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Position |
Associate Professor |
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Research Field |
Life Science / Applied biochemistry, Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering, Nanotechnology/Materials / Bio chemistry |
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External Link |
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Graduating School 【 display / non-display 】
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Tokyo Institute of Technology Faculty of Life Science and Engineering Graduated
- 2001.3
Graduate School 【 display / non-display 】
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Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering Doctor's Course Completed
- 2006.3
Campus Career 【 display / non-display 】
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KONAN UNIVERSITY Frontier of Institute for Biomolecular Engineering Research in Science and Technology Department of Nanobiochemistry Associate Professor
2016.4
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KONAN UNIVERSITY Frontier of Institute for Biomolecular Engineering Research in Science and Technology Department of Nanobiochemistry Lecturer
2009.4 - 2016.3
External Career 【 display / non-display 】
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岡山大学大学院自然科学研究科
2006.4 - 2009.3
Country：Japan
Professional Memberships 【 display / non-display 】
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Division of Biofunctional Chemistry, The Chemical Society of Japan
2012.9
Papers 【 display / non-display 】
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Identification of Endogenous Sequences Interacting with METTL3/METTL14 RNA Methyltransferase Reviewed
T. Endoh, Y. Ling, S. Okuda, and M. Imanishi
ChemBioChem 2025.4
Authorship：Lead author
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Contrasting effect of different crowding agents on pseudoknot RNA stability Reviewed
S. Satpathi, T, Endoh, and N. Sugimoto
Med. Chem. Res. 33 2079 - 2084 2024.8
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Guanidine modification improves functions of natural RNA-targeting alkaloids Reviewed International coauthorship
T. Endoh, S. Satpathi, Y. Chen, S. Matsumoto, T. Ohyama, P. Podbevšek, J. Plavec, K. Onizuka, F. Nagatsugi, N. Sugimoto
New J. Chem. 48 8529 - 8533 2024.5
Authorship：Lead author
DOI： 10.1039/D3NJ05833F
Other Link： https://pubs.rsc.org/en/content/articlelanding/2024/nj/d3nj05833f
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Nearest-neighbor parameters for the prediction of RNA duplex stability in diverse in vitro and cellular-like crowding conditions. Reviewed International journal
Saptarshi Ghosh, Shuntaro Takahashi, Dipanwita Banerjee, Tatsuya Ohyama, Tamaki Endoh, Hisae Tateishi-Karimata, Naoki Sugimoto
Nucleic acids research 51 ( 9 ) 4101 - 4111 2023.5
RNA performs various spatiotemporal functions in living cells. As the solution environments significantly affect the stability of RNA duplexes, a stability prediction of the RNA duplexes in diverse crowded conditions is required to understand and modulate gene expression in heterogeneously crowded intracellular conditions. Herein, we determined the nearest-neighbor (NN) parameters for RNA duplex formation when subjected to crowding conditions with an ionic concentration relevant to that found in cells. Determination of the individual contributions of excluded volume effect and water activity to each of the NN parameters in crowded environments enabled prediction of the thermodynamic parameters and their melting temperatures for plenty of tested RNA duplex formation in vitro and in cell with significant accuracy. The parameters reported herein will help predicting RNA duplex stability in different crowded environments, which will lead to an improved understanding of the stability-function relationship for RNAs in various cellular organelles with different molecular environments.
DOI： 10.1093/nar/gkad020
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Endogenous G-quadruplex-forming RNAs inhibit the activity of SARS-CoV-2 RNA polymerase. Invited Reviewed International journal
Tamaki Endoh, Shuntaro Takahashi, Naoki Sugimoto
Chemical communications (Cambridge, England) 59 ( 7 ) 872 - 875 2023.1
Authorship：Lead author
Replication of RNA viruses is catalysed by virus-specific polymerases, which can be targets of therapeutic strategies. In this study, we used a selection strategy to identify endogenous RNAs from a transcriptome library derived from lung cells that interact with the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. Some of the selected RNAs weakened the activity of RdRp by forming G-quadruplexes. These results suggest that certain endogenous RNAs, which potentially form G-quadruplexes, can reduce the replication of viral RNAs.
DOI： 10.1039/d2cc05858h
Books and Other Publications 【 display / non-display 】
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核酸科学ハンドブック
杉本 直己, 日本核酸化学会, 講談社サイエンティフィク（ Role： Contributor , 第II部 核酸科学の最前線 15. リボスイッチ）
講談社 2020.12 （ ISBN:9784065207864 ）
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生体分子化学 基礎から応用まで
杉本直己、内藤昌信、橋詰蜂雄、高橋俊太郎、田中直毅、建石寿枝、遠藤玉樹、津本浩平、長門石曉、松原輝彦、上田実、朝山章一郎（ Role： Joint author , 第６章 セントラルドグマ）
講談社 2017.1 （ ISBN:978-4-06-156806-8 ）
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生体分子化学 : 基礎から応用まで = biomolecular chemistry
杉本 直己, 内藤 昌信, 橋詰 峰雄, 高橋 俊太郎, 田中 直毅, 建石 寿枝, 遠藤 玉樹, 津本 浩平, 長門石 曉, 松原 輝彦, 上田 実, 朝山 章一郎, 講談社サイエンティフィク
講談社 2017 （ ISBN:9784061568068 ）
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CSJカレントレビュー ここまで進んだバイオセンシング・イメージング 1分子から細胞、脳まで
遠藤玉樹、杉本直己（ Role： Joint author , 細胞内核酸化学 （pp 86-91））
化学同人 2012
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特定配列RNAの検出法 「新しいDNAチップの科学と応用」
遠藤玉樹（ Role： Sole author）
講談社サイエンティフィック 2007
、関根光雄 編集（講談社サイエンティフィック）、194-204 (2007)
Review Papers (Misc) 【 display / non-display 】
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Creation of artificial viral capsid encapsulated quadruplex DNA
石井楽乃, 稲葉央, 遠藤玉樹, 建石寿枝, 杉本直己, 松浦和則
日本化学会春季年会講演予稿集(Web) 104th 2024
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環境応答性を示す非二重らせん核酸構造のスクリーニング法の構築
遠藤玉樹, 奥田修二郎, 凌一葦, 建石寿枝, 杉本直己, 杉本直己
日本生化学会大会(Web) 95th 2022
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Nucleic Acids Chemistry and Engineering: Special Issue on Nucleic Acid Conjugates for Biotechnological Applications
Tamaki Endoh, Eriks Rozners, Takashi Ohtsuki
APPLIED SCIENCES-BASEL 11 ( 8 ) 2021.4
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高橋俊太郎, 遠藤玉樹, BHOWMIK Sudipta, 杉本直己
高圧討論会講演要旨集 59th 159 2018.11
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分子クラウディング環境下におけるFMNリボスイッチ由来のアプタマードメインの分子挙動
遠藤玉樹, RODE B.Ambadas, RODE B.Ambadas, 杉本直己
日本RNA学会年会要旨集 20th 30 2018.7
Presentations 【 display / non-display 】
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New Data Science in Nucleic Acids Chemistry (20) : G-quadruplex DNA formations depending on the environments in the mitochondrial matrix
L. Liu, S. Takahashi, G. Sarptarshi, T. Endoh, N. Yoshinaga, K. Numata, N. Sugimoto
日本化学会第105回春季年会
Event date： 2025.3
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Construction of artificial viral capsid encapsulating quadruplex DNA and its intracellular delivery
K. Matsuura, M. Ishii, H. Inaba, T. Endoh, H. Tateshi-Karimata
日本化学会第105回春季年会
Event date： 2025.3
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New Data Science in Nucleic Acids Chemistry (13): Global and local molecular crowding effects depending on the size of crowding cosolute on stability of pseudoknot RNA
T. Endoh, S. Satpathi, N. Sugimoto
日本化学会第105回春季年会
Event date： 2025.3
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Predictability of environment-dependent formation of the behavior of DNAs in human mitochondria
S. Takahashi, L. Liu, S. Ghosh, T. Endoh, N. Yoshinaga, K. Numata and N. Sugimoto
To B or Not to B Symposium 2025
Event date： 2025.3
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RNA conformational dynamics in gene regulation system that applicable for designing functional materials
T. Endoh
MNP/BioNano Seminar
Event date： 2024.12
Industrial property rights 【 display / non-display 】
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核酸の検出方法
小畠 英理、三重 正和、遠藤 玉樹
Announcement no：特開2006-055017
Country of applicant：Domestic
【特許コード】 P06P003883
Academic Awards Received 【 display / non-display 】
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バイオ関連化学シンポジウム 講演賞
2013.9 第7回バイオ関連化学シンポジウム
遠藤玉樹
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ISNAC Outstanding Oral Presentation Award for Young Scientist in 2012
2012.11 核酸化学シンポジウム組織委員会
遠藤玉樹
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The First International Symposium on Biofunctional Chemistry (ISBC2012) Poster Award
2012.11 日本化学会 生体機能関連化学部会
遠藤玉樹
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日本化学会第92春季年会 優秀講演賞（学術）
2012.3 日本化学会
遠藤玉樹
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遺伝子・デリバリー研究会 第8回シンポジウム 奨励賞
2008.5 遺伝子・デリバリー研究会
遠藤玉樹
Grant-in-Aid for Scientific Research 【 display / non-display 】
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いつ、どこで、どのように、核酸の高次構造は形成し機能するのかを予測する
2022.4 - 2027.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(S)
Authorship：Coinvestigator(s)
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Elucidation of the mechanism for dimensional response genome
2021.8 - 2024.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid (B) (Tentative)
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生物種の分類枠組みを超えた網羅解析による多元応答深化の解明
2021 - 2023.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid (B) (Tentative)
Authorship：Principal investigator
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細胞内で機能するRNA構造スイッチの最適化および合理的設計技術の構築
2019.4 - 2022.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
本研究では、細胞内で効率良く機能するRNA構造スイッチを合理的に設計する技術基盤を確立する。
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Rational control of gene expressions by chemically regulating topologies of nucleic acid structures
2019.4 - 2022.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(A)
Sugimoto Naoki
In this research project, gene regulation mechanisms based on nucleic acid structures, whose topological properties dynamically fluctuate depending on the molecular environment in cells, were investigated through quantitative analyses of their structures and stabilities. Physicochemical factors that affect the structures and stabilities of nucleic acids have been elucidated under molecular crowding conditions. Correlations between the nucleic acid structures and their functions to modulate gene expressions were also investigated. Furthermore, the construction of artificial molecules was demonstrated to apply to the regulation of nucleic acid functions based on the modulation of the dynamics and stabilities of their structures. The results of this research project are expected to provide great advances in not only the academic chemistry and biology of nucleic acids but also in a wide range of applied fields such as therapeutic, diagnostic, and medicinal applications.
Other External funds procured 【 display / non-display 】
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翻訳反応を調節し得るmRNA構造の熱安定性と構造特性との相関解析
2014.4 - 2015.3
ひょうご科学技術協会 ひょうご科学技術協会学術研究助成
Preferred joint research theme 【 display / non-display 】
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幹細胞分化制御 大学等の研究機関との共同研究を希望する。