Papers 【 display / non-display 】
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Bottom-up fabrication of redispersible β-1,3-1,6-glucan nanoparticle powders with enhanced aqueous solubility and improved macrophage accessibility Reviewed
Ayumu Kodama, Yasushi Nishida, Masaya Miwa, Nanako Doi, Ryoji Motoji, Toshio Suzuki, and Kazuya Koumoto
J. Biotechnol. 430 124 - 135 2026.9
Authorship：Last author, Corresponding author
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Structure–property relationships and hydrated-matrix-mediated aromatic guest inclusion in renatured β-1,3-1,6-glucan nanoparticles
391 125847 2026.9
Authorship：Last author, Corresponding author
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Alkali-Neutralization-Induced β-1,3-1,6-Glucan Nanoparticles Enhance the Aqueous Dispersibility, Stability, and Antioxidant Activity of Quercetin Reviewed
Shoma Kannan, Nanako Doi, Toshio Suzuki and Kazuya Koumoto
Nutraceuticals 6 53 2026.8
Authorship：Last author, Corresponding author
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Microwave-induced modulation of intracellular distribution of peptides based on mitochondrial targeting sequences Reviewed International journal
Fumihiro Kayamori, Takuto Kariya, Momo Hirata, Yonejiro Arimoto, Tamaki Endoh, Nobuhiro Nakanishi & Kenji Usui
Scientific Reports 2026.6
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Exclusion of RNA-binding domains from G-quadruplex condensates by G-quadruplex ligands Invited Reviewed International coauthorship
Yoshiki Hashimoto, Ryosuke Suzuki, Mizuho Aya, Nagisa Takamiya, Mitsuki Tsuruta,Takeru Torii, Toshiyuki Goto, Keiko Kawauchi and Daisuke Miyoshi
RSC Chemical Biology (Inside cover art) 7 ( 8 ) 1578 - 1588 2026.6
Authorship：Last author, Corresponding author
DOI： 10.1039/D6CB00020G
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Identification of Ligand-Responsive RNA G-Quadruplexes in the 3′ UTRs of Dengue Virus Serotypes Reviewed
Mohammad Jafar Sheikhi, Ayuka Onuma, Yutaro Imachi, Akira Shiraishi, Shoko Mori, Kohtaro Sugahara, Daisuke Miyoshi, Yue Ma, Takayuki Hishiki, Kazuo Nagasawa and Masayuki Tera
Biomolecules 2026.6
DOI： 10.3390/biom16070946
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A Comparative Study on the Relative Quantification of Oligonucleotide Impurities Using Several Different Types of Liquid Chromatography-Mass Spectrometers at Analytical Facilities of Multiple Institutions Reviewed
Ryutaro Takamine, Takao Yamaguchi, Kenji Hirose, Mitsuaki Sekiguchi, Kaoru Karasawa, Noriyuki Iwasaki, Kentaro Takahara, Hiroshi Sezaki, Yoshihiro Hayakawa, Hiroyuki Togawa, Takashi Okubo, Hiroo Nagano, Amane Sakurai, Nae Sakimoto, Elisa Tomita-Sudo, Tokuyuki Yoshida, Takao Inoue, Satoshi Obika, Junji Kawakami
Pharmaceutical and Medical Device Regulatory Science 57 ( 3 ) 234 - 252 2026.6
Authorship：Last author, Corresponding author
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Position-dependent stabilization of DNA/RNA duplexes by site-specific incorporation of LNA nucleosides Reviewed
Elisa Tomita-Sudo, Tomoka Akita, Nae Sakimoto, Saori Tahara-Takamine, Renshin Sano, Shigenori Iwai, Junji Kawakami
Journal of Nucleic Acids 2026 2026:7266073 2026.5
Authorship：Last author, Corresponding author
DOI： 10.1155/jna/7266073
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Cy3-Conjugated Biocompatible Polymer Nanoparticles for Long-Term Mitochondrial Imaging Reviewed
ChemBioChem ChemBioChem Research Article Full Access Cy3-Conjugated Biocompatible Polymer Nanoparticles for Long-Term Mitochondrial Imaging Souma Kawashima, Mitsuo Inui, Izumi Takaba, Haruka Taniguchi, Koji Nagahama
ChemBioChem 27 ( 8 ) e70323 2026.4
Authorship：Last author, Corresponding author
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Effects of N–1-mer impurities in antisense oligonucleotides on the target RNA suppression Reviewed
Tomoka Akita, Elisa Tomita-Sudo, Renshin Sano, Nae Sakimoto, Shigenori Iwai, Hirokazu Nankai, Satoshi Obika, Takao Inoue, Junji Kawakami
Nucleic Acid Therapeutics 36 109 - 116 2026.4
Authorship：Last author, Corresponding author
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Impact of Defects and Particle Size on the Reversible Structural Transformation between Metal-Organic Frameworks Reviewed
S. Tanaka, Y. Kanao, T. Tsuruoka, K. Akamatsu, Y. Takashima
Chem. Mater. 38 2669 - 2679 2026.3
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Electroplating of Ni using a polyelectrolyte membrane: effect of deposition conditions on interfacial ion-transport kinetics and current efficiency Reviewed
S. Yamada, Y. Takashima, T. Tsuruoka, K. Akamatsu
Electrochemistry 94 037006 2026.3
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Impact of Defects and Particle Size on the Reversible Structural Transformation between Metal-Organic Frameworks Reviewed
Shintaro Tanaka, Yuta Kanao, Takaaki Tsuruoka, Kensuke Akamatsu, Yohei Takashima
Chem. Mater. 38 2669 - 2679 2026.3
Authorship：Last author, Corresponding author
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Loss of p53 Provokes NF-κB-Dependent Disruption of Nucleolar Cap and Nucleoplasmic Redistribution of Fibrillarin During Nucleolar Stress
Takeru Torii, Mako Sumida, Atsushi Kobayashi, Toshiyuki Goto, Ryosuke Suzuki, Shin Kuwamoto, Wataru Nakajima, Wataru Sugimoto, Kohei Takeuchi, Yuma Tanaya, Masayuki Tera, Nobuyuki Tanaka, Hiroaki Hirata, Hisae Tateishi-Karimata, Takahito Nishikata, Miwako Kato Homma, Daisuke Miyoshi, Keiko Kawauchi
BIOMOLECULES 16 ( 2 ) 2026.2
DOI： 10.3390/biom16020296
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Loss of p53 Provokes NF-κB-Dependent Disruption of Nucleolar Cap and Nucleoplasmic Redistribution of Fibrillarin During Nucleolar Stress. Reviewed
Torii T, Sumida M, Kobayashi A, Goto T, Suzuki R, Kuwamoto S, Nakajima W, Sugimoto W, Takeuchi K, Tanaya Y, Tera M, Tanaka N, Hirata H, Tateishi-Karimata H, Nishikata T, Homma MK, Miyoshi D, Kawauchi K.
Biomolecules. 16 ( 2 ) 296 2026.2
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Loss of p53 Provokes NF-κB-Dependent Disruption of Nucleolar Cap and Nucleoplasmic Redistribution of Fibrillarin During Nucleolar Stress Invited Reviewed
Torii T, Sumida M, Kobayashi A, Goto T, Suzuki R, Kuwamoto S, Nakajima W, Sugimoto W, Takeuchi K, Tanaya Y, Tera M, Tanaka N, Hirata H, Tateishi-Karimata H, Nishikata T, Kato Homma M, Miyoshi D, Kawauchi K
Biomolecules ( 16 ) 296 2026.2
Authorship：Last author, Corresponding author
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Electroplating of Ni using a polyelectrolyte membrane: effect of deposition conditions on interfacial ion-transport kinetics and current efficiency Reviewed
Shunsuke Yamada, Yohei Takashima, Takaaki Tsuruoka, Kensuke Akamatsu
Electrochemistry 94 037006 2026.2
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Development of a Microwave-Assisted Method for Enhancing the Cellular Uptake of Arginine-Rich Peptides Reviewed International journal
Fumihiro Kayamori, Momo Hirata, Takuto Kariya, Yonejiro Arimoto, Ryuji Osawa, Mami Ishikawa, Tamaki Endoh, Nobuhiro Nakanishi, Kenji Usui
Processes 14 ( 3 ) 497 2026.1
Joint Work
Authorship：Last author, Corresponding author
Cell-penetrating peptides (CPPs) have been extensively explored as tools for the intracellular delivery of diverse molecular cargoes. Although substantial progress has been made in elucidating their uptake mechanisms and sequence-dependent functions, limitations in cellular internalization efficiency remain a major challenge, hindering their broader biomedical application. To address this issue, the present study investigated whether microwave (MW) irradiation at 2.45 GHz can enhance CPP-mediated delivery. Using confocal laser scanning microscopy and fluorescence spectroscopy, we examined the effects of MW irradiation on the cellular uptake of arginine-rich peptides. Our results suggested that MW irradiation enhanced the cellular uptake of the peptides. These findings imply that CPP-mediated delivery assisted by MW irradiation is an effective method for improving intracellular transport and may open new avenues for the development of advanced drug delivery systems.
DOI： 10.3390/pr14030497
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Development of a Microwave-Assisted Method for Enhancing the Cellular Uptake of Arginine-Rich Peptides Reviewed
14 ( 3 ) 2026.1
DOI： 10.3390/pr14030497
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Investigation of the physicochemical and functional properties of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated aptamers. International journal
Seojung Cho, Jumpei Morimoto, Yutaro Saito, Yukiko Nagai, Asuka Sakata, Keitaro Yoshimoto, Mitsuki Tsuruta, Daisuke Miyoshi, Shinsuke Sando
Biomaterials science 14 ( 1 ) 232 - 239 2026.1
Polymer conjugation is a common strategy to improve the pharmacokinetics of aptamers, yet its effects on aptamer properties are incompletely understood. Poly(ethylene glycol) (PEG) is the most widely used polymer for this purpose, but concerns about anti-PEG immune responses have prompted interest in alternative polymers. We previously reported that conjugation with the zwitterionic polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) significantly prolongs the circulation time of a DNA aptamer while avoiding anti-PEG antibody recognition. In this study, we evaluated the physicochemical and functional consequences of PMPC conjugation of aptamers. Biophysical analyses suggested that the secondary structure and target-binding affinity of the aptamer were preserved, while functional consequences upon PMPC conjugation varied with the targets. The activity of a membrane receptor-targeting aptamer partially decreased, likely due to spatial constraints around the cell membrane, while RB005, targeting soluble activated coagulation factor IX, retained its full activity. In addition, PMPC conjugation significantly prolonged the in vivo plasma retention of RB005. By elucidating the effects of PMPC on aptamer properties and introducing another example that further supports the general applicability of PMPC conjugation in enhancing aptamer pharmacokinetics, these findings support PMPC as a promising alternative to PEG.
DOI： 10.1039/d5bm01078k