論文 - 本多 大輔
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Yohei Ishibashi, Hatsumi Goda, Rie Hamaguchi, Keishi Sakaguchi, Takayoshi Sekiguchi, Yuko Ishiwata, Yuji Okita, Seiya Mochinaga, Shingo Ikeuchi, Takahiro Mizobuchi, Yoshitake Takao, Kazuki Mori, Kosuke Tashiro, Nozomu Okino, Daiske Honda, Masahiro Hayashi, Makoto Ito
Communications Biology 4 ( 1 ) 2021年12月
出版者・発行元:Springer Science and Business Media LLC
Abstract
The demand for n-3 long-chain polyunsaturated fatty acids (n-3LC-PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), will exceed their supply in the near future, and a sustainable source of n-3LC-PUFAs is needed. Thraustochytrids are marine protists characterized by anaerobic biosynthesis of DHA via polyunsaturated fatty acid synthase (PUFA-S). Analysis of a homemade draft genome database suggested that Parietichytrium sp. lacks PUFA-S but possesses all fatty acid elongase (ELO) and desaturase (DES) genes required for DHA synthesis. The reverse genetic approach and a tracing experiment using stable isotope-labeled fatty acids revealed that the ELO/DES pathway is the only DHA synthesis pathway in Parietichytrium sp. Disruption of the C20 fatty acid ELO (C20ELO) and ∆4 fatty acid DES (∆4DES) genes with expression of ω3 fatty acid DES in this thraustochytrid allowed the production of EPA and n-3docosapentaenoic acid (n-3DPA), respectively, at the highest level among known microbial sources using fed-batch culture. -
Draft Genome Sequence of Sicyoidochytrium minutum DNA Virus Strain 001 査読あり
Yumi Murakoshi, Takayuki Shimeki, Daiske Honda, Yoshitake Takao
Microbiology Resource Announcements 10 ( 23 ) 2021年6月
出版者・発行元:American Society for Microbiology
Sicyoidochytrium minutum DNA virus strain 001 (SmDNAV 001) is a double-stranded DNA (dsDNA) virus that infects the marine fungoid protist Sicyoidochytrium minutum . We report the draft genome sequence of SmDNAV 001. The 236,345-bp genome contained 358 coding sequences (CDSs) and three tRNA-coding sequences.
DOI: 10.1128/mra.00418-21
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Taming chlorophylls by early eukaryotes underpinned algal interactions and the diversification of the eukaryotes on the oxygenated Earth. 査読あり 国際共著
Kashiyama, Y., Yokoyama, A., Shiratori, T., Hess, S., Not, F., Bachy, C., Gutierrez-Rodriguez, A., Kawahara, J., Suzaki, T., Nakazawa, M., Ishikawa, T., Maruyama, M., Wang, M., Chen, M., Gong, Y., Seto, K., Kagami, M., Hamamoto, Y., Honda, D., Umetani, T., Shihongi, A., Kayama, M., Matsuda, M., Taira, J., Yabuki, A., Tsuchiya, M., Hirakawa, Y., Kawaguchi, A., Nomura, M., Nakamura, A., Namba, N., Matsumoto, M., Tanaka, T., Yoshino, T., Higuchi, R., Yamamoto, A., Maruyama, T., Yamaguchi, A., Uzuka, A., Miyagishima, S., Tanifuji, G., Kawachi, M., Kinoshita, Y., Tamiaki, H.
The ISME Journal 13 1899 - 1910 2019年2月
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Nutritional intake of Aplanochytrium (Labyrinthulea, Stramenopiles) from living diatoms revealed by culture experiments suggesting the new prey–predator interactions in the grazing food web of the marine ecosystem. 査読あり
Hamamoto, Y., Honda, D.
PLoS ONE 14 ( 1 ) e0208941 2019年1月
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Iwata I, Honda D.
Protist 169 ( 6 ) 978 - 979 2018年12月
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Abe E, Ikeda K, Nutahara E, Hayashi M, Yamashita A, Taguchi R, Doi K, Honda D, Okino N, Ito M.
PLoS ONE 13 ( 8 ) e0203016 - e0203016 2018年8月
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Elemental composition and ultrafine structure of the skeleton in shellbearing protists—A case study of phaeodarians and radiolarians 査読あり
Nakamura, Y., Iwata, I., Hori, R. S., Uchiyama, N., Tuji, A., Fujita, M. J., Honda, D., Ohfuji, H.
Journal of Structural Biology 204 45 - 51 2018年7月
共著
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Nutritional intake by ectoplasmic nets of Schizochytrium aggregatum (Labyrinthulomycetes, Stramenopiles). 査読あり
Iwata, I., Honda, D.
Protist 169 727 - 743 2018年6月
共著
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Possible aplanochytrid (Labyrinthulea) prey detected using 18S metagenetic diet analysis in the key copepod species Calanus sinicus in the coastal waters of the subtropical western North Pacific 査読あり
Hirai, J., Hamamoto, Y., Honda, D., Hidaka, K.
Plankton and Benthos Research 13 ( 2 ) 75 - 82 2018年5月
共著
DOI: 10.3800/pbr.13.75
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Proposal of Monorhizochytrium globosum gen. nov., comb. nov.(Stramenopiles, Labyrinthulomycetes) for former Thraustochytrium globosum based on morphological features and phylogenetic relationships 査読あり
Doi, K., Honda, D.
Phycological Research 65 ( 3 ) 188 - 201 2017年7月
共著
DOI: 10.1111/pre.12175
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Bothrosome formation in Schizochytrium aggregatum (Labyrinthulomycetes, Stramenopiles) during zoospore settlement 査読あり
Izumi Iwata, Kei Kimura, Yuji Tomaru, Taizo Motomura, Kanae Koike, Kazuhiko Koike, Daiske Honda
Protist 168 ( 2 ) 206 - 219 2017年4月
共著
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Ecological dynamics of two distinct viruses infecting marine eukaryotic decomposer thraustochytrids (Labyrinthulomycetes, Stramenopiles) 査読あり
Yoshitake Takao, Yuji Tomaru, Keizo Nagasaki, Daiske Honda
PLOS ONE 10 ( 7 ) e0133395 2015年7月
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Seasonal dynamics of culturable thraustochytrids (Labyrinthulomycetes, Stramenopiles) in estuarine and coastal waters 査読あり
Ueda, M., Nomura, Y., Doi, K., Nakajima, M., Honda, D.
Aquatic Microbial Ecology 74 187 - 204 2015年3月
共著
DOI: 10.3354/ame01736
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Novel lysophospholipid acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b responsible for generation of palmitate-docosahexaenoate-phosphatidylcholine and phosphatidylethanolamine. 査読あり
Abe, E., Ikeda, K., Nutahara, E., Hayashi, M., Yamashita A., Taguchi, R., Doi K., Honda D., Okino N., Ito, M.
PLoS ONE 9 ( 8 ) e102377 2014年8月
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Bacillus ligniniphilus sp. nov., an alkaliphilic and halotolerant bacterium isolated from sediments of the South China Sea. 査読あり
Zhu, D., Tanabe, S., Xie, C., Honda, D., Sun, J., Ai, L.
International Journal of Systematic and Evolutionary Microbiology 64 1712 - 1717 2014年5月
共著
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TLC screening of thraustochytrid strains for squalene production. 査読あり
Nakazawa, A., Kokubun, Y., Matsuura, H., Yonezawa, N., Kose, R., Yoshida, M., Tanabe, Y., Kusuda, E., Thang, D. V., Ueda, M., Honda, D., Mahakhant, A., Kaya, K., Watanabe, M. M.
Journal of Applied Phycology 26 ( 1 ) 29 - 41 2014年2月
共著
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Effect of trace elements on growth of marine eukaryotes, tharaustochytrids 査読あり
Nagano N, Taoka Y, Honda D, Hayashi M.
Journal of Bioscience and Bioengineering 116 ( 3 ) 337 - 339 2013年9月
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Analysis of delta-12-fatty acid desaturase function revealed that two distinct pathways are active for the synthesis of PUFAs in T. aureum ATCC 34304 査読あり
Matsuda T, Sakaguchi K, Hamaguchi R, Kobayashi T, Abe E, Hama Y, Hayashi M, Honda D, Okita Y, Sugimoto S, Okino N, Ito M
Journal of Lipid Research 53 1210 - 1222 2012年2月
共著
DOI: 10.1194/jlr.M024935
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Versatile Transformation System That Is Applicable to both Multiple Transgene Expression and Gene Targeting for Thraustochytrids 査読あり
Sakaguchi K, Matsuda T, Kobayashi T, Ohara J, Hamaguchi R, Abe E, Nagano N, Hayashi M, Ueda M, Honda D, Okita Y, Taoka Y, Sugimoto S, Okino N, Ito M
Applied and Environmental Microbiology 78 ( 9 ) 3193 - 3202 2012年2月
共著
DOI: 10.1128/AEM.07129-11
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On the bio-rearrangement into fully saturated fatty acidscontaining triglyceride in Aurantiochytrium sp. 査読あり
Matsuura H, Nakazawa A, Ueda M, Honda D, Watanabe MM, Kaya K
Procedia Environmental Sciences 15 66 - 72 2012年
共著
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Optimization of culture conditions of the thraustochytrid Aurantiochytrium sp. strain 18W-13a for squalene production 査読あり
Nakazawa A, Matsuura H, Kose R, Kato S, Honda D, Inouye I, Kaya K, Watanabe MM
Bioresource Technology 109 287 - 291 2012年
共著
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Optimization of biomass and fatty acid production by Aurantiochytrium sp. strain 4W-1b 査読あり
Nakazawa A, Matsuura H, Kose R, Ito K, Ueda M, Honda D, Inouye I, Kaya K, Watanabe MM
Procedia Environmental Sciences 15 27 - 33 2012年
共著
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Thraustochytrid Aurantiochytrium sp. 18W-13a accumulates high amounts of squalene. 査読あり
Kaya, K., Nakazawa, A., Matsuura, H., Honda, D., Inouye, I., and Watanabe, M. M.
Bioscience, Biotechnology and Biochemistry 75 ( 11 ) 2246 - 2248 2011年11月
共著
DOI: 10.1271/bbb.110430
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Detection of genes involved in fatty acid elongation and desaturation in thraustochytrid marine eukaryotes. 査読あり
Nagano, N., Sakaguchi, K., Taoka, Y., Okita, Y., Honda, D., Ito, M., and Hayashi, M.
Journal of Oleo Science 60 ( 9 ) 475 - 481 2011年8月
共著
DOI: 10.5650/jos.60.475
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Increase of eicosapentaenoic acid in thraustochytrids through thraustochytrid ubiquitin promoter-driven expression of a fatty acid ∆5 desaturase gene. 査読あり
Kobayashi, T., Sakaguchi, K., Matsuda, T., Abe, E., Hama, Y., Hayashi, M., Honda, D., Okita, Y., Sugimoto, S., Okino, N., and Ito, M.
Applied and Environmental Microbiology 77 ( 11 ) 3870 - 3876 2011年6月
共著
DOI: 10.1128/AEM.02664-10
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Increase of EPA in Thraustochytrids through Expression of a Fatty Acid 5 Desaturase Gene driven by the Thraustochytrid Ubiquitin Promoter
Takumi Kobayashi, Keishi Sakaguchi, Takanori Matsuda, Eriko Abe, Yoichiro Hama, Masahiro Hayashi, Daisuke Honda, Yuji Okita, Shinichi Sugimoto, Nozomu Okino, Makoto Ito
Journal of Biochemistry 2011年1月
共著
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The distribution of extracellular cellulase activity in marine eukaryotes, thraustochytrids. 査読あり
Nagano, N., Matsui, S., Kuramura, T., Taoka, Y., Honda, D., and Hayashi, M.
Marine Biotechnology 13 133 - 136 2011年
共著
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Optimization of culture conditions for growth and docosahexaenoic acid production by a marine thraustochytrid, Aurantiochytrium limacinum mh0186. 査読あり
Nagano, N., Taoka, Y., Honda, D., and Hayashi, M.
Journal of Oleo Science 58 ( 12 ) 623 - 628 2009年11月
共著
DOI: 10.5650/jos.58.623
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Olpidiopsis bostrychiae sp. nov.: an endoparasitic oomycete that infects Bostrychia and other red algae (Rhodophyta). 査読あり
Sekimoto, S., Klochkova, T. A., West, J. A., Beakes, G. W., and Honda, D.
Phycologia 48 ( 6 ) 460 - 472 2009年10月
共著
DOI: 10.2216/08-11.1
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Labyrinthulomycetes phylogeny and its implications for the evolutionary loss of chloroplasts and gain of ectoplasmic gliding. 査読あり
Tsui, C. K. M., Marshall, W., Yokoyama, R., Honda, D., Lippmeier, J. C., Craven, K. D., Peterson, P. D., and Berbee, M. L.
Molecular Phylogenetics and Evolution 50 ( 1 ) 129 - 140 2009年1月
共著
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Isolation and characterization of a ∆5-desaturase from Oblongichytrium sp. 査読あり
Kumon, Y., Kamisaka, Y., Tomita, N., Kimura, K., Uemura, H., Yokochi, T., Yokoyama, R., and Honda, D.
Bioscience, Biotechnology, and Biochemistry 72 ( 8 ) 2224 - 2227 2008年8月
共著
DOI: 10.1271/bbb.80235
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The development, ultrastructural cytology, and molecular phylogeny of the basal oomycete Eurychasma dicksonii, infecting the filamentous phaeophyte algae Ectocarpus siliculosus and Pylaiella littoralis. 査読あり
Sekimoto, S., Beakes, G. W., Gachon, C. M. M., Müller, D. G., Küpper, F. C., and Honda, D.
Protist 159 ( 2 ) 299 - 318 2008年4月
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Taxonomy, molecular phylogeny, and ultrastructural morphology of Olpidiopsis porphyrae sp. nov. (Oomycetes, straminipiles), a unicellular obligate endoparasite of Bangia and Porphyra spp. (Bangiales, Rhodophyta). 査読あり
Sekimoto, S., Yokoo, K., Kawamura, Y., and Honda, D.
Mycological Research 112 ( 3 ) 361 - 374 2008年3月
共著
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Morphological and phylogenetic studies on unicellular diazotrophic cyanobacteria (cyanophytes) isolated from the coastal water around Singapore. 査読あり
Ohki, K., Kamiya, M., Honda, D., Kumazawa, S., and Ho, K. K.
Journal of Phycology 44 ( 1 ) 142 - 151 2008年1月
共著
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Taxonomic rearrangement of the genus Ulkenia sensu lato phylogeny based on morphology, chemotaxonomical characteristics and 18S rRNA gene (Thraustochytriaceae, Labyrinthulomycetes): emendation for Ulkenia and erection of Botryochytrium, Parietichytrium and Sicyoichytrium gen. nov. 査読あり
Yokoyama, R., Salleh, B., Honda, D.
Mycoscience 48 ( 6 ) 329 - 341 2007年12月
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Squashed ball-like dsDNA virus infecting a marine fungoid protist Sicyoidochytrium minutum (Thraustochytriaceae, Labyrinthulomycetes).(共著)
Takao, Y., Nagasaki, K., Honda, D.
Aquatic Microbial Ecology 49 2007年11月
共著
Aquatic Microbial Ecology 49: 101-108 (2007).
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Proposal of Pseudochattonella verruculosa gen. nov., comb. nov. (Dictyochophyceae) for a formar raphidophycean alga Chattonella verruculosa, based on 18S rDNA phylogeny and ultrastructural characteristics. 査読あり
Hosoi-Tanabe, S., Honda, D., Fukaya, S. Otake, I., Inagaki, Y., Sako, Y
Phycological Research 55 ( 3 ) 185 - 192 2007年8月
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Molecular phylogeny of an unidentified Haliphthoros-like marine oomycete and Haliphthoros milfordensis inferred from nuclear-encoded small and large subunit rRNA genes and mitochondrial-encoded cox2 gene.(共著) 査読あり
Sekimoto, S., Hatai, K., Honda, D.
Mycoscience 48 48 212 - 221 2007年8月
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Taxonomic rearrangement of the genus Schizochytrium sensu lato based on morphology, chemotaxonomical characteristics and 18S rRNA gene phylogeny (Thraustochytriaceae, Labyrinthulomycetes): emendation for Schizochytrium and erection of Aurantiochytrium and Oblongichytrium gen. nov.(共著) 査読あり
Yokoyama, R., Honda, D.
Mycoscience 48 ( 4 ) 199 - 211 2007年8月
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Takao Y, Tomaru Y, Nagasaki K, Sasakura Y, Yokoyama R, Honda D.
Plankton and Benthos Research 2 ( 2 ) 91 - 97 2007年5月
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Homologs of the sexually induced gene 1 (sig1) product constitute the stramenopile mastigonemes. 査読あり
Honda, D., Shono, T., Kimura. K., Fujita, S., Iseki, M., Makino, Y., Murakami, A.
Protist 158 ( 1 ) 77 - 88 2007年1月
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A new labyrinthulid isolate that produces only docosahexaenoic acid 査読あり
Kumon Y, Yokoyama R, Haque Z, Yokochi T, Honda D, Nakahara T.
Marine Biotechnology 8 ( 2 ) 170 - 177 2006年
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Shirai Y, Takao Y, Mizumoto H, Tomaru Y, Honda D, Nagasaki K.
Journal of the Marine Biological Association of the United Kingdom 86 ( 3 ) 475 - 483 2006年
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Takao Y, Mise K, Nagasaki K, Okuno T, Honda D.
Journal of General Virology 87 ( 3 ) 723 - 733 2006年
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Yuasa T, Takahashi O, Dolven J.K, Mayama S, Matsuoka A, Honda D, Bj?rklund K.R.
Marine Micropaleontology 59 ( 2 ) 104 - 114 2006年
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Phylogenetic analyses of the polycystine Radiolaria based on the 18S rDNA sequences of the Spumellariada and Nessellarida. (共著)
Yuasa T, Takahashi O, Honda D, Mayama S.
Eur. J. Protistol.41 2005年11月
共著
Eur. J. Protistol. 41: 287-298 (2005)
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Isolation and characterization of a novel single-stranded RNA virus (SssRNAV) infectious to a marine fungoid protist Schizochytrium sp. (Thraustochytriaceae, Labyrinthulae). (共著)
Yoshitake Takao, Keizo Nagasaki, Kazuyuki Mise, Tetsuro Okuno, Daiske Honda.
Applied and Environmental Microbiology71 2005年11月
共著
Applied and Environmental Microbiology 71: 4516-4522 (2005).
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養殖ノリに被害を与える壺状菌Olpidiopsis sp.(卵菌綱,クロミスタ界)のPCRによる早期検出.(共著)
横尾一成,関本訓士,川村嘉応,本多大輔
日本水産学会誌71 2005年11月
共著
日本水産学会誌71,917-922 (2005)
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Molecular phylogeny of solitary shell-bearing Polycystinea (Radiolaria).(共著)
Osamu Takahashi, Tomoko Yuasa, Daiske Honda, Shigeki Mayama.
Revue de Micropaleontologie47 2004年11月
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Revue de Micropaleontologie 47: 111-118 (2004)
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Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes. (共著)
Jianzhong Huang, Tsunehiro Aki, Toshihiro Yokochi, Toro Nakahara, Daiske Honda, Seiji Kawamoto, Seiko Shigeta, Kazuhisa Ono, and Osamu Suzuki.
Marine Biotechnology 5 2003年11月
共著
Marine Biotechnology 5: 450-457 (2003)
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A new labyrinthulid isolate, which solely produces n-6 docosapentaenoic acid 査読あり
Kumon Y, Yokoyama R, Yokochi T, Honda D, Nakahara T.
Applied Microbiology and Biotechnology 63 ( 1 ) 22 - 28 2003年
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Ultrastructure and taxonomy of pelagic golden flagellate Phaeomonas parva gen. et sp. nov. (Pinguiophyceae) with particular emphasis on the flagellar apparatus architecture. (共著)
Daiske Honda and Isao Inouye.
Phycological Research50 2002年11月
共著
Phycological Research 50: 75-89 (2002).
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The Pinguiophyceae classis nova, a new class of chromophyte algae whose members produce large amounts of omega-3 fatty acids. (共著)
Masanobu Kawachi, Isao Inouye, Daiske Honda, Charles J. O'Kelly, J. Craig Bailey, Robert R. Bidigare and Robert A. Andersen.
Phycological Research 50 2002年11月
共著
Phycological Research 50: 31-47 (2002).
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Phylogenetic analysis of psychrotrophic bacteria isolated from the Japan Trench, including a description of the deep-sea species Psychrobacter pacificensis sp. nov.(共著)
Maruyama, A., Honda, D., Yamamoto, H., Kitamura, K., Higashihara, T.
International Journal of Systematic and Evolutionary Microbiology50 2000年11月
共著
International Journal of Systematic and Evolutionary Microbiology 50: 835-846.
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A deeply branched novel phylotype found in Japanese paddy soils. 査読あり
HONDA Daiske
Microbiology 146 2309 - 2315 2000年
単著
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Detection of seven major evolutionary lineages in Cyanobacteria based on the 16S rRNA gene sequence analysis with new sequences of five marine Synechococcus strains.(共著)
Honda, D., Yokota, A., Sugiyama, J.
Journal of Molecular Evolution48 1999年11月
共著
Journal of Molecular Evolution 48: 723-739.
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Molecular phylogeny of labyrinthulids and thraustochytrids based on the sequencing of 18S ribosomal RNA gene. (共著)
Honda, D., Yokochi, T., Nakahara, T., Raghukumar, S., Nakagiri, A., Schaumann, K., Higashihara, T.
Journal of Eukaryotic Microbiology46 1999年11月
共著
Journal of Eukaryotic Microbiology 46: 637-647.
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Schizochytrium limacinum sp. nov., a new thraustochytrid from mangrove area in the west Pacific Ocean(共著)
Honda, D., Yokochi, T., Nakahara, T, Erata, M & Higashihara, T.
Mycological Research102 1998年11月
共著
Mycological Research 102: 439-448.
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Optimization of docosahexaenoic acid production by Schizochytrium limacinum SR21. (共著)
Yokochi, T., Honda, D., Higashihara, T. & Nakahara, T.
Applied Microbiology and Biotechnology 49 1998年11月
共著
Applied Microbiology and Biotechnology 49: 72-76.
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Production of docosahexaenoic and docosapentaenoic acids by Schizochytrium sp. isolated from Yap Islands. (共著)
Nakahara, T., Yokochi, T., Higashihara, T., Tanaka, S., Yaguchi, T. & Honda, D.
Journal of the American Oil Chemists' Society73 1996年11月
共著
Journal of the American Oil Chemists' Society 73: 1421-1426.
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Chrysocystis fragilis gen. nov., sp. nov. (Chrysophyceae, Sarcinochrysidales), with note on other macroscopic chrysophytes (golden algae) on Guam reefs.(共著)
Lobban, C.S., Honda, D., Chihara, M. & Schefter, M.
Micronesica28 91 - 102 1995年11月
共著
Micronesica 28: 91-102
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Ultrastructure and reconstruction of the flagellar apparatus architecture in Ankylochrysis lutea (Chrysophyceae, Sarcinochrysidales). 査読あり
Honda, D. and Inouye, I.
Phycologia 34 215 - 227 1995年3月
共著
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Sulcochrysis biplastida gen. et sp. nov.: Cell structure and absolute configuration of the flagellar apparatus of an enigmatic chromophyte alga. 査読あり
Honda, D., Kawachi, M. and Inouye, I.
Phycological Research 43 1 - 16 1995年3月