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Position |
Associate Professor |
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Research Field |
Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering, Life Science / Applied biochemistry, Nanotechnology/Materials / Bio chemistry |
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External Link |
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Graduating School 【 display / non-display 】
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Tokyo Institute of Technology Faculty of Life Science and Engineering Graduated
- 2001.3
Graduate School 【 display / non-display 】
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Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering Doctor's Course Completed
- 2006.3
Campus Career 【 display / non-display 】
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KONAN UNIVERSITY Frontier of Institute for Biomolecular Engineering Research in Science and Technology Department of Nanobiochemistry Associate Professor
2016.4
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KONAN UNIVERSITY Frontier of Institute for Biomolecular Engineering Research in Science and Technology Department of Nanobiochemistry Lecturer
2009.4 - 2016.3
External Career 【 display / non-display 】
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岡山大学大学院自然科学研究科
2006.4 - 2009.3
Country：Japan
Professional Memberships 【 display / non-display 】
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Division of Biofunctional Chemistry, The Chemical Society of Japan
2012.9
Papers 【 display / non-display 】
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5-Triazolyl uracil improves nucleobase stacking, pyrimidine recognition, biological activity, and specificity of RNA-binding triplex-forming peptide nucleic acids Reviewed
S. F Saei, T. Endoh, V. Baskevics, I. Kumpina, M. Katkevics, N. Sugimoto, Eriks Rozners
Nucleic Acids Res. 54 gkag249 2026.3
DOI： 10.1093/nar/gkag249
DOI： 10.1093/nar/gkag249
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Development of a Microwave-Assisted Method for Enhancing the Cellular Uptake of Arginine-Rich Peptides Reviewed
F. Kayamori, M. Hirata, T. Kariya, Y. Arimoto, R. Osawa, M. Ishikawa, T. Endoh, N. Nakanishi, K. Usui
Processes 14 497 2026.1
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Identification of Endogenous Sequences Interacting with METTL3/METTL14 RNA Methyltransferase. International journal
Tamaki Endoh, Yiwei Ling, Shujiro Okuda, Miki Imanishi
Chembiochem : a European journal of chemical biology 26 ( 11 ) e202500006 2025.6
N6-methyladenosine (m6A) is the most abundant RNA modification in mRNA and regulates various biological processes. The RNA-binding properties of m6A writer proteins play an important role in determining RNA modification sites. METTL3 and METTL14 form the core of the m6A writer complex, with METTL3 as the catalytic methyltransferase and METTL14 as the RNA-binding scaffold. Thus far, the comprehensive RNA-binding properties of METTL3/14 remain unknown. Using RNA-capturing microsphere particles (R-CAMPs), immobilizing RNA fragments derived from endogenous RNAs of human lung carcinoma cells, RNA fragments that interacted with the METTL3/14 methyltransferase domain are isolated. Bioinformatics analysis reveals that the pool of isolated sequences contains significantly more regions with the potential to form RNA G-quadruplexes (rG4s) than the randomly extracted RNA sequence pool and that the (GGA) repeat sequences are most enriched. Circular dichroism spectroscopy, gel mobility shift assays, and methylation experiments demonstrate that METTL3/14 binds to RNA sequences containing (GGA) repeats that form rG4 structure much stronger than RNAs that do not form rG4s. This study shows the potential of RNA G-quadruplex structures as a modulator of epitranscriptomic modification of m6As.
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Predictability of environment-dependent formation of G-quadruplex DNAs in human mitochondria Reviewed International journal
L. Liu, S. Takahashi, S. Ghosh, T. Endoh, N. Yoshinaga, K. Numata, N. Sugimoto
Communications Chemistry 8 ( 1 ) 135 - 135 2025.5
Molecular crowding affects the stability of nucleic acids (DNA and RNA) and induces their non-canonical structures. As the level of molecular crowding varies spatio-temporally in cells, it would be beneficial to predict the behaviour of DNA and RNA structures depending on the local cellular environments. This has applications in human mitochondria, which possess an especially crowded condition. In this study, the predictability of guanine-quadruplex (G4) DNA formation in the environment specific to human mitochondria was investigated. In accordance with the stability of duplexes predicted by our nearest-neighbour parameters, the G-rich duplex stability was found to effectively decrease and G4 formation was induced in mitochondrion-like conditions compared to the nucleus-like conditions. Using a peptide-based mitochondrial targeting system, a G4 reporter assay performed in mitochondria indicated that G4 formation were more favoured in mitochondria more than in the nucleus. These findings provide insights useful for the prediction of the behaviour of nucleic acids in mitochondria.
DOI： doi.org/10.1038/s42004-025-01532-z
DOI： doi.org/10.1038/s42004-025-01532-z
Other Link： https://www.nature.com/articles/s42004-025-01532-z
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Contrasting effect of different crowding agents on pseudoknot RNA stability Reviewed
S. Satpathi, T, Endoh, and N. Sugimoto
Med. Chem. Res. 33 2079 - 2084 2024.8
Books and Other Publications 【 display / non-display 】
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核酸科学ハンドブック
杉本 直己, 日本核酸化学会, 講談社サイエンティフィク（ Role： Contributor , 第II部 核酸科学の最前線 15. リボスイッチ）
講談社 2020.12 （ ISBN:9784065207864 ）
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生体分子化学 基礎から応用まで
杉本直己、内藤昌信、橋詰蜂雄、高橋俊太郎、田中直毅、建石寿枝、遠藤玉樹、津本浩平、長門石曉、松原輝彦、上田実、朝山章一郎（ Role： Joint author , 第６章 セントラルドグマ）
講談社 2017.1 （ ISBN:978-4-06-156806-8 ）
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生体分子化学 : 基礎から応用まで = biomolecular chemistry
杉本 直己, 内藤 昌信, 橋詰 峰雄, 高橋 俊太郎, 田中 直毅, 建石 寿枝, 遠藤 玉樹, 津本 浩平, 長門石 曉, 松原 輝彦, 上田 実, 朝山 章一郎, 講談社サイエンティフィク
講談社 2017 （ ISBN:9784061568068 ）
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CSJカレントレビュー ここまで進んだバイオセンシング・イメージング 1分子から細胞、脳まで
遠藤玉樹、杉本直己（ Role： Joint author , 細胞内核酸化学 （pp 86-91））
化学同人 2012
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特定配列RNAの検出法 「新しいDNAチップの科学と応用」
遠藤玉樹（ Role： Sole author）
講談社サイエンティフィック 2007
、関根光雄 編集（講談社サイエンティフィック）、194-204 (2007)
Review Papers (Misc) 【 display / non-display 】
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Construction of artificial viral capsid encapsulating quadruplex DNA and its intracellular delivery
松浦和則, 石井楽乃, 稲葉央, 遠藤玉樹, 建石寿枝, 杉本直己
日本化学会春季年会講演予稿集(Web) 105th 2025
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Creation of artificial viral capsid encapsulated quadruplex DNA
石井楽乃, 稲葉央, 遠藤玉樹, 建石寿枝, 杉本直己, 松浦和則
日本化学会春季年会講演予稿集(Web) 104th 2024
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New Data Science in Nucleic Acids Chemistry (9): Conformational Transition of Nucleic Acids with Virus Genome Sequences inside Cell-like Nanoconfinements
SARKAR Sunipa, TATEISHI-KARIMATA Hisae, ENDOH Tamaki, MATSUURA Kazunori, MATSUURA Kazunori, SUGIMOTO Naoki, SUGIMOTO Naoki
日本化学会春季年会講演予稿集(Web) 104th 2024
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New Data Science in Nucleic Acids Chemistry (8): Real-time monitoring of nucleic acids conformational change in living cells using high-speed confocal imaging system
ENDOH Tamaki, TATEISHI-KARIMATA Hisae, TSUTSUI Keita, FUKAYA Yoko, TSUKIJI Shinya, SUGIMOTO Naoki, SUGIMOTO Naoki
日本化学会春季年会講演予稿集(Web) 104th 2024
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New Data Science in Nucleic Acids Chemistry (1): Development of new nearest neighbor parameters that can predict nucleic acids structure in cells
SUGIMOTO Naoki, SUGIMOTO Naoki, SAPTARSHI Ghosh, DIPANWITA Banerjee, OHYAMA Tatsuya, ENDOH Tamaki, TAKAHASHI Shuntaro, TATEISHI-KARIMATA Hisae
日本化学会春季年会講演予稿集(Web) 104th 2024
Presentations 【 display / non-display 】
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New Data Science in Nucleic Acids Chemistry (26): Comprehensive survey of small chemicals’ RNA targets based on stabilization effect provided by the interaction
T. Endoh, M. Otsu, and E. Czarina Morishita
Event date： 2026.3
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RNA-capturing microsphere particles (R-CAMPs) for developing functional RNAs
T. Endoh
Event date： 2025.12
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Selection of equol aptamer based on base pair switching for construction of conformational switching sensor International coauthorship
T. Endoh, H. Yaku, P. Podbevsek, J. Plavec, N. Sugimoto
The 52nd International Symposium on Nucleic Acids Chemistry
Event date： 2025.11
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イオン液体生成を利用するDNAの共抽出とPCRによる増幅の試み
加古柾哉, 岩月聡, 永井秀典, 遠藤玉樹, 茶山健二
日本分析化学会第74年会
Event date： 2025.9
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ヒトミトコンドリア内でのグアニン四重鎖DNA の形成予測
Liu Lutan, 高橋 俊太郎, Saptarshi Ghosh, 遠藤 玉樹, 吉永 直人, 沼田 圭司, 杉本 直己
第19回バイオ関連化学シンポジウム
Event date： 2025.9
Industrial property rights 【 display / non-display 】
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核酸の検出方法
小畠 英理、三重 正和、遠藤 玉樹
Announcement no：特開2006-055017
Country of applicant：Domestic
【特許コード】 P06P003883
Academic Awards Received 【 display / non-display 】
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バイオ関連化学シンポジウム 講演賞
2013.9 第7回バイオ関連化学シンポジウム
遠藤玉樹
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The First International Symposium on Biofunctional Chemistry (ISBC2012) Poster Award
2012.11 日本化学会 生体機能関連化学部会
遠藤玉樹
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ISNAC Outstanding Oral Presentation Award for Young Scientist in 2012
2012.11 核酸化学シンポジウム組織委員会
遠藤玉樹
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日本化学会第92春季年会 優秀講演賞（学術）
2012.3 日本化学会
遠藤玉樹
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遺伝子・デリバリー研究会 第8回シンポジウム 奨励賞
2008.5 遺伝子・デリバリー研究会
遠藤玉樹
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Drug discovery strategy based on construction of a database for comprehensive interactions between RNAs and bio-related molecules
2023.4 - 2027.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(B)
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Quantitative prediction of nucleic acid structures and functions affected by spaciotemporal environmental factors in cells
2022.4 - 2027.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(S)
Authorship：Coinvestigator(s)
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Elucidation of the mechanism for dimensional response genome
2021.8 - 2024.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid (B) (Tentative)
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Comprehensive analysis of nucleic acid structures involved in modulation of gene expression across species
2021 - 2023.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid (B) (Tentative)
Authorship：Principal investigator
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Rational control of gene expressions by chemically regulating topologies of nucleic acid structures
2019.4 - 2022.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(A)
Sugimoto Naoki
In this research project, gene regulation mechanisms based on nucleic acid structures, whose topological properties dynamically fluctuate depending on the molecular environment in cells, were investigated through quantitative analyses of their structures and stabilities. Physicochemical factors that affect the structures and stabilities of nucleic acids have been elucidated under molecular crowding conditions. Correlations between the nucleic acid structures and their functions to modulate gene expressions were also investigated. Furthermore, the construction of artificial molecules was demonstrated to apply to the regulation of nucleic acid functions based on the modulation of the dynamics and stabilities of their structures. The results of this research project are expected to provide great advances in not only the academic chemistry and biology of nucleic acids but also in a wide range of applied fields such as therapeutic, diagnostic, and medicinal applications.
Other External funds procured 【 display / non-display 】
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翻訳反応を調節し得るmRNA構造の熱安定性と構造特性との相関解析
2014.4 - 2015.3
ひょうご科学技術協会 ひょうご科学技術協会学術研究助成
Preferred joint research theme 【 display / non-display 】
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幹細胞分化制御 大学等の研究機関との共同研究を希望する。