写真a

KAWAKAMI Junji

Position

Professor

Research Field

Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules, Nanotechnology/Materials / Bio chemistry, Life Science / Pharmaceutical analytical chemistry and physicochemistry, Life Science / Molecular biology, Life Science / Structural biochemistry

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Graduating School 【 display / non-display

  • Graduate School of Hokkaido University   Pharmaceutical Sciences   Graduated

    1991.4 - 1994.3

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  • Graduate School of Osaka University   Pharmaceutical Sciences   Graduated

    1989.4 - 1991.3

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  • Osaka University   Faculty of Pharmaceutical Science   Graduated

    1985.4 - 1989.3

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Graduate School 【 display / non-display

  • Hokkaido University   Graduate School, Division of Pharmaceutical Sciences   Doctor's Course   Completed

    1991.4 - 1994.3

  • Osaka University   Graduate School, Division of Pharmaceutical Sciences   Master's Course   Completed

    1989.4 - 1991.3

Studying abroad experiences 【 display / non-display

  • 2001.3
    -
    2002.3

    Yale University   Visiting Scholar

Campus Career 【 display / non-display

  • KONAN UNIVERSITY   Department of Nanobiochemistry, FIRST   Professor

    2009.4

  •   理工学部 機能分子化学科   准教授

    2007.4 - 2009.3

  •   理工学部 機能分子化学科   助教授

    2005.4 - 2007.3

  •   理工学部 機能分子化学科   講師

    2001.4 - 2005.3

  •   理学部 化学科   講師

    1996.4 - 2001.3

External Career 【 display / non-display

  • Professor, Department of Nanobiochemistry, FIRST, Konan University

    2009

  • 甲南大学 フロンティアサイエンス学部 教授

    2009

  • Associate Professor, Faculty of Science and Engineering, Konan University

    2005 - 2009

  • Visiting Fellow, Yale University

    2001 - 2002

  • YALE大学 客員研究員

    2001 - 2002

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Professional Memberships 【 display / non-display

  • NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN

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  • Nucleic Acids Therapeutics Society of Japan

    2015.4

  • The Japan Society of Nucleic Acids Chemistry

    2017.11

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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  • American Association for the Advancement of Science

    1996.4

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Papers 【 display / non-display

  • Sequencing of Morpholino Antisense Oligonucleotides Using Electron Capture Dissociation Mass Spectrometry Reviewed

    Kaoru Karasawa, Eva Duchoslav, Lyle Burton, Junji Kawakami, Takashi Baba

    Analytical Chemistry   95 ( 44 )   16352 - 16358   2023.10

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  • Mitochondrial Dynamics of Bcl-2 Family Proteins during 17-β-Estradiol-Induced Apoptosis Correlate with the Malignancy of Endometrial Cancer Cells Reviewed

    Takahiro Yaguchi, Misaki Kameno, Hirofumi Taira, and Junji Kawakami

    Biochemstry   62 ( 21 )   3041 - 3049   2023.10

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  • Comparison of Analysis Data of Model Oligonucleotide Therapeutics Obtained with Different Types of Liquid Chromatograph- Mass Spectrometers Reviewed

    Kenji Hirose, Tokuyuki Yoshida, Maki Terasaki, Hiroshi Sezaki, Kaoru Karasawa, Noriyuki Iwasaki, Kentaro Takahara, Naomi Takiguchi, Mitsuaki Sekiguchi, Hirokazu Nankai, Emi Saito, Hideaki Sato, Takashi Osawa, Takao Yamaguchi, Kosuke Ito, Junji Kawakami, Satoshi Obika, and Takao Inoue

    Pharmaceutical and Medical Device Regulatory Science   54   439 - 454   2023.10

  • Not all 2',4'-bridged modifications stabilize DNA/RNA duplexes Reviewed

    Tomoka Akita, Elisa Tomita-Sudo, Shin Itoh, Nae Sakimoto, Takeshi Masuda, Akifumi Nakamura, Yoshiyuki Onishi, Makoto Koizumi Junji Kawakami

    Nucleosides, Nucleotides & Nucleic Acids   2023.3

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  • Actin Filament in the First Cell Cycle Contributes to the Determination of the Anteroposterior Axis in Ascidian Development Reviewed

    Toshiyuki Goto, Shuhei Torii, Aoi Kondo, Kazumasa Kanda, Junji Kawakami, Yosky Kataoka, Takahito Nishikata

    Journal of Developmental Biology   10 ( 1 )   10 - 10   2022.2

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    Publisher:MDPI AG  

    In many animal species, the body axis is determined by the relocalization of maternal determinants, organelles, or unique cell populations in a cytoskeleton-dependent manner. In the ascidian first cell cycle, the myoplasm, including mitochondria, endoplasmic reticulum (ER), and maternal mRNAs, move to the future posterior side concomitantly (called ooplasmic segregation or cytoplasmic and cortical reorganization). This translocation consists of first and second phases depending on the actin and microtubule, respectively. However, the transition from first to second phase, that is, translocation of myoplasmic components from microfilaments to microtubules, has been poorly investigated. In this study, we analyzed the relationship between these cytoskeletons and myoplasmic components during the first cell cycle and their role in morphogenesis by inhibitor experiments. Owing to our improved visualization techniques, there was unexpected F-actin accumulation at the vegetal pole during this transition period. When this F-actin was depolymerized, the microtubule structure was strongly affected, the myoplasmic components, including maternal mRNA, were mislocalized, and the anteroposterior axis formation was disordered. These results suggested the importance of F-actin during the first cell cycle and the existence of interactions between microfilaments and microtubules, implying the enigmatic mechanism of ooplasmic segregation. Solving this mystery leads us to an improved understanding of ascidian early development.

    DOI: 10.3390/jdb10010010

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Books and Other Publications 【 display / non-display

  • 不純物の分析法と化学物質の取り扱い

    騰川博之、大久保貴史、野中祐美、山口卓男、小比賀聡、川上純司( Role: Sole author ,  核酸医薬品の不純物の分析)

    技術情報協会   2024 

  • 核酸医薬品のCMC管理戦略 −品質評価・不純物管理−

    冨田恵麗沙, 秋田智香, 川上純司( Role: Contributor ,  核酸医薬品と核酸化学)

    サイエンス&テクノロジー  2022.9  ( ISBN:9784864282925

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  • 核酸科学ハンドブック

    川上純司( Role: Contributor ,  アンチセンス核酸のメカニズム)

    講談社  2020.12  ( ISBN:9784065207864

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  • 医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略

    川上 純司(アンチセンス核酸医薬の作用機序)

    情報機構  2019.10 

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  • ゼロからはじめるバイオ実験マスターコース③ 細胞培養トレーニング

    西方敬人, 川上純司, 藤井敏司, 長濱宏治, 川内敬子( Role: Joint author)

    学研メディカル秀潤社  2015.4  ( ISBN:9784780909036

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Review Papers (Misc) 【 display / non-display

  • 核酸医療の基礎知識 修飾核酸 Invited

    秋田 智香、冨田 恵麗沙、川上 純司

    月刊 臨床神経科学   41 ( 5 )   639 - 642   2023.5

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 日本発の核酸医薬を世界に向けて

    川上純司

    SCAS NEWS   2023-1   1 - 2   2023

  • LC/MSを使用したオリゴ核酸の不純物分析

    瀬崎浩史、内藤厚子、林明生、川上純司、井上貴雄、山口卓男、小比賀聡

    Medical Science Digest   49 ( 14 )   780 - 782   2023

  • 製造委託の際に知っておきたい核酸医薬の特性ー品質と安全性評価面を中心に  Invited

    川上 純司

    Pharm Tech Japan    38 ( 12 )   2017 - 2022   2022.9

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 核酸医薬の化学 総論 −修飾核酸と機能評価

    秋田智香、川上純司

    実験医学   39 ( 17 )   2716 - 2722   2021

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Presentations 【 display / non-display

  • Ligation reaction on Capped RNA substrates by a Ligase Ribozyme

    Nae Sakimoto, Riki Hatakenaka, Emily Matsusaka, Natsuki Doi, Akane Kiyose and Junji Kawakami

    The 50th International Symposium on Nucleic Acids Chemistry The 7th Annual Meeting of Japan Society of Nucleic Acids Chemistry  (Miazaki Civic Plaza)  2023.11 

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    Event date: 2023.11

    Country:Japan  

  • Sequence-dependent effects on kinetic parameters of nucleic acid duplex formation

    Elisa Tomita-Sudo, Tomoka Akita, Renshin Sano, Ayumu Kashiwagi, Junji Kawakami

    The 50th International Symposium on Nucleic Acids Chemistry The 7th Annual Meeting of Japan Society of Nucleic Acids Chemistry  (Miazaki Civic Plaza)  2023.11 

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    Event date: 2023.11

    Country:Japan  

  • Sequence-dependent effects on kinetic parameters of nucleic acid duplex formation

    Elisa Tomita-Sudo, Tomoka Akita, Renshin Sano, Ayumu Kashiwagi, Junji Kawakami

    The 50th International Symposium on Nucleic Acids Chemistry The 7th Annual Meeting of Japan Society of Nucleic Acids Chemistry  (Miazaki Civic Plaza)  2023.11 

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    Event date: 2023.11

    Country:Japan  

  • Sequences that destabilize DNA/RNA duplexes

    Shizuka Közaki, Ayumu Kashiwagi, Shuichiro Fujiki, Tomoka Akita, Junji Kawakami

    The 50th International Symposium on Nucleic Acids Chemistry The 7th Annual Meeting of Japan Society of Nucleic Acids Chemistry  (Miazaki Civic Plaza)  2023.11 

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    Event date: 2023.11

    Country:Japan  

  • Efficient Method Development and Identification of Oligonucleotides Therapeutics Impurities

    Risa Suzuki, Shinichi Fujisaki, Junji Kawakami, Takao Inoue, Satoshi Obika, Yoshihiro Hayakawa

    19th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS, at Barcelona)  (Fira de Barcelona)  2023.10 

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    Event date: 2023.10

    Country:Spain  

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Grant-in-Aid for Scientific Research 【 display / non-display

  • ヘアピンループDNA/RNAを認識するモデルペプチドの速度論的機能評価

    2004.4 - 2006.3

    JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists(B)

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    ヘアピンループDNA/RNAを認識するモデルペプチドの速度論的機能評価
    領域・整理
    ・課題番号
    4706
    7305
    16750150

  • ヘアピンループDNA/RNAを認識するモデルペプチドの速度論的機能評価

    2004.4 - 2006.3

    JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists(B)

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    ヘアピンループDNA/RNAを認識するモデルペプチドの速度論的機能評価
    領域・整理
    ・課題番号
    4706
    7305
    16750150

  • ヘアピンループDNA/RNAを認識するモデルペプチドの速度論的機能評価

    2004.4 - 2006.3

    JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists(B)

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    ヘアピンループDNA/RNAを認識するモデルペプチドの速度論的機能評価
    領域・整理
    ・課題番号
    4706
    7305
    16750150

Preferred joint research theme 【 display / non-display

  • 新規機能性核酸(アプタマー等)の取得

  • リアルタイムPCR等を使用した遺伝子の定量解析

  • 人為的遺伝子発現調節(翻訳)

 

Committee Memberships 【 display / non-display

  • 2015.4   日本核酸医薬学会  評議員、幹事、事務局

  • 2016.9   日本核酸化学会  評議員

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  • 2004.4 - 2017.3   高分子学会  バイオ・高分子研究会 運営委員

  • 2015.12   日本核酸医薬学会  事務局長

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  • 2015.4   日本核酸医薬学会  評議員

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Social Activities 【 display / non-display

  • 出張模擬講義

    2014.12

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    毒学 - 薬学へのいざない/兵庫県立舞子高等学校

  • 模擬講義

    2014.12

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    毒学/兵庫大学附属須磨ノ浦高等学校

  • サイエンスパートナーシッププロジェクト

    2014.8

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    自然科学入門講座「身近な生活から最先端の遺伝子研究について学ぶ」- 遺伝子鑑定/兵庫県立星陵高等学校

  • etc

    2014.3

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    遺伝子鑑定の精度・信憑性/兵庫県警察本部 刑事部

  • 模擬講義

    2013.12

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    くすりの科学/須磨ノ浦女子高等学校

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