論文 - 川内 敬子
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Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments. 査読あり 国際誌
Takeru Torii, Wataru Sugimoto, Katsuhiko Itoh, Natsuki Kinoshita, Masaya Gessho, Toshiyuki Goto, Ikuno Uehara, Wataru Nakajima, Yemima Budirahardja, Daisuke Miyoshi, Takahito Nishikata, Nobuyuki Tanaka, Hiroaki Hirata, Keiko Kawauchi
Cell death & disease 14 ( 11 ) 766 - 766 2023年11月
共著
担当区分：最終著者, 責任著者
Tumor suppressor p53 plays a central role in response to DNA damage. DNA-damaging agents modulate nuclear actin dynamics, influencing cell behaviors; however, whether p53 affects the formation of nuclear actin filaments remains unclear. In this study, we found that p53 depletion promoted the formation of nuclear actin filaments in response to DNA-damaging agents, such as doxorubicin (DOXO) and etoposide (VP16). Even though the genetic probes used for the detection of nuclear actin filaments exerted a promotive effect on actin polymerization, the detected formation of nuclear actin filaments was highly dependent on both p53 depletion and DNA damage. Whilst active p53 is known to promote caspase-1 expression, the overexpression of caspase-1 reduced DNA damage-induced formation of nuclear actin filaments in p53-depleted cells. In contrast, co-treatment with DOXO and the pan-caspase inhibitor Q-VD-OPh or the caspase-1 inhibitor Z-YVAD-FMK induced the formation of nuclear actin filament formation even in cells bearing wild-type p53. These results suggest that the p53-caspase-1 axis suppresses DNA damage-induced formation of nuclear actin filaments. In addition, we found that the expression of nLifeact-GFP, the filamentous-actin-binding peptide Lifeact fused with the nuclear localization signal (NLS) and GFP, modulated the structure of nuclear actin filaments to be phalloidin-stainable in p53-depleted cells treated with the DNA-damaging agent, altering the chromatin structure and reducing the transcriptional activity. The level of phosphorylated H2AX (γH2AX), a marker of DNA damage, in these cells also reduced upon nLifeact-GFP expression, whilst details of the functional relationship between the formation of nLifeact-GFP-decorated nuclear actin filaments and DNA repair remained to be elucidated. Considering that the loss of p53 is associated with cancer progression, the results of this study raise a possibility that the artificial reinforcement of nuclear actin filaments by nLifeact-GFP may enhance the cytotoxic effect of DNA-damaging agents in aggressive cancer cells through a reduction in gene transcription.
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Development of a pseudo-cellular system to quantify specific interactions determining G-quadruplex function in cells. 査読あり 国際誌
Journal of the American Chemical Society 146 ( 12 ) 8005 - 8015 2024年2月
共著
出版者・発行元：Journal of the American Chemical Society
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Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci. 査読あり 国際誌
Ryota Nomura, Yuto Suehiro, Fumikazu Tojo, Saaya Matayoshi, Rena Okawa, Masakazu Hamada, Shuhei Naka, Michiyo Matsumoto-Nakano, Rika Unesaki, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Tatsuya Akitomo, Chieko Mitsuhata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano
International journal of molecular sciences 25 ( 2 ) 2024年1月
Shikonin is extracted from the roots of Lithospermum erythrorhizon, and shikonin extracts have been shown to have inhibitory effects on several bacteria. However, shikonin extracts are difficult to formulate because of their poor water solubility. In the present study, we prepared a shikonin dispersion, which was solubilized by the inclusion of β-1,3-1,6 glucan, and analysed the inhibitory effects of this dispersion on Streptococcus mutans and non-mutans streptococci. The shikonin dispersion showed pronounced anti-S. mutans activity, and inhibited growth of and biofilm formation by this bacterium. The shikonin dispersion also showed antimicrobial and antiproliferative effects against non-mutans streptococci. In addition, a clinical trial was conducted in which 20 subjects were asked to brush their teeth for 1 week using either shikonin dispersion-containing or non-containing toothpaste, respectively. The shikonin-containing toothpaste decreased the number of S. mutans in the oral cavity, while no such effect was observed after the use of the shikonin-free toothpaste. These results suggest that shikonin dispersion has an inhibitory effect on S. mutans and non-mutans streptococci, and toothpaste containing shikonin dispersion may be effective in preventing dental caries.
DOI： 10.3390/ijms25021075
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Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite. 査読あり 国際誌
Momoko Usuda, Mariko Kametani, Masakazu Hamada, Yuto Suehiro, Saaya Matayoshi, Rena Okawa, Shuhei Naka, Michiyo Matsumoto-Nakano, Tatsuya Akitomo, Chieko Mitsuhata, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano, Ryota Nomura
International journal of molecular sciences 24 ( 14 ) 2023年7月
Hydroxyapatite adsorbs various substances, but little is known about the effects on oral bacteria of adsorption onto hydroxyapatite derived from scallop shells. In the present study, we analyzed the effects of adsorption of Streptococcus mutans onto scallop-derived hydroxyapatite. When scallop-derived hydroxyapatite was mixed with S. mutans, a high proportion of the bacterial cells adsorbed onto the hydroxyapatite in a time-dependent manner. An RNA sequencing analysis of S. mutans adsorbed onto hydroxyapatite showed that the upregulation of genes resulted in abnormalities in pathways involved in glycogen and histidine metabolism and biosynthesis compared with cells in the absence of hydroxyapatite. S. mutans adsorbed onto hydroxyapatite was not killed, but the growth of the bacteria was inhibited. Electron microscopy showed morphological changes in S. mutans cells adsorbed onto hydroxyapatite. Our results suggest that hydroxyapatite derived from scallop shells showed a high adsorption ability for S. mutans. This hydroxyapatite also caused changes in gene expression related to the metabolic and biosynthetic processes, including the glycogen and histidine of S. mutans, which may result in a morphological change in the surface layer and the inhibition of the growth of the bacteria.
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The iron chelator deferriferrichrysin induces paraptosis via extracellular-signal-regulated kinase activation in cancer cells 査読あり 国際共著
Kinoshita N, Gessho M, Torii T, Ashida Y, Akamatsu M, Guo AK, Lee S, Katsuno T, Nakajima W, Budirahardja Y, Miyoshi D, Todokoro T, Ishida H, Nishikata T, Kawauchi K
Genes to Cells 28 ( 9 ) 653 - 662 2023年6月
担当区分：最終著者, 責任著者
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Simple and fast screening for structure-selective G-quadruplex ligands. 査読あり 国際誌
Yoshiki Hashimoto, Yoshiki Imagawa, Kaho Nagano, Ryuichi Maeda, Naho Nagahama, Takeru Torii, Natsuki Kinoshita, Nagisa Takamiya, Keiko Kawauchi, Hisae Tatesishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Chemical communications (Cambridge, England) 59 ( 33 ) 4891 - 4894 2023年4月
共著
Structural selectivity of G-quadruplex ligands is essential for cellular applications since there is an excess of nucleic acids forming duplex structures compared to G-quadruplex structures in living cells. In this study, we developed new structure-selective G-quadruplex ligands utilizing a simple and fast screening system. The affinity, selectivity, enzymatic inhibitory activity and cytotoxicity of the structure-selective G-quadruplex ligands were demonstrated along with a structural selectivity-cytotoxicity relationship of G-quadruplex ligands.
DOI： 10.1039/d3cc00556a
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Controlling liquid-liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner. 査読あり 国際誌
Mitsuki Tsuruta, Takeru Torii, Kazuki Kohata, Keiko Kawauchi, Hisae Tateishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Chemical communications (Cambridge, England) 58 ( 93 ) 12931 - 12934 2022年11月
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We constructed a minimum liquid-liquid phase separation model system to form liquid droplets using only G-quadruplex-forming oligonucleotides and R- and G-rich oligopeptides. We found that the G-quadruplex structure is an essential component for RNA to form droplets with the peptide. Based on this model system and our findings, droplet redissolution via structure transition from a G-quadruplex to a duplex was achieved in a sequence-specific manner.
DOI： 10.1039/d2cc04366a
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Wataru Sugimoto, Natsuki Kinoshita, Minori Nakata, Tatsuya Ohyama, Hisae Tateishi-Karimata, Takahito Nishikata, Naoki Sugimoto, Daisuke Miyoshi, Keiko Kawauchi
Chemical Communications 58 ( 1 ) 48 - 51 2022年1月
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担当区分：最終著者, 責任著者 出版者・発行元：Royal Society of Chemistry (RSC)
We identified cytosine-rich regions adjacent to guanine-rich regions in the TMPRSS2 gene, which showed structural competition between a G-quadruplex and a hairpin loop. Furthermore, this competition significantly affected transcription efficiency.
DOI： 10.1039/d1cc05523b
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Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells 査読あり 国際誌
Dobrokhotov O, Sunagawa M, Torii T, Mii S, Kawauch K, Enomoto A, Sokabe M, Hirata H.
Frontiers in Cell and Developmental Biology 11 2021年11月
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Detection of Intracellular Reactive Oxidative Species Using the Fluorescent Probe Hydroxyphenyl Fluorescein 招待あり 査読あり 国際誌
Wataru Sugimoto, Daisuke Miyoshi, Keiko Kawauchi
Methods Mol Biol. 2274 207 - 215 2021年5月
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Novel Strategy of Photodynamic Therapy Targeting RAS mRNA with G-Quadruplex Ligands for Cancer Treatment 招待あり 査読あり 国際誌
Takeru Torii, Wataru Sugimoto, Keiko Kawauchi, Daisuke Miyoshi
Journal of Data Mining in Genomics & Proteomics 11 ( 2 ) 2020年8月
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担当区分：責任著者
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MMP24 as a Target of YAP is a Potential Prognostic Factor in Cancer Patients 査読あり 国際誌
Wataru Sugimoto, Katsuhiko Ito, Hiroaki Hirata, Yoshinori Abe, Takeru Torii, Yasumasa Mitsui, Yemima Budirahardja, Nobuyuki Tanaka, Keiko Kawauchi
Bioengineering 7 ( 18 ) 1 - 12 2020年2月
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DMPK is a new candidate mediator of tumor suppressor p53-dependent cell death. 査読あり 国際誌
Itoh K, Ebata T, Hirata H, Torii T, Sugimoto W, Onodera K, Nakajima W, Uehara I, Okuzaki D, Yamauchi S, Budirahardja Y, Nishikata T, Tanaka N, Kawauchi K
Molecules (Basel, Switzerland) 24 ( 17 ) 2019年9月
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Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity. 査読あり 国際誌
Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald FL, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y.
Science Adv. 5 2019年9月
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Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells. 査読あり 国際誌
Araki K, Kawauchi K, Sugimoto W, Tsuda D, Oda H, Yoshida R, Ohtani K.
Communications Biol. 6 550 - 561 2019年1月
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An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex 査読あり 国際誌
Kawauchi K, Sugimoto W, Yasui T, Murata K, Itoh K, Takagi K, Tsuruoka T, Akamatsu K, Tateishi-Karimata H, Sugimoto N, Miyoshi D.
Nature Commun. 9 2271 2018年6月
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担当区分：筆頭著者, 責任著者
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Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2. 査読あり 国際誌
Sugimoto W, Itoh K, Mitsui Y, Ebata T, Fujita H, Hirata H, Kawauchi K
Cell adhesion & migration 12 ( 2 ) 101 - 108 2018年3月
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Nanocomposite injectable gels capable of self-replenishing regenerative extracellular microenvironments for in vivo tissue engineering 査読あり 国際誌
Koji Nagahama, Naho Oyama, Kimika Ono, Atsushi Hotta, Keiko Kawauchi, Takahito Nishikata
Biomater Sci. 6 550 - 561 2018年2月
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Destabilization of DNA G-quadruplexes by chemical environment changes during tumor progression facilitates transcription 査読あり 国際誌
Hisae Tateishi-Karimata, Keiko Kawauchi, Naoki Sugimoto
J Am Chem Soc. 140 642 - 651 2018年1月
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NF-kappaB prevents oncogenic Ras-induced b-actin cleavage in p53-deficient cells 査読あり
Wataru Sugimoto, Katsuhiko Itoh, Toshiya Kotari, Alvin K. Guo,Takahiro Ebata, Hiroaki Hirata, Keiko Kawauchi
International Journal of Cancer & Cellular Biology Research 2 ( 1 ) 15 - 18 2017年5月
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Substrate stiffness influences doxorubicin- induced p53 activation via ROCK2 expression 査読あり
Ebata T, Mitsui Y, Sugimoto W, Maeda M, Araki K, Machiyama H, Harada I, Sawada Y, Fujita H, Hirata H, Kawauchi K
BioMed Research International 2017年1月
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MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility. 査読あり
Hirata H, Ku WC, Yip AK, Ursekar CP, Kawauchi K, Roy A, Guo AK, Vedula SR, Harada I, Chiam KH, Ishihama Y, Lim CT, Sawada Y, Sokabe M
Journal of Cell Science 129 ( 19 ) 3574 - 3582 2016年10月
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DOI： 10.1242/jcs.189415
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Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling.
Ebata T, Hirata H, Kawauchi K
BioMed research international 2016 9231057 2016年
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p53 regulates cytoskeleton remodeling to suppress tumor progression.
Araki K, Ebata T, Guo AK, Tobiume K, Wolf SJ, Kawauchi K
Cellular and molecular life sciences : CMLS 72 ( 21 ) 4077 - 4094 2015年11月
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Understanding p53: new insights into tumor suppression.
Kawauchi K, Wolf SJ
Expert review of anticancer therapy 14 ( 10 ) 1101 - 1103 2014年10月
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Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers.
Higuchi S, Watanabe TM, Kawauchi K, Ichimura T, Fujita H
Journal of bioscience and bioengineering 117 ( 6 ) 749 - 755 2014年6月
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Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization.
Araki K, Kawauchi K, Hirata H, Yamamoto M, Taya Y
eLife 2 e01228 2013年12月
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Myosin II-dependent exclusion of CD45 from the site of Fcγ receptor activation during phagocytosis.
Yamauchi S, Kawauchi K, Sawada Y
FEBS letters 586 ( 19 ) 3229 - 3235 2012年9月
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p130Cas-dependent actin remodelling regulates myogenic differentiation.
Kawauchi K, Tan WW, Araki K, Abu Bakar FB, Kim M, Fujita H, Hirata H, Sawada Y
The Biochemical journal 445 ( 3 ) 323 - 332 2012年8月
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Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts.
Watanabe TM, Higuchi S, Kawauchi K, Tsukasaki Y, Ichimura T, Fujita H
Biochemical and biophysical research communications 418 ( 4 ) 742 - 747 2012年2月
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Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3.
Ando M, Uehara I, Kogure K, Asano Y, Nakajima W, Abe Y, Kawauchi K, Tanaka N
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 77 ( 2 ) 97 - 105 2010年4月
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The molecular mechanism of glucose metabolism hampered by p53 tumor suppressor protein.
Kawauchi K
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 77 ( 1 ) 48 - 49 2010年2月
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Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification.
Kawauchi K, Araki K, Tobiume K, Tanaka N
Proceedings of the National Academy of Sciences of the United States of America 106 ( 9 ) 3431 - 3436 2009年3月
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IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors. 査読あり
Araki K, Kawauchi K, Tanaka N
Oncogene 27 ( 43 ) 5696 - 5705 2008年9月
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Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation.
Kawauchi K, Araki K, Tobiume K, Tanaka N
Biochemical and biophysical research communications 372 ( 1 ) 137 - 141 2008年7月
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Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibition-induced apoptosis in PC12 cells.
Kawauchi K, Tobiume K, Iwashita K, Inagaki H, Morikawa T, Shibukawa Y, Moriyama Y, Hirata H, Kamata H
Bioscience, biotechnology, and biochemistry 72 ( 6 ) 1564 - 1570 2008年6月
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p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
Kawauchi K, Araki K, Tobiume K, Tanaka N
Nature cell biology 10 ( 5 ) 611 - 618 2008年5月
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Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.
Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N
Proceedings of the National Academy of Sciences of the United States of America 105 ( 12 ) 4838 - 4843 2008年3月
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Suppression of AP-1 activity by cycloprodigiosin hydrochloride.
Kawauchi K, Tobiume K, Kaneko S, Kaneshiro K, Okamoto S, Ueda E, Kamata H, Moriyama Y, Hirata H
Biological & pharmaceutical bulletin 30 ( 9 ) 1792 - 1795 2007年9月
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The negative regulation of p53 by hedgehog signaling 査読あり
Abe Yoshinori, Oda-Sato Eri, Tobiume Kei, Kawauchi Keiko, Okamoto Koji, Taya Yoichi, Tanaka Nobuyuki
CANCER RESEARCH 66 ( 8 ) 2006年4月
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Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.
Qu X, Kawauchi-Kamata K, Miah SM, Hatani T, Yamamura H, Sada K
Biochemistry 44 ( 10 ) 3891 - 3898 2005年3月
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Cycloprodigiosin up-regulates inducible nitric oxide synthase gene expression in hepatocytes stimulated by interleukin-1beta.
Teshima S, Nakanishi H, Kamata K, Kaibori M, Kwon AH, Kamiyama Y, Nishizawa M, Ito S, Okumura T
Nitric oxide : biology and chemistry 11 ( 1 ) 9 - 16 2004年8月
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Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation.
Kyo S, Sada K, Qu X, Maeno K, Miah SM, Kawauchi-Kamata K, Yamamura H
Genes to cells : devoted to molecular & cellular mechanisms 8 ( 10 ) 825 - 836 2003年10月
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Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase.
Maeno K, Sada K, Kyo S, Miah SM, Kawauchi-Kamata K, Qu X, Shi Y, Yamamura H
The Journal of biological chemistry 278 ( 27 ) 24912 - 24920 2003年7月
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Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops.
Kamata H, Manabe T, Oka Si, Kamata K, Hirata H
FEBS letters 519 ( 1-3 ) 231 - 237 2002年5月
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Synergistic effects induced by cycloprodigiosin hydrochloride and epirubicin on human breast cancer cellsYamamoto D 査読あり
Tanaka K, Nakai K, Baden T, Inoue K, Yamamoto C, Takemoto H, Kamata K, Hirata H, Morikawa S, Inubushi T, Hioki K
Breast Cancer Research and Treatment 72 2002年
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Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB 査読あり
Kamata K, Okamoto S, Oka S, Kamata H, Yagisawa H, Hirata H
FEBS Letters 507 2001年
担当区分：筆頭著者
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Cycloprodigiosin hydrochloride, a H+/Cl- symporter, induces apoptosis in human colon cancer cell lines in vitro
Yamamoto C, Takemoto H, Kuno K, Yamamoto D, Nakai K, Baden T, Kamata K, Hirata H, Watanabe T, Inoue K
Oncology Reports 8 2001年
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Cycloprodigiosin hydrochloride, H(+)/CL(-) symporter, induces apoptosis and differentiation in HL-60 cells 査読あり
Yamamoto D, Uemura Y, Tanaka K, Nakai K, Yamamoto C, Takemoto H, Kamata K, Hirata H, Hioki K
International Journal of Cancer 88 2000年
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N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases 査読あり
Oka S, Kamata H, Kamata K, Yagisawa H, Hirata H
FEBS Letters 2000年
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Demonstration of Cl- requirement for inhibition of vacuolar acidification by cycloprodigiosin in situ 査読あり
Nakayasu T, Kawauchi K, Hirata H, Shimmen T
Plant & Cell Physiol 41 2000年
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Cycloprodigiosin hydrochloride, a new H(+)/Cl(-) symporter, induces apoptosis in human and rat hepatocellular cancer cell lines in vitro and inhibits the growth of hepatocellular carcinoma xenografts in nude mice 査読あり
Yamamoto C, Takemoto H, Kuno K, Yamamoto D, Tsubura A, Kamata K, Hirata H, Yamamoto A, Kano H, Seki T, Inoue K
Hepatology 1999年
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Cycloprodigiosin hydrochloride inhibits acidification of plant vacuole 査読あり
Nakayasu T, Kawauchi K, Hirata H, Shimmen T
Plant & Cell Physiol 40 1999年
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Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent 査読あり
Kim HS, Hayashi M, Shibata Y, Wataya Y, Mitamura T, Horii T, Kawauchi K, Hirata H, Tsuboi S, Moriyama Y
Biol. Pharm. Bull 22 1999年
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Cycloprodigiosin uncouples H+-pyrophosphatase of plant vacuolar membranes in the presence of chloride ionMaeshima 査読あり
M, Nakayasu, T, Kawauchi, K, Hirata, H, Shimmen, T
Plant & Cell Physiol 1999年
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A possible immunosuppressant, cycloprodigiosin hydrochloride, obtained from Pseudoalteromonas denitrificans 査読あり
Kawauchi K, Shibutani K, Yagisawa H, Kamata H, Nakatsuji S, Anzai H, Yokoyama Y, Ikegami Y, Moriyama Y, Hirata H
Biochem. Biophys. Res. Commun, 237 1997年
担当区分：筆頭著者