Position |
Associate Professor |
Research Field |
Life Science / Molecular biology, Life Science / Tumor biology |
External Link |
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Graduating School 【 display / non-display 】
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Himeji Institute of Technology Faculty of Science Graduated
1991.4 - 1995.3
Graduate School 【 display / non-display 】
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姫路工業大学大学院 理学研究科 生命科学専攻 Doctor's Course Completed
1998.4 - 2002.3
Campus Career 【 display / non-display 】
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KONAN UNIVERSITY Faculty of Frontiers of Innovative Research in Science and Technology Faculty of Frontiers of Innovative Research in Science and Technology Department of Nanobiochemistry Associate Professor
2018.4
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KONAN UNIVERSITY Faculty of Frontiers of Innovative Research in Science and Technology Faculty of Frontiers of Innovative Research in Science and Technology Department of Nanobiochemistry Lecturer
2014.4 - 2018.3
External Career 【 display / non-display 】
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神戸大学大学院 工学研究科
2021.12
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日本医科大学 先端医学研究所
2014.4 - 2021.3
Country:Japan
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National University of Singapore Mechanobiology Institute
2010.5 - 2014.3
Country:Singapore
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日本医科大学 老人病研究所
2008.10 - 2011.12
Country:Japan
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日本医科大学 老人病研究所
2007.4 - 2008.9
Country:Japan
Papers 【 display / non-display 】
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Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite
Usuda M, Kametani M, Hamada M, Suehiro Y, Matayoshi S, Okawa R, Naka S, Matsumoto-Nakano M, Akitomo T, Mitsuhata C, Koumoto K, Kawauchi K, Nishikata T, Yagi M, Mizoguchi T, Fujikawa K, Taniguchi T, Nakano K, Nomura R
International Journal of Molecular Sciences 24 11371 2023.7
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The iron chelator deferriferrichrysin induces paraptosis via extracellular-signal-regulated kinase activation in cancer cells
Kinoshita N, Gessho M, Torii T, Ashida Y, Akamatsu M, Guo AK, Lee S, Katsuno T, Nakajima W, Budirahardja Y, Miyoshi D, Todokoro T, Ishida H, Nishikata T, Kawauchi K
Genes to Cells 2023.6
Authorship:Last author, Corresponding author
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Simple and fast screening for structure-selective G-quadruplex ligands. International journal
Yoshiki Hashimoto, Yoshiki Imagawa, Kaho Nagano, Ryuichi Maeda, Naho Nagahama, Takeru Torii, Natsuki Kinoshita, Nagisa Takamiya, Keiko Kawauchi, Hisae Tatesishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Chemical communications (Cambridge, England) 59 ( 33 ) 4891 - 4894 2023.4
Structural selectivity of G-quadruplex ligands is essential for cellular applications since there is an excess of nucleic acids forming duplex structures compared to G-quadruplex structures in living cells. In this study, we developed new structure-selective G-quadruplex ligands utilizing a simple and fast screening system. The affinity, selectivity, enzymatic inhibitory activity and cytotoxicity of the structure-selective G-quadruplex ligands were demonstrated along with a structural selectivity-cytotoxicity relationship of G-quadruplex ligands.
DOI: 10.1039/d3cc00556a
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Controlling liquid-liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner. International journal
Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Chemical communications (Cambridge, England) 58 ( 93 ) 12931 - 12934 2022.11
We constructed a minimum liquid-liquid phase separation model system to form liquid droplets using only G-quadruplex-forming oligonucleotides and R- and G-rich oligopeptides. We found that the G-quadruplex structure is an essential component for RNA to form droplets with the peptide. Based on this model system and our findings, droplet redissolution via structure transition from a G-quadruplex to a duplex was achieved in a sequence-specific manner.
DOI: 10.1039/d2cc04366a
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Wataru Sugimoto, Natsuki Kinoshita, Minori Nakata, Tatsuya Ohyama, Hisae Tateishi-Karimata, Takahito Nishikata, Naoki Sugimoto, Daisuke Miyoshi, Keiko Kawauchi
Chemical Communications 58 ( 1 ) 48 - 51 2022.1
Authorship:Last author, Corresponding author Publisher:Royal Society of Chemistry (RSC)
We identified cytosine-rich regions adjacent to guanine-rich regions in the TMPRSS2 gene, which showed structural competition between a G-quadruplex and a hairpin loop. Furthermore, this competition significantly affected transcription efficiency.
DOI: 10.1039/d1cc05523b
Books and Other Publications 【 display / non-display 】
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がん研究読本 6
川内敬子(RASによるがん悪性化に、p53を介したアクチン細胞骨格の変化がブレーキをかける道筋を解明!)
がん研究分野の特性等を踏まえた支援活動総括支援活動班 2016
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ゼロからはじめるバイオ実験マスター3細胞培養トレーニング
西方敬人, 川上純司, 藤井敏司, 長濱宏治, 川内敬子( Role: Joint author)
学研メディカル集潤社 2015.3
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細胞培養トレーニング
西方 敬人, 川上 純司, 藤井 敏司, 長濱 宏治, 川内 敬子
学研メディカル秀潤社, 学研マーケティング (発売) 2015 ( ISBN:9784780909036 )
Review Papers (Misc) 【 display / non-display 】
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細胞内環境で安定化される核酸非構造を狙った分子標的薬の開発 Invited
川内敬子・橋本佳樹・杉本 渉・三好大輔
バイオマテリアル-生体材料 40 ( 3 ) 206 - 211 2022.8
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“Development of New Materials and New Functions for Biomaterials” Molecularly Targeted Molecules for Non-Canonical Nucleic Acid Structures Stabilized Under Cellular Molecular Crowding Conditions
川内敬子, 橋本佳樹, 杉本渉, 三好大輔
バイオマテリアル(Web) 40 ( 3 ) 2022
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Future perspective of ligands for G-quadruplex nucleic acids as therapeutic agents
木下菜月, 取井猛流, 川内敬子, 三好大輔
Bio Clinica 37 ( 4 ) 2022
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Photodynamic therapy targeting nucleic acid G-quadruplexes
取井猛流, 木下菜月, 浦野諒人, 三好大輔, 川内敬子
日本女性科学者の会学術誌(Web) 22 2022
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核小体ストレスにより形成するrDNA G-quadruplex集合体とその機能
杉本 渉, 桑本 慎, 建石 寿枝, 岩根 敦子, 高橋 宏隆, 三好 大輔, 川内 敬子
日本薬学会年会要旨集 141年会 29V05 - am10S 2021.3
Publisher:(公社)日本薬学会
Presentations 【 display / non-display 】
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がん細胞における核酸のグアニン四重らせん構造の機能の解明とその制御法の確立
川内敬子、建石寿枝、杉本直己、三好大輔
2022年度先端モデル動物支援プラットフォーム 成果発表会 2023.2
Event date: 2023.2
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液-液相分子により形成されるグアニン四重らせん構造集合体の役割 Invited
川内敬子、取井猛流、谷口慎也、木下菜月、建石寿枝、杉本直己、三好大輔
第45回日本分子生物学会 2022.12
Event date: 2022.11 - 2022.12
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Structural alterations in ribosomal DNA under nucleolar stress Invited
Keiko Kawauchi, Takeru Torii, Hisae Karimata Tateishi, Naoki Sugimoto, Takahito Nishikata, Daisuke Miyoshi
The 44th Annual Meeting of Molecular Biology Society of Japan 2021.12
Event date: 2021.12
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Novel strategy of cancer treatment targeting RAS mRNA Invited
Keiko Kawauchi
Seminar in University of Melbourne - Department of Biochemistry and Pharmacology 2021.9
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RASによるがん悪性化機構の解明と制御法の開発
川内敬子
SJWS 新春シンポジウム2021 (オンライン) 日本女性科学者の会
Event date: 2021.1
Industrial property rights 【 display / non-display 】
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核酸の立体構造を制御する方法及びその用途、並びに、細胞内分子クラウディング環境を再現するための組成物
建石 寿枝、川内 敬子、高橋 俊太郎、杉本 直己
Application no:特願2022-189538
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光増感剤輸送キャリア
大谷 亨、川内 敬子、三好 大輔
Application no:特願2022-128296
Academic Awards Received 【 display / non-display 】
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村尾育英会 学術賞
2019.3 一般財団法人 村尾育英会
川内敬子
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神奈川難病財団研究奨励賞
2008.12 神奈川難病財団
川内敬子
Grant-in-Aid for Scientific Research 【 display / non-display 】
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「匂いシグナル」で制御される口腔がん細胞の細胞融合誘導機構の解析
2022.4 - 2025.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
荒木 啓吾, 川内 敬子
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がん抑制因子p53の機能低下が惹起する異常な核小体ストレス応答の分子機構解明
2021.4 - 2024.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
川内 敬子
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Model system for nucleic acid-protein liquid-liquid phase separation
2021.4 - 2024.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(B)
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Formation and function of nucleolus depending on rRNA G-quadruplexes
2020.7 - 2022.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
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Regulation of stress granule formation by RNA G-quadruplex
2018.6 - 2020.3
JSPS Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
Other External funds procured 【 display / non-display 】
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低酸素ストレス耐性を獲得したがん細胞を標的とした治療薬の開発
2023.1 - 2024.3
公益財団法人テルモ生命科学振興財団 研究開発助成金 財団等研究助成金
Authorship:principal_investigator
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核内アクチン線維構造の制御による 新たながん治療創薬への挑戦
2018.4 - 2020.3
甲南学園 甲南学園平生太郎基金科学研究奨励助成金