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Position |
Research Assistant Professor Fellowship |
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Research Field |
Life Science / Bioorganic chemistry |
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Graduating School 【 display / non-display 】
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Toyama Medical and Pharmaceutical University Faculty of Pharmaceutical Science Graduated
Campus Career 【 display / non-display 】
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KONAN UNIVERSITY Faculty of Frontiers of Innovative Research in Science and Technology Faculty of Frontiers of Innovative Research in Science and Technology Department of Nanobiochemistry Research Assistant Professor Fellowship
2022.7
External Career 【 display / non-display 】
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マイクロ波化学株式会社
2017.10 - 2022.6
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住友化学株式会社
2013.4 - 2017.9
Papers 【 display / non-display 】
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Development of a Microwave-Assisted Method for Enhancing the Cellular Uptake of Arginine-Rich Peptides Reviewed
Fumihiro Kayamori, Momo Hirata, Takuto Kariya,Yonejiro Arimoto,Ryuji Osawa, Mami Ishikawa,Tamaki Endoh, Nobuhiro Nakanishi, Kenji Usui
Processes 14 497 2026.1
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Development of a CaCO3 Precipitation Method Using a Peptide and Microwaves Generated by a Magnetron Reviewed
Fumihiro Kayamori Hiroyuki Togashi Natsumi Endo Makoto Ozaki Kan Hirao Yonejiro Arimoto Ryuji Osawa Takaaki Tsuruoka Takahito Imai Kin-ya Tomizaki Tomohiro Umetani Nobuhiro Nakanishi Kenji Usui
Processes 12 ( 7 ) 1327 2024.6
Microwave applications, such as microwave ovens and mobile phones, are ubiquitous and indispensable in modern society. As the utilization of microwave technology is becoming more widespread, the effects of microwaves on living organisms and physiological processes have received increased attention. This study aimed to investigate the effects of microwaves on calcium carbonate biomineralization as a model biochemical process. A magnetron oscillator was used to generate 2450 MHz microwaves because magnetrons are relatively inexpensive and widespread. We conducted transmission electron microscopy (TEM), atomic force microscopy (AFM), TEM-electron energy-loss spectroscopy (EELS), dynamic light scattering (DLS), and high-performance liquid chromatography (HPLC) measurements to analyze the calcium carbonate precipitates. Our findings showed the formation of string-like precipitates of calcium carbonate upon microwave irradiation from one direction, similar to those obtained using a semiconductor oscillator, as reported previously. This implied that the distribution of the frequency had little effect on the morphology. Furthermore, spherical precipitates were obtained upon microwave irradiation from two directions, indicating that the morphology could be controlled by varying the direction of microwave irradiation. Magnetrons are versatile and also used in large-scale production; thus, this method has potential in medical and industrial applications.
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Kenji Usui, Makoto Ozaki, Kan Hirao, Tsubasa Kosaka, Natsumi Endo, Shuhei Yoshida, Shin-ichiro Yokota, Yonejiro Arimoto, Ryuji Osawa, Nobuhiro Nakanishi, Kin-ya Tomizaki, Tomohiro Umetani, Fumihiro Kayamori
Scientific Reports 13 12027 2023.7
Authorship：Last author, Corresponding author
Microwaves are used for diverse applications such as mobile phones, ovens, and therapy devices. However, there are few reports on the effects of microwaves on diseases other than cancer, and on physiological processes. Here, we focused on CaCO3 mineralization as a model of biomineralization and attempted to elucidate the effect of microwaves on CaCO3 mineralization using peptides. We conducted AFM, ζ potential, HPLC, ICP-AES, and relative permittivity measurements. Our findings show that microwaves alter the nanomorphology of the CaCO3 precipitate, from sphere-like particles to string-like structures. Furthermore, microwaves have little effect on the mineralization when the mineralization ability of a peptide is high, but a large effect when the precipitation ability is low. Our findings may be applicable to not only the treatment of teeth and bones but also the development of organic–inorganic nanobiomaterials. This methodology can be expanded to other molecular/atomic reactions under various microwave conditions to alter reaction activity parameters.
Books and Other Publications 【 display / non-display 】
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マイクロ波の工業応用事例集
栢森 史浩、有本 米次郎、中西 伸浩、臼井 健二（ Role： Contributor , ナノバイオ分野におけるマイクロ波の影響に関する研究と産業応用を目指した技術開発）
技術情報協会 2025.2
Review Papers (Misc) 【 display / non-display 】
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Effect of Microwave on Protein Conformations and Enzymatic Reactions Reviewed
Fumihiro Kayamori, Kenji Usui
Molecules 31 1843 2026.5
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凝集性ペプチドのモノマー化 Invited Reviewed
栢森史浩、臼井健二
化学と生物 63 ( 11 ) 480 - 482 2025.11
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ナノバイオ分野におけるマイクロ波の影響に関する研究 Invited Reviewed
栢森 史浩、中西 伸浩、臼井 健二
色材協会誌 97 ( 6 ) 156 - 159 2024.6
Authorship：Lead author, Last author
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タンパク質の構造や酵素反応へのマイクロ波の影響 Reviewed
栢森 史浩、平尾 莞、鶴岡 孝章、中西 伸浩、臼井 健二
日本電磁波エネルギー応用学会論文誌 7 1 - 9 2023.12
Authorship：Lead author, Corresponding author
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様々な分野に適用可能な皮膚感作性試験法の開発
臼井健二、宮﨑 洋、山下 邦彦、栢森 史浩、有海秀人
アレルギーの臨床 2023.10
Presentations 【 display / non-display 】
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ペプチド固相合成を題材とした基礎実験の実施と教育効果の検証
臼井 健二, 栢森 史浩, 石川 真実, 梅谷 智弘
日本化学会第106春季年会 2026.3
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ゲルろ過クロマトグラフィーを用いて線維形成ペプチド探索法を評価する
小林もえ, 寺尾泰晟, 栢森史浩, 臼井健二
第40回関西地区ペプチドセミナー 2025.11
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アミロイドβペプチドの凝集における電磁波による影響解析に向けて
高橋亜衣加, 栢森史浩, 臼井健二
第40回関西地区ペプチドセミナー 2025.11
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FABRICATION OF β-BARREL NANOPORES COMPOSED OF β-SHEET PEPTIDES CONJUGATED WITH VARIOUS FUNCTIONAL GROUPS AND MOLECULES
Aika Takahashi, Moe Kobayashi, Yoshio Hamada, Zugui Peng, Izuru Kawamura, Ryuji Kawano, Fumihiro Kayamori, Kenji Usui
The 62nd Japanese Peptide Symposium 2025.10
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実測データを用いた統計解析によるペプチド配列のナノポア形成能や凝集能の予測
小林もえ, 栢森史浩, 寺尾泰晟, 彭祖癸, 川村出, 川野竜司, 臼井健二
第19回バイオ関連化学シンポジウム 2025.9
Social Activities 【 display / non-display 】
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日本電磁波エネルギー応用学会 生態影響と安全利用ワーキンググループ
Role(s)： Organizing member
2023
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キャリア支援イベント「リードオフセミナー」
Role(s)： Lecturer
2022.12