論文 - 甲元 一也
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Hydrophilic ether-modified carboxybetaines: a molecular design approach for enzyme activation and stabilization 査読あり
Takuma Aoki, Koki Takagi, Yuichi Nakagawa, Kazuya Koumoto
Bulletin of the Chemical Society of Japan 98 uoaf075 2025年8月
担当区分：最終著者, 責任著者
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Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci 査読あり
Ryota Nomura, Yuto Suehiro, Fumikazu Tojo, Saaya Matayoshi, Rena Okawa, Masakazu Hamada, Shuhei Naka, Michiyo Matsumoto-Nakano, Rika Unesaki, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Tatsuya Akitomo, Chieko Mitsuhata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi and Kazuhiko Nakano
25 1075 2024年1月
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Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite 査読あり
Momoko Usuda, Mariko Kametani, Masakazu Hamada, Yuto Suehiro, Saaya Matayoshi, Rena Okawa, Shuhei Naka, Michiyo Matsumoto-Nakano, Tatsuya Akitomo, Chieko Mitsuhata, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano and Ryota Nomura
Int J Mol Sci 24 11371 2023年7月
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ポリエチレングリコールによるアトピー性皮膚炎予防の可能性
厳原美穂、甲元一也
Fragrance Journal 50 ( 11 ) 54 - 57 2022年11月
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Hydrostatic pressure-regulated cellular calcium responses 査読あり 国際誌
Minami Fukuchi, Kotaro Oyama, Hiroaki Mizuno, Akihisa Miyagawa, Kazuya Koumoto, Gaku Fukuhara
Langmuir 37 ( 2 ) 820 - 826 2021年1月
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Mechanism toward turn-on of polysaccharide-porphyrin complexes for fluorescence probes and photosensitizers in photodynamic therapy in living cells 査読あり 国際誌
Shodai Hino, Rikushi Funada, Kouta Sugikawa, Riku Kawasaki, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
ChemMedChem 15 ( 1 ) 1 - 12 2020年10月
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Modification of the release rate of curcumin from the cavity of renatured β-1,3-1,6-glucan nanoparticles by changing the molecular weight of the constituent polysaccharide chains 査読あり
Yuki Nonoguchi, Ayumu Kodama, Toshio Suzuki, Kazuya Koumoto
Chemistry Letters 49 ( 10 ) 1150 - 1153 2020年7月
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Solubilization of poorly water-soluble bioactive molecules in neutral aqueous media by complexation with renatured beta-1,3-1,6-glucan nanoparticles 査読あり 国際誌
Ayumu Kodama, Akifumi Nakagawa, Yuki Nonoguchi, Haruka Sakurai, Chieko Yano, Toshio Suzuki, Kazuya Koumoto
Biopolymers 111 ( 4 ) e23349 2020年2月
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Improved stability and photodynamic activity of water-soluble 5,15-diazaporphyrins incorporated in beta-(1,3-1,6)-D-glucan with on-off switch 査読あり 国際誌
Shodai Hino, Shuhei Satake, Hideyuki Shinmori, Shigeki Kawabata, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Kouta Sugikawa, Riku Kawasaki, Atsushi Ikeda
Chemistry an Asian Journal 15 ( 3 ) 365 - 370 2019年12月
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Structural effect of amine N-oxides on the facilitation of alpha-glucosidase-catalyzed hydrolysis reaction 査読あり 国際誌
Takuma Aoki, Yuichi Nakagawa, Ryutaro Genjima, Kazuya Koumoto
Bioprocess Biosys. Eng. 43 ( 3 ) 541 - 548 2019年11月
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Turn-on fluorescence and photodynamic activity of beta-(1,3-1,6)-D-glucan-complexed with porhyrin derivative inside HeLa cells 査読あり 国際誌
Shodai Hino, Rikushi Funada, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
Photochem. Photobiol. Sci. 18 ( 12 ) 2854 - 2858 2019年11月
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研究課題設定を重視した科学技術人材育成プログラムROOTのデザインと実装
伊藤 真之, 臼井 英之, 長野 寛之, 巳波 弘佳, 甲元 一也, 蛯名 邦禎
日本科学教育学会年会論文集 43 399 - 400 2019年8月
共著
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Atsushi Ikeda, Tatsuya Iizuka, Naotake Maekubo, Kazuyuki Nobuswa, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Motofusa Akiyama
Chemistry an Asian Journal 12 ( 10 ) 1069 - 1074 2017年3月
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Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yua Kashijima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda
Organic & Biomolecular Chemistry 15 ( 9 ) 1990 - 1997 2017年2月
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Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy 査読あり 国際誌
Masafumi Ueda, Kengo Ashizawa, Kouta Sugikawa, Kazuya Koumoto, Takeshi Nagasaki, Atsushi Ikeda
Organic & Biomolecular Chemistry 15 ( 7 ) 1565 - 1569 2016年10月
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Increased yield of β-glucosidase-catalyzed hydrolysis reactions in the presence of betaine-type metabolite analog 査読あり 国際誌
Shiro Sehata, Ryojun Suzuki, Kazuya Koumoto
Bioprocess Biosystem Engineering 40 ( 1 ) 153 - 159 2016年9月
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Cryoprotective ability of betaine-type metabolite analogs during freezing denaturation of enzymes 国際誌
Yuichi Nakagawa, Masahiro Sota, Kazuya Koumoto
BIOTECHNOLOGY LETTERS 37 ( 8 ) 1607 - 1613 2015年8月
出版者・発行元：SPRINGER
To evaluate an analog library of betaine-type cellular metabolites, which are naturally found in polar fish for survival in subzero temperatures, for preventing denaturation of enzymes during freezing.Comparison of the cryoprotective ability of reported cryoprotectants, such as dimethylsulfoxide, glycerol, ectoine, hydroxyectoine, and trehalose, with betaine-type analogs using alpha-glucosidase revealed that analogs introducing C-3-C-6 alkyl chains into an ammonium cation retained 20 % higher activity than the control cryoprotectants at the same concentration. In particular, the analog possessing triplicate n-butyl chains showed a profound effect. It allowed retention of enzyme activity to 95 % even after 100 freeze-thaw cycles, while addition of the control cryoprotectants decreased the activity to 10-20 %. The cryoprotective ability of betaine-type analogs can be applied not only to alpha-glucosidase but also other enzymes such as beta-glucosidase, alkaline phosphatase, lactose dehydrogenase, sulfatase, and horseradish peroxidase.Synthetic betaine-type metabolite analogs possess practicable cryoprotective ability for various enzymes, and are considerably superior to previously reported cryoprotectants.
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Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size 査読あり 国際誌
Koji Nagahama, Takayuki Kumano, Yuichi Nakagawa, Naho Oyama, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, Jun Matsui
BIOCONJUGATE CHEMISTRY 26 ( 8 ) 1775 - 1781 2015年8月
出版者・発行元：AMER CHEMICAL SOC
The design and synthesis of materials capable of activating the immune system in a safe manner is of great interest in immunology and related fields. Lactobacilli activate the innate immune system of a host when acting as probiotics. Here, we constructed lactobacilli-mimicking materials in which polysaccharide peptidoglycan complexes (PS PGs) derived from lactobacilli were covalently conjugated to the surfaces of polymeric microparticles with a wide variety of sizes, ranging from 200 nm to 3 mu m. The artificial lactobacilli successfully stimulated macrophages without cytotoxicity. Importantly, we found that the size of artificial lactobacilli strongly influenced their immunostimulating activities, and that artificial lactobacilli of 1 mu m exhibited 10-fold higher activity than natural lactobacilli. One major advantage of the artificial lactobacilli is facile control of size, which cannot be changed in natural lactobacilli. These findings provide new insights into the design of materials for immunology as well as the molecular biology of lactobacillus.
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Mechanistic study of unusual enzyme activation caused by addition of inert betaine-type metabolite and the analogs
Yuichi Nakagawa, Kazuya Koumoto
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 249 2015年3月
出版者・発行元：AMER CHEMICAL SOC
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Synthesis and lmmunestimulating Activity of Lactobacilli-Originated Polysaccharide-Polymeric Microparticle Conjugates 査読あり 国際誌
Koji Nagahama, Takayuki Kumano, Tsubasa Nakata, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, Jun Matsui
LANGMUIR 31 ( 4 ) 1489 - 1495 2015年2月
出版者・発行元：AMER CHEMICAL SOC
The design and synthesis of biomaterials capable of activating the immune system are of interest in immunology-related fields because of their ability to tune up the immune defenses of the host. Lactobacilli are a major constituent of normal human indigenous flora, and some specific strains are known to activate the immune system of the host as probiotics. In this study, we first fabricated novel biohybrid materials in which lactobacilli (L. casei strain Shirota, LcS)-originated polysaccharide-peptidoglycan complexes (PS-PGs) are conjugated with polymeric microparticles (MPs). PS-PGs conjugated onto polymeric MPs surfaces bound its specific antibody, suggesting that PS-PGs kept their original molecular recognition ability. The PS-PGs-based hybrid MPs with an appropriate density of conjugated PS-PGs effectively induced high levels of IL-12 production from macrophages without cytotoxicity. These results suggest that LcS-originated PS-PGs could be available bio-originated materials for developing novel biomaterials capable of activating the immune system in a safe manner.
DOI： 10.1021/la5041757
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Cryoprotective ability of betaine-type metabolite analogs during freezing denaturation of enzymes 査読あり
Yuichi Nakagawa, Masahiro Sota, Kazuya Koumoto
Biotechnology Letters 37 1607 - 1613 2015年
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担当区分：筆頭著者
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Synthesis and Immunestimulating Activity of Lactobacilli-Originated Polysaccharide-Polymeric Microparticle Conjugates 査読あり
Koji Nagahama, Takayuki Kumano, Tsubasa Nakata, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, Jun Matsui
Langmuir 31 1489 - 1495 2015年
共著
担当区分：筆頭著者
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Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size 査読あり
Koji Nagahama, Takayuki Kumano, Yuichi Nakagawa, Naho Oyama, Hirokazu Tsuji, Kaoru moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, Jun Matsui
Bioconjugate Chemistry 26 ( 8 ) 1775 - 1781 2015年
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担当区分：筆頭著者
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Significance of anionic functional group in betaine-type metabolite analogs on the facilitation of enzyme reactions 国際誌
Yuichi Nakagawa, Kotomi Takagi, Ryutaro Genjima, Kazuya Koumoto
Bioprocess and Biosystems Engineering 38 ( 9 ) 1811 - 1817 2015年
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Enhanced Chromogenic Sensitivity of Horseradish Peroxidase-catalyzed Oxidative Reactions in the Presence of Betaine-type Metabolite Analogs 査読あり
Kotomi Takagi, Yasuhiro Kashima, Satoshi Fujii, Kazuya Koumoto
Bulletin of the Chemical Society of Japan 88 ( 8 ) 1074 - 1082 2015年
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化学修飾技術を利用した乳酸菌模倣粒子による免疫賦活 招待あり
甲元一也、長濱宏治、松井淳
バイオインダストリー 32 ( 9 ) 42 - 47 2015年
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担当区分：筆頭著者
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Mechanistic study on the facilitation of enzymatic hydrolysis by alpha-glucosidase in the presence of betaine-type metabolite analogs 査読あり
Yuichi Nakagawa, Shiro Sehata, Satoshi Fujii, Hiroaki Yamamoto, Akihiko Tsuda, Kazuya Koumoto
TETRAHEDRON 70 ( 35 ) 5895 - 5903 2014年9月
出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD
Recently we reported that betaine-type metabolite analogs structure-dependently facilitate enzymatic hydrolysis reaction for alpha-glucosidases, beta-glucosidases, and alkaliphosphatases. To understand the facilitation mechanism for enzymes, in this study we expanded the analog library and measured the properties of analog solutions. The structural investigation on alpha-glucosidase-mediated hydrolysis reaction indicated that suitable structures to facilitate the enzyme reaction efficiently should have the ammonium cation in the betaine structure possess triplicate aliphatic chains from Cl to C7 without any polar functional groups. Analyses of the solution properties revealed that such analogs possess a large hydration layer with low water density. Such a specific hydration environment is generated by the characteristic structure of the betaine-type metabolite analogs. The characteristic hydration indirectly regulates enzyme activity and stability. These findings not only increase our understanding enzyme activation by betaine-type metabolite analogs, but also will contribute to the molecular design of enzyme regulators. (C) 2014 Elsevier Ltd. All rights reserved.
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Mechanistic study on the facilitation of enzymatic hydrolysis by α-glucosidase in the presence of betaine-type metabolite analogs 査読あり
Yuichi Nakagawa, Shiro Sehata, Satoshi Fujii, Hiroaki Yamamoto, Akihiko Tsuda, Kazuya Koumoto
Tetrahedron 70 5895 - 5903 2014年
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担当区分：筆頭著者
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Cellular zwitterionic metabolite analogs simultaneously enhance reaction rate, thermostability, salt tolerance, and substrate specificity of alpha-glucosidase 査読あり
Eisuke Deguchi, Kazuya Koumoto
Bioorganic and Medicinal Chemistry 19 3128 - 3134 2011年4月
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担当区分：筆頭著者
天然の代謝産物を模倣し、化学的に合成した代謝産物アナログがα−グルコシダーゼ、β−グルコシダーゼ、アルカリフォスファターゼといった加水分解酵素の活性（反応速度、耐熱性、耐塩性、基質選択性等）を溶液に共存させるだけで向上させることを明らかとした。
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Reversible stability switching of a hairpin DNA via a photo-responsive linker unit 招待あり 査読あり
Li Wu, Kazuya Koumoto, Naoki Sugimoto
Chemical Communications 1915 - 1917 2009年4月
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ヘアピンDNAのループ部位に導入し、光異性化によってヘアピンDNA全体の安定性を制御できる新規光応答性ユニットの開発に成功した。このユニットをヘアピン部位に導入したDNAは紫外光、可視光の照射に伴って安定性が可逆的に制御することができた。
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Structural effect of synthetic zwitterionic cosolutes on the stability of DNA duplexes 査読あり
甲元一也
Tetrahedron ( 64 ) 168 - 174 2008年11月
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担当区分：筆頭著者
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Artificial G-wire Switch with 2,2’-Bipyridine Units Responsive to Divalent Metal Ions
甲元一也
J. Am. Chem. Soc ( 129 ) 5919 - 5925 2007年11月
単著
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５）天然高分子 核酸 エネルギーデータベースに基づく核酸医薬の設計
甲元一也
絵で見てわかるナノDDS 遺伝子医学MOOK別冊（メディカルドゥ） 63 - 69 2007年11月
単著
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Conformational switch of a functional nanowire based on the DNA G-quadruplex
甲元一也
Nucleic Acids Symp. Ser. ( 51 ) 251 - 252 2007年11月
単著
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Delivery of antisense oligonucleotides to nuclear telomere RNA by use of a complex between polysaccharide and polynucleotide
甲元一也
Bull. Chem. Soc. Jpn ( 80 ) 1091 - 1098 2007年11月
単著
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Schizophyllan, beta-1,3-glucan,-oligoamine conjugates as non-viral vector 査読あり
Takeshi Nagasaki, Atsushi Uno, Kazuya Koumoto, Kazuo Sakurai, Seiji Shinkai
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 234 2007年8月
出版者・発行元：AMER CHEMICAL SOC
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Galactose-PEG Dual Conjugation of b-(1→3)-D-glucan schizophyllan for antisense oligonucleotide delivery to enhance cellular uptake
甲元一也
Biomaterials, ( 27 ) 1626 - 1635 2006年11月
単著
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CpG DNA/zymosan complex to enhance cytokine secretion owing to the cocktail effect
甲元一也
Bioorg. Med. Chem. Lett ( 16 ) 1301 - 1304 2006年11月
単著
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Competition between Polysaccharide/Polynucleotide Complexation vs. Polynucleotide Hybridization; Salt Concentration Dependence of the Reaction Direction
甲元一也
e-J. Surface Sci. Nanotech. ( 3 ) 30 - 37 2005年11月
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PEG-appended b-(1→3)-D-glucan schizophyllan to deliver antisense-oligonucleotides with avoiding lysosomal degradational of New Modification Technique for Linear Double-Stranded DNAs Using the Polysaccharide Schizophyllan
甲元一也
Biomaterials ( 26 ) 4866 - 4873 2005年11月
単著
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Schizophyllan-Poly(N-isopropylacrylamide) Conjugate for Selective Recovery of Polynucleotides by Precipitation
甲元一也
Polym. J., ( 37 ) 177 - 185 2005年11月
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In situ monitoring of polysaccharide-polynucleotide interaction using a schizophyllan-immobilized QCM device
甲元一也
Sensors & Actuators B: Chemicals ( 105 ) 490 - 494 2005年11月
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Parallel vs. anti-parallel orientation in a curdlan/oligo(dA) complex as estimated by a FRET technique
甲元一也
Org. Biomol. Chem., ( 3 ) 2255 - 2261 2005年11月
単著
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Transferrin-appended b-(1→3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake
甲元一也
J. Contr. Rel. ( 108 ) 529 - 539 2005年11月
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Transferrin-appended b-(1→3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake
甲元一也
e-J. Surface Sci. Nanotech ( 3 ) 195 - 202 2005年11月
単著
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Cholesterol-appended b-(1,3)-D-glucan schizophyllan for antisense oligonucleotide delivery to enhance cellular uptake
甲元一也
Bull. Chem. Soc. Jpn. ( 78 ) 1821 - 1830 2005年11月
単著
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A Polysaccharide Carrier for Immunostimulatory CpG DNAs to Enhance Cytokine Secretion
甲元一也
J. Am. Chem. Soc. ( 126 ) 8372 - 8373 2004年11月
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Removal of the side-chain glucose groups from schizophyllan improves the thermal stability of the polycytidylic acid complex under the physiological conditions
甲元一也
Biopolymers ( 75 ) 403 - 411 2004年11月
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Schizophyllans carrying oligosaccharide appendages as potential candidates for cell-targeted antisense carrier
甲元一也
Org. Biomol. Chem ( 2 ) 3091 - 3098 2004年11月
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Proposal of New Modification Technique for Linear Double-Stranded DNAs Using the Polysaccharide Schizophyllan
甲元一也
Bioorg. Med. Chem. Lett ( 14 ) 5655 - 5659 2004年11月
単著
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多糖・核酸複合体を用いた機能性高分子コンジュゲート −核酸医薬デリバリーへの挑戦−
甲元一也
高分子加工 ( 53 ) 561 - 568 2004年11月
単著
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Chemically modified polysaccharide schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake efficiency
甲元一也
Biochim. Biophys. Acta ( 1670 ) 91 - 104 2004年11月
単著
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Lactose-appended schizophyllan as a potential candidate for hepatocyte-targetted antisense carrier
甲元一也
Chem. Commun 382 - 383 2004年11月
単著
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Protection of polynucleotides against nuclease-mediated hydrolysis by complexation with schizophyllan
甲元一也
Biomaterials ( 25 ) 3109 - 3116 2004年11月
単著
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Antisense oligonucleotides bound in the polysaccharide complex and the enhanced antisense effect due to the low hydrolysis
甲元一也
Biomaterials ( 25 ) 3117 - 3123 2004年11月
単著
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Long-Term Expression with Cationic Polymer Derived from a Natural Polysaccharide: Schizophyllan
甲元一也
Bioconjugate Chem ( 15 ) 249 - 259 2004年11月
単著
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Polysaccharide/Polynucleotide Complexes Part 6: Complementary-Strand-Induced Release of Single-stranded DNA Bound in the Schizophyllan Complex
甲元一也
Chemistry & Biodiversity ( 1 ) 520 - 529 2004年11月
単著
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Enhancement of antisense effect by reducing interactions between proteins and ODNs
甲元一也
Bull. Chem. Soc. Jpn. ( 77 ) 1101 - 1110 2004年11月
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First observation by Fluorescence Polarization of Complexation between mRNA and the Natural Polysaccharide Schizophyllan
甲元一也
Chemistry & Biodiversity ( 1 ) 634 - 639 2004年11月
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Molecular weight control of curdlan (b-1,3-glucan polysaccharide) provides unique polynucleotide binding properties
甲元一也
Polym. J. ( 36 ) 380 - 385 2004年11月
単著
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Low Mw sulfated curdlan with improved water-solubility forms macromolecular complexes with polycytidylic acid
甲元一也
Carbohydr. Res ( 339 ) 161 - 167 2004年11月
単著
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Microanalysis of Nucleic Acids Using the Limulus G Test
甲元一也
Anal. Sci ( 19 ) 1567 - 1568 2003年11月
単著
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アンチセンス治療に向けた多糖系遺伝子キャリアー
甲元一也
月刊BIOINDUSTRY 20 ( 10 ) 30 - 37 2003年11月
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Polysaccharide-Polynucleotide Complexes Part 7. Hydrogen-ion and Salt Concentration Dependence of Complexation between Schizophyllan and Single-Stranded Homo RNAs
甲元一也
Bioorg. Chem ( 31 ) 216 - 226 2003年11月
単著
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Supramolecular structure of a sugar-appended organogelator explored with synchrotron X-ray small angle scattering
甲元一也
Langmuir, ( 19 ) 8211 - 8217 2003年11月
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Polysaccharide-polynucleotide complexes Part 17. Solvent effects on conformational-transition of polydeoxyadenylic acid in the complex with schizophyllan
甲元一也
Polym. J. ( 35 ) 714 - 720 2003年11月
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Polysaccharide-polynucleotide Complexes (15): Thermal Stability of Schizophyllan(SPG)/Poly(C) Triple Strands is Controllable by the a-Amino Acid Modification
甲元一也
Bioorg. Chem ( 31 ) 163 - 171 2003年11月
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Molecular Design of “Super” Hydrogelators: Understanding the Gelation process of Azobenzene-Based Sugar Derivatives in Water
甲元一也
Org. Lett., ( 4 ) 1423 - 1426 2002年11月
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Chemical modification of curdlan: Characteristic complexation with polynucleotides by control of the molecular weight
甲元一也
Polym. Prep 43 ( 2 ) 721 - 723 2002年11月
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Novel DNA-polysaccharide triple helix and its application to a gene carrier
甲元一也
Polym. Prep 43 ( 2 ) 691 - 692 2002年11月
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Polysaccharide-polynucleotide Interaction (XI); Novel Separation System of RNAs by Using Schizophyllan-appended Column
甲元一也
Chem. Lett. 1240 - 1241 2002年11月
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Polysaccharide-Polynucleotide Complexes Part 12: Enhanced affinity for various polynucleotide chains by site-specific chemical modification of schizophyllan
甲元一也
Perkin Trans. 1 2477 - 2484 2002年11月
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Sol-gel phase transition induced by fiber-vesicle structural changes in sugar-based bolaamphiphiles
甲元一也
Perkin Trans 2 1930 - 1936 2002年11月
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Gel formation properties of a uracil-appended cholesterol gelator and cooperative effects of the complementary nucleobases
甲元一也
Tetrahedron ( 58 ) 8863 - 8873 2002年11月
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Polysaccharide-Polynucleotide Complexes Part 8. Cation Induced Complex Formation between Polyuridylic Acid and Schizophyllan
甲元一也
Biopolymers ( 65 ) 1 - 9 2002年11月
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Thermally induced conformational–transition of polydeoxyadenosine in the complex with schizophyllan and the base-length dependence of its stability
甲元一也
Chem. Commun. 429 - 430 2001年11月
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分子転写法による新素材の開発 –生体分子を超える分子認識材料開発を目指して-
甲元一也
未来材料 1 ( 5 ) 35 - 41 2001年11月
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Polysaccharide-Polynucleotide Complexes (IV): Anti-hydrolysis effect of the schizophyllan/poly(C) complex and the complex dissociation induced by amines
甲元一也
Bioorg. Chem., ( 29 ) 178 - 185 2001年11月
単著
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Application of schizophyllan as a novel gene carrier
甲元一也
Nucleic Acids Res. Supplement ( 1 ) 223 - 224 2001年11月
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A novel technique to specifically separate RNAs by Schizophyllan
甲元一也
Nucleic Acids Res. Supplement ( 1 ) 283 - 284 2001年11月
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Chemical Modification of Curdlan to Induce an Interaction with Poly(C)
甲元一也
Chem. Lett 908 - 909 2001年11月
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Chemical modification of schizophyllan by introduction of a cationic charge into the side chain which enhances the thermal stability of schizophyllan/poly(C) complexes
甲元一也
Chem. Commun 1962 - 1963 2001年11月
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Organization of Nucleosides Supported by Boronic-Acid-Appended poly(L-Lysine): Creation of a Novel RNA Mimic
甲元一也
Bull. Chem. Soc. Jpn ( 74 ) 1311 - 1317 2001年11月
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TEM and SEM observations of super-structures constructed in organogel systems from a combination of boronic-acid-appended bola-amphiphiles with chiral diols
甲元一也
Nanotechnology, ( 12 ) 25 - 31 2000年11月
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Polysaccharide-Polynucleotide Complex (III): A novel interaction between the b-1,3-Glucan Family and the Single-Strand RNA: Poly(C)
甲元一也
Chem. Lett 1242 - 1243 2000年11月
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The First Example of Positive Allosterism in an Aqueous Saccharide-Binding System Designed on a Ce(IV) Bis(porphyrinate) Double Decker Scaffold
甲元一也
Tetrahedron ( 56 ) 4717 - 4723 2000年11月
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Colorimetric Sugar Sensing Method Useful in “Neutral” Aqueous Media
甲元一也
Chem. Lett., 856 - 857 2000年11月
単著