Details of Database of Faculty members and Researchers - NAGAHAMA Koji

Papers - NAGAHAMA Koji

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Thixotropic β-Chitin Nanofiber Hydrogel with a Living Body-Responsive Self-Hardening Property and Its Application as a Sprayable Antiadhesion Barrier Reviewed International journal

Koji Nagahama, Kaho Tobiishi, Natsumi Ueda, Tatsuya Dode, Shahidul Islam Sobuj, Fumiya Yuasa, Kazuhiko Yamashita, Takahito Nishikata

ACS Applied Bio Materials 6 ( 7 ) 2636 - 2643 2023.7

Authorship：Lead author,　Corresponding author

DOI： doi.org/10.1021/acsabm.3c00221

Covalent Stem Cell-Combining Injectable Materials with Enhanced Stemness and Controlled Differentiation In Vivo Reviewed

Natsumi Ueda, Shiho Sawada, Fumiya Yuasa, Karen Kato, Koji Nagahama

ACS Applied Materials & Interfaces 14 ( 47 ) 52618 - 52633 2022.11

Authorship：Last author,　Corresponding author

DOI： https://doi.org/10.1021/acsami.2c12918

Two-Dimensional Metal–Organic Framework-Based Cellular Scaffolds with High Protein Adsorption, Retention, and Replenishment Capabilities Reviewed

Tokitaka Katayama, Shintaro Tanaka, Takaaki Tsuruoka, and Koji Nagahama

ACS Applied Materials & Interfaces 14 ( 30 ) 34443 - 34454 2022.8

Authorship：Last author,　Corresponding author

Exportin-inspired artificial cell nuclear-exporting nanosystems Reviewed

Mitsuo Inui , Yuta Hamada , Nana Sejima , Natsumi Ueda , Tokitaka Katayama , Kimika Ono, Koji Nagahama

Nanoscale Advances 4 2637 - 2641 2022.5

Authorship：Last author,　Corresponding author

Angiogenesis Promotion by Combined Administration of DFO and Vein Endothelial Cells Using Injectable, Biodegradable, Nanocomposite Hydrogel Scaffolds Reviewed

Kimika Ono, Manami Sumiya, Naohiro Yoshinobu, Tatsuya Dode, Tokitaka Katayama, Natsumi Ueda, Koji Nagahama

ACS Applied Bio Materials 5 ( 2 ) 471 - 482 2022.2

Authorship：Last author,　Corresponding author

Injectable Biocatalytic Nanocomposite Hydrogel Factories for Focal Enzyme-Prodrug Cancer Therapy Reviewed

Kimika Ono, Hiroyuki Hashimoto, Tokitaka Katayama, Natsumi Ueda, Koji Nagahama

Biomacromolecules 22 ( 10 ) 4217 - 4227 2021.10

Authorship：Last author,　Corresponding author

Biological Tissue-Inspired Living Self-Healing Hydrogels Based on Cadherin-Mediated Specific Cell–Cell Adhesion Reviewed

Koji Nagahama, Seika Aoyama, Natsumi Ueda, Yuka Kimura, Tokitaka Katayama, Kimika Ono

ACS Macro Letters 10 ( 8 ) 1073 - 1079 2021.8

Authorship：Lead author,　Corresponding author

Covalent cell-loading injectable hydrogel scaffold significantly promotes tissue regeneration in vivo compared with a conventional physical cell-loading hydrogel scaffold Reviewed

Yuka Kimura, Seika Aoyama, Natsumi Ueda, Tokitaka Katayama, Kimika Ono, Koji Nagahama

Advanced Biology 5 2000106 2021.2

Joint Work

美容医療　new horizon　－幹細胞への期待－ Invited Reviewed

市橋正光、長濱宏治

日本香粧品学会誌 44 30 - 35 2020

Joint Work

細胞移植用インジェクタブルゲルの開発 Invited Reviewed

長濱宏治

Precision Medicine 3 724 - 728 2020

Single Work

A thin hydrogel barrier linked onto cell surface sialic acids through covalent bonds induces cancer cell death in vivo Reviewed

Kimika Ono, Yuka Sanada, Yuka Kimura, Seika Aoyama, Natsumi Ueda, Tokitaka Katayama, Koji Nagahama

Biomaterials Science 8 577 - 585 2020

Joint Work

Bioinspired cell nuclear nanotransporters generated by self‐assembly of amphiphilic polysaccharide‐amino acid derivatives conjugates Reviewed

Koji Nagahama, Yoshinori Sano, Mitsuo Inui, Seika Aoyama, Tokitaka Katayama, Kimika Ono

Advanced Biosystems 4 1900189 2020

Joint Work

細胞移植用スマートゲルの開発 Invited

長濱宏治、小野公佳、木村友香、青山青海

ケミカルエンジニヤリング 64 17 - 26 2019

Joint Work

Living functional hydrogels generated by bioorthogonal cross-linking reactions of azide-modified cells with alkyne-modified polymers Reviewed

K. Nagahama, Y. Kimura, A. Takemoto

Nature Communications ( 9 ) 2195 2018.6

Joint Work

Authorship：Lead author

Nanocomposite injectable gels capable of self-replenishing regenerative extracellular microenvironments for in vivo tissue engineering Reviewed

K. Nagahama, N. Oyama, K. Ono, A. Hotta, K. Kawauchi, T. Nishikata

Biomaterials Science ( 6 ) 550 - 561 2018.2

Joint Work

Authorship：Lead author

Quantitative relationship between chemical properties and bioactivities of anti-microRNA oligonucleotides targeted to tumor-associated microRNA-21 Reviewed

Koji Nagahama, Kenta Iseda, Daichi Kawano, Junji Kawakami

Biochimie 137 124 - 131 2017.6

Joint Work

Authorship：Lead author

PEG-based nanocomposite hydrogel: Thermoresponsive sol-gel transition controlled by PLGA-PEG-PLGA molecular weight and solute concentration Reviewed

Makoto Miyazaki, Tomoki Maeda, Kenji Hirashima, Naruki Kurokawa, Koji Nagahama, Atsushi Hotta

Polymer 115 246 - 254 2017.4

Joint Work

Authorship：Lead author

細胞核DDSのためのナノトランスポーターの設計 Invited Reviewed

長濱宏治

Drug Delivery System 31 482 - 483 2016.11

Single Work

Authorship：Lead author

Curcumisome nanovesicles generated by self-assembly of curcumin amphiphiles toward cancer theranostics Reviewed

K. Nagahama, T. Utsumi, T. Kumano, S. Maekawa, N. Oyama, J. Kawakami

Scientific Reports 6 30962 2016.8

Joint Work

Authorship：Lead author

Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size Reviewed

Koji Nagahama, Takayuki Kumano, Yuichi Nakagawa, Naho Oyama, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, and Jun Matsui

Bioconjugate Chemistry 26 1775 - 1781 2015.8

Joint Work

Authorship：Lead author

生命分子－合成高分子ハイブリッドの開発とナノバイオマテリアル，その可能性 Invited

長濱宏治

Materials Stage 7 18 - 21 2015.7

Single Work

Authorship：Lead author

Anticancer drug-based multifunctional nanogels through self-assembly of dextran-curcumin conjugates toward cancer theranostics Reviewed

Koji Nagahama, Yoshinori Sano, Takayuki Kumano

Bioorganic & Medical Chemistry Letters 25 2519 - 2522 2015.6

Joint Work

Authorship：Lead author

Self-Assembling Polymer Micelle/Clay Nanodisk/Doxorubicin Hybrid Injectable Gels for Safe and Efficient Focal Treatment of Cancer Reviewed

Koji Nagahama, Daichi Kawano, Naho Oyama, Ayaka Takemoto, Takayuki Kumano, Junji Kawakami

Biomacromolecules 16 880 - 889 2015.3

Joint Work

Authorship：Lead author

Synthesis and Immunestimulating Activity of Lactobacilli-Originated Polysaccharide-Polymeric Microparticle Conjugates Reviewed

Koji Nagahama, Takayuki Kumano, Tsubasa Nakata, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, and Jun Matsui

Langmuir 31 1489 - 1495 2015.1

Joint Work

Authorship：Lead author

A nanocomposite approach to develop biodegradable thermogels exhibiting excellent cell-compatibility for injectable cell delivery Reviewed

N. Oyama, H. Minami, D. Kawano, M. Miyazaki, T. Maeda, K. Toma, A. Hotta, K. Nagahama

Biomaterials Science 2 ( 8 ) 1057 - 1062 2014.6

Joint Work

Authorship：Lead author

Biodegradable polymers exhibiting temperature-responsive sol-gel transition as injectable biomedical materials Reviewed

Koji Nagahama, Akihiro Takahashi, Yuichi Ohya

Reactive and Functional Polymers ( 73 ) 979 - 985 2013.5

Joint Work

Authorship：Lead author

Enhanced stereocomplex formation of enantiomeric polylactides grafted on a polyrotaxane platform Reviewed

Koji Nagahama, Rie Aoki, Toshifumi Saito, Tatsuro Ouchi, Yuichi Ohya and Nobuhiko Yui

Polymer Chemistry ( 4 ) 1769 - 1773 2013.3

Joint Work

Authorship：Lead author

Design of Biodegradable Injectable Polymers Exhibiting Temperature-Responsive Sol-Gel Transition Reviewed

Y. Ohya, H. Suzuki, K. Nagahama, A. Takahashi, T. Ouchi, A. Kuzuya

Advances in Science and Technology ( 86 ) 9 - 16 2013.3

Joint Work

Biodegradable Stereocomplex Materials of Polylactide-grafted Dextran Exhibiting Soft and Tough Properties in Dry and Wet States Reviewed

K. Nagahama, K. Shimizu, S. Ichimura, A. Takahashi, T. Ouchi, Y. Ohya

Journal of Polymer Science Part A: Polymer Chemistry ( 50 ) 2669 - 2676 2012.5

Joint Work

Authorship：Lead author

Biodegradable Polymeric Assemblies for Biomedical Materials Invited Reviewed

Y. Ohya, A. Takahashi, K. Nagahama

Advances in Polymer Science ( 247 ) 65 - 114 2012.4

Joint Work

Authorship：Lead author

Biodegradable Nano-aggregates of Star-Shaped 8-arm PEG-PLLA Block Co-polymers for Encapsulation of Water-Soluble Macromolecules Reviewed

K. Nagahama, T. Saito, T. Ouchi, Y. Ohya

Journal of Biomaterials Science, Polymer Edition 22 407 2011.1

Joint Work

Authorship：Lead author

“生きたバイオマテリアル”としての機能性細胞 Invited Reviewed

長濱宏治

バイオマテリアル 28 193 2010.8

Single Work

Authorship：Lead author

Preparation of Nanoaggregates through Self-assembly of Amphiphilic Polyrotaxane Composed of PLLA–PEG–PLLA Triblock Copolymer and α-Cyclodextrins Reviewed

Koji Nagahama, Junpei Ohmura, Hiromi Sakaue, Tatsuro Ouchi, Yuichi Ohya and Nobuhiko Yui

Chemistry Letters 39 250 2010.4

Joint Work

Authorship：Lead author

Biodegradable poly(l-lactide)-grafted α-cyclodextrin copolymer displaying specific dye absorption by host-guest interact Reviewed

Koji Nagahama, Keiko Shimizu, Tatsuro Ouchi, Yuichi Ohya

Reactive and Functional Polymers 69 891 2009.10

Joint Work

Authorship：Lead author

Thermo-Sensitive Sol-Gel Transition of Poly(depsipeptide-co-lactide)-g-PEG Copolymers in Aqueous Solution Reviewed

Koji Nagahama, Yuichiro Imai, Teppei Nakayama, Junpei Ohmura, Tatsuro Ouchi, Yuichi Ohya

Polymer 50 3547 2009.10

Joint Work

Authorship：Lead author

Polyrotaxane Composed of Poly-L-Lactide and α-Cyclodextrin Exhibiting Protease-Triggered Hydrolysis Reviewed

Yuichi Ohya, Seigo Takamido, Koji Nagahama, Tatsuro Ouchi, Ryo Katoono, Nobuhiko Yui

Biomacromolecules 10 2261 2009.10

Joint Work

Hydrophobically Modified Biodegradable Poly(ethylene glycol) Copolymers that Form Temperature-Responsive Nanogels Reviewed

Koji Nagahama, Mihoko Hashizume, Hidetoshi Yamamoto, Tatsuro Ouchi, Yuichi Ohya

Langmuir 25 9734 2009.8

Joint Work

Authorship：Lead author

Biodegradable Shape-Memory Polymers Exhibiting Sharp Thermal Transitions and Controlled Drug Release Reviewed

Koji Nagahama, Yuichi Ueda, Tatsuro Ouchi, Yuichi Ohya

Biomacromolecules 10 1789 2009.8

Joint Work

Authorship：Lead author

Nuclease Resistant Methylphosphonate-DNA/LNA Chimeric Oligonucleotides Reviewed

Koji Nagahama, Rakesh Veedu, Jesper Wengel

Bioorganic and Medicinal Chemistry Letters 19 2707 2009.3

Joint Work

Authorship：Lead author

Effects of Polydepsipeptide Side-Chain Groups on the Temperature Sensitivity of Triblock Copolymers Composed of Polydepsipeptides and Poly(ethylene glycol) Reviewed

Yuichi Ohya, Hidetoshi Yamamoto, Koji Nagahama, Tatsuro Ouchi

Journal of Polymer Science, Part A: Polymer Chemistry 47 3892 2009.2

Joint Work

Temperature-Induced Hydrogel through Self-Assembly of Cholesterol-substituted Star PEG-b-PLLA Copolymers as an Injectable Scaffold for Tissue Engineering Reviewed

K. Nagahama, T. Ouchi, Y. Ohya,

Adv. Funct. Mater. 18 ( 8 ) 1220 - 1231 2008.11

Joint Work

Authorship：Lead author

Biodegradable Nanogels Prepared by Self-Assembly of Poly(L-Lactide)-Grafted Dextran: Entrapment and Release of Protein Reviewed

K. Nagahama, T. Ouchi, Y. Ohya,

Macromol. Biosci. 8 ( 11 ) 1044 - 1952 2008.11

Joint Work

Authorship：Lead author

Irreversible Temperature-Responsive Formation of High-strength Hydrogel from an Enantiomeric Mixture of Starburst Triblock Copolymers Consisting of 8-arm PEG and PLLA or PDLA Reviewed

K. Nagahama, K. Fujiura, S. Enami, T. Ouchi, Y. Ohya,

J. Polym. Sci. Part A Polym. Chem., 46 ( 18 ) 6317 - 6332 2008.11

Joint Work

Design of Polylactide-Based Hydrogels as Biodegradable Soft-Biomaterials

Koji NAGAHAMA

2008.3

Single Work

Impacts of Stereoregularity and Stereocomplex Formation on Physicochemical, Protein Adsorption and Cell Adhesion Behaviors of Star-Shaped 8-Arms Poly(ethylene glycol)-Poly(lactide) Block Copolymer Films Reviewed

K. Nagahama, Y. Nishimura, Y. Ohya,

Polymer, 48 ( 9 ) 2649 - 2658 2007.11

Joint Work

Authorship：Lead author

Exhibition of Soft and Tenacious Characters Based on Liquid Crystal Formation by Introduction of Cholesterol Groups on Biodegradable Lactide Copolymer Reviewed

K. Nagahama, Y. Ueda, T. Ouchi, Y. Ohya

Biomacromolecules, 8 ( 12 ) 3938 - 3943 2007.11

Joint Work

Authorship：Lead author

Molecular “Screw and Nut”: α-Cyclodextrin Recognizes Polylactide Chirality Reviewed

Y. Ohya, S. Takamido, K. Nagahama, T. Ouchi, T. Ooya, R. Katoono, N. Yui

Macromolecules, 40 ( 18 ) 6441 - 6444 2007.11

Joint Work

Biodegradable Nanogel Formation of Polylactide-Grafted Dextran Copolymer in Dilute Aqueous Solution and Enhancement of Its Stability by Stereocomplexation, Reviewed

K. Nagahama, Y. Mori Y. Ohya, T. Ouchi

Biomacromolecules 8 ( 7 ) 2135 - 2141 2007.11

Joint Work

Authorship：Lead author

The Suppression of Cell and Platelet Adhesion to Star-Shaped Poly(ethylene glycol)-Poly(L-lacitde) Block Copolymer Film, Reviewed

K. Nagahama, Y. Ohya, T. Ouchi,

Macromol. Biosci. 6 ( 6 ) 412 - 419 2006.11

Joint Work

Authorship：Lead author

Synthesis of Star-Shaped 8arms Poly(ethylene glycol)-Poly(L-lacitde) Block Copolymer and Physical Properties of Its Solution Cast Film as Soft Biomaterial Reviewed

K. Nagahama, Y. Ohya, T. Ouchi,

Polym. J., 38 ( 8 ) 852 - 860 2006.11

Joint Work

Authorship：Lead author

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