写真a

MUKAI Masanori

Position

Professor

Graduating School 【 display / non-display

  •  
    -
    1990.03

    Shizuoka University   Faculty of Science   Graduated

Graduate School 【 display / non-display

  •  
    -
    1995.03

    Hiroshima University  Graduate School, Division of Natural Science  Doctor's Course  Completed

Campus Career 【 display / non-display

  • 2017.04
    -
    Now

    KONAN UNIVERSITYFaculty of Science and Engineering   Faculty of Science and Engineering Department of Biology   Professor  

  • 2012.04
    -
    2017.03

    KONAN UNIVERSITYFaculty of Science and Engineering   Associate Professor  

  • 2007.04
    -
    2012.03

    KONAN UNIVERSITYFaculty of Science and Engineering   Lecturer  

 

Published Papers 【 display / non-display

  • A truncated form of a transcription factor Mamo activates vasa in Drosophila embryos.

    Shoichi Nakamura, Seiji Hira, Masato Fujiwara, Nasa Miyagata, Takuma Tsuji, Akane Kondo, Hiroshi Kimura, Yuko Shinozuka, Makoto Hayashi, Satoru Kobayashi, Masanori Mukai

    Communications biology     2019.11  [Refereed]

    Joint Work

    DOI

  • H3K36 Trimethylation-Mediated Epigenetic Regulation is Activated by Bam and Promotes Germ Cell Differentiation During Early Oogenesis in Drosophila

    Mukai M, Hira S, Nakamura K, Nakamura S, Kimura H, Sato M, Kobayashi S.

    Biol Open.     2015  [Refereed]

    Joint Work

    ヒストン修飾H3K36me3が生殖幹細胞の分化制御に関与することを明らかにした。

  • Innexin2 gap junctions in somatic support cells are required for cyst formation and for egg chamber formation in Drosophila

    M. Mukai, H. Kato, S. Hira, K. Nakamura, H. Kita, S. Kobayashi

    Mech. Dev.   128   510 - 523   2011.10  [Refereed]

    Joint Work

    Germ cells require intimate associations with surrounding somatic cells during gametogenesis. During oogenesis, gap junctions mediate communication between germ cells and somatic support cells. However, the molecular mechanisms by which gap junctions regulate the developmental processes during oogenesis are poorly understood. We have identified a female sterile allele of innexin2 (inx2), which encodes a gap junction protein in Drosophila. In females bearing this inx2 allele, cyst formation and egg chamber formation are impaired. In wild-type germaria, Inx2 is strongly expressed in escort cells and follicle cells, both of which make close contact with germline cells. We show that inx2 function in germarial somatic cells is required for the survival of early germ cells and promotes cyst formation, probably downstream of EGFR pathway, and that inx2 function in follicle cells promotes egg chamber formation through the regulation of DE-cadherin and Bazooka (Baz) at the boundary between germ cells and follicle cells. Furthermore, genetic experiments demonstrate that inx2 interacts with the zero population growth (zpg) gene, which encodes a germline-specific gap junction protein. These results indicate a multifunctional role for Inx2 gap junctions in somatic support cells in the regulation of early germ cell survival, cyst formation and egg chamber formation. Inx2 junctions may mediate the transfer of nutrients and signal molecules between germ cells and somatic support cells, as well as play a role in the regulation of cell adhesion.

  • Binding of Drosophila maternal Mamo protein to chromatin and specific DNA sequences

    S. Hira, T. Okamoto, M. Fujiwara, H. Kita, S. Kobayashi and M. Mukai

    Biochem. Biophys Res. Commun.     2013

    Joint Work

  • Genetically encoded system to track histone acetylation in vivo

    Y. Sato, M. Mukai, J. Ueda, M. Muraki, T. J. Stasevich, N. Horikoshi, T. Kujirai, H. Kita, T. Kimura, S. Hira, Y. Okada, Y. Hayashi-Takanaka, C. Obuse, H. Kurumizaka, A. Kawahara, K. Yamagata, N. Nozaki, and H. Kimura

    Scientific Reports     2013  [Refereed]

    Joint Work

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Review Papers (Misc) 【 display / non-display

  • ショウジョウバエの母性因子SVA53による減数分裂課程の染色体構造制御(共著)

    向 正則、小林 悟

    生物の科学 遺伝 ( (株)エヌ・ティー・エス )  ( 21 ) 47 - 51   2007.03

    Introduction and explanation (scientific journal)   Joint Work

    ショウジョウバエの母性因子SVA53による減数分裂課程の染色体構造制御

Grant-in-Aid for Scientific Research 【 display / non-display

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2016.04  -  2019.03 

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2009.04  -  2011.03