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Bottom-up fabrication of redispersible β-1,3-1,6-glucan nanoparticle powders with enhanced aqueous solubility and improved macrophage accessibility 査読あり
Ayumu Kodama, Yasushi Nishida, Masaya Miwa, Nanako Doi, Ryoji Motoji, Toshio Suzuki, and Kazuya Koumoto
J. Biotechnol. 430 124 - 135 2026年9月
担当区分：最終著者, 責任著者
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Structure–property relationships and hydrated-matrix-mediated aromatic guest inclusion in renatured β-1,3-1,6-glucan nanoparticles
Yukina Kometani, Shoma Kannan, Yasushi Nishida, Toshio Suzuki, and Kazuya Koumoto
391 125847 2026年9月
担当区分：最終著者, 責任著者
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Alkali-Neutralization-Induced β-1,3-1,6-Glucan Nanoparticles Enhance the Aqueous Dispersibility, Stability, and Antioxidant Activity of Quercetin 査読あり
Shoma Kannan, Nanako Doi, Toshio Suzuki and Kazuya Koumoto
Nutraceuticals 6 53 2026年8月
担当区分：最終著者, 責任著者
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Microwave-induced modulation of intracellular distribution of peptides based on mitochondrial targeting sequences 査読あり 国際誌
Fumihiro Kayamori, Takuto Kariya, Momo Hirata, Yonejiro Arimoto, Tamaki Endoh, Nobuhiro Nakanishi & Kenji Usui
Scientific Reports 2026年6月
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Exclusion of RNA-binding domains from G-quadruplex condensates by G-quadruplex ligands 招待あり 査読あり 国際共著
Yoshiki Hashimoto, Ryosuke Suzuki, Mizuho Aya, Nagisa Takamiya, Mitsuki Tsuruta,Takeru Torii, Toshiyuki Goto, Keiko Kawauchi and Daisuke Miyoshi
RSC Chemical Biology (Inside cover art) 7 ( 8 ) 1578 - 1588 2026年6月
担当区分：最終著者, 責任著者
DOI： 10.1039/D6CB00020G
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Identification of Ligand-Responsive RNA G-Quadruplexes in the 3′ UTRs of Dengue Virus Serotypes 査読あり
Mohammad Jafar Sheikhi, Ayuka Onuma, Yutaro Imachi, Akira Shiraishi, Shoko Mori, Kohtaro Sugahara, Daisuke Miyoshi, Yue Ma, Takayuki Hishiki, Kazuo Nagasawa and Masayuki Tera
Biomolecules 2026年6月
DOI： 10.3390/biom16070946
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複数種の液体クロマトグラフ質量分析計を用いたオリゴヌクレオチド不純物の相対定量の比較解析 査読あり
髙嶺竜太朗, 山口卓男, 廣瀬賢治, 関口光明, 唐澤薫, 岩崎了教, 高原健太郎, 瀬崎浩史, 早川禎宏, 騰川博之, 大久保貴史, 長野裕夫, 櫻井周, 嵜本捺愛, 冨田恵麗沙, 吉田徳幸, 井上貴雄, 小比賀聡, 川上純司
医薬品医療機器レギュラトリーサイエンス 57 ( 3 ) 234 - 252 2026年6月
担当区分：最終著者, 責任著者
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Position-dependent stabilization of DNA/RNA duplexes by site-specific incorporation of LNA nucleosides 査読あり
Elisa Tomita-Sudo, Tomoka Akita, Nae Sakimoto, Saori Tahara-Takamine, Renshin Sano, Shigenori Iwai, Junji Kawakami
Journal of Nucleic Acids 2026 2026:7266073 2026年5月
担当区分：最終著者, 責任著者
DOI： 10.1155/jna/7266073
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Cy3-Conjugated Biocompatible Polymer Nanoparticles for Long-Term Mitochondrial Imaging 査読あり
ChemBioChem ChemBioChem Research Article Full Access Cy3-Conjugated Biocompatible Polymer Nanoparticles for Long-Term Mitochondrial Imaging Souma Kawashima, Mitsuo Inui, Izumi Takaba, Haruka Taniguchi, Koji Nagahama
ChemBioChem 27 ( 8 ) e70323 2026年4月
担当区分：最終著者, 責任著者
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Effects of N–1-mer impurities in antisense oligonucleotides on the target RNA suppression 査読あり
Tomoka Akita, Elisa Tomita-Sudo, Renshin Sano, Nae Sakimoto, Shigenori Iwai, Hirokazu Nankai, Satoshi Obika, Takao Inoue, Junji Kawakami
Nucleic Acid Therapeutics 36 109 - 116 2026年4月
担当区分：最終著者, 責任著者
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Impact of Defects and Particle Size on the Reversible Structural Transformation between Metal-Organic Frameworks 査読あり
S. Tanaka, Y. Kanao, T. Tsuruoka, K. Akamatsu, Y. Takashima
Chem. Mater. 38 2669 - 2679 2026年3月
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Electroplating of Ni using a polyelectrolyte membrane: effect of deposition conditions on interfacial ion-transport kinetics and current efficiency 査読あり
S. Yamada, Y. Takashima, T. Tsuruoka, K. Akamatsu
Electrochemistry 94 037006 2026年3月
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Impact of Defects and Particle Size on the Reversible Structural Transformation between Metal-Organic Frameworks 査読あり
Shintaro Tanaka, Yuta Kanao, Takaaki Tsuruoka, Kensuke Akamatsu, Yohei Takashima
Chem. Mater. 38 2669 - 2679 2026年3月
担当区分：最終著者, 責任著者
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Loss of p53 Provokes NF-κB-Dependent Disruption of Nucleolar Cap and Nucleoplasmic Redistribution of Fibrillarin During Nucleolar Stress
Takeru Torii, Mako Sumida, Atsushi Kobayashi, Toshiyuki Goto, Ryosuke Suzuki, Shin Kuwamoto, Wataru Nakajima, Wataru Sugimoto, Kohei Takeuchi, Yuma Tanaya, Masayuki Tera, Nobuyuki Tanaka, Hiroaki Hirata, Hisae Tateishi-Karimata, Takahito Nishikata, Miwako Kato Homma, Daisuke Miyoshi, Keiko Kawauchi
BIOMOLECULES 16 ( 2 ) 2026年2月
DOI： 10.3390/biom16020296
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Loss of p53 Provokes NF-κB-Dependent Disruption of Nucleolar Cap and Nucleoplasmic Redistribution of Fibrillarin During Nucleolar Stress. 査読あり
Torii T, Sumida M, Kobayashi A, Goto T, Suzuki R, Kuwamoto S, Nakajima W, Sugimoto W, Takeuchi K, Tanaya Y, Tera M, Tanaka N, Hirata H, Tateishi-Karimata H, Nishikata T, Homma MK, Miyoshi D, Kawauchi K.
Biomolecules. 16 ( 2 ) 296 2026年2月
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Loss of p53 Provokes NF-κB-Dependent Disruption of Nucleolar Cap and Nucleoplasmic Redistribution of Fibrillarin During Nucleolar Stress 招待あり 査読あり
Torii T, Sumida M, Kobayashi A, Goto T, Suzuki R, Kuwamoto S, Nakajima W, Sugimoto W, Takeuchi K, Tanaya Y, Tera M, Tanaka N, Hirata H, Tateishi-Karimata H, Nishikata T, Kato Homma M, Miyoshi D, Kawauchi K
Biomolecules ( 16 ) 296 2026年2月
担当区分：最終著者, 責任著者
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Electroplating of Ni using a polyelectrolyte membrane: effect of deposition conditions on interfacial ion-transport kinetics and current efficiency 査読あり
Shunsuke Yamada, Yohei Takashima, Takaaki Tsuruoka, Kensuke Akamatsu
Electrochemistry 94 037006 2026年2月
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Development of a Microwave-Assisted Method for Enhancing the Cellular Uptake of Arginine-Rich Peptides 査読あり 国際誌
Fumihiro Kayamori, Momo Hirata, Takuto Kariya, Yonejiro Arimoto, Ryuji Osawa, Mami Ishikawa, Tamaki Endoh, Nobuhiro Nakanishi, Kenji Usui
Processes 14 ( 3 ) 497 2026年1月
共著
担当区分：最終著者, 責任著者
Cell-penetrating peptides (CPPs) have been extensively explored as tools for the intracellular delivery of diverse molecular cargoes. Although substantial progress has been made in elucidating their uptake mechanisms and sequence-dependent functions, limitations in cellular internalization efficiency remain a major challenge, hindering their broader biomedical application. To address this issue, the present study investigated whether microwave (MW) irradiation at 2.45 GHz can enhance CPP-mediated delivery. Using confocal laser scanning microscopy and fluorescence spectroscopy, we examined the effects of MW irradiation on the cellular uptake of arginine-rich peptides. Our results suggested that MW irradiation enhanced the cellular uptake of the peptides. These findings imply that CPP-mediated delivery assisted by MW irradiation is an effective method for improving intracellular transport and may open new avenues for the development of advanced drug delivery systems.
DOI： 10.3390/pr14030497
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Development of a Microwave-Assisted Method for Enhancing the Cellular Uptake of Arginine-Rich Peptides 査読あり
Fumihiro Kayamori, Momo Hirata, Takuto Kariya, Yonejiro Arimoto, Ryuji Osawa, Mami Ishikawa, Tamaki Endoh, Nobuhiro Nakanishi , Kenji Usui
14 ( 3 ) 2026年1月
DOI： 10.3390/pr14030497
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Investigation of the physicochemical and functional properties of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated aptamers. 国際誌
Seojung Cho, Jumpei Morimoto, Yutaro Saito, Yukiko Nagai, Asuka Sakata, Keitaro Yoshimoto, Mitsuki Tsuruta, Daisuke Miyoshi, Shinsuke Sando
Biomaterials science 14 ( 1 ) 232 - 239 2026年1月
Polymer conjugation is a common strategy to improve the pharmacokinetics of aptamers, yet its effects on aptamer properties are incompletely understood. Poly(ethylene glycol) (PEG) is the most widely used polymer for this purpose, but concerns about anti-PEG immune responses have prompted interest in alternative polymers. We previously reported that conjugation with the zwitterionic polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) significantly prolongs the circulation time of a DNA aptamer while avoiding anti-PEG antibody recognition. In this study, we evaluated the physicochemical and functional consequences of PMPC conjugation of aptamers. Biophysical analyses suggested that the secondary structure and target-binding affinity of the aptamer were preserved, while functional consequences upon PMPC conjugation varied with the targets. The activity of a membrane receptor-targeting aptamer partially decreased, likely due to spatial constraints around the cell membrane, while RB005, targeting soluble activated coagulation factor IX, retained its full activity. In addition, PMPC conjugation significantly prolonged the in vivo plasma retention of RB005. By elucidating the effects of PMPC on aptamer properties and introducing another example that further supports the general applicability of PMPC conjugation in enhancing aptamer pharmacokinetics, these findings support PMPC as a promising alternative to PEG.
DOI： 10.1039/d5bm01078k