Micro Regimes 査読あり
S. Diring, S. Furukawa, Y. Takashima, T. Tsuruoka, S. Kitagawa
Chem. Mater. 22 4531 - 4538 2010年
共著
-
光化学還元法によるガラス基板上への銅のダイレクトパターニング
有村英俊、中道良太、木村明寛、鶴岡孝章、赤松謙祐、縄舟秀美
エレクトロニクス実装学会誌 13 46 - 51 2010年
共著
-
Synthesis of pH-Responsive Nanocomposite Microgels with Size-Controlled Gold Nanoparticles from Ion-Doped, Lightly Cross-Linked Poly(vinylpyridine) 査読あり
K. Akamatsu, M. Shimada, T. Tsuruoka, H. Nawafune, S. Fujii, Y. Nakamura
Langmuir 26 1254 - 1259 2010年
共著
-
Synthesis and Characterization of Polypyrrole-Palladium Nanocomposite-coated Latex Particles and Their Use as a Catalyst for Suzuki Coupling Reaction in Aqueous Media 査読あり
S. Fujii, S. Matsuzawa, Y. Nakamura, A. Ohtaka, T. Teratani, K. Akamatsu, T. Tsuruoka, H. Nawafune
Langmuir 26 6230 - 6239 2010年
共著
-
Fabrication of Copper Damascene Patterns on Polyimide Using Direct Metallization on Trench Templates Generated by Imprint Lithography 査読あり
Y. Matsumura, Y. Enomoto, T. Tsuruoka, K. Akamatsu, H. Nawafune
Langmuir 26 12448 - 12454 2010年
共著
-
Periodic Molecular Boxes in Entangled Enantiomorphic lcy Nets 査読あり
Yohei Takashima, Charlotte Bonneau, Shuhei Furukawa, Mio Kondo, Ryotaro Matsuda, Susumu Kitagawa
Chem. Commun 46 4142 - 4144 2010年
共著
-
Controlled Multiscale Synthesis of Porous Coordination Polymers in Nano/Micro Regimes 査読あり
St?phane Diring, Shuhei Furukawa, Yohei Takashima, Takaaki Tsuruoka, Susumu Kitagawa
Chem. Mater. 22 4531 - 4538 2010年
共著
-
Control over the Nucleation Process determines the Framework Topology of Porous Coordination Polymers 査読あり
Mio Kondo, Yohei Takashima, Joobeom Seo, Susumu Kitagawa, Shuhei Furukawa
CrystEngComm 12 2350 - 2353 2010年
共著
-
Stabilization of Three-Way Junctions of DNA under Molecular Crowding Conditions 査読あり
Sanjukta Muhuri, Kenta Mimura, Daisuke Miyoshi, and Naoki Sugimoto
J. Am. Chem. Soc. 131 9268 - 9280 2009年12月
共著
-
Neuronal differentiation of neural progenitor cells by intracellular delivery of synthetic oligopeptide derived from von Hippel-Lindau protein 査読あり
H. Kanno, S. Nakano, A. Kubo, T. Mimura, N. Tajima, and N. Sugimoto
Protein & Peptide Letters 16 1291 - 1296 2009年12月
共著
-
Dynamics and energetics of the base flipping conformation studied with base pair-mimic nucleosides 査読あり
S. Nakano, H. Oka, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Biochemistry 48 11304 - 11311 2009年12月
共著
DOI： 10.1021/bi901496q
-
Face-to-face porphyrin moieties assembled with spacing for pyrazine recognition in molecularly imprinted polymers 査読あり
Matsui, J., Sodeyama, T., Saiki, Y., Miyazawa, T., Yamada, T., Tamaki, K., Murashima, T.
Biosensors and Bioelectronics 25 ( 3 ) 635 - 639 2009年11月
共著
-
Hydration of Watson-Crick base pairs and dehydration of Hoogsteen base pairs inducing structural polymorphism under molecular crowding conditions
三好大輔
J. Am. Chem. Soc. ( 131 ) 3522 - 3531 2009年11月
単著
-
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity 査読あり 国際共著
Kenji Usui, John D. Hulleman, Johan F. Paulsson, Sarah J. Siegel, Evan T. Powers, Jeffery W. Kelly
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 ( 44 ) 18563 - 18568 2009年11月
出版者・発行元：NATL ACAD SCIENCES
Accumulation of amyloid beta-peptide (A beta) and tau aggregates, possibly linked to age-associated deficiencies in protein homeostasis, appear to cause Alzheimer's disease. Schiff-base formation between A beta and the aldehyde-bearing cholesterol oxidation product 3-beta-hydroxy-5-oxo-5,6-secocholestan-6-al is known to increase A beta amyloidogenicity. Here, we synthesized A beta variants site-specifically modified with the cholesterol aldehyde at Asp-1, Lys-16, or Lys-28, rather than studying mixtures. These distinct modifications have a similar effect on the thermodynamic propensity for aggregation, enabling aggregation at low concentrations. In contrast, the modification site differentially influences the aggregation kinetics; Lys-16-modified A beta formed amorphous aggregates fastest and at the lowest concentration (within 2 h at a concentration of 20 nM), followed by the Lys-28 and Asp-1 conjugates. Also, the aggregates resulting from A beta Lys-16 cholesterol aldehyde conjugation were more toxic to primary rat cortical neurons than treatment with unmodified A beta under identical conditions and at the same concentration. Our results show that A beta modification by cholesterol derivatives, especially at Lys-16, renders it kinetically and thermodynamically competent to form neurotoxic aggregates at concentrations approaching the physiologic concentration of A beta.