写真a

KAYAMORI Fumihiro

Position

Research Assistant Professor Fellowship

Research Field

Life Science / Bioorganic chemistry
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Graduating School 【 display / non-display 】

  • Toyama Medical and Pharmaceutical University   Faculty of Pharmaceutical Science   Graduated

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Campus Career 【 display / non-display 】

  • KONAN UNIVERSITY   Faculty of Frontiers of Innovative Research in Science and Technology   Faculty of Frontiers of Innovative Research in Science and Technology Department of Nanobiochemistry   Research Assistant Professor Fellowship

    2022.7

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External Career 【 display / non-display 】

  • マイクロ波化学株式会社

    2017.10 - 2022.6

  • 住友化学株式会社

    2013.4 - 2017.9

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Papers 【 display / non-display 】

  • Development of a CaCO3 Precipitation Method Using a Peptide and Microwaves Generated by a Magnetron Reviewed

    Fumihiro Kayamori Hiroyuki Togashi Natsumi Endo Makoto Ozaki Kan Hirao Yonejiro Arimoto Ryuji Osawa Takaaki Tsuruoka Takahito Imai Kin-ya Tomizaki Tomohiro Umetani Nobuhiro Nakanishi Kenji Usui

    Processes   12 ( 7 )   1327   2024.6

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    Microwave applications, such as microwave ovens and mobile phones, are ubiquitous and indispensable in modern society. As the utilization of microwave technology is becoming more widespread, the effects of microwaves on living organisms and physiological processes have received increased attention. This study aimed to investigate the effects of microwaves on calcium carbonate biomineralization as a model biochemical process. A magnetron oscillator was used to generate 2450 MHz microwaves because magnetrons are relatively inexpensive and widespread. We conducted transmission electron microscopy (TEM), atomic force microscopy (AFM), TEM-electron energy-loss spectroscopy (EELS), dynamic light scattering (DLS), and high-performance liquid chromatography (HPLC) measurements to analyze the calcium carbonate precipitates. Our findings showed the formation of string-like precipitates of calcium carbonate upon microwave irradiation from one direction, similar to those obtained using a semiconductor oscillator, as reported previously. This implied that the distribution of the frequency had little effect on the morphology. Furthermore, spherical precipitates were obtained upon microwave irradiation from two directions, indicating that the morphology could be controlled by varying the direction of microwave irradiation. Magnetrons are versatile and also used in large-scale production; thus, this method has potential in medical and industrial applications.

  • Effect of linearly polarized microwaves on nanomorphology of calcium carbonate mineralization using peptides Reviewed

    Kenji Usui, Makoto Ozaki, Kan Hirao, Tsubasa Kosaka, Natsumi Endo, Shuhei Yoshida, Shin-ichiro Yokota, Yonejiro Arimoto, Ryuji Osawa, Nobuhiro Nakanishi, Kin-ya Tomizaki, Tomohiro Umetani, Fumihiro Kayamori

    Scientific Reports   13   12027   2023.7

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    Authorship：Last author,　Corresponding author  

    Microwaves are used for diverse applications such as mobile phones, ovens, and therapy devices. However, there are few reports on the effects of microwaves on diseases other than cancer, and on physiological processes. Here, we focused on CaCO3 mineralization as a model of biomineralization and attempted to elucidate the effect of microwaves on CaCO3 mineralization using peptides. We conducted AFM, ζ potential, HPLC, ICP-AES, and relative permittivity measurements. Our findings show that microwaves alter the nanomorphology of the CaCO3 precipitate, from sphere-like particles to string-like structures. Furthermore, microwaves have little effect on the mineralization when the mineralization ability of a peptide is high, but a large effect when the precipitation ability is low. Our findings may be applicable to not only the treatment of teeth and bones but also the development of organic–inorganic nanobiomaterials. This methodology can be expanded to other molecular/atomic reactions under various microwave conditions to alter reaction activity parameters.

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Review Papers (Misc) 【 display / non-display 】

  • ナノバイオ分野におけるマイクロ波の影響に関する研究 Invited Reviewed

    栢森 史浩、中西 伸浩、臼井 健二

    色材協会誌   97 ( 6 )   156 - 159   2024.6

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    Authorship：Lead author,　Last author  

  • タンパク質の構造や酵素反応へのマイクロ波の影響 Reviewed

    栢森 史浩、平尾 莞、鶴岡 孝章、中西 伸浩、臼井 健二

    日本電磁波エネルギー応用学会論文誌   7   1 - 9   2023.12

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    Authorship：Lead author,　Corresponding author  

  • 様々な分野に適用可能な皮膚感作性試験法の開発

    臼井健二、宮﨑 洋、山下 邦彦、栢森 史浩、有海秀人

    アレルギーの臨床   2023.10

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Presentations 【 display / non-display 】

  • 直線偏波マイクロ波による沈殿能の異なるペプチドを用いた CaCO3 沈殿物の形状変化

    平尾莞、中西伸浩、栢森史浩、臼井健二

    日本化学会第 104 春季年会  2024.3 

  • 光開裂リンカー固定化ビーズを用いたbeta-バレル型ペプチドナノポアの作製

    仮屋拓斗、栢森史浩、臼井健二

    日本化学会第 104 春季年会  2024.3 

  • 線維形成に関連する実測データと分子記述子を用いた細胞接着能を有するペプチド配列の探索

    寺尾泰晟、武川公、梅谷智弘、栢森史浩、臼井健二

    日本化学会第 104 春季年会  2024.3 

  • ペプチドを用いたミネラリゼーションや細胞膜透過へのマイクロ波の影響

    栢森史浩

    第17回日本電磁波エネルギー応用学会 研究会  2024.1 

  • ペプチドとマイクロ波を利用して薬物送達の高効率化を目指す

    栢森史浩、臼井健二

    第 38 回関西地区ペプチドセミナー  2023.12 

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Social Activities 【 display / non-display 】

  • 日本電磁波エネルギー応用学会 生態影響と安全利用ワーキンググループ

    Role(s)： Organizing member

    2023

  • キャリア支援イベント「リードオフセミナー」

    Role(s)： Lecturer

    2022.12

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