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Professor |
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Research Field |
Nanotechnology/Materials / Analytical chemistry, Nanotechnology/Materials / Inorganic/coordination chemistry, Nanotechnology/Materials / Fundamental physical chemistry |
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Graduating School 【 display / non-display 】
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Nagoya University Faculty of Science Graduated
- 1997.3
Graduate School 【 display / non-display 】
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Nagoya University Graduate School, Division of Natural Science Doctor's Course Accomplished credits for doctoral program
- 2002.3
Campus Career 【 display / non-display 】
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KONAN UNIVERSITY Faculty of Science and Engineering Professor
2016.4
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KONAN UNIVERSITY Faculty of Science and Engineering Associate Professor
2012.4 - 2016.3
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KONAN UNIVERSITY Faculty of Science and Engineering Lecturer
2007.9 - 2012.3
External Career 【 display / non-display 】
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The University of Auckland
2013.3 - 2014.3
Country：New Zealand
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早稲田大学理工学研究所
2011.4 - 2024.3
Country：Japan
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早稲田大学理工学研究所
2006.9 - 2011.3
Country：Japan
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（財）放射線利用振興協会分析技術部
2006.4 - 2007.3
Country：Japan
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早稲田大学理工学総合研究センター
2006.4 - 2006.9
Country：Japan
Papers 【 display / non-display 】
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Detailed Reaction Mechanism of Anthracene-Bridged bis(3-Pyridiniumboronic Acid) Chemosensor with D-Glucose Reviewed International journal
Rei Tanaka, Keigo Matsuo, Shota Suzuki, Gento Mikami, Yota Suzuki, Tomoaki Sugaya, Satoshi Iwatsuki, Masahiko Inamo, Koji Ishihara
ChemistrySelect 9 e202304924 2024.3
Joint Work
Detailed reaction mechanisms of 4-(N-methyl)pyridinium boronic acid (1) and anthracene-bridged bis(pyridinium boronic acid) compounds (diboronic acids 2 and 3) with D-glucose were kinetically investigated in aqueous methanolic solutions. The crystal structure of diboronic acid 3 was determined using X-ray crystallography. The pKa values of the two boronic acid moieties of diboronic acid (2 or 3) differed by one unit, indicating electronic interactions between the two boronic acid moieties. The kinetics of the reaction of boronic acid 1 with D-glucose showed that both trigonal boronic acid and tetrahedral boronate ions were reactive with D-glucose. UV-Vis spectrophotometry and 1HNMR spectrometry of the reactions of phenylboronic acid with some model compounds of D-glucose showed that the reactive moiety of α-D-glucofuranose towards phenylboronic acid was not the 1,2-diol site, but the 3,5,6-triol site. In the reactions of diboronic acids 2 and 3 with D-glucose, the 3,5,6-triol site of α-D-glucofuranose reacts first with one of the two equivalent boronic acid moieties of diboronic acid to form a 3,5-bicoordinate intermediate as a rate-determining step, followed by the reaction of the 1,2-diol site of α-Dglucofuranose with another boronic acid moiety of diboronic acid to form the final 1,2 : 3,5-tetracoordinate cyclic compound as a fast step.
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Twisted Intramolecular Charge Transfer-Based Fluorometric Detection of D-fructose by Boronic Acid-Containing BF2-β-Diketonate Complexes Reviewed
Hitomi Saito, Yukika Sobue, Tomoaki Sugaya, Satoshi Iwatsuki, Masahiko Inamo, Koji Ishihara
ChemPhotoChem 7 e202200271 2023.7
Joint Work
Novel BF2-β-diketonate complexes 1–4 bearing phenylboronic acid moieties and methoxyphenyl or dimethylaminophenyl groups were synthesized and their photophysical properties, pH response, and reactivity to D-fructose were evaluated. Complexes 1 and 2 bearing a methoxyphenyl group luminesced with high intensity in a range of non-polar to polar solvents, except in DMSO, whereas complexes 3 and 4 containing a dimethylaminophenyl group with twisted intramolecular charge transfer (TICT) properties showed a dramatic decrease in luminescence intensity with increasing solvent polarity. The luminescence intensity of complexes 1 and 2 decreased with increasing pH due to intermolecular vibration which associated with hydrogen bonding between the complexes and solvent water molecules, whereas it increased when they reacted with D-fructose due to the suppression of the intermolecular vibration. In contrast, the luminescence intensity of complexes 3 and 4 increased with increasing pH and upon reaction with D-fructose due to the loss of its TICT properties. The photophysical properties of complexes 1–4 and the TICT properties of complexes 3 and 4 were supported by density functional theory
calculations. -
Asymmetrical Platinum and Rhodium Dinuclear Complex Strongly Bound to Filled dz2 Complexes by Unbridged Pt-metal Bonds Toward Heterometallic-Extended Metal Atom Chains Reviewed International journal
Kazuhiro Uemura, Yuya Ikeda, Atsushi Takamori, Tomoyuki Takeyama, Satoshi Iwatsuki
Chemistry - A European Journal 29 e202204057 2023.3
Joint Work
Authorship：Last author
Abstract: Heterometallic extended metal atom chains (EMACs) aligned with three types of metal were rationally synthesized by forming unbridged metal-metal bonds based on the interactions between highest occupied and lowest unoccupied molecular orbitals at the dz2 orbital. These chains form pentanuclear structures aligned as Rh-Pt-M-Pt-Rh with relatively large formation constants of 5.0×10^13 M^-2 for M = Pt and 6.3×10^11 M-2 for M = Pd, while retaining their backbones in solution. In the case of M = Cu, the original Cu(+2) atoms were reduced to Cu(+1) during the synthetic process. Cu(+1) has an unprecedented trigonal bipyramidal coordination geometry. The reported synthesis based on asymmetrical dinuclear complexes provides a guideline for the synthesis of hetero-EMACs to allow several analogs through judicious combinations realized by tuning the number of metal nuclei and metal species.
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Detailed Reaction Mechanism of Bis-(o-Aminomethylphenylboronic Acid)-based Receptors with Various Length Methylene-chain Linkers with D-Glucose Reviewed
Yuki Ohno, Rei Tanaka, Yota Suzuki, Tomoaki Sugaya, Satoshi Iwatsuki, Masahiko Inamo, Koji Ishihara
ChemistrySelect 7 e202200603 2022.8
Joint Work
The detailed reaction mechanisms of several bis-(o-aminomethylphenylboronic acid)-based receptors, linked with methylene chains of different lengths (i. e., DBAn (n=2, 3, and 4) having 2n methylene groups), with D-glucose were kinetically investigated in methanolic aqueous solutions. The pKa measurements showed that the two boronic acid moieties in DBAn were equivalent and had no electronic interaction between them. DBA2 reacted with D-glucose to form a 1:1 product, in which two boronic acid moieties in one molecule of DBA2 were bound to two reactive sites in one molecule of D-glucose. DBA3 and DBA4 reacted with D-glucose to form a 1:2 product, in which the two boronic acid moieties in one molecule of DBA3 or DBA4 were bound to two molecules of D-glucose simultaneously through one reactive site. Thus, in the recognition of D-glucose, the distance between the two boronic acid moieties in DBAn was optimal for n=2 and too long for n=3 or 4.
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Synthesis and characterization of a uranyl(VI) complex with 2,6-pyridine-bis(methylaminophenolato) and its ligand-centred aerobic oxidation mechanism to a diimino derivative Reviewed
Tomoyuki Takeyama, Satoshi Iwatsuki, Satoru Tsushima, Koichiro Takao
Dalton Transactions 51 6576 - 6586 2022.5
Joint Work
A uranyl(VI) complex with 2,6-bis(3,5-di-tert-butyl-o-phenolateaminomethyl)pyridine (UO2(tBu-pdaop), 1) was synthesized and thoroughly characterized by 1H NMR, IR, elemental analysis, and single-crystal XRD. Right after the dissolution of complex 1 in pyridine or DMSO, the solution was pale red, whereas it gradually turned to dark purple under an ambient atmosphere. 1H NMR spectra at the initial and final states suggested that both of the two aminomethyl groups in 1 were converted to azomethine ones through aerobic oxidation. Indeed, a uranyl(VI) complex with 2,6-bis(3,5-di-tert-butyl-o-phenolateiminomethyl) pyridine (UO2(tBu-pdiop), 2) was obtained from the concentrated solution once the reaction was completed, and was characterized by IR, and single-crystal XRD. Kinetic analyses as well as mechanistic studies based on quantum chemical calculations suggested that hydrogen atom transfer from one of the amino groups in complex 1 to nearby O2 initiates the stepwise oxidation processes to finally afford 2. The present findings demonstrate the novel reactivity of a uranyl(VI) complex, and provide new insights to construct thermally-driven molecular conversion systems by a UO2^2+ complex catalyst.
Presentations 【 display / non-display 】
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Reaction analyses for chelate complex formations of boronic acids: Kinetic reactivities of boronic acid and boronate ion
Satoshi Iwatsuki
第43回配位化学国際会議（基調講演）
Event date： 2018.7 - 2018.8
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Kinetic Study on Cyclopalladation in Palladium(II) Complexes Containing an Indole Moiety
Satoshi Iwatsuki, Takuya Suzuki, Syogo Tanooka, Tatsuo Yajima, Yuichi Shimazaki
第33回溶液化学国際会議（招待講演）
Event date： 2013.7
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溶液反応論が見出す面白い反応 －溶液の希釈に伴って進行する金属－炭素結合生成反応
岩月聡史
第72回分析化学討論会（依頼講演）
Event date： 2012.5
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強酸性水溶液中における3-ピリジニウムボロン酸とヒノキチオールとの錯形成反応の速度論的研究
岩月聡史・石原浩二
第57回錯体化学討論会 (報告)
Event date： 2007.9
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錯体溶液反応を正確に理解する -反応機構論研究の意義と可能性-
岩月聡史
第57回錯体化学討論会 (依頼講演)
Event date： 2007.9
Grant-in-Aid for Scientific Research 【 display / non-display 】
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温度昇降により水溶性ホウ素を分離する親水・疎水制御型ハイブリッド機能高分子の開発（研究代表者）
2022.4 - 2025.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
Authorship：Principal investigator
ホウ素は、科学技術を支える主要な元素である一方、排出規制物質でもあり、特に水溶性ホウ素の分離・回収技術には未だ課題が多い。本研究では、従来の樹脂による固相分離法よりも効率的に水溶性ホウ素を分離・回収可能な『親水・疎水制御型ハイブリッド機能高分子』を開発する。この高分子は、低温で水溶性であり、溶液状態で水溶性ホウ素を高速吸脱着できる。一方、高温では高分子が固化し、ろ過で簡単に分離できるため、温度変化とろ過だけでホウ素を分離できる環境にやさしい新技術となり得る。本研究はさらに、ハイブリッド機能高分子に検出センサー部位を導入し、ホウ素の分離・回収のみならず、検出も可能な多機能高分子の開発を試みる。
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イオン液体生成を利用する化学物質の高速抽出分離法の創成（研究分担者）
2021.4 - 2024.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
Authorship：Coinvestigator(s)
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ボロン酸に関する基礎研究を基盤とするジボロン酸型糖比色および蛍光センサーの開発（研究分担者）
2021.4 - 2024.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
Authorship：Coinvestigator(s)
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水溶性ホウ素の分離・回収・検出機能を兼ね備えた三元ハイブリッド機能樹脂の開発（研究代表者）
2018.4 - 2021.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
Authorship：Principal investigator
本申請課題は、科学技術を支える主要な元素である一方で排出規制物質でもあるホウ素化合物をターゲットとし、水溶性ホウ素の濃縮・分離・回収に優れ、なおかつ検出機能を兼ね備えた高次機能化樹脂の開発を目指す。具体的には、(A)申請者が近年開発した穏和なpH制御による定量的なホウ素の捕集・脱着が期待される『キレート配位子－陽イオンハイブリッド機能樹脂』のさらなる機能性向上と、(B)この樹脂にさらにホウ素センシング部位を導入した『三元ハイブリッド機能樹脂』を創製する。この樹脂の開発により、(1)強酸性・強塩基性条件を必要しない環境調和型ホウ素分離－回収技術の実現、(2)樹脂中のホウ素の捕集具合が視覚的にわかる検出機能による利便性の向上、さらには(3)水溶性ホウ素の簡易検出・定量センサーへの展開など、環境にやさしく汎用性の高い分離・分析ツールとなることが期待される。（研究代表者）
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ボロン酸とグルコースの反応に関する基礎研究-ジボロン酸金属錯体による特異的定量-（研究分担者）
2017.4 - 2020.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
Authorship：Coinvestigator(s)
糖類検出を目的とするボロン酸センサーは有機・生命化学分野において数多く開発されているが、これらの開発研究では「反応を利用する」点に主眼が置かれており、より本質的な課題であるボロン酸と糖の反応活性種の特定や詳細な反応機構の解明は全く行われて来ていない。本研究の目的は、ボロン酸センサーの究極的なターゲットである血糖中のD-グルコースを特異的にセンシングするための基礎研究として、(1)「フェニルボロン酸とD-グルコースの反応の反応活性種の特定と反応機構の解明」を行い、D-グルコースの特異的センシングのモデル反応として、(2)「ジボロン酸とD-グルコースの反応の反応活性種の特定と反応機構の解明」を行うとともに、(3)「D-グルコースを特異的に検出可能な高発光性ジボロン酸金属錯体試薬の開発」を行うことである。（研究分担者として参加）
Other External funds procured 【 display / non-display 】
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水溶性ホウ素の簡易分析に資する擬キレート配位子金属錯体試薬の開発
2017.4 - 2018.3
自治体 ひょうご科学技術協会平成29年度研究助成
Preferred joint research theme 【 display / non-display 】
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ホウ素の関わる分析化学（検出試薬・反応系の構築、分離技術開発）
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イオン液体に関する溶液化学的、分析化学的基礎研究
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溶液化学（反応機構）に関する研究
Committee Memberships 【 display / non-display 】
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2023.3 日本分析化学会 近畿支部庶務幹事
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2022.3 - 2025.2 日本分析化学会 近畿支部副支部長
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2020.3 - 2023.2 日本分析化学会 近畿支部常任幹事（ぶんせき講習会委員、2022年度委員長）
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2016.3 - 2018.2 日本分析化学会 近畿支部常任幹事（若手セミナー委員、2017年度委員長）
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2014.4 日本分析化学会（国内） 近畿支部幹事
Qualification acquired 【 display / non-display 】
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Hazardous Material Handler (first kind)
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High School Teacher Specialization License
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First Kind of High School Teacher License
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Junior High School Teacher Specialization License
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First Kind of Junior High School Teacher License