Review Papers (Misc) -
-
Molecular imprinting under molecular crowding conditions: An aid to the synthesis of a high-capacity polymeric sorbent for triazine herbicides
Jun Matsui, Shou Goji, Takashi Murashima, Daisuke Miyoshi, Satoshi Komai, Aiko Shigeyasu, Takuho Kushida, Toshifumi Miyazawa, Takashi Yamada, Katsuyuki Tamaki, Naoki Sugimoto
ANALYTICAL CHEMISTRY 79 ( 4 ) 1749 - 1757 2007.2
Publisher：AMER CHEMICAL SOC
Molecular crowding, an important feature of the molecular environments in biological cells, was applied to the synthesis of antibody-mimic polymers selective for a group of biologically active compounds, the triazine herbicides. Synthesis of these polymers was conducted using molecular imprinting under molecular crowding conditions, whereby atrazine (a template molecule) was complexed with methacrylic acid (a functional monomer) in the presence of a macromolecular crowding agent (either poly(methyl methacrylate) (PMMA) or polystyrene (PS)) followed by cross-linking with ethylene glycol dimethacrylate. After removal of atrazine from the polymer matrix, the retention properties and selectivity of the resultant polymers were assessed by chromatographic tests. The addition of a crowding-inducing agent resulted in polymers with superior retention properties and excellent selectivity for triazine herbicides, as compared to polymers prepared without addition of a crowding-inducing agent. An imprinted polymer prepared in the presence of PS as a crowding agent exhibited a retention factor for atrazine an order of magnitude larger than that of an imprinted polymer prepared in the absence of a crowding agent. NMR results suggest that the crowding agent is capable of promoting hydrogen bond formation between atrazine and methacrylic acid, which could account for the effect of crowding on molecular imprinting.
DOI： 10.1021/ac060441m
-
Conformational switch of a functional nanowire based on the DNA G-quadruplex. International journal
Hisae Karimata, Daisuke Miyoshi, Takeshi Fujimoto, Kazuya Koumoto, Zhong-Ming Wang, Naoki Sugimoto
Nucleic acids symposium series (2004) 51 ( 51 ) 251 - 2 2007
A G-wire composing of multiple G-rich sequences in parallel orientations via G-quartet formations is promising as a structurally well-defined nanowire. Here, in order to control the G-wire by the metal ion, we incorporated 2,2'-bipyridine unit, which has two aromatic rings rotating arbitrarily by coordination with metal ions, into the main chain of d(G4T4G4) instead of thymine (G1). Circular dichroism (CD) spectra showed that G1 formed an antiparallel G-quadruplex. Interestingly, Ni(2+) induces G1 to switch from an antiparallel G-quadruplex to a parallel. On the other hand, the parallel G-quadruplex reversed the structural transition to an antiparallel G-quadruplex by the addition of Na2EDTA. Moreover, the study of the atomic force microscopy (AFM) showed that G1 formed a long nanowire ( approximately 200 nm) in the presence of Ni(2+), whereas no significant image was observed in the absence of Ni(2+) or in the presence of both Ni(2+) and Na2EDTA. From these results, it can be concluded that Ni(2+) induces a structural transition of G1 from an antiparallel G-quadruplex to a G-wire and that metal ion chelator induces the reverse structural transition from the G-wire to the antiparallel G-quadruplex. The G-wire responsive to metal ions would be useful for development of functional nanomaterials.
-
銅ナノ粒子分散複合体のパターニングと樹脂・金属間接合
池田慎吾、赤松謙祐、縄舟秀美
表面技術 58 756 - 751 2007
Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings) Publisher：表面技術協会
-
インクジェット法を利用するポリイミド樹脂表面への銅微細配線
赤松謙祐、池田慎吾、縄舟秀美
マテリアルステージ ( 6 ) 15 - 17 2007
Publishing type：Article, review, commentary, editorial, etc. (other) Publisher：a
-
Atomic beam-Induced fluorination of polyimide and its application to site-selective Cu metallization
M. Tagawa, K. Maeda, T. Kajita, K. Yokota, K. Akamatsu, H. Nawafune
Langmuir 23 ( 23 ) 11351 - 11354 2007
-
Controlled magnetic properties of Ni nanoparticles embedded in polyimide films
S. Tomita, P. E. Jonsson, K. Akamatsu, H. Nawafune, H. Takayama
Phys. Rev. B 76 ( 17 ) 174432 2007
-
Copper/polyimide heterojunction: controlling interfacial structures through an additive-based, all-wet chemical process using ion-doped precursors
S. Ikeda, H. Yanagimoto, K. Akamatsu, H. Nawafune
Adv. Funct. Mater. 17 ( 6 ) 889 - 897 2007
-
ポリエチレングリコール誘導体の予備吸着を利用する銅電析プロセスによるULSI微細配線の形成
尾山祐斗、有村英俊、赤松謙祐、縄舟秀美
表面技術 58 ( 7 ) 425 - 429 2007
-
Photosensitization of oxygen molecules by surface-modified hydrophilic porus Si
M. Fujii, N. Nishimura, H. Fumon, S. Hayashi, K. Akamatsu, T. Tsuruoka, M. Shimada, H. Katayama, D. Kovalev, B. Goller
Euro. Phys. J. D 43 193 - 196 2007
-
One-step synthesis of polypyrrole-coated silver nanocomposite particles and their application as a coloured particulate emulsifier
S. Fujii, A. Aichi, K. Akamatsu, H. Nawafune and Y. Nakamura
J. Mater. Chem. 17 ( 36 ) 3777 - 3779 2007
-
Synthesis, structure and thermal stability of fully hydrophobic porphyrin-DNA conjugates.
Tetrahedron Lett. 48 ( 48 ) 8514 - 8517 2007
-
Secondary alcohols act as better nucleophiles than primary alcohols in the lipase-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxyls.
Tetrahedron Lett. 48 ( 47 ) 8334 - 8337 2007
-
ペプチドライブラリを用いるタンパク質相互作用検出チップ Reviewed
富崎欣也・臼井健二・三原久和
Electrochemistry 75 ( 12 ) 981 - 985 2007
Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：電気化学会
-
細胞の分子クラウディング効果
杉本直己・中野修一
現代化学 428 ( 11 ) 53 - 58 2006.11
Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：東京化学同人
-
DNAによる三次元ナノ構造体形成法の進展
川上純司
高分子 55 ( 5 ) 362 2006.5
Authorship：Lead author Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings) Publisher：高分子学会
-
分子クラウディング環境は生命分子の物性と機能をいかに変えるか
中野修一・杉本直己
生物物理 46 ( 5 ) 251 - 256 2006.5
Authorship：Lead author Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings) Publisher：日本生物物理学会
-
デザイナブル核酸修飾
杉本直己・中野修一・大道達雄
先端生物医学研究・医療のため遺伝子導入テクノロジー「ウイルスを用いない遺伝子導入法の材料、技術、方法論の新たな展開」 245 - 251 2006.4
Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：メディカルドゥ
-
CpG DNA/zymosan complex to enhance cytokine secretion owing to the cocktail effect
T Anada, N Okada, J Minari, R Karinaga, M Mizu, K Koumoto, S Shinkai, K Sakurai
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16 ( 5 ) 1301 - 1304 2006.3
Publisher：PERGAMON-ELSEVIER SCIENCE LTD
Zymosan, classified among beta-(1-->3)-D-glucans, is produced from the cell wall of yeast and well known to induce proinflammatory cytokines when ingested by immune cells. We found that zymosan forms a complex with immunostimulatory CpG DNA, where both zymosan and CpG DNA can induce cytokine secretion according to the different mechanisms (i.e., recognized by different receptors). The complex activated macrophages and induced cytokine secretion, more efficiently than separate administration of zymosan or CpG DNA. Microscopic observation showed that this increment of the cytokine secretion can be explained by the fact that zymosan and zymosan/CpG DNA complex are up-taken more than naked CpG DNA. Additionally, existence of two different immunostimulants in the same cells may enhance the immunoresponse. This report presents a new strategy to construct a delivering vehicle for CpG DNA and to enhance its activity with the 'cocktail effect' of the two immunostimulants. (C) 2005 Elsevier Ltd. All rights reserved.
-
Galactose-PEG dual conjugation of beta-(1 -> 3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake
R Karinaga, T Anada, J Minari, M Mizu, K Koumoto, J Fukuda, K Nakazawa, T Hasegawa, M Numata, S Shinkai, K Sakurai
BIOMATERIALS 27 ( 8 ) 1626 - 1635 2006.3
Publisher：ELSEVIER SCI LTD
Antisense oligonucleotides (AS ODNs) are applied to silence a particular gene, and this approach is one of the potential gene therapies. However, naked oligonucleotides are easy to be degraded or absorbed in biological condition. Therefore, we need a carrier to deliver AS ODNs. This paper presents galactose moieties that were conjugated to the side chain of SPG to enhance cellular ingestion through endocytosis mediated by asialoglycoprotein receptor specifically located on parenchymal liver cells. We introduced galactose with two types of chemical bonds; amide and amine, and the amine connection showed lower ingestion and more toxicity than the amide one. Since PEG was known to induce endocytosis escape, we combined PEG and galactose aiming to provide both cellular up-take and subsequent endocytosis escape. We designed lactose or galactose moieties to attach to the end of the PEG chain that connects to the SPG side chain. When the PEG had the molecular weight of 5000-6000, the antisense effect reached the maximum. We believe that this new type of galactose and PEG dual conjugation broaden the horizon in antisense delivery. (c) 2005 Elsevier Ltd. All rights reserved.
-
Molecularly-imprinted polymeric logic gates selective for predetermined chemical input species
Jun Matsui, Takuji Sodeyama, Katsuyuki Tamaki, Naoki Sugimoto
CHEMICAL COMMUNICATIONS ( 30 ) 3217 - 3219 2006
Publisher：ROYAL SOC CHEMISTRY
Selective AND and OR logic gates were fabricated by molecular imprinting with simultaneous use of two kinds of template species, with the resultant binding behaviour (AND or OR) of the imprinted polymers governed by intermolecular interactions between the two template species.
DOI： 10.1039/b604354b