論文 - 川上 純司
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Kaoru Karasawa, Eva Duchoslav, Lyle Burton, Junji Kawakami, Takashi Baba
Analytical Chemistry 95 ( 44 ) 16352 - 16358 2023年10月
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Mitochondrial Dynamics of Bcl-2 Family Proteins during 17-β-Estradiol-Induced Apoptosis Correlate with the Malignancy of Endometrial Cancer Cells 査読あり
Takahiro Yaguchi, Misaki Kameno, Hirofumi Taira, and Junji Kawakami
Biochemstry 62 ( 21 ) 3041 - 3049 2023年10月
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複数種の液体クロマトグラフ質量分析計を用いたモデル核酸医薬品の分析データの比較 査読あり
Kenji Hirose, Tokuyuki Yoshida, Maki Terasaki, Hiroshi Sezaki, Kaoru Karasawa, Noriyuki Iwasaki, Kentaro Takahara, Naomi Takiguchi, Mitsuaki Sekiguchi, Hirokazu Nankai, Emi Saito, Hideaki Sato, Takashi Osawa, Takao Yamaguchi, Kosuke Ito, Junji Kawakami, Satoshi Obika, and Takao Inoue
54 439 - 454 2023年10月
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Not all 2',4'-bridged modifications stabilize DNA/RNA duplexes 査読あり
Tomoka Akita, Elisa Tomita-Sudo, Shin Itoh, Nae Sakimoto, Takeshi Masuda, Akifumi Nakamura, Yoshiyuki Onishi, Makoto Koizumi Junji Kawakami
Nucleosides, Nucleotides & Nucleic Acids 2023年3月
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Toshiyuki Goto, Shuhei Torii, Aoi Kondo, Kazumasa Kanda, Junji Kawakami, Yosky Kataoka, Takahito Nishikata
Journal of Developmental Biology 10 ( 1 ) 10 - 10 2022年2月
出版者・発行元：MDPI AG
In many animal species, the body axis is determined by the relocalization of maternal determinants, organelles, or unique cell populations in a cytoskeleton-dependent manner. In the ascidian first cell cycle, the myoplasm, including mitochondria, endoplasmic reticulum (ER), and maternal mRNAs, move to the future posterior side concomitantly (called ooplasmic segregation or cytoplasmic and cortical reorganization). This translocation consists of first and second phases depending on the actin and microtubule, respectively. However, the transition from first to second phase, that is, translocation of myoplasmic components from microfilaments to microtubules, has been poorly investigated. In this study, we analyzed the relationship between these cytoskeletons and myoplasmic components during the first cell cycle and their role in morphogenesis by inhibitor experiments. Owing to our improved visualization techniques, there was unexpected F-actin accumulation at the vegetal pole during this transition period. When this F-actin was depolymerized, the microtubule structure was strongly affected, the myoplasmic components, including maternal mRNA, were mislocalized, and the anteroposterior axis formation was disordered. These results suggested the importance of F-actin during the first cell cycle and the existence of interactions between microfilaments and microtubules, implying the enigmatic mechanism of ooplasmic segregation. Solving this mystery leads us to an improved understanding of ascidian early development.
DOI： 10.3390/jdb10010010
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Miho Takagi-Sato, Koji Morita, Yoshiyuki Onishi, Yuuka Watahiki, Taku Ishigaki, Tomoka Akita, Erisa Tomita, Junji Kawakami, Makoto Koizumi
Nucleosides, Nucleotides & Nucleic Acids 39 ( 6 ) 838 - 852 2020年6月
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好熱性細菌および酵母菌による多段階培養発酵技術から得られた 発酵エキスの皮膚に対する有用性 査読あり
川野 大地, 廖 筝筝, 聶 菁, 伊達 朗, Eduardo Perez, Jose Fernandez, Corey Webb, Kristen Huber, Jeffry B. Stock, 川上 純司, 付 子華
日本香粧品学会誌 44 ( 3 ) 194 - 202 2020年
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Different reactivity of Sp and Rp isomers of phosphorothioate-modified oligonucleotides in a duplex structure 査読あり
Md Ariful Islam, Aki Fujisaka, Junji Kawakami, Takao Yamaguchi, Satoshi Obika
Bioorg. Med. Chem. Lett. 30 ( 14 ) 127166 - 127166 2020年
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Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides 査読あり
T. Shimo, K. Tachibana, Y. Kawawaki, Y. Watahiki, T. Ishigaki, Y. Nakatsuji, T. Hara, J. Kawakami and S. Obika
Chem. Commun. 55 6850 - 6853 2019年4月
共著
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Influence of intracellular environment on allosteric ribozyme activity
Misaki Kameno, Mika Sawada, Nae Sakimoto and Junji Kawakami
Proc. 44th Intl. Symp. Nucleic Acid Chemistry 178 - 179 2017年11月
共著
担当区分：筆頭著者
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Quantification of stabilization effect of co-solutes on RNA tertiary interaction
Natsumi Sasaki, Daisuke Miyoshi and Junji Kawakami
Proc. 44th Intl. Symp. Nucleic Acid Chemistry 174 - 175 2017年11月
共著
担当区分：筆頭著者
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Quantitative relationship between chemical properties and bioactivities of anti-microRNA oligonucleotides targeted to tumor-associated microRNA-21 査読あり
Koji Nagahama, Kenta Iseda, Daichi Kawano, Junji Kawakami
BIOCHIMIE 137 124 - 131 2017年6月
共著
担当区分：最終著者, 責任著者 出版者・発行元：ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Synthetic anti-microRNA oligonucleotides (AMOs) are promising drug candidates to inactivate disease related microRNAs because of their sequence-specific binding to their targets and the variety of chemical modifications available. Over the last decade, the qualitative relationships between the chemical properties of AMOs and bioactivity (inactivation of their target miRNAs) have been studied to enhance their bioactivity. On the other hand, in real-world drug development, drugs must be designed case-by case, taking many factors into account. Thus, in order to design AMOs that target specific miRNA, understanding the quantitative relationship between the chemical properties of AMOs and inactivation of their target miRNA is necessary. Here, we aimed to find the specific quantitative relationship of AMOs targeted to tumor-associated miR-21 through direct comparison of their inactivation efficacies with systematically varied chemical properties, including sequence-specific binding affinity, nuclease resistance, and RNase H activation. As a result, we newly found the quantitative relationships; (1) sequence specific binding affinity of AMOs against miR-21 is the main determining factor for inactivation efficacy, (2) nuclease resistance of AMOs impacts their miR-21 inactivation efficacy acting cooperatively with the binding affinity, although nuclease resistance alone does not affect the miRNA inactivation efficacy, and (3) RNase H activation is unnecessary. This study also demonstrates the utility of the obtained relationship for the design of AMO-based drugs targeted to miR-21, through cell-based analyses. Thus, the obtained quantitative relationship would make it possible to predict the miR-21 inactivation efficacy of AMOs which are newly designed. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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Quantitative relationship between chemical properties and bioactivities of anti-microRNA oligonucleotides targeted to tumor-associated microRNA-21 査読あり
Koji Nagahama, Kenta Iseda, Daichi Kawano, Junji Kawakami
Biochimie 137 124 - 131 2017年3月
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担当区分：筆頭著者
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Influence of intracellular environment on allosteric ribozyme activity
M. Kameno, M. Sawada, N. Sakimoto, J. Kawakami
Proc. 44th Intl. Symp. Nucleic Acid Chemistry 178 - 179 2017年
共著
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Quantification of stabilization effect of co-solutes on RNA tertiary interaction
N. Sasaki, D. Miyoshi, J. Kawakami
Proc. 44th Intl. Symp. Nucleic Acid Chemistry 174 - 175 2017年
共著
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Characterization of functional RNA to perform self-cleavage reaction under low pH condition
N. Sakimoto, M. Kameno, N. Sasaki, J. Kawakami
Proc. 43rd Intl. Symp. Nucleic Acid Chemistry 284 - 285 2016年9月
共著
担当区分：筆頭著者
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Discovery of a new function of curcumin which enhances its anticancer therapeutic potency 査読あり
Koji Nagahama, Tomoya Utsumi, Takayuki Kumano, Saeko Maekawa, Naho Oyama, Junji Kawakami
Scientific Reports 6 30962 2016年8月
共著
DOI： 10.1038/srep30962
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Characterization of functional RNA to perform self-cleavage reaction under low pH condition
N. Sakimoto, M. Kameno, N. Sasaki, J. Kawakami
Proc. 43rd Intl. Symp. Nucleic Acid Chemistry 284 - 285 2016年
共著
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Discovery of a new function of curcumin which enhances its anticancer therapeutic potency
K. Nagahama, T. Utsumi, T. Kumano, S. Maekawa, N. Oyama, J. Kawakami
Scientific Reports 6 30962 2016年
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Self-Assembling Polymer Micelle/Clay Nanodisk/Doxorubicin Hybrid Injectable Gels for Safe and Efficient Focal Treatment of Cancer 査読あり
Koji Nagahama, Daichi Kawano, Naho Oyama, Ayaka Takemoto, Takayuki Kumano, Junji Kawakami
BIOMACROMOLECULES 16 ( 3 ) 880 - 889 2015年3月
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出版者・発行元：AMER CHEMICAL SOC
The purpose of this study was to fabricate a safe and effective doxorubicin (DOX)-delivery system for focal cancer chemotherapy. A novel biodegradable injectable gel was developed through self-assembly of poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer micelles, clay nanodisks (CNDs), and DOX. We discovered that DOX loaded in the hybrid gels acts as an anticancer drug and as a building block to organize new gel networks. Accordingly, long-term sustained release of DOX from hybrid injectable gels without initial burst release was achieved. Moreover, it was revealed that the DOX incorporated into gel networks controls its own release profile. This hybrid injectable gel is a self-controlled drug release system, which is a novel concept in controlled drug release. Importantly, a single injection of PLGA-PEG-PLGA/CND/DOX hybrid gel provides long-term sustained antitumor activity in vivo against human xenograft tumors in mice, suggesting the potential of hybrid gels as a valuable local DOX-delivery platform for cancer focal therapy.
DOI： 10.1021/bm5017805
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Comparison of Kinetic and Thermodynamic Analyses for Duplex Formation
E. Tomita, M. Sumimoto, S. Itoh, M. Takashima, and J. Kawakami
Proc. 42nd Intl. Symp. Nucleic Acid Chemistry 142 - 143 2015年
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Curcumisome nanovesicles generated by self-assembly of curcumin amphiphiles toward cancer theranostics
Koji Nagahama, Takayuki Kumano, Naho Oyama, Junji Kawakami
BIOMATERIALS SCIENCE 3 ( 12 ) 1566 - 1578 2015年
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出版者・発行元：ROYAL SOC CHEMISTRY
Curcumin (CCM) is an important molecule for achieving cancer theranostics because CCM is a naturally-occurring biocompatible material that exhibits both anticancer activity and strong fluorescence property that can be used for bio-imaging. However, CCM has never been utilized in clinical trials due to its extremely low water solubility, its rapid hydrolysis in aqueous conditions at neutral pH, and its low cellular uptake into cancer cells. Taking advantage of the strong hydrophobicity, p-conjugated frameworks, and ketone and enol groups that generate hydrogen bonds in CCM, we herein fabricated novel CCM-based biodegradable nanovesicles, which we termed as "curcumisome", through the self-assembly of amphiphilic CCM-poly(ethylene glycol) conjugates in aqueous media to develop multifunctional nanobiomaterials for use in cancer theranostics. A high CCM loading content in the curcumisomes was achieved, and the curcumisomes showed high water dispersibility with improved hydrolysis resistance. Importantly, the curcumisomes were effectively internalized into cancer cells and exhibited strong fluorescence for a long period, which is favorable for cancer cell imaging, although only a small amount of the curcumisomes penetrated into normal cells and showed very weak fluorescence. Moreover, curcumisomes effectively induced apoptosis of cancer cells. Thus, curcumisomes may act as multifunctional nanobiomaterials for the development of CCM-based cancer theranostics.
DOI： 10.1039/c5bm00212e
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Thermodynamic Features Provided by an ENA Introduction to Nucleic Acid Drugs
E. Tomita, M. Sumimoto, and J. Kawakami
Proc. 41st Intl. Symp. Nucleic Acid Chemistry 188 - 189 2014年11月
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担当区分：筆頭著者
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Effects of oligonucleotide length and locked nucleic acid content on splice-switching oligonucleotide activity
T. Shimo, K. Tachibana, K. Saito, T. Yoshida, E. Tomita, R. Waki, T. Yamamoto, T. Doi, T. Inoue, J. Kawakami, and S. Obika
Proc. 41st Intl. Symp. Nucleic Acid Chemistry 332 - 333 2014年11月
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A novel ribozyme core to perform self-cleavage reaction
S. Tanaka, N. Sakimoto, M. Kameno, N. Sasaki, and J. Kawakami
Proc. 41st Intl. Symp. Nucleic Acid Chemistry 340 - 341 2014年11月
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担当区分：筆頭著者
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Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro 査読あり
T. Shimo, K. Tachibana, K. Saito, T. Yoshida, E. Tomita, R. Waki, T. Yamamoto, T. Doi, T. Inoue, J. Kawakami and S. Obika
Nucleic Acids Res. 42 8174 - 8187 2014年6月
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Thermodynamic Features Provided by an ENA Introduction to Nucleic Acid Drugs
E. Tomita, M. Sumimoto, J. Kawakami
Proc. 41st Intl. Symp. Nucleic Acid Chemistry 188 - 189 2014年
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Positional Effect of 2',4'-BNA/LNA Introduction into DNA/RNA Duplexes on Thermodynamic Parameters
S. Tahara, E. Tomita, H. Nagai, S. Obika, and J. Kawakami
Proc. 40th Intl. Symp. Nucleic Acid Chemistry 190 - 191 2013年11月
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担当区分：筆頭著者
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Specific recognition of cytosine by hypoxanthine in pyrrolidinyl peptide nucleic acid 査読あり
C. Vilaivan, W. Srinarang, N. Yotapan, W. Mansawat, C. Boonlua, J. Kawakami, Y. Yamaguchi, Y. Tanaka, and T. Vilaivan
Org. Biomol. Chem. 11 2310 - 2317 2013年
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Construction of a trans-acting system of a L-histidine dependent ribozyme based on the secondary structure
S. Tanaka, Y. Yamaguchi, R. Takamine, and J. Kawakami
Proc. 39th Intl. Symp. Nucleic Acid Chemistry 234 - 235 2012年11月
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担当区分：筆頭著者
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Structure-function relationship of a histidine dependent ribozyme
Y. Yamaguchi, Y. Ishibashi, S. Tanaka, A. Tanigawa, I. Matsunaga, and J. Kawakami
Proc. 38th Intl. Symp. Nucleic Acids Chemistry 194 - 195 2011年11月
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担当区分：筆頭著者
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Triplet analysis that identifies unpaired regions of functional RNAs（共著） 査読あり
J. Kawakami, Y. Yamaguchi, and N. Sugimoto
Journal of Nucleic Acids 2011 doi:10.4061/2011/471843 2011年10月
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Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone - A conformationally constrained PNA with unusual hybridization properties
C. Vilaivan, C. Srisuwannaket, C. Ananthanawat, C. Suparpprom, J. Kawakami, Y. Yamaguchi, Y. Tanaka, T. Vilaivan
Artificial DNA: PNA & XNA 2 11 2011年
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Comparative thermodynamic analysis of RNA-protein interaction on surface and in solution（共著）
Y. Tanaka, K. Ishidate, K. Kishimoto, N. Sugimoto, and J. Kawakami
Proc. 37th Intl. Symp. Nucleic Acids Chemistry 276 - 277 2010年11月
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担当区分：筆頭著者
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Accurate curve fitting procedure for UV melting analysis of highly thermostable RNA hairpins（共著）
J. Kawakami, Y. Tanaka, and K. Kishimoto
Nucleic Acids Symp. Ser. 53 227 - 228 2009年9月
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Recognition of a flipped base in a hairpinloop DNA by a small peptide （共著） 査読あり
J. Kawakami, S. Okabe, Y. Tanabe, and N. Sugimoto
Nucleoside, Nucleotides and Nucleic Acids 27 292 - 308 2008年2月
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Functional role of the cofactor on activation process of L-histidine dependent ribozyme（共著）
J. Kawakami, C. Maiya, and N. Sugimoto
Nucleic Acids Symp. Ser. 50 241 - 242 2006年11月
共著
担当区分：筆頭著者
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A novel stable RNA pentaloop that interacts specifically with a motif peptide of lambda-N protein（共著） 査読あり
J. Kawakami, H. Tokitoh, Y. Tanabe, and N. Sugimoto
Nucleoside, Nucleotides and Nucleic Acids 25 397 - 416 2006年4月
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Specific recognition of the basic N peptide by an RNA（共著）
J. Kawakami, H. Tokitoh, Y. Tanabe, and N. Sugimoto
Nucleic Acids Symposium Series 49 353 - 354 2005年9月
共著
担当区分：筆頭著者
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Thermodynamic analysis of duplex formation of the heterochiral DNA with L-deoxyadenosine（共著） 査読あり
J. Kawakami, K. Tsujita, and N. Sugimoto
Analytical Sciences 21 ( 2 ) 77 - 82 2005年2月
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担当区分：筆頭著者
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Introduction of peptide function into DNA by Nucleic Acid Peptides, NAPs（共著）
J. Kawakami, Z.-M. Wang, H. Fujiki, S. Izumi, and N. Sugimoto
Chemistry Letters 33 ( 12 ) 1554 - 1555 2004年12月
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Stabilization of a DNA duplex under molecular crowding conditions of PEG （共著）
H. Karimata, S. Nakano, T. Ohmichi, J. Kawakami, and N. Sugimoto
Nucleic Acids Symp. Ser. 48 107 - 108 2004年11月
共著
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Analysis of the secondary structure of a ribozyme that requires His as a cofactor（共著）
J. Kawakami, C. Maiya, and N. Sugimoto
Nucleic Acids Symp. Ser. 48 203 - 204 2004年11月
共著
担当区分：筆頭著者
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The effect of molecular crowding with nucleotide length and cosolute structure on DNA duplex stability（共著） 査読あり
S. Nakano, H. Karimata, T. Ohmichi, J. Kawakami, and N. Sugimoto
Journal of American Chemical Society 126 14330 - 14331 2004年10月
共著
DOI： 10.1021/ja0463029
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Novel biomaterials derived from deoxyribozyme and NAPzyme 査読あり
Y. Okumoto, H. Fujiki, J. Kawakami, S. Nakashima, S. Nakano, T. Ohmichi, D. Miyoshi and N. Sugimoto
Macromol. Chem. Phys., Macromol. Symp. 201 245 - 252 2003年
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A Stable DNA Tetraloop and Its Structural Tolerance for Modification
KAWAKAMI Junji, YONEYAMA Mari, MIYOSHI Daisuke, SUGIMOTO Naoki
Chemistry letters 2001 ( 3 ) 258 - 259 2001年3月
出版者・発行元：The Chemical Society of Japan
Structural features of a stable hairpin DNA with a tetraloop, dAGGC(TTCG)GCCT (CORE), and its six abasic mutants were investigated by the melting behavior of the UV absorption and circular dichroism spectra. The CORE and an abasic mutant at the second position of the loop exhibit considerable thermodynamic stability and have similar structural features suggesting the same folding with an identical base orientation of the two hairpin DNAs except for the second base in the loop.
DOI： 10.1246/cl.2001.258
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Utilization of ribozymes for loss-of-function analyses of the early development of the ascidian Ciona intestinalis
M. Katano, A. Yamada, K. J. Tanaka, A. Murakami, K. Taira, J. Kawakami, N. Sugimoto and T. Nishikata
Mem. Konan Univ., Sci. Eng. Ser. 48 11 - 20 2001年
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Thermodynamic stability of base pairs between 2-hydroxyadenine and incoming nucleotides as a determinant of nucleotide incorporation specificity during replication 査読あり
J. Kawakami, H. Kamiya, K. Yasuda, H. Fujiki, H. Kasai and N. Sugimoto
Nucleic Acids Research 29 3289 - 3296 2001年
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In vitro selection of aptamers that act with Zn2+ 査読あり
J. Kawakami, H. Imanaka, Y. Yokota and N. Sugimoto
J. Inorg. Biochem. 82 197 - 206 2000年
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A selection of short peptides that interact with a porphyrin as a small target by immobilized phage display 査読あり
J. Kawakami, T. Kitano and N. Sugimoto
Chem. Commun. 1765 - 1766 1999年
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Development of New Biotechnology for the 21st Century ((]G0002[))-Structural and thermodynamic studies of PNA/DNA hybrids containing single bulge nucleotides-
Junji Kawakami
Mem, Konan Univ., Sci. Ser. 46 61 1999年
単著
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Stability of DNA duplexes containing mirror-image DNA
J. Kawakami, K. Tsujita and N. Sugimoto
Nucleic Acids Symp. Ser. 39 55 - 56 1998年
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生命関連分子の微視的相互作用(4)-ミスマッチを含むRNA/DNAハイブリッドの安定性に及ぼすミスマッチの隣接塩基対の影響-
川上 純司
甲南大学紀要,理学編 45 135 1998年
単著
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Minimization of genomic human hepatitis delta virus ribozyme 査読あり
H. Fauzi, A. Chiba, F. Nishikawa, M. Roy, J. Kawakami and S. Nishikawa
Anal. Chim. Acta 365 309 - 317 1998年
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In vitro selection of aptamers that recognize a monosaccharide
J. Kawakami, Y. Kawase and N. Sugimoto
Anal. Chim. Acta 365 95 - 100 1998年
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Evolution of a phosphorothioate RNA library during in vitro selection
J. Kawakami and N. Sugimoto
Nucleic Acids Symp. Ser. 37 201 - 202 1997年
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Analysis of the cleavage reaction of a trans-acting human hepatitis delta virus ribozyme 査読あり
H. Fauzi, J. Kawakami, F. Nishikawa and S. Nishikawa
Nucleic Acids Research 25 3124 - 3130 1997年
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Selection in vitro of trans-acting genomic human hepatitis delta virus (HDV) ribozymes 査読あり
F. Nishikawa, J. Kawakami, A. Chiba, K. Yuda, M. Shirai, P.K.R. Kumar and S. Nishikawa
Eur. J. Biochem. 327 712 - 718 1996年
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Constructing an efficient trans-acting genomic HDV ribozyme 査読あり
J. Kawakami, K. Yuda, Y.-A. Suh, P.K.R. Kumar, F. Nishikawa, H. Maeda, K. Taira, E. Ohtsuka and S. Nishikawa
FEBS Lett. 394 132 - 136 1996年
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生命関連分子の微視的相互作用(I)-バルジを含むDNA二重らせんの熱力学的安定性に及ぼすイノシン置換の影響-
川上 純司
甲南大学紀要,理学編 43 37 - 47 1996年
単著
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ANALYSIS OF FUNCTIONAL STRUCTURE OF HDV RIBOZYME BY MODIFICATION INTERFERENCE AND IN-VITRO SELECTION-STRATEGIES
S NISHIKAWA, YH JEOUNG, P KUMAR, J KAWAKAMI, F NISHIKAWA, A CHIBA, K YUDA, P VILLJANEN, K TAIRA
JOURNAL OF CELLULAR BIOCHEMISTRY 19A 227 - 227 1995年1月
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Designing of HDV ribozyme by in vitro selection 査読あり
S. Nishikawa, F. Nishikawa, J. Kawakami, A. Chiba, K. Yuda, Y.-H. Jeoung, P.K.R. Kumar and K. Taira
Antisense Research and Development 54 104 - 105 1995年
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ヒトδ型肝炎ウイルス（HDV）リボザイムの構造活性相関に関する研究
川上純司
1994年3月
単著
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Monoclonal antibodies with affinity to self-complementary left-handed DNA containing cyclonucleosides with high anti conformation 査読あり
J. Kawakami, S. Uesugi, M. Ikehara, T. Itoh, K. Miura and E. Ohtsuka
Nucleosides & Nucleotides 13 421 - 427 1994年
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Systematic substitution of individual bases in two important single-stranded regions of the HDV ribozyme for evaluation of the role of specific bases 査読あり
Y.-A. Suh, P.K.R. Kumar, J. Kawakami, F. Nishikawa, K. Taira, and S. Nishikawa
FEBS Lett. 326 158 - 162 1993年
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Chemical probing studies of the hepatitis delta virus (HDV) genomic ribozyme
S. Nishikawa, P.K.R. Kumar, Y.-H. Jeong, J. Kawakami, F. Nishikawa, Y.-A. Suh, E. Ohtsuka and K. Taira
Nucleic Acids Symp. Ser. 29 119 - 120 1993年
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Identification of important bases in a single-stranded region (SSrC) of the hepatitis delta ribozyme 査読あり
J. Kawakami, P.K.R. Kumar, Y.-A. Suh, F. Nishikawa, K. Kawakami, K. Taira, E. Ohtsuka and S. Nishikawa
Eur. J. Biochem. 217 29 - 36 1993年
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Random mutations to evaluate the role of bases at two important single-stranded regions of genomic HDV ribozyme 査読あり
P.K.R. Kumar, Y.-A. Suh, H. Miyashiro, F. Nishikawa, J. Kawakami, K. Taira and S. Nishikawa
Nucleic Acids Research 20 3919 - 3924 1992年
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Ribozymes as molecular scissors for suppressing AIDS virus 査読あり
J. Ohkawa, T. Shimayama, N. Yuyama, S. Sawata, Y. Takagi, A. Wada, K. Yasuda, J. Kawakami, P.K.R. Kumar, Y.-A. Suh, F. Nishikawa, M. Oda, S. Shinshi, M. Uebayashi, T. Uchimaru, K. Furukawa, S. Nishikawa and K. Taira
Now & Future 8 8 - 12 1992年
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Identification of important bases for the self-cleavage activity at two single-stranded regions of genomic HDV ribozyme
Junji Kawakami
Nucleic Acids Symposium Series 27 41 1992年
単著