論文 - 三好 大輔
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Quantification of the concentration in a droplet formed by liquid–liquid phase separation of G-quadruplex-forming RNA 査読あり
Kohei Yokosawa, Mitsuki Tsuruta, Shinji Kajimoto, Naoki Sugimoto, Daisuke Miyoshi, Takakazu Nakabayashi
Chem. Phys. Lett. 2023年6月
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The iron chelator deferriferrichrysin induces paraptosis via extracellular signal-related kinase activation in cancer cells 招待あり 査読あり
Natsuki Kinoshita, Masaya Gessho, Takeru Torii, Yukako Ashida, Minori Akamatsu, Alvin Kunyao Guo, Sunmin Lee, Tatsuya Katsuno 3, Wataru Nakajima Yemima Budirahardja, Daisuke Miyoshi, Takehiko Todokoro, Hiroki Ishida, Takahito Nishikata, Keiko Kawauchi
Genes Cells 2023年6月
DOI: 10.1111/gtc.13053
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Biomolecular Liquid–Liquid Phase Separation for Biotechnology 招待あり 査読あり
Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi and Daisuke Miyoshi
BioTech 12 ( 2 ) 26 2023年3月
担当区分:責任著者
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Simple and fast screening for structure-selective G-quadruplex ligands 査読あり
Yoshiki Hashimoto, Yoshiki Imagawa, Kaho Nagano, Ryuichi Maeda, Naho Nagahama, Takeru Torii, Natsuki Kinoshita, Nagisa Takamiya, Keiko Kawauchi, Hisae Tatesishi-Karimata, Naoki Sugimoto and Daisuke Miyoshi
Chem. Commun. 59 4891 - 4894 2023年2月
担当区分:責任著者
DOI: 10.1039/D3CC00556A
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Controlling liquid–liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner 査読あり
Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi-Karimata, Naoki Sugimoto and Daisuke Miyoshi
Chem. Commun. 2022年11月
DOI: 10.1039/D2CC04366A
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細胞内環境で安定化される核酸非構造を狙った分子標的薬の開発 招待あり
川内敬子・橋本佳樹・杉本 渉・三好大輔
バイオマテリアル = Journal of Japanese Society for Biomaterials : 生体材料 40 ( 3 ) 206 - 211 2022年7月
担当区分:責任著者
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核酸の化学修飾と構造や相分離能の相関 招待あり
鶴田 充生・取井 猛流・杉本 渉・川内 敬子・三好 大輔
月刊「細胞」(ニューサイエンス社) 53 ( 14 ) 910 - 913 2022年6月
担当区分:最終著者, 責任著者
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Significant structural change in human c-Myc promoter G-quadruplex 査読あり 国際共著
Nikita Kundu, Taniya Sharma, Sarvpreet Kaur, Mamta Singh, Vinit Kumar, Uttam Sharma, Aklank Jain, Jadala Shankaraswamy, Daisuke Miyoshi, Sarika Saxena
RSC Adv. 12 7594 - 7604 2022年4月
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Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene 査読あり
Wataru Sugimoto, Natsuki Kinoshita, Minori Nakata, Tatsuya Ohyama, Hisae Minatojima-Minaminachi, Takahito Nishikata, Naoki Sugimoto, Daisuke Miyoshi, Keiko Kawauchi
Chem. Commun. 58 48 - 51 2022年1月
担当区分:責任著者
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rDNAおよびrRNAが形成する四重らせん構造による核小体機能の制御 招待あり
川内敬子、取井猛流、月生雅也、木下菜月、三好大輔
月刊細胞 54 ( 12 ) 36 - 39 2022年
担当区分:責任著者
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核酸の四重らせん構造を狙った治療薬の展望 招待あり
木下菜月、取井猛流、川内敬子、三好大輔
37 ( 4 ) 52 - 55 2022年
担当区分:責任著者
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Detection of Intracellular Reactive Oxidative Species Using the Fluorescent Probe Hydroxyphenyl Fluorescein 招待あり 査読あり
Wataru Sugimoto, Daisuke Miyoshi, Keiko Kawauchi
2274 207 - 215 2021年5月
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がん関連RNAを破壊する分子標的型光線力学療法 招待あり 査読あり
杉本 渉・橋本 佳樹・川内 敬子・三好 大輔
BIO Clinica 36 ( 5 ) 65 - 67 2021年5月
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Combined Effects of Methylated Cytosine and Molecular Crowding on the Thermodynamic Stability of DNA Duplexes 招待あり 査読あり
Combined Effects of Methylated Cytosine and Molecular Crowding on the Thermodynamic Stability of DNA Duplexes
Int. J. Mol. Sci. 22 ( 2 ) 947 2021年1月
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Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy 招待あり 国際誌
Keiko Kawauchi, Ryoto Urano, Natsuki Kinoshita, Shin Kuwamoto, Takeru Torii, Yoshiki Hashimoto, Shinya Taniguchi, Mitsuki Tsuruta, Daisuke Miyoshi
Genes 11 ( 11 ) 1340 2020年11月
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TakahiroYamauchi, Takafumi Kubodera, Daisuke Miyoshi, Naoki Sugimoto, Shuji Hirohata
Journal of Bioscience and Bioengineering 2020年10月
共著
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杉本 渉, 川内 敬子, 三好 大輔
Medical Science Digest 46 ( 9 ) 26 - 27 2020年7月
共著
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Takeru Torii, Wataru Sugimoto, Keiko Kawauchi, Daisuke Miyoshi
Journal of Data Mining in Genomics & Proteomics 2020年6月
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Kazuki Kohata, Daisuke Miyoshi
Biophys. Rev. 12 669 - 676 2020年5月
共著
Living cells are highly crowded with large and small biomolecules. The total concentration of biomolecules can reach 400 mg/ml, and 40% of the cell volume is occupied by biomolecules. Droplet formation in cells via liquid-liquid phase separation may play a role in controlling biochemical reactions in this complex molecular environment. Liquid-liquid phase separation generally involves nucleic acids and proteins as anionic and cationic components, respectively. Significant characteristics of droplets, which make them different from protein aggregation or fibril formation, are reversibility of formation and responsiveness to the molecular environment. In this review, we quantitatively describe the molecular environment inside cells and droplets that participate in controlling central dogma reactions. Finally, we discuss the importance of droplets under conditions of molecular crowding within living cells.
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Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA 査読あり
H. Tateishi-Karimata, D. Banerjee, T. Ohyama, S. Matsumoto, D. Miyoshi, S. Nakano, and N. Sugimoto
Biochemical and Biophysical Research Communications 525 ( 1 ) 177 - 183 2020年4月