論文 - 甲元 一也
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Bottom-up fabrication of redispersible β-1,3-1,6-glucan nanoparticle powders with enhanced aqueous solubility and improved macrophage accessibility 査読あり
Ayumu Kodama, Yasushi Nishida, Masaya Miwa, Nanako Doi, Ryoji Motoji, Toshio Suzuki, and Kazuya Koumoto
J. Biotechnol. 430 124 - 135 2026年9月
担当区分：最終著者, 責任著者
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Structure–property relationships and hydrated-matrix-mediated aromatic guest inclusion in renatured β-1,3-1,6-glucan nanoparticles
Yukina Kometani, Shoma Kannan, Yasushi Nishida, Toshio Suzuki, and Kazuya Koumoto
391 125847 2026年9月
担当区分：最終著者, 責任著者
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Alkali-Neutralization-Induced β-1,3-1,6-Glucan Nanoparticles Enhance the Aqueous Dispersibility, Stability, and Antioxidant Activity of Quercetin 査読あり
Shoma Kannan, Nanako Doi, Toshio Suzuki and Kazuya Koumoto
Nutraceuticals 6 53 2026年8月
担当区分：最終著者, 責任著者
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Hydrophilic ether-modified carboxybetaines: a molecular design approach for enzyme activation and stabilization 査読あり
Takuma Aoki , Koki Takagi , Yuichi Nakagawa , Kazuya Koumoto
Bulletin of the Chemical Society of Japan 98 ( 9 ) uoaf075 2025年8月
担当区分：責任著者
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Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci 査読あり
Ryota Nomura, Yuto Suehiro, Fumikazu Tojo, Saaya Matayoshi, Rena Okawa, Masakazu Hamada, Shuhei Naka, Michiyo Matsumoto-Nakano, Rika Unesaki, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Tatsuya Akitomo, Chieko Mitsuhata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi and Kazuhiko Nakano
25 1075 2024年1月
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Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite 査読あり
Momoko Usuda, Mariko Kametani, Masakazu Hamada, Yuto Suehiro, Saaya Matayoshi, Rena Okawa, Shuhei Naka, Michiyo Matsumoto-Nakano, Tatsuya Akitomo, Chieko Mitsuhata, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano and Ryota Nomura
Int J Mol Sci 24 11371 2023年7月
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ポリエチレングリコールによるアトピー性皮膚炎予防の可能性
厳原美穂、甲元一也
Fragrance Journal 50 ( 11 ) 54 - 57 2022年11月
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Hydrostatic pressure-regulated cellular calcium responses 査読あり 国際誌
Minami Fukuchi, Kotaro Oyama, Hiroaki Mizuno, Akihisa Miyagawa, Kazuya Koumoto, Gaku Fukuhara
Langmuir 37 ( 2 ) 820 - 826 2021年1月
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Mechanism toward turn-on of polysaccharide-porphyrin complexes for fluorescence probes and photosensitizers in photodynamic therapy in living cells 査読あり 国際誌
Shodai Hino, Rikushi Funada, Kouta Sugikawa, Riku Kawasaki, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
ChemMedChem 15 ( 1 ) 1 - 12 2020年10月
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Modification of the release rate of curcumin from the cavity of renatured β-1,3-1,6-glucan nanoparticles by changing the molecular weight of the constituent polysaccharide chains 査読あり
Yuki Nonoguchi, Ayumu Kodama, Toshio Suzuki, Kazuya Koumoto
Chemistry Letters 49 ( 10 ) 1150 - 1153 2020年7月
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Solubilization of poorly water-soluble bioactive molecules in neutral aqueous media by complexation with renatured beta-1,3-1,6-glucan nanoparticles 査読あり 国際誌
Ayumu Kodama, Akifumi Nakagawa, Yuki Nonoguchi, Haruka Sakurai, Chieko Yano, Toshio Suzuki, Kazuya Koumoto
Biopolymers 111 ( 4 ) e23349 2020年2月
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Improved stability and photodynamic activity of water-soluble 5,15-diazaporphyrins incorporated in beta-(1,3-1,6)-D-glucan with on-off switch 査読あり 国際誌
Shodai Hino, Shuhei Satake, Hideyuki Shinmori, Shigeki Kawabata, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Kouta Sugikawa, Riku Kawasaki, Atsushi Ikeda
Chemistry an Asian Journal 15 ( 3 ) 365 - 370 2019年12月
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Structural effect of amine N-oxides on the facilitation of alpha-glucosidase-catalyzed hydrolysis reaction 査読あり 国際誌
Takuma Aoki, Yuichi Nakagawa, Ryutaro Genjima, Kazuya Koumoto
Bioprocess Biosys. Eng. 43 ( 3 ) 541 - 548 2019年11月
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Turn-on fluorescence and photodynamic activity of beta-(1,3-1,6)-D-glucan-complexed with porhyrin derivative inside HeLa cells 査読あり 国際誌
Shodai Hino, Rikushi Funada, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
Photochem. Photobiol. Sci. 18 ( 12 ) 2854 - 2858 2019年11月
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研究課題設定を重視した科学技術人材育成プログラムROOTのデザインと実装
伊藤 真之, 臼井 英之, 長野 寛之, 巳波 弘佳, 甲元 一也, 蛯名 邦禎
日本科学教育学会年会論文集 43 399 - 400 2019年8月
共著
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Atsushi Ikeda, Tatsuya Iizuka, Naotake Maekubo, Kazuyuki Nobuswa, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Motofusa Akiyama
Chemistry an Asian Journal 12 ( 10 ) 1069 - 1074 2017年3月
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Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yua Kashijima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
Organic & Biomolecular Chemistry 15 ( 9 ) 1990 - 1997 2017年2月
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Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy 査読あり 国際誌
Masafumi Ueda, Kengo Ashizawa, Kouta Sugikawa, Kazuya Koumoto, Takeshi Nagasaki, Atsushi Ikeda
Organic & Biomolecular Chemistry 15 ( 7 ) 1565 - 1569 2016年10月
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Increased yield of β-glucosidase-catalyzed hydrolysis reactions in the presence of betaine-type metabolite analog 査読あり 国際誌
Shiro Sehata, Ryojun Suzuki, Kazuya Koumoto
Bioprocess Biosystem Engineering 40 ( 1 ) 153 - 159 2016年9月
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Cryoprotective ability of betaine-type metabolite analogs during freezing denaturation of enzymes 国際誌
Yuichi Nakagawa, Masahiro Sota, Kazuya Koumoto
BIOTECHNOLOGY LETTERS 37 ( 8 ) 1607 - 1613 2015年8月
出版者・発行元：SPRINGER
To evaluate an analog library of betaine-type cellular metabolites, which are naturally found in polar fish for survival in subzero temperatures, for preventing denaturation of enzymes during freezing.Comparison of the cryoprotective ability of reported cryoprotectants, such as dimethylsulfoxide, glycerol, ectoine, hydroxyectoine, and trehalose, with betaine-type analogs using alpha-glucosidase revealed that analogs introducing C-3-C-6 alkyl chains into an ammonium cation retained 20 % higher activity than the control cryoprotectants at the same concentration. In particular, the analog possessing triplicate n-butyl chains showed a profound effect. It allowed retention of enzyme activity to 95 % even after 100 freeze-thaw cycles, while addition of the control cryoprotectants decreased the activity to 10-20 %. The cryoprotective ability of betaine-type analogs can be applied not only to alpha-glucosidase but also other enzymes such as beta-glucosidase, alkaline phosphatase, lactose dehydrogenase, sulfatase, and horseradish peroxidase.Synthetic betaine-type metabolite analogs possess practicable cryoprotective ability for various enzymes, and are considerably superior to previously reported cryoprotectants.