論文 - 遠藤 玉樹
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Co-transcriptional molecular assembly results in a kinetically controlled irreversible RNA conformational switch 査読あり
Endoh T. and Sugimoto N.
Anal. Chem. 90 ( 19 ) 11193 - 11197 2018年10月
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Pursuing origins of (poly)ethylene glycol-induced G-quadruplex structural modulations 査読あり 国際共著
M. Trajkovski,* T, Endoh,* H. Tateishi-Karimata, T. Ohyama, S. Tanaka, J. Plavec and N. Sugimoto [* Equal contribution]
Nucleic Acids Res. 46 4301 - 4315 2018年5月
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Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins 査読あり 国際共著
E. Natan, T. Endoh, L. Haim-Vilmovsky, T. Flock, G. Chalancon, J. T. S. Hopper, B. Kintses, P. Horvath, L. Daruka, G. Fekete, C. Pál, B. Papp, E. Oszi, Z. Magyar, J. A. Marsh, A. H. Elcock, M. N. Babu, C. V. Robinson, N. Sugimoto, and S. A. Teichmann
Nat. Struct. Mol. Biol. 25 279 - 288 2018年3月
共著
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Synthetic Chlorophyll-A Derivatives Stabilize DNA G-Quadruplex Structures
Nagano Yasunobu, Endoh Tamaki, Ogasawara Shin, Sugimoto Naoki, Tamiaki Hitoshi
BIOPHYSICAL JOURNAL 114 ( 3 ) 599A 2018年2月
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Crowding Shifts the FMN Recognition Mechanism of Riboswitch Aptamer from Conformational Selection to Induced Fit 査読あり
A. B. Rode, T. Endoh, and N. Sugimoto
Angew. Chem. Int. Ed. 2018年
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Conformational Dynamics of mRNA in Gene Expression as New Pharmaceutical Target 招待あり 査読あり
T. Endoh and N. Sugimoto
Chem. Rec. 17 ( 9 ) 817 - 832 2017年9月
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tRNA Shifts the G-quadruplex–Hairpin Conformational Equilibrium in RNA towards the Hairpin Conformer 査読あり
A. B. Rode, T. Endoh, and N. Sugimoto
Angew. Chem. Int. Ed. 55 14315 - 14319 2016年11月
共著
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Triplex-forming PNA modified with unnatural nucleobases: the role of protonation entropy in RNA binding 査読あり 国際共著
T. Endoh, C. Annoni, D. Hnedzko, E. Rozners, and N. Sugimoto
Phys. Chem. Chem. Phys. 18 32002 - 32006 2016年11月
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Correction: Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing. 国際共著
Annoni C, Endoh T, Hnedzko D, Rozners E, Sugimoto N
Chemical communications (Cambridge, England) 52 ( 91 ) 13417 - 13418 2016年11月
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Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing 査読あり 国際共著
Annoni C, Endoh T, Hnedzko D, Rozners E, Sugimoto N
Chem. Commun. 52 7935 - 7938 2016年6月
共著
DOI： 10.1039/C6CC02164F
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Site-specific control of silica mineralization on DNA using a designed peptide 査読あり
Ozaki M, Nagai K, Nishiyama H, Tsuruoka T, Fujii S, Endoh T, Imai T, Tomizaki KY, Usui K
Chem. Commun. 52 ( 21 ) 4010 - 4013 2016年3月
共著
DOI： 10.1039/c5cc07870a
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Mechanical insights into ribosomal progression overcoming RNA G-quadruplex from periodical translation suppression in cells 査読あり
Endoh T, Sugimoto N
Sci. Rep. 6 22719 2016年3月
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Real-time monitoring of G‑quadruplex formation during transcription 査読あり
Endoh T, Rode AB, Takahashi S, Kataoka Y, Kuwahara M, Sugimoto N
Anal. Chem. 88 ( 4 ) 1984 - 1989 2016年2月
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Nucleobase-modified PNA suppresses translation by forming a triple helix with a hairpin structure in mRNA in vitro and in cells 査読あり 国際共著
Endoh T, Hnedzko D, Rozners E, Sugimoto N
Angew. Chem. Int. Ed. 55 ( 3 ) 899 - 903 2016年1月
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Rational design and tuning of functional RNA switch to control an allosteric intermolecular interaction 査読あり
Endoh T, Sugimoto N
Anal. Chem. 87 7628 - 7635 2015年8月
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Key tertiary interactions in FMN riboswitch aptamers required for ligand binding 査読あり
Rode A B, Endoh T, Sugimoto N
Bull. Chem. Soc. Jpn. 88 946 - 948 2015年7月
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Tuning riboswitch-mediated gene regulation by rational control of aptamer ligand binding properties 査読あり
Rode A B, Endoh T, Sugimoto N
Angew. Chem. Int. Ed. 54 905 - 909 2015年1月
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Aptamer-based universal fluorometric sensors based on allosteric modulation of RNA–peptide Interactions 査読あり
Endoh T, Sugimoto N
ChemMedChem 9 2045 - 2048 2014年9月
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Unusual −1 ribosomal frameshift caused by stable RNA G-quadruplex in open reading frame 査読あり
Endoh T, Sugimoto N
Anal. Chem., 85 11435 - 11439 2013年12月
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担当区分：筆頭著者
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Unusual-1 Ribosomal Frameshift Caused by Stable RNA G-Quadruplex in Open Reading Frame
Tamaki Endoh, Naoki Sugimoto
ANALYTICAL CHEMISTRY 85 ( 23 ) 11435 - 11439 2013年12月
共著
担当区分：筆頭著者 出版者・発行元：AMER CHEMICAL SOC
Tertiary structures formed by mRNAs impact the efficiency of the translation reaction. Ribosomal frameshift is a well-characterized recoding process that occurs during translation elongation. Pseudoknot and stem-loop structures may stimulate frameshifting by causing a translational halt at a slippery sequence. In this study, we evaluated the efficiency of an unusual 1 frameshift caused by a noncanonical RNA G-quadruplex structure in mammalian cells. The reporter gene construct consisting of a fluorescent protein and Luciferase enabled evaluation of apparent and absolute values of the 1 frameshift efficiency and revealed significant increase of the efficiency by G-quadrupex forming potential sequence. In addition, berberine, a small molecule that binds to and stabilizes G-quadruplex structures, further increased the frameshift efficiency. These results indicate that the stable G-quadruplex structure stimulates the unusual -1 frameshift and has a potential to regulate the frameshift with its ligand.
DOI： 10.1021/ac402497x